Best Large Grants for Nonprofit Organizations

The Wausau Marathon County Impact Grants support innovative projects that enhance the quality of life in the greater Wausau area and Marathon County. Funded by the Community Foundation of North Central Wisconsin, these grants focus on the arts, education, health and human services, and resource preservation. They aim to provide long-term, tangible benefits to the community, encouraging nonprofits to propose impactful solutions to pressing needs.

The PLTW Launch program, in collaboration with Arrow Electronics, offers grants of $15,000 to support STEM and CTE curriculum implementation in schools within 25 miles of Alpharetta, GA. Schools must provide at least two different PLTW Launch modules over two academic years and meet specific program requirements. The funding can be used for essential equipment and training, while certain expenses, such as salaries and benefits, are ineligible. This initiative aims to enhance STEM education across various grade levels.

The Sustainability Project Grant by the DOE Office of Sustainability supports NYC Public Schools in implementing impactful sustainability projects. Schools can apply for funding up to $5,000 for initiatives that enhance environmental education, create gardens, or promote climate action. The grant aims to empower diverse school communities and foster climate literacy, ultimately contributing to healthier environments and social equity. Priority is given to schools with higher economic need and those that haven't received funding previously.

The Shelby Foundation Grant aims to enhance community quality of life by providing financial assistance to 501(c)(3) organizations and government agencies. By supporting local schools and programs, the foundation seeks to foster a safe, prosperous environment for residents. The initiative focuses on one-time grants for specific purposes, excluding funding for annual operating expenses or projects tied to regular school curriculums, thus ensuring impactful community development.

The Marietta McNeill Morgan & Samuel Tate Morgan, Jr. Trust, established in 1962, aims to enhance educational and human services in Virginia. It focuses on specific capital expenditures rather than general campaigns. The Trust encourages matching and challenge grants while excluding requests for debt reduction, scholarships, and funds for media production. Grants are not available to individuals or government agencies primarily funded by tax revenue, ensuring that resources are directed to impactful community projects.

The Facts on Fire Pilot Grant, funded by the Texas Education Agency, aims to enhance mathematics fact fluency for students in Farmersville ISD and Castleberry ISD. This initiative focuses on providing stipends and materials to implement evidence-based programs designed to improve numeracy and computational skills. By supplementing core mathematics instruction with targeted, short duration tasks, the grant seeks to elevate student performance and engagement in mathematics.

The ACLS Graduate Internships on the Spiritual Infrastructure of the Future program offers summer opportunities for current PhD students in the humanities and social sciences to engage with organizations addressing the evolving American religious landscape. This initiative aims to cultivate future leaders by providing practical experiences that demonstrate the value of doctoral training beyond academia. Supported by the Templeton Religion Trust, the internships encourage collaboration between fellows and community organizations, fostering a deeper understanding of spiritual infrastructures.

The Walter & Jessie Francisco Charitable Foundation Grant provides funding to nonprofit organizations serving Janesville and Rock County, Wisconsin. Grants focus on areas such as arts and culture, education, human and social services, religious initiatives, and scientific endeavors. Eligible applicants must be 501(c)(3) organizations, while individuals are not permitted to apply. This grant aims to support community development and enhance the quality of life for local residents.

The Tropf Family Scholarships, offered by the Community Foundation of Howard County, provide four scholarships worth $1,000 each to senior students at Atholton, Wilde Lake, Long Reach, and Oakland Mills High Schools. These scholarships aim to support students pursuing studies in mathematics, physical sciences, or engineering at a four-year college or university. Eligible students must maintain a minimum 3.0 GPA and plan to study full-time at an accredited institution.

Who We Are

Our mission is to enhance the quality of life in our region.

We pursue our mission through resource development, community grantmaking, collaboration and public leadership — connecting passion to purpose since 1973.

In the early 1970s, a group of estate-planning attorneys learned of a sizeable estate gift that left Springfield because there wasn’t a place here to accept a general gift for community betterment. Those 11 founders, supported by then-Springfield Mayor Jim Payne and businesswoman Anne Drummond, created the region’s first public charitable foundation in 1973.

Today, the CFO is governed by community volunteers and run by a professional staff that serves a network of donors, regional affiliate foundations, nonprofit partners and professional advisors through approximately 3,700 charitable funds.

Finley River Affiliate Grantmaking Program

The Finley River Community Foundation works to improve the quality of life for individuals in Finley River Community Foundation through thoughtful grantmaking and community leadership. The Finley River Community Foundation is governed by a Board of Directors, chosen for their knowledge of the area. Grant decisions are made by the grant committee. The unique role of a community foundation is to conduct a flexible community grantmaking program which addresses the most important needs of the community at any one time. The flexibility this requires is made possible by charitable donors who established unrestricted or field-of-interest funds and place the decision-making in the hands of the community leaders serving on our Board of Directors as well as dollars raised by the Finley River Community Foundation.

The Lane and Elizabeth C. Dwinell Charitable Trust Grant aims to strengthen communities and foster positive social change in New Hampshire. Established by Lane and Elizabeth Dwinell, who dedicated their lives to civic engagement, the trust supports diverse charitable organizations, especially those focused on reducing healthcare costs and enhancing local culture. The foundation prioritizes projects that address community needs, particularly in Lebanon and the Upper Valley, while adhering to specific eligibility criteria.

The Crawford County Community Fund, established in 2008, is a permanent endowment aimed at boosting economic development in the region. It provides annual grants to non-profits, schools, and local government agencies for community projects. Managed by a volunteer advisory board, the fund encourages local engagement and supports initiatives that address the evolving needs of the community, ensuring that contributions effectively enhance the quality of life in Crawford County.

Texas Education Agency

The Texas Education Agency will improve outcomes for all public school students in the state by providing leadership, guidance, and support to school systems. TEA, under the leadership of the commissioner of education, carries out the following functions:

• Administers the distribution of state and federal funding to public schools
• Administers the statewide assessment program and accountability system
• Provides support to the State Board of Education (SBOE) in the development of the statewide curriculum
• Assists the SBOE in the instructional materials adoption process and managing the instructional materials distribution process
• Administers a data collection system on public school information
• Performs the administrative functions and services of the State Board for Educator Certification
• Supports agency operations, including carrying out duties related to the Permanent School Fund
• Monitors for compliance with certain federal and state guidelines.

Online Educator Resources Production and Maintenance Services

The purpose of the 2026–2029 Online Educator Resources Production and Maintenance Services grant is to provide and support content development, adaptation, management, and maintenance of professional learning content and instructional resources within TEA Learn, the statewide Learning Management System (LMS). This grant offers strategic support for the development of professional, high-quality learning resources, from project planning and learning design to media production and marketing, it additionally provides support for the transition of existing instructional materials into accessible, high-quality digital formats, optimized for delivery through Canvas and other supported platforms. Services include project planning, instructional design for platform integration, media production, and marketing. These digital professional learning resources are designed to enhance instructional practices and support educators across Texas. The grant also supports the expansion of TEA’s digital credentialing program and the sustainability of online and hybrid learning offerings.

The Kelley Foundation

The Kelley Foundation was established by Robert and Judy Kelley and their daughter Marla. The Kelleys are native Oklahomans and longtime residents of Southern Oklahoma.

The foundation is primarily focused on humanitarian projects in Oklahoma, with an emphasis on Southern Oklahoma. Our mission is to develop and strengthen our community, state, and nation by providing essential resources to those in need.

The Kelley Foundation Grant

The Kelley Foundation is a private, charitable foundation, incorporated under the laws of the State of Oklahoma and operated exclusively for providing support through its gifts and grants to religious, charitable, scientific, and educational institutions which are qualified under section 501(c)(3) and which are not private foundations within the meaning of section 509(a) of the Internal Revenue Service Code.

The Thornapple Area Enrichment Foundation (TAEF) Grant, offered by the Barry Community Foundation, supports educational and community enrichment projects in Middleville, Michigan. Grants range from $50 to $5,000 throughout the year, focusing on initiatives that promote positive change and enhance the lives of residents. This collaborative effort invites nonprofit, educational, and government partners to participate in initiatives that align community needs with available resources, fostering sustainable development and impactful programs.

The Holt Family Foundation, originally founded as The Daybrook Foundation post-Hurricane Katrina, aims to enhance community life in Louisiana. It offers grants to 501(c)(3) non-profit organizations focusing on arts, early childhood education, and community engagement. Additionally, the Foundation provides college scholarships to Louisiana students, emphasizing innovative programs and education to foster positive community development. Its mission reflects the founder's commitment to supporting local families and organizations.

The L’Oréal USA For Women in Science Fellowship empowers women postdoctoral scientists by providing annual grants to support their research in STEM fields. This initiative not only recognizes their contributions but also encourages them to serve as role models for future generations. With a long-standing partnership with the AAAS, the program has awarded over $5 million to 105 scientists, demonstrating a strong commitment to advancing women's roles in science and technology.

The Aaron Howard Townsend Civil Engineering Scholarship, offered by Montana State University, supports students pursuing a degree in Civil Engineering. This scholarship is available for full-time students who are juniors or seniors with a minimum GPA of 3.0. It represents an opportunity for students to receive financial assistance while pursuing their academic goals in engineering, aligning with the university's commitment to fostering academic excellence.

The RJJB Family Foundation, established in 1997 by Rodney and Jeanna Pilot, aims to foster a legacy of philanthropy in coastal Alabama. Committed to supporting 501(c)(3) non-profits, the foundation focuses on education, community economic needs, and Christian ministry. Guided by the Pilot family's shared values and passions, the foundation strives to create lasting positive changes in the community, ensuring their contributions lead to causes of eternal significance.

The Somatic Mosaicism across Human Tissues (SMaHT) Program aims to enhance understanding of biological processes and disease mechanisms due to somatic mutations in human tissues. Since 2023, it has produced multi-omic datasets from various human tissues. The NIH plans to advance this initiative by establishing the National Somatic Mosaicism Commons Data Analysis & Organizational Center, which will oversee data management, develop analytical tools, and provide training to facilitate research and clinical applications.

The Foundations of Trusted Systems initiative seeks innovative research to develop secure, resilient, and affordable technologies for Command, Control, Communications, Computers, and Intelligence (C4I) and Cyber systems. This Broad Agency Announcement (BAA) aims to establish trusted foundations for hardware and software, building on previous work to enhance information processing systems. Researchers are encouraged to submit white papers for evaluation and potential funding.

The Bloomberg Data Science Ph.D. Fellowship invites exceptional doctoral students to apply for support in groundbreaking research for the 2024-2025 academic year. The fellowship covers full tuition and provides a stipend of $42,000, along with mentorship and internship opportunities. Applicants must be full-time students with a graduation date by 2027 and must complete a 14-week research internship. This prestigious fellowship aims to foster innovation in AI/ML research and contribute to the field's advancement.

The Ruth L. Kirschstein National Research Service Award (NRSA) Postdoctoral Research Training Grant supports institutions in developing clinical and translational science training programs. This program aims to enhance the research training of postdoctoral individuals holding doctoral degrees, ensuring a diverse pool of scientists equipped to tackle critical health challenges. Applications must be submitted by 5:00 PM local time of the applicant organization, and non-U.S. entities are not eligible.

The County Executive's Community Support Grants Program in Anne Arundel County aims to enhance the effectiveness of non-profit organizations by funding operating costs and essential equipment purchases. This program prioritizes proposals that address COVID-19 safety net needs and focus on underserved populations, community health, equity, and inclusion. Collaborative projects are preferred but not mandatory. Organizations are encouraged to apply for funding to improve their impact and sustain operations.

The Beazley Foundation Grants support educational, charitable, and religious initiatives, primarily awarding funds to 501(c)(3) organizations. While historically favoring projects in Portsmouth, the Foundation extends its reach throughout South Hampton Roads and beyond. Applicants must consult with the Foundation's president prior to submission, and grants are not available to individuals or for certain projects, including environmental and arts initiatives, unless deemed compelling by the Board.

The NASA Innovative Advanced Concepts (NIAC) Phase I program invites proposals for groundbreaking aerospace concepts, aiming to transform potential in aeronautics. This initiative supports innovative research through multiple award phases, focusing on Phase I requirements and evaluation criteria. A virtual forum will be held on October 7, 2026, to discuss the Appendix’s details and clarify submission guidelines. Additional information will be available on the NSPIRES page, ensuring participants are well-informed about the process.

The Ruth L. Kirschstein National Research Service Award (NRSA) offers predoctoral training grants aimed at enhancing clinical and translational science. Administered by the NCATS, this program supports institutions in training aspiring researchers for a PhD or equivalent, ensuring a diverse cohort of scientists equipped to tackle pressing health challenges. The ultimate goal is to cultivate a skilled workforce capable of advancing biomedical research and addressing community health needs effectively.