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Get operating grants for nonprofits covering essential expenses, staffing, program delivery, and organizational sustainability.
33,000+
Available grants
$9.00B
Total funding
$6K
Median grant
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Implementing Germline and Somatic Testing for Precision Medicine in Community-Based Prostate Cancer Care
The intent of this Request for Proposal (RFP) is to invite organizations to submit applications to host a 2.5-to-3 hour medical education program at or nearby the organization, to be led by 1-2 Visiting Professors (VPs) with expertise matched to the organization’s unmet educational and pragmatic needs related to integrating and acting on germline and somatic (tumor and/or ctDNA) testing for patients with prostate cancer. Following the education program, organizations will implement their action plan to incorporate, increase, or improve the use of guideline-concordant germline and somatic testing to improve prostate cancer patient care.
The total budget for the RFP is $250,000 USD, with plans to support 5-7 organizations. Individual project budgets should not exceed $50,000 USD.
About Us
For more than eight decades, this principle has remained at the heart of UNCF, enabling us to raise more than $6 billion and help more than 550,000 students and counting not just attend college, but thrive, graduate and become leaders.
We do this in three ways: By awarding more than 11,000 students scholarships, worth more than $62 million, each year. By providing financial support to 37 historically Black colleges and universities (HBCUs). And by serving as the nation’s leading advocate for the importance of minority education and community engagement.
This three-pronged approach is powerful: Since our founding in 1944, we’ve helped to more than double the number of minorities attending college. The six-year graduation rate for UNCF African American scholarship recipients is 70%. This is 11% higher than the national average and 31% higher than the national average for all African Americans.
Thelma M. Shafran Endowed Scholarship
Summary
The Connecticut Department of Mental Health & Addiction Services (DMHAS) is the primary funding entity for Supported Education (SEd) services for adults with mental health disorders, or co-occurring mental health and substance use disorders. DMHAS seeks to continue providing a highquality statewide network of SEd services. The goals of SEd are to increase integrated educational support for the target population described above.
Purpose
To continue to provide a statewide network of SEd services to assist adults with mental health disorders or co-occurring mental health and substance use disorders to pursue educational goals
llinois Department on Aging
The MISSION of the Illinois Department on Aging is to serve and advocate for older Illinoisans and their caregivers by administering quality and culturally appropriate programs that promote partnerships and encourage independence, dignity, and quality of life.
Rural Support
The Connecting Rural Older Illinoisans Grant opportunity directs funds to organizations to address rural area specific service issues, including transportation, technology, volunteer force development, and workforce development, that create barriers to older adults meeting their full potential.
The Rural Support Older Illinoisans Grant funds are to be used for one of the following activities:
The exact nature of the activities and the staff time required for the activities will vary based on identified community needs and priorities. AAAs may conduct the activities and opportunities through direct provision, partnership and/or contract with another organization, or utilization of a combination of the above.
Donald and Mary Frink Scholarship
The scholarship provides support for students who are hearing impaired.
Award Amount:
About Us
The South Carolina Developmental Disabilities Council was established in 1971 by Executive Order of the Governor and was reauthorized in 2010 and again in 2015. Not less than 60% of the total Council membership is consumers and family members. Additional members come from state agencies, DD Act partners and non-governmental organizations.
The Council is federally funded under the Developmental Disabilities Act. The Council engages in activities that contribute to a coordinated, consumer and family centered and directed, comprehensive system that includes needed community services, individualized supports and other forms of assistance that promote self-determination for individuals with developmental disabilities and their families.
DD Council Small Grants
Small Grant Funding is awarded to evidence-based,organized activities that enhance knowledge and skills in priority areas outlined in our Five-Year State Plan, specifically Community Supports, Employment, and Self-Advocacy.
Organizations are limited to one small grant per program year, from July 1 to June 30.
About
The Community Foundation of the Dan River Region is an independent, public charity established in September 1996 by a steering committee of local civic leaders to gather permanent funds to support our area.
The Foundation’s service area now includes Danville, Pittsylvania and Halifax counties in Virginia as well as Caswell County, NC.
Scholarship Information
Currently, The Community Foundation administers 75 separate endowed scholarship funds. Established by individuals or organizations, these funds help area students achieve their academic and career-oriented goals.
Scholarships through the Community Foundation support individuals of all ages who reside within the Dan River Region – Danville, VA; Pittsylvania and Halifax counties, VA; and Caswell County, NC. In 2025, we awarded more than $370,000 to 152 students.
Susan L. Edwards Memorial Scholarship
Open applications for students who are pursuing the field of radiologic technology, and if no applicants for radiologic technology, then nursing school applicants will be considered.
The WIOA, Title II: Adult Education and Family Literacy Act (AEFLA) grant provides supplemental funds over a 4 year grant cycle for adult education to:
Operating grants for nonprofits provide essential funding to support day-to-day operations, staff salaries, and infrastructure. The following grants help organizations build capacity, maintain sustainability, and focus on achieving their mission-driven goals.
Explore 8,000+ funding opportunities for operational support, with $3.34B in resources. Instrumentl helps nonprofits secure essential funding by offering grant discovery tools, deadline tracking, and strategic funder analysis to ensure long-term success.
How common are grants in this category?
Quite common — grants in this category are more prevalent than in others.
Over the past year, when are grant deadlines typically due for Operating grants for Nonprofits?
Most grants are due in the first quarter.
What's the typical grant amount funded for Operating Grants for Nonprofits?
Grants are most commonly $32,500.
Nonprofits of all types can apply for operating grants, but they are especially useful for organizations needing flexible funding to support the core work of their mission. Operating grants are ideal for nonprofits involved in general population well-being. Specific sectors include healthcare, education, social services, and the arts. Unlike project-based grants that fund specific initiatives, operating grants help with essential costs like staff salaries, rent, and general admin costs. Funders often look for groups with a clear mission who serve a meaningful purpose and have potential for long-term impact.
Based on Instrumentl’s live grant database for operating, grant deadlines are most common in Q1, accounting for 29.7% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.
Operating grants exist to help nonprofits function smoothly and grow effectively. The goal is to give organizations the financial means they need to focus on their mission, serve their communities, and support long-term stability. These grants allow nonprofits to improve everyday operations, invest in staff development, and expand programs. Funders want to see nonprofits thrive, not just survive, and providing operational support is a key element to making that happen.
Funding for operating grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $32,500, while the average grant awarded is $633,837. Understanding these funding trends can help nonprofits set realistic expectations when applying.
Operating grants are often funded by private foundations like the popular Ford Foundation. Some government agencies offer grants to strengthen nonprofit infrastructure, especially in sectors like health, education, and social services. Corporate giving programs may also support nonprofits that align with their values and create lasting impact.
To improve the chances of getting operating grants, nonprofits should:
For more advice on finding and winning operating grants, check out our step-by-step guide to general operating grants.
Instrumentl simplifies the process of applying for operating grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.
Check out how Habitat for Humanity delivered over 200% ROI within just a few weeks.