Best Grants for Rare Diseases in Texas

Nonprofit organizations in Texas that are 501(c)(3)s and run programs for children, education, or health and human services can seek monetary support that may benefit rare disease initiatives. Grants from Costco Foundation help fund community-based programs demonstrating measurable outcomes, strong collaboration, and diverse financial support within areas where Costco operates.

Texas 501(c)(3) nonprofits with innovative human services or health-related programs can seek funding to address current social problems, including rare and respiratory diseases. Focused on new approaches to societal issues, Creag Foundation invites smaller or evolving organizations to submit letters of inquiry for invitation-only grant consideration after holding 501(c)(3) status for at least one year.

501(c)(3) nonprofits serving children’s health, education, development, and welfare in Texas and beyond can apply for DanPaul Foundation grants, with awards up to US $15,000 for direct youth-focused programs. Organizations working on child welfare, early childhood development, homelessness, poverty, refugee enrichment, or environmental responsibility for youth may be eligible.

Nonprofit and NGO programs using technology for crisis response, education access, or economic empowerment in Texas and worldwide can seek Global Impact Cash Grants, with awards up to US $100,000. Cisco Systems Foundation prioritizes innovative, early-stage solutions serving predominantly economically underserved communities, including initiatives that may support rare disease populations through education, resilience, or livelihood programs.

Texas educational institutions, government programs, 501(c)(3) nonprofits, and 501(c)(4) volunteer fire companies can access funding through State Farm Companies Foundation for safety, education, and community development initiatives. Programs may include auto and home safety, disaster preparedness and recovery, affordable housing, job training, financial literacy, food insecurity, and K–12 or higher education, including STEM and college-career pathways.

The Hearst Foundation: Culture Grant aims to support outstanding nonprofits that enhance cultural engagement and artistic talent in the U.S. With a focus on programs that reach young people, the grant prioritizes organizations that create lasting impacts in the arts and sciences. The Foundation allocates 25% of its funding to cultural initiatives, favoring established organizations with a history of significant results. Eligible nonprofits must encourage inclusivity and sustainability in their programs.

The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.

The Labcorp Charitable Foundation, a private 501(c)(3) entity, aims to enhance healthcare access and education for all. With grant opportunities focusing on food programs, healthcare services for underserved populations, and STEM initiatives, it seeks to support community health and well-being. Organizations eligible for funding must be U.S.-based and hold tax-exempt status. Requests are reviewed biannually, in March and September, to foster impactful community projects.

Organizations and social enterprises in Texas working on education, children’s health, or family economic stability for urban low-income youth can apply for Michael & Susan Dell Foundation grants of more than US $50,000 for project support or scaling. Eligible entities include nonprofits, schools, governments, and other mission-aligned organizations; rare disease programs serving these children may be eligible.

Nonprofit 501(c)(3) organizations in Texas communities where PNC has a significant presence can seek funding for early childhood education or community economic development initiatives. PNC Foundation provides support for programs such as early learning, workforce readiness, affordable housing, small business assistance, arts and culture, and services for low- and moderate-income families.

Nonprofit charities running humanitarian, health, education, community, or contemporary arts projects in Texas and worldwide can seek philanthropic support for high-quality, sustainable initiatives. Focused on humanitarian and social development, science education, community and environment, and arts and culture, Roche invites accredited charities to propose innovative projects that may engage local affiliates and employees.

Nonprofit and humanitarian organizations working on health, education, or disaster relief can access funding that may support rare disease and related health initiatives in Texas and worldwide. Semnani Family Foundation provides support for programs serving marginalized communities, including efforts in the U.S. and multiple countries, with a focus on vulnerable populations’ health and welfare.

Nonprofit 501(c)(3) organizations funding charitable, scientific, medical, or educational programs in Texas may be eligible for support that must be used within the U.S. With a mission to strengthen charitable, scientific, medical, and educational work, Sidney Stern Memorial Trust provides broad-based funding; Texas rare disease and respiratory health initiatives may qualify if they fit these priorities.

Nonprofit 501(c)(3) organizations and aligned for-profits seeking support to tell impactful stories about their work can apply for the J.W. Couch Foundation Storytelling Grant, offering more than US $50,000. Focused on preservation, education, and wellness, it may benefit Texas programs, including those touching mental health or community wellbeing alongside rare disease efforts.

Kleberg Foundation provides Texas wildlife and animal science organizations with funding for applied research, habitat restoration, and studies that improve animal or human health. Eligible applicants include 501(c)(3) public charities and public universities, primarily serving South Texas counties such as Kleberg, Brooks, Jim Wells, Kenedy, and Nueces, with competitive, relationship-prioritized awards.

Texas 501(c)(3) organizations active for over three years and serving the Southern region can access funding through Robinson Foundation for programs in medical assistance, poverty relief, disaster relief, and related services. Health nonprofits working on respiratory or rare disease care, education, or support may be eligible if they demonstrate fiscal responsibility and tangible, meaningful impact.

With a mission to strengthen communities, Insperity provides Texas community services nonprofits with philanthropic grants and event sponsorships to support key service and fundraising goals. Eligible applicants must be 501(c)(3) organizations connected to Insperity employees, clients, or communities, and may apply once per year for either a grant or an event sponsorship.

Nonprofit 501(c)(3) organizations, public schools, and qualified local government entities in Texas communities near Georgia-Pacific manufacturing facilities can apply for Georgia-Pacific Foundation’s grants to support education, entrepreneurship, environmental initiatives, and community enrichment. Programs serving GP communities, including those touching rare or chronic disease impacts through community services, may be eligible if they meet the foundation’s investment priorities.

Nonprofit 501(c)(3) organizations near TJX locations in Texas can seek funding for basic needs, youth enrichment, workforce readiness, and safety from domestic violence. The TJX Foundation supports programs helping vulnerable families and children; health nonprofits serving rare disease populations may be eligible if their work fits these community impact areas.

Nonprofit 501(c)(3) organizations, public schools, and libraries seeking support for environmental or human services programs, including work in Texas, can apply for unrestricted grants ranging from US $5,000 - US $10,000. With a mission to support environmental and human services causes, Lawrence Foundation provides program or general operating funding that may benefit organizations addressing rare disease–related community needs.

The Max and Victoria Dreyfus Foundation offers grants to support diverse initiatives, including museums, educational programs, and environmental activities. Aiming to make a significant impact with modest funding, the Foundation targets IRS-qualified non-profits in the U.S. Grants typically range from $1,000 to $20,000, fostering community development and enhancement. Organizations focused on youth, seniors, and individuals with disabilities are particularly encouraged to apply, as the Foundation seeks to empower those in need.

Focused on basic needs and community vitality, Ameriprise Financial invites U.S. 501(c)(3) nonprofits to apply for funding that addresses hunger, shelter, adult self-sufficiency, and cultural enrichment. Texas organizations working on community health or rare disease–adjacent support services may be eligible, especially where Ameriprise employees or advisors are actively engaged as volunteers.

Nonprofit 501(c)(3) organizations in Texas can seek project funding for health care, education, social services, civic and cultural, environmental, and community initiatives. Grants from Dr Scholl Foundation help U.S. organizations, including those addressing rare or respiratory diseases, with one-year awards of US $5,000 - US $25,000 through an annual October–March cycle.

Texas 501(c)(3) nonprofits improving community health, economic stability, or disaster resilience can seek funding for projects, operations, or capital needs that benefit underserved residents. Grants from O'Reilly Automotive Foundation help organizations addressing health and social services, workforce development, poverty, hunger, homelessness, and related community services in areas where O’Reilly Auto Parts operates across the U.S.

Texas 501(c)(3) public charities working on safety, workforce development, community vitality, or environmental sustainability can apply for Union Pacific Foundation’s Community Ties Local Grants, awarding US $5,000 - US $30,000 for direct services and capacity building. Organizations serving Texas communities on Union Pacific’s service list, including health and basic-needs programs that may support rare disease populations, may be eligible.

Texas nonprofits and charities working on youth development, food security, housing support, or environmental stewardship can access funding through Chick Fil A Foundation’s True Inspiration Awards. Eligible U.S. 501(c)(3)s and equivalent charities in select countries may receive US $30,000 - US $350,000 to expand impactful community programs that could benefit families affected by rare diseases.

Nonprofit organizations in Texas that lead strong, replicable community partnerships may be eligible for Mutual of America Foundation’s national Community Partnership Award, which honors collaborations tackling significant social issues. U.S. nonprofits, including those addressing respiratory or rare diseases through cross-sector partnerships, can showcase measurable community impact and innovative, scalable approaches.