Best Large Grants for Nonprofit Organizations

The Enhancement Riparian Buffer Grant, offered by Watersheds United Vermont, supports organizations focused on implementing effective riparian buffer plantings along waterways using native plants. With a minimum buffer width of 35 feet and a density of at least 300 stems per acre, this grant is crucial for enhancing water quality and ecological resilience in Vermont's watersheds. Organizations must adhere to the 2023 DEC Clean Water Initiative Program Funding Policy to qualify.

The Kentucky Conference Mission Grants provide financial support for mission work within the Kentucky Annual Conference and internationally. Grants of up to $2,000 are awarded to churches, institutions, and projects that align with the mission of the United Methodist Church, focusing on outreach in areas such as addiction, food insecurity, and support for refugees. This initiative aims to foster community transformation through various mission efforts across Kentucky.

The Quadratec Cares 'Energize The Environment' Grant Program is dedicated to supporting individuals and organizations in the U.S. focused on environmental improvement. With two grants of $3,500 awarded annually, the program encourages initiatives like trail restoration and community educational projects. This grant aims to empower passionate individuals to enhance environmental awareness and stewardship, ensuring a healthier planet for future generations.

Harry C. Anthony, Jr. Scholarship

Essay:

• Describe yourself and explain why you are interested in a career in medicine.

Awards:

• One-time award of $2,500

The Montana Indigenous Water Research Fellowship Program provides financial support for indigenous students pursuing water-related studies. With an annual budget of $10,000, the program funds tuition, research projects, and travel for conferences. Applications are accepted on a rolling basis, encouraging mentors to connect prospective students. This initiative aims to enhance educational opportunities and support within the indigenous community, fostering a deeper understanding of water issues relevant to their environments.

The Charles River Life Sciences Scholarship at Western Michigan University supports undergraduate students majoring in biological sciences. This scholarship funds educational and research materials, encouraging outstanding academic performance with a minimum GPA of 3.0. The scholarship has evolved from previous awards, highlighting its commitment to fostering student success in the biological sciences field. This opportunity not only aids in financial support but also enhances the educational experience for dedicated students.

The C.D. Besadny Conservation Grants support grassroots conservation and education projects in Wisconsin, with funding ranging from $500 to $5,000. The grants prioritize initiatives that engage marginalized communities, protect rare species, and enhance climate resiliency. Eligible applicants include public charities, governmental units, and accredited educational institutions. The total project budget cannot exceed $10,000, and matching contributions are encouraged. This funding opportunity aims to strengthen connections between people and Wisconsin's natural resources.

SerVermont VISTA Program RPF

This cohort will begin service on August 10, 2026.

AmeriCorps VISTA members are made available through SerVermont through a VISTA Supervision Grant from AmeriCorps, the federal agency that oversees National Service. SerVermont has administered the VISTA Umbrella Project on behalf of AmeriCorps since 2011 (now in its 15th year) and is currently the only VISTA project in Vermont. The statewide SerVermont VISTA project seeks to end poverty in Vermont by building capacity in organizations that address homelessness, provide job training, invest in food security, provide nutrition education, and promote disaster resiliency. In the 2026-2027 Program Year, SerVermont is anticipating the availability of up to 21 VISTA member positions.

SerVermont is especially interested in partnering with organizations with a focus on disaster mitigation, recovery and resilience, in addition to organizations that address housing security and support workforce development initiatives.

Every VISTA Project Host Site must fall within the VISTA Programming Framework:

Anti-Poverty Focus - The purpose of VISTA is to support efforts to eliminate poverty. The goal of every project must be to help individuals and communities move out of poverty, not simply make poverty more tolerable. The project should focus on long-term solutions rather than short-term services.

Community Empowerment - VISTA Project Sponsors and Host Sites must ensure that their project engages residents of the low-income community in planning, developing, implementing, and evaluating the project. The project must be responsive and relevant to the lives of residents in the community, and should tap into inherent community assets, strengths, and resources.

Sustainable Solutions - As originally designated in the Domestic Volunteer Service Act and reinforced in the Serve America Act, VISTA members are a short-term (one-year) resource who serve to build the long-term sustainability of anti-poverty programs. All VISTA projects should be developed with a goal to phase out the need for VISTA members and strengthen the ability of the project to continue without them. VISTA projects typically last three years, occasionally longer. From the beginning of the project planning process, the sponsor and community must think about how to use the VISTA project to phase in other resources and systems to replace the VISTA resource.

Capacity Building - Through activities such as fundraising, establishment of volunteer recruitment and management systems, community outreach, and partnership development, VISTAs help sponsors achieve lasting solutions to poverty. In order to build capacity, VISTAs do not perform direct service. Direct service is defined as activities that immediately address individual clients’ needs, and these activities are usually focused on short term goals. Ideally, VISTAs work their position out of existence and create systems that remain long after their service ends. 

The Alabama State University Anniston/Calhoun County Alumni Scholarship Fund aims to support African American graduating seniors from Calhoun County who plan to attend Alabama State University. Established by the ASU Alumni, this fund reflects a commitment to education and community enhancement. It provides one-time scholarships for students pursuing associate or bachelor’s degrees, or approved workforce training programs, ensuring they receive necessary financial assistance for their educational journey.

The Grants for Creative Individuals program by the Mass Cultural Council offers unrestricted $5,000 grants to support artists, culture bearers, and creative practitioners in Massachusetts. This initiative aims to promote creativity and cultural expression across diverse disciplines while ensuring equitable access. The grants are awarded based on a review process that prioritizes geographic diversity and the needs of historically underfunded communities. Eligible applicants must be 18+, residents of Massachusetts, and not enrolled in full-time education.

About The New York Community Trust:

As New York's largest community foundation, The New York Community Trust (The Trust) fosters and engages in enduring and innovative philanthropy, making grants that bring together the local knowledge and expertise of its team, nonprofits, and partners to help donors fulfill their vision for the causes they love. From education and the arts to health care and the environment, The Trust seeks to improve every aspect of the cultural and civic life of New York City, Long Island, and Westchester.

The Trust is a regional philanthropic leader. In addition to a distinguished competitive grantmaking program, The Trust hosts donor-advised funds that make grants throughout the United States as well as funder collaboratives that work on the leading edge of philanthropy to improve the lives of New Yorkers. In 2025, it made close to 11,000 grants totaling nearly $230 million.

Having celebrated its centennial anniversary in 2024, The Trust has catalyzed innovations in philanthropy ranging from establishing the first donor-advised fund in the 1930s to making landmark grants, including some of the first to fight AIDS, build the High Line, support immigrant communities in the region, and respond quickly in the early days of the COVID-19 pandemic.

The four broad priorities of this grantmaking program are to:

• Mitigate climate change by reducing greenhouse gas emissions and removing legacy carbon from the atmosphere and oceans;
• Adapt and become more resilient to the consequences of a warming world;
• Protect public health from toxic chemicals and other environmental hazards; and
• Preserve and create ecological connectivity by supporting terrestrial and marine conservation corridors. 

Grants made pursuant to this request for proposals will be for national projects, i.e., projects working in the United States (including its territories). Grants will not exceed $150,000 per year for up to two years.

The Anne Arundel County Forestry and Forested Land Protection Grant Program, in partnership with the Chesapeake Bay Trust, aims to fund forestry projects and land protection initiatives in Anne Arundel County. This program focuses on cost-effective reforestation and greening efforts to enhance protected forested land, improve soil and water quality, reduce erosion, and provide essential ecological services. By supporting these initiatives, the program contributes to environmental sustainability and climate resilience.

The McInroy-Sheffer People Trust Scholarship supports students from specific Pennsylvania counties—Cumberland, Dauphin, Lycoming, Tioga, or York—who are graduating high school and planning to enroll as freshmen. Eligible candidates must demonstrate financial need and intend to study at one of several local colleges in fields like Culinary Arts, Nursing, or Business. This scholarship is a one-time award, aiming to assist students in their educational pursuits.

The Wisconsin Fast Forward Grants provide essential funding for health care sector training, supporting projects that enhance collaboration between businesses and workforce partners. With awards ranging from $5,000 to $400,000, these grants aim to address skill shortages, ensuring workers gain necessary training for sustainable employment. This initiative focuses on the health sciences and related fields, promoting professional growth and economic advancement for participants while fostering partnerships among multiple employers.

The NIDDK High Risk Multi-Center Clinical Study Implementation Planning Cooperative Agreements (U34) aims to support high-risk, multi-center clinical studies by facilitating early peer review and assessment of study designs. This program helps in the development of necessary operational documents and essential elements for conducting hypothesis-driven studies focused on diseases relevant to NIDDK. Applications are due by 5:00 PM local time, and consulting with NIDDK staff is strongly encouraged.

The CFNWPA Catholic Social Ministry Grant supports projects that align with Catholic social teachings and serve the 13 counties of the Roman Catholic Diocese of Erie. Funding is available for initiatives that provide counseling services, marriage support, community building, elderly care, and emergency services for the poor. Eligible organizations include Catholic nonprofits and parishes. The grant prioritizes projects that demonstrate sustainability and community impact, fostering long-term support for vital ministries.

The Delta Extension Fellowship, hosted by California Sea Grant and the Delta Stewardship Council, aims to enhance community resilience and social well-being in the Delta region. Over 24 months, the fellow will support a community outreach campaign for the Delta Residents Survey, analyze research on water management impacts, and organize resilience training for residents. This initiative addresses the Delta's challenges, including climate change and resource vulnerability, fostering informed decision-making and sustainable practices among local communities.

Sky Lakes Health System is dedicated to enhancing community health through its Community Grants program. With a mission to inspire better health, the program supports local non-profit organizations and civic groups, offering up to $5,000 in funding. Proposals should align with priority areas such as health, wellness, STEM education, and economic development, promoting equity and access to services. This initiative aims to foster collaborative efforts that address pressing health issues within the Klamath Falls area.

The Edgar A. Thurman Charitable Foundation for Children provides financial support to 501(c)(3) organizations serving needy children in Virginia, particularly in the Western region and Roanoke Valley. Grants typically range from $3,000 to $10,000 for first-time applicants, while returning grantees may receive up to $20,000. Eligible organizations must demonstrate a commitment to the welfare and education of children, ensuring compliance with all grant conditions.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program Funding 

The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).

Grant recipients will select activities from broad RHTP initiatives designed to advance the overarching goals of improving health outcomes and access to care for rural Minnesotans, sustainably expanding the rural health care workforce, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments. 

Entity Type: Hospitals

Estimated Number of Awards: 94

Estimated Maximum Award in Budget Period 1: $1,400,000

Applicants may request up to the maximum award.

The W.H. & Mary Ellen Cobb Charitable Trust Grant Program aims to support local charities in the Texas Panhandle that focus on children's well-being. Established by the Cobbs, who valued children's welfare, this trust provides grants ranging between $10,000 and $20,000 to organizations that meet their eligibility criteria. Applicants must be geographically located within the Texas Panhandle and primarily serve children, ensuring that the funds directly benefit young individuals in need.

The Allianz Life Insurance Company's Financial Stability Grant aims to reduce barriers to economic inclusion by supporting nonprofit organizations that enhance financial stability for low- to moderate-income families. With grants ranging from $50,000 to $75,000, this program prioritizes groups that serve diverse communities, promote equity, and collaborate with local organizations. By focusing on basic needs such as food, shelter, and affordable housing, Allianz is committed to fostering sustainable economic independence within the Twin Cities metro area.

The Giant Company and Keep Pennsylvania Beautiful Healing the Planet Grants support tree planting initiatives in Pennsylvania, enhancing environmental health and community well-being. This program, initiated by the non-profit PA CleanWays, empowers local volunteers to tackle litter and illegal dumping while providing funding of up to $4,000 for projects. By investing in green spaces, the program aims to significantly improve water and air quality, contributing to a cleaner and more beautiful Pennsylvania for all residents.

The United Way of Forsyth County provides Tier 1 Community Impact Grants of up to $10,000 to 501(c)(3) nonprofits serving Forsyth and Dawson Counties. These grants support short-term projects that align with focus areas such as Youth Opportunity, Healthy Community, Financial Security, and Community Resiliency. Ideal for innovative pilots and collaborations, the grants aim to create measurable community impact over a 12-month term, fostering a spirit of collaboration and community improvement.

The Carl & Marilynn Thoma Foundation offers Collections-Related Grants for Nonprofits, aimed at enhancing public interest in art through innovative projects. Grants support exhibitions, academic convenings, research, and catalog publication, focusing on art from the Spanish Americas, digital media, and more. The foundation prioritizes proposals from 501(c)(3) organizations in the U.S., particularly from New Mexico, Oklahoma, and Texas, fostering partnerships that advance art scholarship and cultural engagement.

The Minnesota Youth at Work Competitive Grant supports workforce development for economically disadvantaged youth aged 14-24. Administered by the Minnesota Department of Employment and Economic Development (DEED), it prioritizes programs that provide career education, serve under-represented communities, and assist youth with disabilities. Applicants can request up to $850,000 annually, with potential for continued funding based on performance in the first year.

Humane Housing Grants

The Buhl Regional Health Foundation (BRHF) invites proposals from nonprofit organizations serving Mercer County to support initiatives that strengthen Humane Housing for children, youth, and their families. Humane Housing is one of the seven Vital Conditions for a Thriving Community Framework now guiding BRHF’s funding strategy. This is a foundational factor influencing long-term well-being.

In Mercer County, access to safe, stable, and dignified housing remains a critical determinant of physical, emotional, and mental health. Youth who experience housing instability or unsafe living conditions face significant barriers to healthy development, educational success, and long-term thriving. Through this RFP, BRHF seeks programs that prevent housing instability, improve living conditions, promote family stability, and ensure that all young people have access to safe environments where they can grow, learn, and thrive. Projects may focus on prevention, early intervention, housing-related support, or innovative community partnerships that strengthen long-term stability for youth and families.

Focus Areas

Proposals should clearly address one or more of the following priority areas and reflect the principle that Humane Housing is a vital community condition essential for child well-being:

Programs that prevent youth homelessness or housing displacement

• Transitional housing support for youth or youth-led households
• Family stabilization programs that keep children safely housed
• Efforts that reduce unsafe or unstable living situations

Improving Housing Conditions

• Program that addresses critical home repairs that allow youth to remain safely housed 
• Program that addresses environmental hazards (mold, air quality, utilities issues) 
• Partnerships offering safe, temporary placements for youth in crisis

Housing Navigation & Supportive Services

• Case management, advocacy, and navigation for families facing housing challenges
• Coordinated care approaches that reduce system barriers
• Programs connecting families to long-term housing solutions