Best Large Grants for Nonprofit Organizations

The Systemic Sclerosis with Interstitial Lung Disease Fund, managed by the HealthWell Foundation, aims to reduce financial barriers for underinsured patients suffering from systemic sclerosis. This rare autoimmune disease leads to excessive collagen production, causing serious health issues. The fund assists with prescription copays and insurance premiums to ensure patients receive necessary treatments. In 2024, HealthWell awarded over $1.2 billion in grants, supporting more than 1.1 million patients in accessing vital healthcare services.

The Cancer-Related Behavioral Health Fund, established by the HealthWell Foundation, provides financial assistance to individuals diagnosed with cancer for behavioral health treatments. This fund covers costs associated with prescription drugs, counseling services, and transportation. Aiming to alleviate financial burdens, it ensures that underinsured patients can access necessary care without delay. In 2024, the foundation awarded over $1.2 billion, emphasizing its commitment to improving health outcomes for cancer patients across the United States.

The Santa Fe Baby Fund Grant supports nonprofits in Mora, Rio Arriba, San Miguel, and Santa Fe counties focused on infants, toddlers, and their caregivers. Priority is given to organizations enhancing access to quality childcare, supporting the early childhood workforce, and advocating for young parents and kin caregivers. Nonprofits led by marginalized communities are especially encouraged to apply, fostering inclusive growth and improved early childhood services in the region.

The Dee & King Webster Fund for Greater Lawrence, managed by the Essex County Community Foundation, supports educational opportunities for youth aged 0-8th grade in Greater Lawrence, Massachusetts. It aims to address achievement gaps by funding innovative programs that enhance skill development and social-emotional health. Organizations must have 501(c)(3) status and focus on collaborative efforts with local schools. Grants of up to $40,000 are available, promoting access and equity in education for underserved communities.

The Winter Grant Cycle from the Thomas P. and Lewise S. Parsley Fund supports essential community initiatives in Western Virginia. Focused on providing prescription medications for the elderly and addressing substance abuse, the fund seeks to enhance the quality of life for financially needy individuals. Organizations in Martinsville, Roanoke, and surrounding counties are encouraged to apply, although the fund does not support deficit reduction or religious programs. This grant aims to foster impactful community outreach.

The ACCF Youth (TAG Team) Grants support youth development initiatives in Allegan County, inviting high school students to represent their peers through the T.A.G (Teens Aiding Growth) Team. This funding opportunity prioritizes programs that enhance early childhood education, promote mental and physical health, and support youth-led social change. Grants are available for 501(c)3 non-profits and governmental units, ensuring they meet specific eligibility criteria to benefit local youth aged 0-19.

The Ewing Marion Kauffman Foundation offers sponsorships for events in the Kansas City area, with a focus on connecting people and supporting vital programs. Funding amounts range from $1,000 to $10,000, depending on event size and benefits. Organizations not currently funded by the Foundation are eligible to apply, with one request considered per year. Note that current grantees are ineligible, and sponsorships are not retroactive or recurring.

The Generosity Collective Grantmaking Program, led by the Community Foundation of the Ozarks, aims to address pressing local issues in Springfield by funding impactful projects. With a total of $120,000 available, grants of $30,000 will be awarded to one agency in each of four categories: early childhood development, child abuse prevention, mental health support, and affordable housing. This initiative fosters community collaboration and empowers organizations to create meaningful change.

South Carolina Arts Commission

The mission of the South Carolina Arts Commission is to expand access to the arts and foster creativity for all South Carolinians.

For more than 50 years, the agency has worked to build a thriving arts environment that benefits all South Carolinians, regardless of their circumstances or where they live.

We help artists and arts providers offer unique arts experiences to residents and visitors. From free poetry readings and gallery crawls to sweetgrass basketry workshops and ticketed dance, music, or theatre performances, they create an environment that contributes to quality of life from three “corner” counties of Oconee, Horry, and Beaufort to the 43 arranged inside.

Since 1967, the SCAC has awarded more than $132 million in grants to artists, arts organizations, school districts, schools, and teachers!

Festivals Grants

Purpose

To provide support for a broad range of arts activities at festivals that take place in—and have an impact on—S.C. communities, increasing opportunities for public engagement and participation in arts and culture.

A festival is a day or period of celebration or gathering of people that:

• Happens in a condensed period of time (i.e., an annual celebration or anniversary or an organized series of concerts, plays, movies, or performances held in the same place).
• Has an easily identifiable or unifying theme or specified focus.

Restrictions

• The festival cannot span the duration of more than two (2) consecutive weekends (no more than 14 consecutive days).
• Seasonal series of presented works, as well as freestanding installations, productions or exhibitions, are ineligible activities for this program.
• Applicants may submit only one (1) application per deadline.

Requirements

• The festival must be held in South Carolina.
• The festival must have identifiable arts activities (visual, media, performing, literary, and/or folk and traditional arts).
• The festival must compensate visual, media, performing, literary, and/or folk and traditional artists.
• The festival must be open to the public and include some aspect of free arts programming.

Funding type: Reimbursement

Matching Requirements

1:1 (grantee:SCAC)

• Up to 50% of the grantee’s match may be through an in-kind donation of materials and/or contracted services.
• An example of “in-kind” is a contracted fee that is waived or discounted as a donation to your project.
• Another SCAC grant and/or federal funds may not be used to match your award.

Indirect Cost Limitation

No more than 10% of the total grant funds may be used for indirect costs (general overhead expenses not directly tied to the project). The remaining 90% must go toward direct costs, which are necessary to carry out the funded project.

• Examples of direct costs: Artist fees, program supplies, travel for project activities, and venue rental.
• Examples of indirect costs: Administrative salaries not directly working on the project, office rent, utilities, and general office supplies.

This ensures that most of the funding directly benefits the project while allowing some flexibility for necessary overhead costs.

Compliance with State and Federal Laws

All grant applicants must ensure their applications, proposed projects, and any related materials comply with all applicable federal, state, and local laws. This includes SC Code § 16-15-305 (2024), which prohibits the dissemination of obscene materials.

Obscene content is strictly prohibited in grant applications and any proposed project activities. Applications that include materials or activities determined to be obscene will not be reviewed or considered for funding.

No component of an SCAC-funded project, including those funded with SCAC funds and those funded with matching funds, can fall into this category. Failure to comply with these regulations may result in the termination of funding and other legal consequences.

We strongly encourage all applicants to carefully review the full legal text of SC Code § 16-15-305 (2024), to ensure their proposals are in full compliance.

Headstream Accelerator 2026

Accelerator Application Cohort VI

The Headstream Accelerator supports entrepreneurs from all backgrounds in scaling digital solutions that improve the mental well-being of teens at risk, with a focus on the education and healthcare sectors. Our four-month, virtual-first program is designed for early-stage innovators, helping them strengthen their business models, refine their value propositions, and build the foundation for sustainable growth and meaningful impact.

Benefits:

• $30,000 non-dilutive stipend 
• Partnership with youth from Headsteam’s Youth Co-Creator Club to gain insights on cultural relevance, age-appropriateness, and user experience, ensuring your solutions resonate deeply and effectively with the next generation 
• Access to a network of expert advisors, connect with a community of founders, and engage with potential investors and capital providers 
• Access to one-on-one and group coaching sessions with our partner, FounderWell

Participant Expectations:

• Attend all activities, including virtual cohort and youth co-creation sessions, advisor calls, and an in-person kickoff event from July 28–30, 2026
• Commit 2–5 hours weekly during the program, including virtual sessions, advisor network office hours, guide calls, and more
• Embed youth voices throughout your product development

Cumberland Community Foundation ("CCF") manages more than 60 scholarship endowment funds created by local individuals, families, civic organizations, and corporations who want to provide a path to higher education for future generations. 

Each year, Cumberland Community Foundation announces more than $1,000,000 in college scholarships to students from southeastern North Carolina.

Cape Fear River Assembly Scholarship

Any high school or college student accepted/enrolled in a college in the Cape Fear River Basin. 

Loene Pooler Guthrie Scholarship Fund

The Loene P. Guthrie Scholarship fund benefits music students in Benton, Linn, and Lincoln counties who plan to engage in the teaching of piano, voice, and orchestral music.

This scholarship fund promotes the teaching of piano, voice and orchestral music by aiding music students in Benton, Linn, and Lincoln Counties who plan to engage in the teaching of piano, voice, and orchestral music. Students who will graduate from Linn, Benton, or Lincoln County high schools or graduates of those high schools currently studying music at an institution of higher learning may apply. The Linn-Benton Chapter of the Oregon Music Teachers Association reviews the applications and selects individuals to perform at an audition open to the public.

The Rare Impact Fund, founded by Selena Gomez, is dedicated to transforming mental health support for young people. With a commitment to mobilizing $100 million, the fund aims to enhance access to mental health services and promote a stigma-free community. Through public Requests for Proposals, the initiative seeks to strengthen the nonclinical youth mental health workforce, ensuring effective support systems that reflect the diverse backgrounds of youth. This innovative approach fosters lasting change in mental health care.

The Heart of Steamboat Community Fund, established in 1984, supports non-profit organizations in Routt and Moffat Counties with annual grants ranging from $500 to $2,500, totaling up to $32,000. Focus areas include mental health, food security, and support for immigrants, seniors, and youth. To be eligible, organizations must have a local presence and be registered as charitable entities in Colorado. Priority is given to initiatives addressing these vital community needs.

The Harris and Frances Block Foundation, established in 2001, supports small grassroots organizations focused on social and environmental justice. They prioritize equitable solutions and sustainable community development, funding initiatives related to environmental education, justice, and food security. Grants are available to non-profit, tax-exempt organizations in specific geographical areas including Vermont, North Carolina, Virginia, and New York City, excluding funding for lobbying, land acquisition, and scholarships.

AARP Foundation

AARP Foundation strengthens financial resilience for and with older adults by empowering individuals and improving systems.

AARP empowers people to choose how they live as they age. There are 125 million Americans who are 50 or older, and people want their money, health and happiness to last as long as they do. We are a wise friend and fierce defender, focusing on the priorities of older Americans.

Purpose Prize® from AARP

Honoring extraordinary people 50-plus who put their purpose into action.

Purpose is a powerful force for good. The Purpose Prize from AARP honors extraordinary older Americans who put their purpose into action to support AARP’s mission of empowering people to choose how they live as they age. Winners receive $75,000 and a year of organizational support from AARP to grow the impact of their nonprofits. Examples of organizational support include data and evaluation, governance and succession planning, fundraising strategy, and prospectus development.

The Minnesota Pollution Control Agency (MPCA) is offering Local Climate Action Implementation Grants to support local jurisdictions in adapting to climate change and reducing their environmental impact. With approximately $1.3 million in funding available, these grants aim to facilitate planning and implementation projects that address extreme weather events and promote sustainable practices. Eligible applicants include local governments and organizations working to enhance community resilience and environmental stewardship.

The Equitable Food Access Initiative: Healthy Corner Stores aims to enhance food access for District residents by supporting corner stores through evidence-based strategies. Managed by the DC Department of Parks and Recreation, this initiative seeks proposals from community-based organizations and local businesses to improve food environments. By fostering partnerships, the program intends to create healthier, more sustainable food access points within the community, ensuring that all residents can benefit from nutritious food options.

The Mother Cabrini Health Foundation's Basic Needs Grant Program aims to address the essential needs of New Yorkers facing challenges such as food insecurity, inadequate housing, and economic instability. This initiative supports organizations that provide access to social services, promote economic mobility, and ensure stable housing and nutrition for underserved communities. Grants of $75,000 or more are available for programs that align with the foundation's mission of fostering health and well-being in New York State.

The Minnesota Pollution Control Agency is offering Local Climate Action Planning Grants to help communities adapt to climate change and reduce their carbon footprint. With approximately $1.3 million in funding available, these grants support projects aimed at addressing extreme weather events and fostering sustainable practices. Eligible jurisdictions can apply for either planning or implementation grants to develop innovative solutions that contribute to a healthier environment and community resilience.

Funding Innovative Research

Cannonball Kids’ cancer Foundation (CKc) prioritizes funding clinical trials, research that is nearing translation to a clinical trial, and young investigator grants.

Grants funded by CKc must be innovative and provide better quality of life or symptom relief than current treatments. 

When possible, CKc will prioritize funding research:

• with a focus on cancers that are under-funded or under-researched,
• with a focus on patient populations who are traditionally underserved.

When possible, CKc will prioritize funding researchers of diverse backgrounds.

For CKc, “innovation” means the invention or application of novel methods or treatments, specifically treatments that have fewer side-effects than standard care, increase a child’s quality of life, and/or create an option for care where there otherwise were few or none (either on primary diagnosis, relapse, or for recalcitrant cancers).

Research Grants

Grant Program: Clinical Trial

$200,000 over 3 years

• PI must hold an academic appointment at the Assistant Professor level or higher
• Preclinical studies must be complete
• If an FDA Investigational New Drug (IND) application is necessary for the proposed clinical study, the IND application should already have passed FDA initial review and be active
• If the PI has recruited additional patient enrollment sites, local IRB approval must be obtained for each site.

• How many treatment options would this study provide for children?
• How accessible is this study for children and families to access?

The Margaret C. Woodson Foundation Grant Program, established in 1955, aims to enhance public welfare through support for charitable, educational, and religious organizations. It focuses on programs addressing social issues, youth at risk, health matters, and cultural arts. Grants are available for 501(c)3 nonprofits and educational institutions primarily serving Rowan and Davie Counties. The foundation prioritizes initiatives that foster constructive change and public service, while excluding capital campaigns and direct support for individuals.

The Smart Growth America Community Connectors Grant Program supports small and mid-sized cities in addressing divisive infrastructure caused by dangerous roads. With funding from the Robert Wood Johnson Foundation, this program aims to reconnect communities through temporary street safety projects while fostering skills and partnerships. Eligible teams must represent populations of 50,000 to 500,000 and include both government and community-based organizations. Priority will be given to projects benefiting low-income communities historically affected by disinvestment.

The Memorial Foundation for Children Grant Program aims to enhance the lives of children in the Richmond Metropolitan Area by funding nonprofit organizations focused on Education and Health and Wellness. Prioritizing evidence-based programs, it supports initiatives that demonstrate long-term impact and serve low-income families. Grants are awarded biennially, emphasizing collaboration among organizations to tackle significant issues affecting children from birth to age 21. The program seeks to ensure that all children can reach their full potential.

Affordable Housing and Sustainable Communities (AHSC) Program Round 10

The AHSC Program funds projects that implement land-use, housing, transportation, and agricultural land preservation practices that reduce greenhouse gas (GHG) emissions.

The AHSC Program provides grants and/or loans for Projects that achieve GHG Reductions and benefit communities across California, particularly DACs, Low-Income Communities, and Low-Income Households, through increasing accessibility of affordable housing, employment centers, and Key Destinations via low-carbon transportation. These investments result in fewer vehicle miles traveled (VMT) through shortened or reduced vehicle trip length or mode shift to transit, bicycling, or walking.

The purpose of these Program Guidelines is to implement Division 44, Part 1 Chapter 2 of the California Public Resources Code (PRC) (commencing with Section 75200), which establishes the Affordable Housing and Sustainable Communities (AHSC) Program, hereinafter referred to as the AHSC Program. Per the California Public Resources Code, the purpose of the AHSC Program is to reduce greenhouse gas (GHG) emissions through Projects that implement land use, housing, transportation, and Agricultural Land preservation practices to support infill and compact development, and that support related and coordinated public policy objectives, including the following:

• Reducing air pollution;
• Improving conditions in Disadvantaged Communities (DACs);
• Supporting or improving public health and other co-benefits as defined in Section 39712 of the Health and Safety Code;
• Improving connectivity and accessibility to jobs, housing, and services;
• Increasing options for mobility, including the implementation of the Active Transportation Program established pursuant to Section 2380 of the Streets and Highway Code;
• Increasing transit ridership;
• Preserving and developing affordable housing for lower income households, as defined in Section 50079.5 of the Health and Safety Code; and
• Protecting Agricultural Lands to support infill development.

The Broadcasters Foundation of America Monthly Grant provides essential financial assistance to broadcasters facing acute hardships due to serious illnesses or accidents. This initiative aims to support those who have dedicated significant years to the broadcasting profession, ensuring they receive medical aid and relief from financial burdens. Eligible applicants can apply for monthly grants if they meet specific employment and hardship criteria, helping them navigate difficult times with dignity and support.

The Visegrad Grants foster innovative regional cooperation in Central Europe, supporting diverse projects that address shared challenges. These grants are aimed at non-governmental organizations, educational institutions, and civic groups committed to enhancing social cohesion and cultural identity. With a focus on collaboration among entities from different V4 countries, projects can range from cultural initiatives to democratic value promotion, ensuring a broad impact across communities in the region.