Best Large Grants for Nonprofit Organizations

Texas Education Agency

The Texas Education Agency is the state agency that oversees primary and secondary public education. It is headed by the commissioner of education. The Texas Education Agency improves outcomes for all public school students in the state by providing leadership, guidance, and support to school systems.

The Division of Governance Interventions supports TEA’s mission and vision by providing exceptional leadership, guidance, and support to school system leadership teams and governing boards. The division collaborates with external field support agents appointed by the TEA Commissioner of Education to build sustainable systems aligned to core TEA initiatives, so that the school system thrives after the release of agency intervention. 

Best Buddies Grant Program

Program Description

The purpose of the Best Buddies grant program is to provide support in creating opportunities for one-to-one friendships, integrated employment, and leadership development for Texas middle school and high school students with intellectual and developmental disabilities (IDD).

The Healthy Tree Canopy Grants for Cities program aims to enhance tree canopies and foster community engagement in tree protection. This initiative offers funding between $10,000 and $50,000 for eligible cities that have completed a tree inventory. It addresses threats to trees from invasive species and promotes public education on tree care while encouraging diversity in the urban forest. A 25% match of total project costs is required, ensuring community investment in local environmental health.

The Utility Arborist Research Fund Grant Program, managed by the TREE Fund and UAA, offers $50,000 in funding for 2024 to support vital research in utility tree care. The program prioritizes proposals focusing on employee safety, service reliability, and regulatory compliance. Grants range from $10,000 to $50,000, with the aim of addressing pressing issues in vegetation management. Applications are welcomed from those aligned with these priorities, promoting safety and efficiency in the utility industry.

Greater Columbus Arts Council

Our mission: To champion and elevate the arts and cultural expression of Greater Columbus.

The Greater Columbus Arts Council supports artists and arts organizations through a spectrum of grant programs, workshops, networking events and services. GCAC also shares a host of resources such as calls for artists, job opportunities, nonprofit board openings and listings of spaces for rent.

GCAC provides marketing services that support artists and organizations through the ColumbusMakesArt.com event calendar, Artist Directory, and Public Art Database. We also produce the annual Big Arts Night recognizing business and individual contributions to the community and the Columbus Arts Festival, the city’s welcome to summer event that takes place each June.

Columbus Motion Picture Incentive

Purpose

The Columbus Motion Picture Incentive (CMPI) fuels the growth of the film industry in Central Ohio by encouraging productions to hire local talent, utilize regional resources, and film within the area—all while supporting local filmmakers and strengthening the creative economy.

The Columbus Motion Picture Incentive (CMPI) is open to any production company, whether local or international, that spends a minimum of $150,000 in Franklin and surrounding counties.

The NIH R25 program enhances clinician-scientists' involvement in research by supporting educational activities aimed at recruiting individuals from diverse backgrounds into biomedical, behavioral, and clinical sciences. This initiative promotes the development of research experiences and mentoring networks to foster a robust research workforce. Applications are due by 5:00 PM local time of the applicant's organization, providing an opportunity for engaging with the NIH's mission.

The William Penn Foundation aims to enhance access to mental health services for young children and caregivers in Philadelphia. This initiative addresses the high rates of adverse childhood experiences in low-income communities and supports families with children aged 0-8 facing barriers such as limited income and cultural challenges. By increasing the number of qualified providers and ensuring culturally competent care, the Foundation seeks to improve mental health outcomes and promote healthier parent-child relationships.

This funding opportunity aims to enhance understanding of chemical-induced skin injuries, particularly those recognized as public health threats. The initiative encourages research focused on identifying commonalities in these injuries and exploring shared signaling pathways. By investigating therapeutic targets, this program seeks to develop effective medical countermeasures. Multiple application deadlines are set from 2025 to 2027, supporting diverse research proposals in this crucial area.

Minnesota Department of Health

Mission: Protecting, maintaining and improving the health of all Minnesotans.

Vision: The vision of MDH is for health equity in Minnesota, where all communities are thriving and all people have what they need to be healthy.

Rural Health Transformation Program Funding 

The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).

Grant recipients will select activities from broad RHTP initiatives designed to advance the overarching goals of improving health outcomes and access to care for rural Minnesotans, sustainably expanding the rural health care workforce, strengthening partnerships between providers to expand service delivery in rural communities, and stabilizing rural provider financial health through strategic investments. 

Entity Type: Certified Community Behavioral Health Clinics (CCBHCs) and Community Mental Health Centers (CMHCs)

Estimated Number of Awards: 16

Estimated Maximum Award in Budget Period 1: $240,000

Applicants may request up to the maximum award.

The Community Development Block Grant (CDBG) program, administered by the Georgia Department of Community Affairs, supports diverse community projects aimed at improving housing, public facilities, and economic development. This initiative is designed to benefit low and moderate-income individuals, ensuring that essential services and opportunities are available to those in need. By fostering local development, CDBG plays a critical role in enhancing community growth and prosperity across Georgia.

Brave Beginnings Grants, under the Will Rogers Motion Picture Pioneers Foundation, focus on enhancing neonatal care by providing vital equipment to hospitals. Since 2006, the program has awarded approximately $1 million annually to Neonatal Intensive Care Units (NICUs) across the U.S. Following a suspension due to COVID-19, the 2026 grant cycle is now open, with applications due by February 13, 2026. This initiative aims to ensure the availability of lifesaving equipment for newborns in critical need.

The Greater Pittsburgh Community Food Bank Impact Grants provide essential funding to organizations facing barriers in delivering food assistance. These small grants, typically ranging from $1,500 for child nutrition programs to $7,500 for agency partners, aim to enhance capacity and improve service delivery. By addressing specific needs, such as equipment or facility repairs, these grants create significant and lasting impacts on food security in the community.

The COPIC Medical Foundation Grants aim to improve healthcare outcomes by funding programs that enhance patient safety and reduce medical errors. With over $10 million awarded since its inception in 1991, the foundation focuses on scalable solutions to address healthcare fragmentation. This final grant cycle emphasizes innovative approaches that can be replicated across the healthcare community. Organizations must be 501(c)(3) certified or have a fiduciary partner to qualify for funding.

The Kansas City Chiefs Charity Game Grant offers a unique opportunity for a 501(c)(3) organization in the greater Kansas City area to partner with the Chiefs for a major fundraising event. The selected organization will receive 90% of the game proceeds, with a commitment to support children and families in crisis. This partnership includes game tickets, promotional support, and the chance to expand fundraising capacity through a well-defined plan, ensuring a significant community impact.

The Mosaic Opioid Recovery Municipal Matching Grant aims to distribute $3.75 million to municipalities in Massachusetts over three years, supporting initiatives to address the opioid crisis. Funded by RIZE, the program matches municipal opioid settlement funds to enhance community efforts in prevention, harm reduction, and recovery services. Eligible projects can receive up to $50,000 individually or $150,000 through collaborative efforts, fostering partnerships among municipalities and nonprofit organizations to improve public health outcomes.

The Laura Turner Dugas Fund for Allen County aims to enhance the community's quality of life by funding programs that address crucial needs such as education, health services, the arts, public recreation, and beautification. This private fund supports 501(c)(3) organizations based in Allen County, prioritizing projects that demonstrate sustainability and measurable outcomes. The fund seeks to build a legacy for future generations, promoting philanthropic giving and community engagement.

The Community Foundation of South Central Kentucky supports philanthropic initiatives aiming to enhance community welfare through grants. Focused on lasting impact, the foundation funds projects in five key areas: education, health and human services, the arts, public recreation, and beautification. Eligible applicants include 501(c)(3) organizations within the BRADD area of Kentucky. The foundation prioritizes projects that address community needs while excluding funding for individuals, capital campaigns, endowments, and general operating expenses.

The PennHOSA Foundation Scholarship promotes healthcare careers by providing scholarships to HOSA student members in Pennsylvania. It aims to enhance compassionate care delivery and community needs. Additionally, the Helen Heidelbaugh Aspire Award is given to one student focusing on community service. Eligible applicants must be HOSA members and enrolled in accredited healthcare programs, demonstrating financial need. This scholarship is a one-time award, reinforcing the commitment to future healthcare professionals.

New Jersey Department of Health

The scope of work for the public health system is ever-expanding, and the Department is on the frontlines in leading the response to public health challenges. The Department has three primary branches – Public Health Services, Health Systems, and Integrated Health. All work collaboratively toward improving health by strengthening New Jersey’s health system.

Our Mission: Protect the public’s health, promote healthy communities, and continue to improve the quality of health care in New Jersey.

Rural Health Transformation Program: Improving Chronic Disease Outcomes in Rural New Jersey

The Division of Health Promotion, through its Community Health and Wellness Unit (CHWU), announces the availability of funding awarded to the State under the Rural Health Transformation (RHT) Grant Program. This funding opportunity is designed to support innovative and sustainable strategies that improve chronic disease outcomes, increase access to quality healthcare services, address health disparities, and strengthen healthcare systems in rural communities.

The grant seeks to advance community-driven solutions that promote health equity, improve health outcomes, and enhance care coordination across rural health systems.

Purpose and Goals

The purpose of the Rural Health Transformation Grant is to support projects that transform rural healthcare delivery by addressing systemic challenges and community-identified needs. Grant goals include, but are not limited to:

• Improving access to healthcare services in rural and underserved areas
• Strengthening rural healthcare infrastructure and workforce capacity
• Enhancing care coordination and integration of services
• Addressing SDOH impacting rural populations
• Promoting preventive care, wellness, and chronic disease management

Proposed Grant Activities

• Activity 5.2a: NJ Rural Southern Physical Activity and Nutrition Program (NJ R-SPAN)
• Activity 5.2b: Umbrella Hub Organization
• Activity 5.3b: Enhancing Rural Cancer-Focused Healthcare (ERCH)
• Activity 5.3c: Rural Pharmacy Medication Management Therapy Program
• Activity 5.3d: Rural Health Screening and Education
• Activity 5.4b: Safe Communities: Youth Violence Prevention in Rural Communities

Activity 5.3d: Rural Health Screening and Education

The Rural Health Screening and Education program will increase access to chronic disease screening and education for rural residents and expand awareness of chronic disease risk factors and their health impacts. The Rural Health Screening and Education Program aims to improve chronic disease outcomes among rural residents by providing walk-in and scheduled screenings, transportation, insurance enrollment, SDOH referrals, follow-up care coordination, and enrollment in evidence-based education programs to manage chronic conditions.

Goal: Enhance and expand early detection, prevention, and management of chronic diseases through coordinated screening and education initiatives encouraging proactive engagement in preventive care, healthier behaviors, and improvement in long-term health outcomes among residents

The Kaulig Foundation grants aim to enhance the well-being of children and families in Northeast Ohio by supporting 501(c)(3) public charities. The foundation focuses on healthcare solutions for children, providing comfort and safety to families, and nurturing children's potential through education and the arts. By funding exemplary programs, it seeks to make a meaningful impact in the community, ensuring that children thrive physically, emotionally, and educationally.

The Lake Forest Garden Club Grant supports community initiatives focused on gardening, horticultural education, and conservation. It prioritizes projects in Lake Forest, Lake Bluff, and Lake County, Illinois. Eligible organizations are encouraged to apply for funding for public, accessible projects such as environmental education and historic garden restoration. The club aims to partner with groups that share its mission of enhancing community engagement and promoting sustainable practices, with a preference for single-year projects.

The Lynne Goldsborough Yowell Scholarship, managed by the Northern Piedmont Community Foundation, supports students from Madison and Culpeper County public high schools. It is awarded to high school graduates or current college students pursuing an Arts Major, defined as visual arts, music, theater, or culinary arts. Emphasizing academic merit and financial need, this scholarship honors the legacy of Lynne Goldsborough Yowell, a dedicated community advocate.

The Tick-borne Pathogen Award, sponsored by Bay Area Lyme Foundation, offers $150,000 to support innovative research on non-Borrelia tick-borne pathogens. This grant aims to attract scientific talent to explore co-infections with Lyme disease and other related infections. Eligible candidates include researchers from academia or the private sector at the post-doctoral level or higher, with a focus on improving diagnostics and therapies for tick-borne diseases. Applications must present a viable proof-of-concept project.

Esther Edie Environmental Scholarship

In 1972, Esther Edie brought together several small environmental protection groups from around the state to form the South Dakota Resources Coalition (SDRC). SDRC’s mission was to preserve and enhance our environment, protect our natural resources, and encourage citizens and businesses to adopt sound environmental practices. In its 40-year existence, SDRC fulfilled its mission through education, legislative advocacy, and litigation. Esther Edie was an effective leader in SDRC’s many projects until she died in 2006.

To provide financial support to students attending a college or university in South Dakota, who is pursuing a career in one of the following areas: Environmental Science, Environmental Geography, Environmental Sociology, Natural Resource Management, or Environmental Law.

Division of Early Childhood

The Department of Human Services Division of Early Childhood (DEC) was established as a standalone IDHS division in 2021 to help strengthen and centralize the state's existing child care, home visiting, and early intervention programs, as well as operationalize and create administrative capacity to establish sustainable infrastructure needs in order to streamline services.

Working hand-in-hand with local communities throughout Illinois, the Division of Early Childhood provides low-income, working families with access to quality, affordable child care; administers community-based prevention and intervention programs; and helps all children between the ages of birth to three with disabilities or delays, to learn and grow.

480-50-3708 Migrant and Seasonal Head Start

Description

Scope of Work

Provide a full-day, comprehensive Head Start child development program to children, ages six weeks to six years, from migrant and seasonal farm-worker families. Program includes early childhood education, school readiness, developmental assessment, mental health screening, field trips, project work, immunizations, nutritious meal service and medical and dental examinations, completion of dental and medical treatment for children who need it, social-service referrals and transportation services.

Announcement Type: Renewal

The BRCFSC Community Grants, offered by the Blue River Community Foundation, support projects in Art & Culture, Health, Education, and Social Services for Shelby County residents. These grants are funded through various unrestricted family and interest funds, promoting initiatives that address beautification, youth support, and disability services. Eligible organizations must demonstrate sound accounting practices, while projects already in progress or focused on travel or political campaigns are ineligible. This competitive grant cycle encourages community-driven development.

The Native Forward Scholars Fund Internship Assistance Program empowers Native students by providing financial support for internships in non-STEM fields. This initiative breaks down financial barriers, enabling students to gain practical experience in areas like public policy, education, and cultural preservation. Through this program, students enhance their skills while contributing positively to their Tribal communities. The funding covers essential costs such as travel and living expenses, ensuring transparency and accountability in financial assistance.

The Furer-Barag-Wolf Post 126 Jewish War Veterans Scholarship Award supports children or grandchildren of JWV Post 126 members, providing merit-based assistance for college or vocational education. Eligible applicants must reside in specific counties in New Jersey or be related to a JWV member. The scholarship covers tuition, books, and living expenses and is open for reapplication annually. This initiative by the Jewish Community Foundation fosters educational opportunities for deserving students.