Best Large Grants for Nonprofit Organizations

The Strategic Projects: Capital Grants by the M J Murdock Charitable Trust offer vital funding opportunities for nonprofit organizations in the Pacific Northwest. These grants support transformative projects that enhance community well-being through construction, renovation, and infrastructure investments. Eligible entities include 501(c)(3) nonprofits and government entities. The Trust emphasizes projects that demonstrate strong community impact and funding diversification, ensuring sustainable growth and lasting benefits for the communities served.

The M J Murdock Charitable Trust offers Strategic Projects: Equipment & Technology Grants to nonprofits in the Pacific Northwest. These grants focus on capacity-building projects and essential equipment, requiring recipients to cover at least 50% of costs. Eligible organizations include 501(c)(3) nonprofits and tribal entities. Priority is given to projects enhancing community services, education, and environmental stewardship, supporting initiatives that foster human flourishing and demonstrate diversified funding.

The Slomo and Cindy Silvian Foundation Grant supports a range of subjects including education, children's welfare, medical care, medical research, and Jewish philanthropic endeavors. Established in honor of Cindy Silvian, the foundation has awarded over $30 million since 2008. Applications are by invitation only, and organizations must meet specific eligibility criteria to be considered for funding. This year, the foundation allocated over $2.4 million to more than 110 organizations, highlighting its commitment to impactful philanthropy.

The M J Murdock Charitable Trust offers the Strategic Projects: Program & Staff Grants to support nonprofits in the Pacific Northwest. These grants focus on capacity-building for mission-driven projects and infrastructure investments. Eligible organizations must demonstrate a commitment to community flourishing, with funding available for new programs or expansion of existing ones. The Trust prioritizes initiatives that align with its strategic goals, fostering sustainable nonprofit growth and impact in the region.

Florida Department of Health

Led by the State Surgeon General, the mission of the Florida Department of Health is to protect, promote, and improve the health of all people in Florida through integrated state, county, and community efforts.

The Live Like Bella Pediatric Cancer Research Initiative

The Florida Department of Health’s Live Like Bella Pediatric Cancer Research Initiative supports the pursuit of identifying cures for pediatric cancer.

The Live Like Bella Pediatric Cancer Research Initiative is established in section 381.922, Florida Statutes, works to advance progress toward curing pediatric cancer through grants awarded through a peer-reviewed, competitive process, to:

• Significantly expand pediatric cancer research capacity in Florida
• Improve both research and treatment through greater pediatric enrollment in clinical trials networks
• Reduce the impact of pediatric cancer on disproportionately impacted individuals

Research Focus

Applications submitted in response to this Funding Opportunity Announcement (FOA) must be responsive to one of the following areas of focus. 

• Prevention and Treatment
• Screening
• Obesity
• Treatment-Related Morbidities
• Technology Transfer Feasibility (TTF)
• Investigational New Drug or Investigational Device Exemption

Efforts to foster collaborations among institutions, researchers, and community practitioners should be included, when possible. Preference will be given to applications that address at least one of the cancers listed in the Research Priorities section of this FOA.

Funding Information

Applicants must request funding in the preceding grant categories to pursue research in the areas of focus outlined in the Research Focus section of this FOA. Preference will be given to applications that address the priorities listed in the Research Priorities section of this FOA. Specific grant funding amounts are available for each grant category.

Grant Categories

Applications in response to this FOA must align to a grant category (depending on the grant program) to pursue an area of focus from the Research Focus section of this FOA. Applications for research infrastructure grants that are reviewed and assigned exceptional scientific merit will be considered for preferential funding. 

The grant categories are: 1) Bridge; 2) Discovery Science; 3) Emerging Therapeutics and Technologies; 4) Equipment; 5) Multicenter Clinical Trials; 6) New Investigator Research (NIR); 7) High-Risk, High-Reward Clinical Research; 8) High-Risk, High-Reward Discovery Science; 9) Non-Typical Clinical Trials/Socio-Behavioral Research; 10) Research Infrastructure

Bella Initiative Grant Categories: High-Risk, High-Reward Clinical Research

Research in this mechanism of support test innovative therapeutic approaches or novel treatment modalities with transformative potential but substantial uncertainty regarding feasibility, safety, or efficacy. These include first-in-human studies, unconventional drug repurposing, or interventions targeting previously undruggable pathways. The high-risk component encompasses potential trial failure, unexpected adverse events, or negative results that could redirect research programs. The high-reward potential includes paradigm-shifting breakthroughs, dramatic clinical improvements, or validation of novel biomarkers that revolutionize personalized medicine.

Maximum Duration: 48 months

The Cecelia Springmeyer Memorial Scholarship, managed by the Decatur County Community Foundation, aims to support North and South Decatur students pursuing post-secondary education in law enforcement, criminal justice, animal husbandry, agronomy, or teaching. Applicants must reside within the Decatur County Community Schools district and may receive a minimum scholarship of $1000 to ease their educational costs. For more details, visit ndsdscholarships.com.

The Social-Impact Investment Pitch Competition aims to enhance the vitality of Southwestern Pennsylvania, particularly in Pittsburgh, by fostering economic development, wildlife conservation, and community health. The Foundation invites nonprofits, public agencies, and socially-driven for-profit companies to apply for funding to implement innovative ideas that address societal challenges. Applications are open to U.S.-based organizations seeking capital and project support, with a focus on creating lasting positive change in the community.

Mission Statement

Beckley Area Foundation exists to inspire and facilitate generous charitable giving that advances our community.

The Beckley Area Foundation is committed to enriching lives and strengthening communities across Southern West Virginia.

Scholarship

Supporting Student Success

The Beckley Area Foundation proudly manages scholarship funds established by individuals, businesses, and organizations dedicated to helping students pursue higher education. Many of these scholarships are tailored for specific schools, fields of study, or graduates from local high schools, while others offer broader opportunities. No matter the path, our scholarships aim to support students from our region as they work toward achieving their educational goals.

Margaret Thorne-Dilley Scholarship for Science Teachers Scholarship

Eligibility

Equally weighted as a need and merit based award for a Raleigh County high school graduate with a 3.5 cumulative GPA; Pursuing baccalaureate degree in education at an accredited institution; Preference will go to students pursuing a science field including the biological, physical and natural sciences. If none apply with the preferences listed, mathematics will also be considered.

The Hazel Miller Foundation Grant supports charitable projects in South Snohomish County, focusing on education, youth services, poverty alleviation, civic services, environmental initiatives, culture, and diversity. Applications are accepted at any time, with quarterly review cycles. The Foundation prioritizes projects that deliver significant community impact and are managed by tax-exempt organizations. Grants are not available for individuals. This initiative aims to foster a resilient and thriving community.

The Marilyn and William Young Foundation Grant aims to foster a vibrant community by supporting leadership development, accessible arts experiences, family support systems, and community grants. Eligible applicants must be recognized 501(c)(3) organizations, focusing on innovative strategies that enhance economic opportunities and well-being. The foundation prioritizes initiatives that impact citizens in Owensboro/Daviess County, and does not support discriminatory practices or funding for operating costs.

The David, Helen and Marian Woodward Fund, established by Marian Woodward Ottley in 1974, aims to support non-profit organizations in Georgia and neighboring states. The fund prioritizes capital projects and educational programs that enhance graduation rates, particularly those with religious affiliations. Grants are awarded exclusively to 501(c)(3) organizations, while governmental agencies can also apply. The foundation's mission underscores a commitment to improving the world for future generations.

Generally the Community Foundation's scholarships are awarded to applicants who have high financial need. Applicants with household income exceeding $100,000 are less likely to be awarded, but applying will allow you to be considered for targeted scholarships.

TowerPinkster Scholarship

Open to high school seniors graduating from a Michigan public high school, studying architecture, landscape architecture, interior design, or structural engineering with a minimum 3.25 GPA.

The Menasha Corporation Foundation, established in 1953, supports nonprofit organizations across North America, focusing on community betterment, education, environmental sustainability, and health initiatives. Grants are awarded to projects that enhance the lives of individuals and strengthen communities, particularly in areas where Menasha Corporation operates. Eligible organizations must be tax-exempt and prioritize non-public funding. The foundation also encourages involvement from Menasha Corporation employees in supported projects.

Osborn scholarship

The Osborn scholarship is for BIPOC students with demonstrated financial need, who are enrolled in or planning to pursue an accredited bachelor’s or master’s degree program in landscape architecture or civil engineering. Priority will be given to students with a demonstrated a commitment to developing public infrastructure and/or public places in the State of Washington. The intention of the scholarship is to create opportunities for those who have faced historic barriers to access to these professions in the United States. The scholarship founders believe that the design challenges of the 21st century require diverse voices to solve. They look forward to the stronger design solutions to which future scholarship recipients will contribute. Scholarship applicants must demonstrate the grit, resiliency and aptitude that is necessary for success in these professions. This may be demonstrated by any combination of at least two of the following characteristics: overcame a significant personal challenge to maintain at least a B average at school, honor roll grade point average, demonstrated ability to juggle multiple responsibilities, demonstrated service contributions to their community.

Awards

• $5,000 - $10,000

The Rural Downtown Economic Development Grants program, administered by the North Carolina Department of Commerce, aims to revitalize downtown areas in the state's most distressed counties. This initiative prioritizes projects that enhance public infrastructure, support economic development, and foster community-wide uses. Eligible local government units can receive grants up to $850,000, focusing on initiatives that leverage downtown assets for economic growth while ensuring a cash match of at least 5% from local resources.

The Responsive Grants program by the Community Foundation of the Holland/Zeeland Area aims to support transformative charitable projects across various sectors including arts, education, and health. Open to eligible nonprofit organizations, the program provides funding for both existing and new initiatives with a focus on sustainable impact. Priority is given to proposals that align with the foundation's mission and demonstrate organizational capacity, ensuring community needs are effectively addressed.

The Community Development Block Grant (CDBG) Program in Westchester County supports essential community development and housing assistance through three grants administered by HUD. Open to municipalities and non-profits in the Westchester Urban County Consortium, this program funds public facility improvements and community services. The maximum funding request is capped at $800,000. Eligible activities include infrastructure improvements, housing rehabilitation, and economic development loans, benefiting income-eligible clients and areas.

The CFSCNY Small Grants Program supports nonprofits in Broome, Chenango, Delaware, Otsego, and Tioga counties. Prioritized projects address critical areas such as equity, housing, and mental health. Grants range from $250 to $5,000 and may cover operational costs, capacity building, or small capital purchases. Applications are accepted quarterly, with the next cycle due on the fourth Monday of January, March, May, and September. This program aims to empower organizations aligned with community needs.

Texas Education Agency

The Texas Education Agency is the state agency that oversees primary and secondary public education. It is headed by the commissioner of education. The Texas Education Agency improves outcomes for all public school students in the state by providing leadership, guidance, and support to school systems.

Every Student Succeeds Act (ESSA)

The Every Student Succeeds Act (ESSA) is a federal K–12 education law. ESSA was signed into law in 2015, replacing No Child Left Behind, and reauthorizing the original Elementary and Secondary Education Act (ESEA), which was signed into law in 1965 by President Lyndon Baines Johnson.

ESSA requires every state to measure performance in reading, math, and science. Every school must inform parents about their standards and their results. 

ESSA requires every state to provide parents important information on test performance in reading, math, and science. The report cards must also provide data on graduation rates, suspensions, absenteeism, teacher qualifications, and many other areas. Texas provides maximum transparency for parents and publicly shares performance information on TXschools.gov and in data reports on the Performance Reporting pages.

Every Student Succeeds Act (ESSA) Consolidated Federal Grant

The Every Student Succeeds Act (ESSA) Consolidated Federal Grant includes: 1) Title I, Part A Grants; 2) Title I, Part C Grants; 3) Title I, Part D, Subpart 1 Grants; 4) Title I, Part D, Subpart 2 Grants; 5) Title II, Part A Grants; 6) Title III, Part A ELA Grants; 7) Title III, Part A Immigrant Grants; and 8) Title IV, Part A, Subpart 1 Grants.

Title I, Part D, Subpart 1 

Program Purpose, Goals, and Objectives

[ESSA, Section 1401(a)]

The purpose of Title I, Part D, Subpart 1 is to do the following:

• Improve educational services for children and youth in local and state institutions for neglected or delinquent children and youth so that such children and youth have the opportunity to meet the same challenging state academic content standards and student academic achievement standards that all children are expected to meet;
• Provide such children and youth with the services needed to make a successful transition from institutionalization to further schooling or employment; and
• Prevent at-risk youth from dropping out of school and provide dropouts and children and youth returning from jails or institutions for neglected or delinquent children and youth with a support system to ensure their continued education and the involvement of their families and communities.

The Texas Juvenile Justice Department (TJJD) and the Windham School District are the eligible state agencies in Texas.

Brooklyn Org is now accepting applications for microgrants to support community-based organizations with budgets under $100,000. These grants aim to empower groups working towards racial justice and provide vital resources to historically marginalized communities. Organizations can apply year-round for funding up to $10,000 for general operating support. This initiative reflects Brooklyn Org's commitment to fostering local philanthropy and strengthening the nonprofit sector in Brooklyn.

The Prolacta Bioscience Foundation Grant supports nonprofit organizations focused on enhancing human health and empowering communities. Established in 2019, the foundation aids in innovative research on human milk and promotes educational initiatives. Grants prioritize organizations that align with the foundation's mission and serve areas where Prolacta employees live. Notable projects include creating resources for parents and organizing community events to showcase the importance of neonatal care, ultimately ensuring a brighter future for vulnerable infants.

The Lena Benas Memorial Fund Grant, established in 1986, aims to support the health, human services, and housing needs of underserved individuals in Litchfield, Connecticut, and nearby communities. The fund prioritizes organizations that serve these populations, particularly in areas such as education, healthcare, and housing maintenance. Special consideration is given to established nonprofits that demonstrate a commitment to improving the lives of those in need, ensuring impactful community support.

About DHHS

DHHS is the largest agency in New Hampshire state government, responsible for the health, safety and well-being of the citizens of New Hampshire. DHHS provides services for individuals, children, families and seniors, and administers programs and services such as mental health, developmental disability, substance misuse, and public health. This is accomplished through partnerships with families, community groups, private providers, other state and local government entities, and many citizens throughout the State who help make New Hampshire a special place in which to live.

RFA-2027-OCOM-03-COMPL: Complaint Investigation Services

Division of Long Term Supports and Services

The New Hampshire Department of Health and Human Services, Division of Long Term Supports and Services (“Department”) is seeking responses to this Request for Applications ("Solicitation" or "RFA") from qualified Vendors to provide statewide Complaint Investigation Services regarding allegations of client rights violations on behalf of individuals with acquired brain disorders or developmental disabilities, pursuant to New Hampshire Administrative Rule He-M 202.   

Qualified Vendors must meet the following minimum qualifications for a complaint investigator, pursuant to New Hampshire Administrative Rule He-M 202.09 (a):

• Hold a bachelor’s degree from an accredited college in social work, sociology, psychology, human services, related behavioral services, or criminal justice and experience in performing complaint investigations totaling two (2) years or more; or 
• Experience in developmental disabilities services in New Hampshire totaling three (3) years or more in an area such as service coordination, program management; or quality assurance.

The Polaris Foundation Grant focuses on long-term community investment, emphasizing areas such as environment, community development, youth safety, and education in STEM and trades. The foundation prioritizes funding requests from 501(c)(3) organizations located in specific communities where Polaris operates. Organizations are encouraged to promote responsible land use and create vibrant environments for residents, while adhering to eligibility requirements and avoiding politically affiliated or discriminatory programs.

The Holthouse Foundation for Kids supports organizations that empower at-risk youth through character education, life skills, and entrepreneurship. They provide grants to non-profit entities recognized under Section 501(c)(3) of the Internal Revenue Code, focusing on community enrichment in Houston and beyond. While inquiry letters are accepted year-round, they do not guarantee funding, and applicants must understand that proposals are not a promise of financial support.

Violence Against Women Justice and Training Program - Texas

Purpose:

The purpose of this announcement is to solicit applications for projects that promote a coordinated, multi-disciplinary approach to improve the justice system’s response to violent crimes against women, including domestic violence, sexual assault, dating violence, and stalking.

Available Funding:

Federal funding is authorized for these projects under the Violence Against Women Act of 2013 Pub. L. No. 113-4 (VAWA 2013). VAWA funds are made available through a Congressional appropriation to the U.S. Department of Justice, Office on Violence Against Women. All awards are subject to the availability of appropriated federal funds and any modifications or additional requirements that may be imposed by law.

Project Period:

Projects may not exceed 12 months and must start on 9/01/2026 and end on 08/31/2027.

Funding Levels

• Minimum: $5,000
• Maximum: No Maximum
• Match Requirement: 30% of the total project (Note: Victim service providers and Native American tribes are exempt from the match requirement.)

The AES Ohio Foundation, a leading corporate foundation in the Dayton region, offers Community Impact Grants aimed at improving quality of life and fostering sustainability. With a focus on poverty reduction, workforce development, and promoting diversity, equity, and inclusion, the foundation supports initiatives that address basic community needs. Organizations seeking funding must align with these priorities while demonstrating measurable outcomes and a commitment to equity. The application deadline for 2024 is October 15, 2024.