Best Large Grants for Nonprofit Organizations

The MGM Resorts Foundation Community Grant Fund supports nonprofit agencies providing essential services in areas such as affordable housing, education, and health. Grants are awarded for a one-year period and focus on regions where MGM Resorts employees live and work. Eligible applicants must comply with diversity policies and serve individuals or families. The foundation does not fund governmental agencies or projects exclusively for medical research. This initiative aims to enhance community well-being through targeted support.

The Roy J. Carver Charitable Trust provides grants primarily to 501(c)(3) tax-exempt organizations in Iowa and parts of Illinois. Focused on enhancing educational opportunities, the Trust supports projects in elementary and secondary education, higher education, medical research, youth services, and recreation. By funding innovative initiatives, it aims to improve access to educational resources and foster scientific advancement, while also addressing the recreational needs of youth and supporting community development.

The BGCF365 Grants, initiated by the Blue Grass Community Foundation, empower emerging philanthropists to collectively fund nonprofit projects that dismantle barriers to employment, transportation, and housing for families in Fayette County. In 2024, grants will focus on enhancing resilience among youth aged 0-22. Members contribute $365 annually, pooling resources to award $30,000 to selected organizations. This initiative fosters community engagement and aims to improve living conditions for all in Lexington.

The Long Island Sound Futures Fund (LISFF) is offering approximately $12 million in grants to enhance the health and living resources of Long Island Sound. Managed by the National Fish and Wildlife Foundation (NFWF) in collaboration with the U.S. EPA and the Long Island Sound Study (LISS), this initiative seeks innovative proposals to support environmental restoration efforts, leveraging major funding from various agencies and foundations.

The Deluxe Corporation Foundation's ERG Grant Program supports diverse and inclusive initiatives by empowering employee resource groups (ERGs) to partner with nonprofits addressing relevant social issues. Each of the ten ERGs will award a $25,000 grant to a selected organization, fostering community impact and collaboration. The foundation, established in 1954, has invested over $109 million in charitable causes, focusing on financial literacy, education, and community support to enhance lives and promote entrepreneurship.

The Broadrick Family Foundation Grant, established in 2010, focuses on supporting local charities dedicated to aiding children and those in need. With a commitment to enhancing community welfare, the foundation raises funds for programs that match at-risk youth with mentors, support research for childhood cancer, and provide educational opportunities. The foundation seeks to collaborate with organizations that demonstrate fiscal responsibility and grassroots impact, ensuring that help reaches those who need it most in the community.

The Virginia Innovation Partnership Corporation (VIPC)’s Commonwealth Commercialization Fund (CCF) Higher Education (HE) Proof-of-Concept (POC) program provides grant funding to Virginia’s public and private colleges and universities and eligible nonprofit Virginia-based research institutes. Applicants may request $75,000 or $150,000, depending on the designated track, to support translation Virginia research-derived innovations into commercial products. Applicants with technologies at a more advanced technology readiness level (TRL) and/or deemed by VIPC to have exceptional strategic value for Virginia may be invited to seek up to $300,000. Each grant requires a minimum one-to-one match and is expected to support the achievement of two to three key milestones during the period of performance (typically 6-15 months). 

The Sacramento District California In-Lieu Fee Program, established by the National Fish and Wildlife Foundation, offers a mitigation option for permittees to compensate for authorized impacts to aquatic resources in California. Approved by multiple agencies, this program facilitates the purchase of mitigation credits to meet compensatory mitigation requirements. It employs a watershed approach to evaluate wetland threats, prioritize restoration, and implement mitigation projects, ensuring effective management of aquatic resources across designated service areas.

The Louisville Water Foundation is dedicated to enhancing global health and well-being through water education and assistance. Their mission focuses on ensuring safe water access for all communities. They support innovative projects that demonstrate clear objectives, community engagement, and sustainability. Eligible applicants include non-profits addressing water-related needs within specified service areas. The foundation emphasizes measurable impacts and reasonable budgeting, fostering a collaborative approach to water stewardship.

The Kirkpatrick Foundation Small Grants program supports diverse initiatives in arts, culture, education, animal wellbeing, environmental conservation, and historic preservation, primarily in Central Oklahoma. With no specific deadlines and monthly reviews, the foundation aims to enhance the quality of life through strategic funding. Organizations that qualify as 501(c)(3) nonprofits and serve the local community are encouraged to apply. This program reflects the foundation's commitment to fostering a vibrant and sustainable environment for all citizens.

The Albemarle-Pamlico National Estuary Partnership (APNEP) offers funding for projects focused on community engagement and stewardship aimed at enhancing environmental literacy and volunteerism in the Albemarle-Pamlico region. Grants typically range from $40,000 to $80,000, supporting initiatives that foster stewardship, promote outdoor experiences, and address environmental inequities, ensuring diverse community involvement in protecting local ecosystems.

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

The Delta Foundation, established by CFD Research Corporation in 2021, aims to enhance community well-being through collective employee-owner contributions. By funding local non-profit organizations, the Foundation supports vital initiatives in arts, mental health, and basic needs, ensuring that every dollar directly benefits the Huntsville area. The Foundation prioritizes organizations that align with its mission to improve quality of life, fostering impactful change through collaboration and community engagement.

Service Objects In-Kind Grants support non-profit organizations dedicated to environmental conservation and sustainability. By leveraging their data validation services, they aim to assist projects that promote ecological health and responsible resource management. The program prioritizes applications with clear, measurable objectives and impactful outcomes within one to three years. Organizations with 501(c)(3) status in the U.S. are eligible, while initiatives lacking detailed plans or focusing on generalized education will not qualify. This grant fosters community involvement in environmental stewardship.

West Virginia Community Advancement and Development

West Virginia Community Advancement and Development works to encourage strong civic engagement through INFRASTRUCTURE, SUSTAINABILITY, COMPLIANCE, and RESILIENCY. WV CAD administers state and federal programs designed to improve the quality of life in West Virginia.

Neighborhood Investment Program

What is NIP?

The Neighborhood Investment Program (NIP) is a tax credit program of $3 million each year, which allows 501(c)3 designated charitable organizations to apply for tax credit vouchers, which began in 1996 with $2 million. When awarded, the organization can distribute the vouchers to business and individuals who contribute a minimum of $500 to organizations, receiving up to 50% in tax credit, allowing the donor or corporation to reduce their West Virginia tax liability no more than 50%. The organizations pay a 3% fee on the donation, which offsets the administrative costs of NIP. 

Benefits of NIP

There are 15,883 non-profits in West Virginia and we assist 200 of them each year with NIP credits, which has leveraged over $143 million in donations since inception.

Projects generally eligible for program participation include but are not limited to the following:

• Health clinics
• Homeless shelters
• Educational programs
• Housing programs
• Preservation/revitalization activities
• Domestic violence shelters
• Children's shelters
• Meal delivery programs
• Senior citizens' centers
• Community foundations
• Scholarship programs
• Hospice care
• Transportation programs
• Day care centers
• Counseling services
• Services for the disabled

The Competitive Graduate Research Fellowship, offered by Maryland Sea Grant, supports graduate students conducting research on critical issues affecting the Chesapeake Bay and coastal waters. This fellowship emphasizes social relevance and community engagement, particularly focusing on underserved populations. Awarded fellows receive a stipend of $34,000, tuition remission, and travel allowance. A professional mentor is required to ensure research aligns with the needs of resource managers and policy makers. Applications are encouraged from a diverse pool of candidates.

The Joseph and Elaine Malama Vierra Scholarship Fund, established in 2016, supports Hawaii residents pursuing degrees in conservation and environmental sciences. Applicants must demonstrate financial need, maintain a minimum GPA of 3.0, and attend an accredited four-year institution. Preference is given to past recipients who continue to meet eligibility requirements. This fund encourages the study of vital fields, including Conservation Biology and Marine Sciences, contributing to the sustainability of Hawaii's natural resources.

The Schwemm Family Foundation Grant supports initiatives promoting environmental enhancement, local history preservation, and community health. It aims to strengthen communities in Oregon, California, and the Chicago area by funding projects that protect ecosystems, document culture, and foster equitable access to resources. Eligible applicants include 501(c)(3) non-profits dedicated to measurable outcomes that align with the Foundation's goals. The Foundation does not fund operating support or scientific research.

The EBSCO Community Impact Grant Program supports initiatives in education, environment, human services, and arts and culture. This grant is available to 501(c)(3) organizations serving specific counties in Alabama. Applicants may submit a Letter of Inquiry, but full proposals are by invitation only. EBSCO is dedicated to enhancing community well-being through innovative programs that promote equitable education, environmental protection, and access to basic human services.

California Department of Health Care Access and Information

Mission: HCAI expands access to quality, equitable, affordable health care for all Californians by supporting high value delivery systems, resilient health facilities and workforces, and actionable health information and strategies.

HCAI is committed to expanding access to quality, equitable, affordable health care for all Californians by supporting high value delivery systems, resilient health facilities and workforces, and actionable health information and strategies.

California Rural Health Transformation (CalRHT) Program – California’s Implementation

The California Rural Health Transformation (CalRHT) program is California’s approach to the federal Rural Health Transformation Program (RHTP), led by the Department of Health Care Access and Information, with Centers for Medicare & Medicaid Services (CMS) oversight. CalRHT is designed to strengthen health care delivery in rural communities where access challenges, workforce shortages, and infrastructure gaps create unique barriers to care.

California Rural Healthcare Transformation (CalRHT) Initiative 1: Transformative Care Model Expand and Support Rural Workforce Capacity

The Family Medicine Obstetrics (FM-OB) Fellowship Subaward Program under Expand and Support Rural Workforce Capacity is intended to fund the programmatic and infrastructure costs of expanding FM-OB fellowship capacity. Primary applicants for the FM-OB Fellowship Subaward Program must be aspiring or existing graduate medical education (GME) sponsoring institutions. The Program expands access to high-quality maternity and perinatal care in California’s rural communities by increasing the number of family physicians with advanced obstetrics training. Through support for family medicine obstetrics fellowship programs and regional collaborative care models, the program builds sustainable obstetric workforce capacity where rural patients receive care, preparing physicians to practice in underserved communities and improving maternal and infant health outcomes.

The SBM Charitable Foundation Grant aims to enhance the quality of life for residents in Hartford, Tolland, and Windham Counties through funding programs in health, education, human services, housing, and the arts. Eligible organizations must be tax-exempt or municipalities, focusing on community benefit. The Foundation prioritizes educational scholarships and health programs, emphasizing direct services and broad-based community projects. Applications are accepted annually, promoting accessibility and support for local initiatives.

The Emergency Solutions Grant (ESG) program, established under the HEARTH Act of 2009, provides crucial funding to local governments for rehabilitating homeless shelters and financing essential services related to these shelters. Eligible entities include 501(c)(3) nonprofit organizations with at least two years of operation. The City of Orlando expects to allocate approximately $194,000 for homelessness prevention, rapid re-housing, and emergency shelter operations, ensuring a comprehensive approach to addressing homelessness in the community.

The Burning Foundation offers grants ranging from $5,000 to $15,000, totaling around $650,000 annually, to support environmental 501(c)(3) organizations in Washington and Oregon. The foundation focuses on preserving habitats that enhance biodiversity and promote quiet recreation. Eligible projects must align with their mission of protecting local rivers, forests, and ecosystems. Preference is given to local initiatives over national organizations, encouraging grassroots efforts in environmental conservation.

The Hind Foundation Standard Grant supports impactful community projects in California since 2006. Funding areas include ecosystem conservation, historical landmark restoration, music and visual arts, wildlife protection, and land conservation. Eligible nonprofit organizations must be California-based, have a 501(c)(3) designation, and demonstrate community support. Projects must provide lasting benefits, align with funding areas, and secure adequate matching funds. Grants are not available for previously funded projects or for educational and administrative costs.

The Children's Guild Foundation Grant supports non-profit organizations in Western New York that cater to children with special needs. The Foundation, operational for over a century, focuses on funding impactful programs addressing developmental, medical, intellectual, behavioral, and mental health challenges. By forming partnerships and advocating for systemic change, the Foundation aims to enhance the lives of these children and their families, ensuring their needs are met effectively and efficiently.

The Community Impact Grants by the United Way of Martin County support local programs focusing on health, education, and financial stability. These grants aim to enhance community well-being by funding organizations that demonstrate measurable outcomes and align with the United Way's mission. Eligible programs must be 501(c)(3) entities, serve Martin County residents, and have a track record of at least two years. A review panel of community leaders evaluates applications to ensure impactful funding.

The IMPLICIT Grant, funded by the Minnesota Department of Health, aims to enhance maternal and perinatal care by implementing the IMPLICIT model in at least five clinics over three years. This initiative addresses critical factors such as smoking and maternal depression to reduce birth defects. A total funding of $130,000 is available, providing annual stipends of $18,000 to participating clinics, which will also receive essential training and support to ensure sustainable healthcare improvements.