Best Large Grants for Nonprofit Organizations

The US Department of Health & Human Services, through the NIH, invites applications for innovative approaches to implement SBIRT/P for addressing alcohol, tobacco, and other drug use in adults facing health disparities. This funding opportunity encourages research that tests screening, brief interventions, and referrals for treatment or prevention services. Applications are due on specified deadlines from February 2024 through March 2027, fostering collaboration with healthcare and community partners to enhance public health outcomes.

The ARF Competitive Grants Program aims to enhance Oregon's agricultural productivity and resource management through research funding at Oregon State University. It supports both emerging and established scientists in launching new research initiatives. By providing catalytic grants, the program encourages innovative approaches in agriculture and natural resource studies. Faculty members at OSU with relevant research interests are invited to apply, contributing to the advancement of sustainable practices in Oregon's agriculture.

The Weston Family Boreal Research Fellowship, supported by the Wildlife Conservation Society Canada, offers financial assistance to graduate students conducting field-based research in the Ontario Northern Boreal and Northern Boreal Mountains. This fellowship encourages projects that align with WCS Canada's conservation objectives and that collaborate with Indigenous communities. Successful applicants will benefit from mentorship and networking opportunities, while contributing to significant conservation efforts in North America's boreal regions.

The Climate Change Investment Initiative Grant Program, funded by the Exelon Foundation, aims to support innovative start-ups focused on climate change solutions within Exelon's service territories. With a commitment of $20 million over ten years, the program promotes not only environmental sustainability but also social equality and economic prosperity. Eligible businesses can benefit from substantial equity investments and valuable in-kind services. The initiative seeks to empower diverse leadership teams, particularly those representing women and minorities, to drive impactful change.

The Louisville Water Foundation aims to enhance community health by ensuring access to safe water through various initiatives. Grants are available to 501c3 organizations within the Louisville service areas for projects that provide drinking water solutions, educational programs, and watershed protection efforts. The application deadline for the water access projects is September 15, encouraging impactful contributions to local water-related challenges.

About the Montana Department of Commerce

Every day, staff at Commerce work alongside private industry and local organizations to create jobs, grow businesses, provide affordable housing and improve community infrastructure.

The economy of the Treasure State continues to grow and diversify. Studies rank Montana as the number one place in the country to start a business. Plus, our workforce has earned some of the highest rankings in both trade and technical skills by having one of the highest STEM (science, technology, engineering and mathematics) concentrations in the country.

Public and Community Facilities

Public and Community Facility Grants

Montana's CDBG Public and Community Facilities grants help local governments fund construction or rehabilitation of infrastructure and facilities that primarily benefit low- to moderate-income (LMI) Montanans, i.e. individuals earning less than 80% of the area median income. These projects can target LMI residents and provide direct benefits by improving or creating access to suitable living environments or necessary services, or these projects can provide an area-wide benefit to the entire community as long as at least 51% of the project’s beneficiaries are determined to be LMI. 

Certain projects such as senior centers, food banks, homeless shelters, youth homes, or head start centers are presumed to serve a limited clientele that is primarily LMI. Therefore, determining exactly what percent of project beneficiaries qualify as LMI is not required. Other projects, such as a wastewater improvements or water treatment improvements provide benefits to the entire community and are considered to have area-wide benefit because both LMI and non-LMI residents are served. Therefore, applicants must document at least 51% of the project’s beneficiaries qualify as LMI for projects considered to have an area-wide benefit.

Healthy Chippewa County Grants

About the Grants

The Healthy Chippewa County (HCC) grant program, supported by endowed funds at the Community Foundation of Chippewa County (CFCC), provides funding to invest in organizations serving the greater Chippewa County area. Grants are awarded to programs that address key health needs across the County. Funding prioritizes programming initiatives that meet current community health needs, while also reducing health disparities. It will also support AODA services, home health and hospice, financial assistance to health care and care for women and infants.

Applicants are limited to one application per cycle and may apply specifically for one of the five priority program areas. Grants are awarded toward the end of June each calendar year and the grants range from $20,000-35,000.

General Community needs such as the arts, community development, animal care and general education are not included in the scope for this opportunity. Grants may not be used to support abortion, contraception, assisted suicide, IVF or embryonic stem cell research.

The Marine Mammal Commission is inviting proposals aimed at developing innovative tools and methods for enhancing marine mammal stock assessments. This initiative focuses on creating cost-effective strategies to estimate population sizes and assess human-caused mortality. Applicants can be from within or outside the U.S., and projects must contribute to science-based management. The funding limit is set at $75,000, encouraging novel approaches to improve the reliability of critical data in marine conservation.

Major Grant Fund

Apply for $50,000 to $200,000 per year, renewable up to two times for a total of three years of funding. Funds may support health-related direct service delivery or advocacy efforts. New for 2026, Major Grant funds can also support evaluation projects.

Funding Principles

Projects funded by the Health Equity Fund should align with the following funding principles:

Improving health outcomes and access

for communities and populations experiencing the deepest and most persistent health and economic disparities in King County.

Actively addressing the issues of systemic, structural, and institutional barriers

including racism, sexism, homophobia, transphobia, income inequality, and other forms of oppression or discrimination that negatively impact healthcare delivery and health outcomes.

Partnering or collaborating with other organizations

to enhance the impact of addressing health disparities.

Building capacity and empowerment

for communities addressing health disparities.

Funding for service delivery is limited to King County. There are no geographic restrictions on the residence of clients served or advocacy efforts, as long as the program can demonstrate the use of funds addressing disparities in health among residents of the Puget Sound region (King, Snohomish, Pierce, and Kitsap counties).

Organizations may not receive two PHPDA grants in the same year for the same project. Applicants can request grant funds for a different project as long as the time period covered by funding ends by the new contract period.

Organizations may only submit one application.

Focus Areas

Specific populations are facing heightened threats to their safety, security, and access to care, and the organizations that support them are experiencing drastic funding cuts. Our Major Grant program aims to support these organizations who are facing disproportionate burdens to their wellbeing. This year, Major Grants will be limited to organizations with projects in one or more of these three focus areas:

• Gender Affirming Care and/or HIV Prevention and Care for LGBTQIA2S+ Communities
• Barrier-Reducing Healthcare Delivery for Immigrant and Refugee Populations that is Responsive to Community Concerns 
• Access to Birth Control and Abortion Care

The Santa Clara County Fish and Game Commission invites applications for Fish and Wildlife Preservation Grants. These funds support projects aimed at enhancing local fish and wildlife resources, including education events and habitat improvements. Established in 1960, the Commission emphasizes ecosystem health and sustainable practices. Eligible organizations can apply for funding to conduct activities that protect and restore wildlife, with applications due 17 days prior to Commission meetings.

The Robinson-Broadhurst Foundation, established in 1984, is dedicated to enhancing the quality of life for residents in Stamford and Worcester, New York, and Winchendon, Massachusetts. By funding charitable 501(c)(3) organizations, the foundation supports various initiatives, including community health services, historical preservation, education, and public safety. Organizations aligned with these goals are encouraged to apply for grants to foster community spirit and cooperation.

The Joseph B. Whitehead Foundation supports various initiatives in metro Atlanta, focusing on early childhood education, K-12 education, human services, health, and youth development. The foundation seeks to enhance educational opportunities and improve quality of life for vulnerable populations. Through collaborations with established organizations, it aims to address community needs and invest in proven solutions that empower children and families, ultimately fostering economic opportunities and health improvements in the region.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The UWGNB Community Impact Grants aim to enhance local communities by funding projects focused on Healthy Community and Child and Youth Opportunity. This initiative prioritizes access to basic needs, mental health, and youth development programs. Eligible applicants include non-profits and public entities, with one application allowed per organization. The funding supports programs that foster health and learning, ultimately helping individuals and families thrive in the Greater New Bedford area.

The Fund for the Arts: Event Artist program invites artists and organizations from the Greater Louisville area to participate in community events. This initiative aims to create a diverse roster of artistic talent, compensating participants for their contributions. Artists can engage in various events, from large public festivals to intimate performances. Applicants must align with the Fund's commitment to equity and inclusion, ensuring a vibrant arts scene that reflects the community's diversity.

Asia-Pacific Network for Global Change Research

The Asia-Pacific region, home to over half the world's population, faces challenges due to its development goals, which strain natural resources, communities, and cultural heritage. These issues are exacerbated by adverse environmental changes. While research has shed light on these problems, it's clear that more challenges lie ahead. The Asia-Pacific Network for Global Change Research (APN) is well-positioned to generate new knowledge and solutions for these evolving global change and sustainability issues by supporting collaborative research and scientific capacity development activities, particularly those aimed at training the next generation of early career professionals.

APN 2025 Call for Proposals: CAPaBLE Programmes

CAPaBLE, our scientific capacity development programme, aims to enhance the capacity of scientists, policymakers and practitioners to assess global change issues, and explore options to resolve issues towards achieving sustainability. Through CAPaBLE, we support activities that enhance capacity at individual, organizational and systemic levels.

Activities of interest under the CAPaBLE Programme

APN supports CAPaBLE activities that enhance existing capacities of developing countries at three levels of individual-based capacity development; group, organisation, network-based capacity development; and societies, governance, and system level capacity development. APN accepts CAPaBLE proposals that engage 1 or more member/approved countries. Proposals must address one or more of the following activities:

SCIENTIFIC CAPACITY DEVELOPMENT ACTIVITIES that promote the following approaches related to one or more of the six thematic areas of APN:

• Utilising and strengthening existing capacity, 
• Creating opportunities to use/instil capacity, 
• Developing new capacity through innovative approaches.

AWARENESS-RAISING AND DISSEMINATION activities through policy- and decision-making communities, civil society, and/or the general public.

SCIENCE-POLICY interfacing in the context of the priority topics.

CAPACITY DEVELOPMENT PARTNERSHIP ACTIVITIES that contribute to the capacity development components of the evolving global change arena, including the UNFCCC Paris Agreement, IPCC, IPBES, post-2015 Sustainable Development Goals, Sendai Framework for Disaster Risk Reduction, and the UN Decade of Ocean Science, and ongoing and new global change and sustainability research programmes.

Activities geared towards using SCIENCE COMMUNICATION to disseminate knowledge generated from projects, particularly to non-science audiences.

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The Harold J. Miossi Charitable Trust Grant Program aims to enhance the quality of life for residents of San Luis Obispo, California, focusing on key areas such as animal welfare, education, environmental protection, support for the Catholic Church, fine arts, and youth development. Grants are available to California-based organizations for specific projects that align with these priorities, promoting community engagement and sustainable development.

The DeKalb County Human Services Grant Program supports local non-profits focused on improving community welfare. Eligible organizations must have 501(c)(3) status and operate for at least two years, serving DeKalb residents in priority areas such as youth development, crisis intervention, and public health. The program aims to enhance public safety and advocate for vulnerable populations, ensuring resources are allocated effectively to foster sustainable communities.

Radio Flyer is committed to enhancing the lives of children through charitable giving and community support. Their philanthropic efforts focus on 501(c)(3) nonprofit organizations that promote outdoor play and well-being for children. Key initiatives include partnerships with national charities and local organizations, such as building playgrounds for underprivileged kids. Ineligible requests include those from individuals, political groups, and organizations outside the contiguous United States. This ensures that their contributions create lasting positive impacts.

The Santander Charitable Sponsorship Program focuses on supporting low- to moderate-income communities primarily in the Northeast and Florida. With a commitment of $100 million in charitable giving, the program addresses key community development needs, including affordable housing, job creation, financial education, and disaster relief. Eligible organizations must have IRS 501(c)(3) status or be public agencies, demonstrating capacity to meet community needs. Unsolicited applications are not accepted.

The National Forest Foundation's Matching Awards Program connects communities to forests by funding stewardship activities that promote engagement with National Forests and nearby public lands. This program aims to create lasting impacts, ensuring that all communities can benefit from the rich resources of these natural areas. By supporting various projects, the program fosters a deeper relationship between people and the environment, ultimately enhancing conservation efforts and community well-being.

The Anschutz Family Foundation Grant supports programs that enhance self-sufficiency and community development for economically disadvantaged individuals in Colorado. With a focus on helping families, the elderly, and individuals with disabilities, the foundation provides grants typically ranging from $5,000 to $10,000. Organizations must be 501(c)(3) tax-exempt public charities or government entities. The foundation encourages alignment with its mission and requires demonstrated financial need and a solid track record of success.

About Us

The Department of Environmental Protection (DEP) is responsible for protecting and restoring Maine's natural resources and enforcing the state's environmental laws. The agency can trace its roots back to the Sanitary Water Board that was created in 1941. The purpose of that Board was to study, investigate, recommend means of eliminating and preventing pollution in waters used for recreational purposes. The Board was renamed the Water Improvement Commission in 1951. In 1969, the Commission's title was abbreviated to the Environmental Improvement Commission.

Solid Waste Diversion Grant Program

The Maine Legislature established the Maine Solid Waste Diversion Grant Program to provide grants to public and private entities to assist in the development, implementation or improvement of programs, projects, initiatives or activities designed to increase the diversion of solid waste from disposal in the State.

Funding will be considered for proposals which include, programs, projects or ideas that address, but are not limited to:

• Establishing municipal or regional composting, organics recovery or recycling programs,
• urchasing infrastructure, equipment or other items necessary to implement such programs or improve existing programs,
• Programs or projects designed to provide equipment for or otherwise support residential composting and recycling,
• Programs or business models designed to collect, transport for processing or process organic or recyclable materials,
• Pilot programs designed to evaluate the feasibility of targeted composting, organics recovery, recycling or other waste management programs or initiatives, or
• Initiatives or programs designed to educate certain categories of individuals or the general public about composting, organics recovery or recycling or to otherwise improve individual or community waste management practices.

Applications should include information demonstrating how programs will:

• Take advantage of regional economies of scale,
• Increase organics management and recycling infrastructure in underserved areas of the state,
• Promote waste reduction through reuse, repair, and sharing economy initiatives,
• Reduce wasted food through donation or other sharing initiatives,
• Enhance the delivery of educational initiatives to promote organics management or recycling efforts,
• Address a statewide need,
• Reduce “carbon footprint” of existing or proposed waste management programs, and/or
• Expand the types of materials managed through composting and recycling.

The Wayne County Children's Resource Fund offers grants to nonprofit organizations aiming to eliminate barriers that hinder children's potential, such as poverty and discrimination. Grants support programs and projects that provide lasting solutions and community benefits. Eligible applicants must be recognized as tax-exempt organizations, while the fund does not support deficit financing or scholarships. The Foundation is dedicated to ensuring effective use of resources for children's welfare in Wayne County, Ohio.

The PGE Foundation's Career Pathways Grant Program aims to enhance economic mobility for Oregonians by providing support for programs that facilitate access to family-wage jobs and entrepreneurship. This initiative prioritizes nonprofit organizations focused on skill development, mentorship, and wrap-around services. The foundation is particularly interested in proposals that address barriers faced by underrepresented communities, including BIPOC and women-owned businesses, and encourages collaborative efforts among nonprofits to achieve measurable outcomes.

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.