Best Large Grants for Nonprofit Organizations

The Greater Pine Area Endowment Grant provides vital funding to support long-term economic and community development initiatives within ISD 578. This grant focuses on projects that create quality jobs, enhance community pride, and improve the lives of vulnerable populations. Organizations eligible for funding include 501(c)(3) nonprofits and local government units, aiming to foster growth and well-being in the greater Pine area.

The Washington County Healthy Living Fund Grant, offered by the Bartlesville Community Foundation, aims to support local organizations addressing health challenges. Grants of up to $10,000 are available for programs that promote prevention and rehabilitation in Washington County. Eligible projects include educational initiatives, rehabilitation for offenders, and adolescent health services. This initiative strengthens community bonds and enhances overall well-being, enabling a healthier future for all residents.

The Creative Entrepreneur Accelerator Program provides $2,000 in funding to support creative entrepreneurs in Pennsylvania. This initiative aims to foster business growth by offering access to consulting services and resources tailored for those starting or developing a for-profit micro business. The program prioritizes diversity, equity, and inclusion, focusing on BIPOC entrepreneurs and those serving low-income communities, thus playing a vital role in economic recovery and innovation.

The Buhl Foundation Grant Program supports initiatives in Southwestern Pennsylvania that enhance community vitality and foster economic development. The foundation prioritizes projects in education, health, and employment, particularly those benefiting Pittsburgh's Northside neighborhoods. By focusing on resident-led initiatives, the foundation aims to empower local communities and ensure sustainable growth. Applicants must be 501(c)(3) tax-exempt organizations, with funding preferences for projects that revitalize neighborhoods and improve access to vital resources.

The Nisqually Watershed Small Grants program, sponsored by Pierce County, aims to improve environmental literacy and enhance water quality in local watersheds. By supporting nonprofit organizations, schools, and individuals, the program encourages projects such as riparian plantings and community clean-ups. Successful initiatives must align with watershed councils' Action Agendas, promoting sustainability and ecological education within the Nisqually River Watershed and beyond.

The Teichert Foundation Grant supports organizations in California that enhance community welfare through civic improvement, culture, education, and environmental sustainability. Established by Teichert Construction, the foundation aims to foster a healthier, educated, and more equitable society. Eligible applicants include nonprofits with 501(c)(3) status and public agencies in specified counties. The foundation prioritizes projects that address community needs and demonstrate fiscal responsibility, ultimately striving to create lasting impact and better health for all.

The Aquatic Lands Enhancement Account supports the protection and enhancement of aquatic lands in Washington State. Established in 1984, it funds projects that improve public access and restore ecological health. Eligible applicants include local and state agencies, as well as Native American tribes. Projects may involve the acquisition or restoration of aquatic lands, with a funding cap of $1 million, of which $500,000 can be allocated for development or restoration efforts.

The Patient-Centered Outcomes Research Institute (PCORI) intends to release an Implementation of Findings From PCORI's Research Investments PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund implementation projects that promote the uptake of peer-reviewed findings from specific PCORI-funded patient-centered comparative clinical effectiveness research (CER) in the context of the body of related evidence. This PFA is an open competition opportunity for principal investigators to propose implementation projects that move evidence toward practical use in improving health care and health outcomes. Applicants may propose projects with budgets up to $1.8 million in total direct costs.

PCORI seeks to fund implementation projects that incorporate active, multicomponent strategies that will lead to uptake and integration of evidence generated by PCORI-funded research in practice settings. Implementation should target specific end users with a clear interest in — and ability to benefit from — the evidence. Proposed implementation projects will adapt findings as needed to facilitate uptake in the proposed settings and accomplish scale-up to reach larger numbers and/or scale-out to reach broader populations and settings. Applicants must demonstrate commitment and buy-in — including from leadership as well as frontline staff critical to the success of the project — from proposed implementation sites across multiple health systems, such that they provide a supportive context and infrastructure for undertaking the proposed project. In addition, projects should involve regional and national stakeholder organizations positioned to extend uptake in broader venues.  

Applications must be guided by an established conceptual model or framework and, where possible, by evidence regarding effective strategies for implementing evidence-based practices and interventions. Additionally, applications must include a rigorous evaluation plan that documents the successful execution of the implementation approach and the impact of the project on health care and health outcomes as feasible and appropriate within the project scope.

The PF Fund for the Baldwin Area, managed by the Maine Community Foundation, aims to enhance the quality of life in Baldwin, Maine. This grant supports nonprofit organizations and initiatives that foster self-reliance, education, and sustainable resource management. Priority is given to projects that can leverage additional funding or address gaps in support. Eligible applicants include nonprofits, municipalities, and public agencies, ensuring diverse community engagement in local development.

The Texas Pride Community Foundation (TPCF) offers Community Grants to support historically disadvantaged LGBTQ+ communities in Texas. Grants up to $10,000 are available for non-profits addressing community needs without requiring specific project plans. TPCF prioritizes funding for underserved geographies, people of color, and individuals with disabilities, fostering an inclusive approach to grantmaking. The foundation emphasizes community-driven solutions to systemic injustices, aiming to enhance the safety and well-being of diverse populations.

The William Penn Foundation invites proposals to reduce barriers to accessing and completing workforce training in Philadelphia. This initiative aims to enhance the effectiveness of quality workforce programs for populations facing significant challenges, such as young individuals not in school or working, returning citizens, and immigrants. With $5 million available, the Foundation seeks projects that will help these groups transition to employment and ensure job retention, fostering economic mobility for themselves and their families.

The PNASH Pilot Project Program at the University of Washington focuses on enhancing agricultural safety and health through innovative research and outreach. The program supports both early-stage and experienced investigators in developing preliminary data, adapting proven tools, and exploring new research directions. With funding of up to $30,000 for pilot projects and an additional $5,000 for education grants, this initiative aims to improve workplace safety for agricultural workers, including those in fishing and forestry. Applications are accepted on a rolling basis.

The Valley Kids Foundation Grant, provided by the Valley of the Sun Active 20-30 Club, supports non-profit organizations dedicated to improving the lives of children in the Valley of the Sun. Since 1988, the Foundation has raised nearly $2.45 million, funding various charitable initiatives that empower youth facing challenges. By fostering community service and leadership among professional women, the Foundation not only enhances personal growth but also makes a significant impact on local children's charities.

The Alabama Power Foundation's Power to Play Grants aim to enhance student success through athletics, arts, and music. With a focus on equitable access, these grants support schools and organizations in creating opportunities for K-12 students. By facilitating extracurricular involvement, the program fosters improved academic performance and graduation rates. Eligible applicants include Title I schools and 501(c)(3) organizations, with funding directed towards new sports, arts programs, and music initiatives, ultimately enriching the educational experience for students across Alabama.

About

As the state economic development agency, the Wyoming Business Council leads economic growth in order to build resilient communities and create opportunities for people to thrive.

Community Economic Development Grant

Wyoming Business Council RD Grant

Community Economic Growth Grants can be used for projects that enhance a community’s quality of life through economic development projects. You will need to show that your project will support or enhance the economic opportunities of your stakeholders. Heavier consideration will be given to projects or initiatives that are collaborative on the organization, community, county, or regional level).

This is an Economic Growth Grant. Economic development is creating a vibrant community where people want to live and work through wealth creation. It's also about transforming economies where people have limited resources (think jobs, money, and opportunity) and choices into ones with greater resources and choices.

Economic development improves the quality of life by:

• Creating jobs
• Attracting and retaining businesses
• Increasing tax revenue
• Promoting local industry
• Developing skilled workers
• Improving public infrastructure necessary for many businesses

The Washington County Community Foundation, a part of the East Tennessee Foundation, focuses on enhancing the quality of life for residents through innovative programs. They prioritize projects that promote life literacy among all age groups, from nutrition education to financial decision-making. Grants can reach up to $50,000, supporting initiatives that demonstrate significant community impact and sustainability beyond the funding period. Collaborative proposals involving multiple organizations are especially encouraged.

The Charles E. Kubly Foundation Grants focus on improving the lives of those affected by depression through funding mental health projects. They prioritize initiatives that raise awareness, reduce stigma, and support suicide prevention. Grant requests are accepted from not-for-profit organizations providing direct services or educational programs. The foundation prefers projects impacting Wisconsin, with measurable outcomes and specific timelines. However, they do not support research, legislative activities, or ongoing operational costs.

The MH253010 grant from the New York State Office of Mental Health aims to fund the development of community behavioral health crisis response pilot programs in urban, suburban, and rural areas. These programs will prioritize health-led responses, utilizing community experts to support individuals in crisis. The initiative seeks to create trauma-informed, culturally humble approaches that emphasize racial equity and harm reduction, addressing a critical need for effective crisis intervention in New York State.

Sea-Changers is a UK charity dedicated to marine conservation, offering one-off grants to charities and not-for-profit organizations. They focus on funding projects that address marine threats, reduce environmental impacts, and enhance knowledge about marine conservation. Their interest lies in grassroots initiatives that foster community involvement and action. The organization encourages projects with clear objectives, start and end dates, and measurable outcomes, ensuring that funding contributes meaningfully to conservation efforts.

The Rapid Evaluation, Stabilization and Treatment (REST) Center, part of the Rural Health Transformation Federal Grant Program, aims to establish up to four 23-hour crisis stabilization centers in Connecticut. These centers will provide accessible mental health and substance use treatment, emphasizing a 'no wrong door' approach for individuals in crisis. The initiative seeks to enhance the continuum of care for adults, ensuring services are person-centered, community-based, and delivered in a trauma-informed manner.

The F26AS00084 Aquatic Invasive Species Grants to Great Lakes Tribes, funded by the U.S. Fish and Wildlife Service, aim to support the development and implementation of Tribal Aquatic Invasive Species Management Plans. Eligible Great Lakes tribes can apply for competitive grants to address invasive species issues within the Great Lakes Basin, including outreach and prevention efforts. This initiative focuses on early detection and control, significantly contributing to the health of the Great Lakes ecosystem.

The Frist Foundation Grant focuses on enhancing the quality of life in Nashville and Middle Tennessee by funding nonprofit organizations. With over 40 years of commitment, it prioritizes projects addressing community challenges in areas such as Arts, Food Insecurity, Health Disparities, and support for underserved residents. The Foundation seeks to empower organizations through General, Technology, and Operational Grants, emphasizing sustainability and long-term impact without funding operational expenses or salaries.

The ACFM Project Support Program offers funding between $2,000 and $20,000 for special projects that enhance public appreciation of contemporary American concert music and jazz. Eligible applicants include performing ensembles and music organizations with a minimum of two years of programming history. Projects must focus on contemporary works by American composers and can involve live performances, recordings, or educational initiatives. This support is pivotal for fostering innovation and creativity in the American music scene.

The FY 2024 - 2026 Broad Agency Announcement by NOAA seeks innovative research and outreach projects that enhance marine and coastal ecosystem viability. This funding opportunity is contingent on appropriations and does not guarantee specific awards or project funding. NOAA emphasizes collaboration with federal, state, and local partners to remain adaptive in addressing climate change and providing vital weather and water services, ensuring ongoing improvement in their information and services.

Davie Community Foundation

Founded in 1988, Davie Community Foundation is a nonprofit corporation dedicated to improving the lives of Davie County residents, today and for generations to come.

Mission: The Davie Community Foundation inspires philanthropy to strengthen Davie County for present and future generations. Vision: We envision Davie County as a vibrant community where everyone can thrive!

Pearls of Empowerment Grants

Pearls of Empowerment is a dynamic giving circle of women that seeks to improve the lives of women and children in Davie County. We recognize that each woman gives in her own way, through time, talent, and treasure, and that individuality is what makes each of us a unique Pearl.

Inspired by the legacy of a cherished strand of pearls, passed from grandmother to daughter to granddaughter, our circle brings together women of all ages, backgrounds, and life experiences. We’re connected not just by our generosity, but by our commitment to growth, learning, and meaningful impact.

Pearls of Empowerment welcomes nonprofit organizations to apply for grants that create meaningful change in the lives of women and children in Davie County. To be considered, programs or projects must focus on one or more of the following areas:

• protecting women and children from abuse
• providing stable and safe housing
• improving mental health and emotional well-being

The Hawaii Women's Legal Foundation (HWLF) has been supporting the rights and welfare of women and children in Hawaii for over 30 years. They provide grants to local nonprofits that enhance access to legal systems, health services, and educational opportunities. With priority given to projects benefiting women and children, HWLF awards micro-grants ranging from $500 to $5,000. The foundation considers grant applications twice a year, focusing on initiatives that promote safety and independence in the community.

The HRE Grants for Local Stewardship Planning, funded by the New York State Department of Environmental Conservation, aims to enhance the Hudson River Estuary ecosystem. With approximately $750,000 available, these grants support projects like feasibility studies, assessments, and the development of guidance documents to improve community infrastructure and protect vital water resources. Minimum grant requests start at $10,500, while the maximum is $75,000, encouraging a wide range of impactful initiatives.