Best Large Grants for Nonprofit Organizations

The Bill Terrell Avian Conservation Grants, offered by the Georgia Ornithological Society, support ground-level bird conservation projects in Georgia. Eligible applicants include government agencies and non-profits focused on protecting resident and migratory birds. Funded initiatives may include habitat restoration, exotic species control, and the installation of nesting boxes. Projects must directly benefit bird species and cannot be used for administrative costs. Matching funding is favored to enhance support.

The NIDDK High Risk Multi-Center Clinical Study Cooperative Agreement (U01 Clinical Trial Not Allowed) invites proposals for high-risk, multi-center observational studies on diseases relevant to NIDDK's mission. Applicants are encouraged to consult with NIDDK staff and must complete planning activities before submission. Key deadlines for applications span from February 2025 to October 2026, with optional Letters of Intent due 30 days prior to full proposals.

Background

The federal Rural Health Transformation Program (RHTP) was created by H.R.1 (Section 71401 of Public Law 119-21) on July 4, 2025. It is a federal initiative to help states support rural communities in improving health care access, quality, and outcomes by transforming the health care delivery ecosystem. The RHTP focuses on promoting innovation, strategic partnerships, infrastructure development, and workforce investment in rural communities. The federal program will grant up to $50 billion to states over five budget periods. Minnesota has outlined their initiatives online (learn more about Minnesota's Rural Health Transformation Program).

This RFP supports the planning and development of regional Child and Adolescent Mental Health Initiatives. These initiatives will serve as a mechanism for regional collaboration to build effective community-based mental health services for children and adolescents across Minnesota. Based on the work of the Minnesota Adult Mental Health Initiatives, this activity brings counties and consortia of counties together to regionally coordinate mental health crisis services and support child and adolescent mental health. While Minnesota has a model of Adult Mental Health Initiatives, the needs of children and adolescents are different from those of adults, and this model should reflect these unique needs. Notably, this activity must be shaped for the needs of children and adolescents.

The Alice M. Ditson Fund provides organizational support for professional performing ensembles and institutions committed to advancing the work of younger and relatively unknown living American composers. Grants are available for general operating or project support, emphasizing contemporary American classical concert music. Eligibility includes organizations without non-profit status if sponsored by a 501(c)(3) entity, while projects featuring American music are prioritized. This funding opportunity encourages innovative performances and fosters greater recognition of emerging talents in the classical music sphere.

Blowitz-Ridgeway Foundation

In the 1950s, Chicago attorney Milroy R. Blowitz and his friend, Dr. Steinman, a psychiatrist, had a dream to build a psychiatric hospital for children in Chicago’s inner city. That dream came true when Ridgeway Hospital opened its doors on Ridgeway Avenue in 1962 as a 99-bed, not-for-profit hospital focusing on the psychiatric treatment of children and adolescents.

In 1984, the Ridgeway Hospital was sold and proceeds from that sale were used to establish The Blowitz-Ridgeway Foundation, named to honor Milroy Blowitz, and the hospital he helped start. In the spirit of the Ridgeway Hospital’s original mission, the Foundation’s primary funding goal was to support non-profit agencies that provided medical, psychiatric, and psychological care to economically disadvantaged children and adolescents. The Foundation began awarding grants in 1985. 

Our Mission: To significantly improve the lives and well-being of Chicago-area residents who are uninsured, underinsured, or low-income by increasing access to high-quality, comprehensive healthcare and safe, affordable housing.

Blowitz-Ridgeway Housing Grant

The Blowitz-Ridgeway Foundation focuses on funding organizations that are dedicated to preventing homelessness and providing safe, affordable housing, or organizations that collaborate with other homeless service providers and local institutions.

We help fund organizations that provide emergency shelters and transitional or permanent housing. We also fund organizations that offer support services to the homeless or unhoused like case management, counseling, job training and placement, healthcare, financial education, meals, etc.

The Foundation prioritizes small to mid-size organizations that serve the homeless where we can have the greatest impact.

The Arthritis National Research Foundation supports early career researchers in their quest to advance understanding and treatment of arthritis and related autoimmune diseases. Annually, the foundation grants 10 to 20 awards of $125,000 each for two years. Focus areas include osteoarthritis, rheumatoid arthritis, lupus, and more. Eligible investigators must hold an M.D. or Ph.D., be affiliated with a U.S. nonprofit research institution, and commit significant research time. Applications from prior grant recipients or those with certain NIH grants are ineligible.

The Fall Research Experiences for Undergraduates (REU) at BIOS offers U.S. undergraduate students a unique opportunity to engage in marine research funded by the National Science Foundation. Participants will work on projects such as coral ecophysiology and marine microbiology under expert mentorship. This internship not only enhances research skills but also promotes diversity by encouraging applications from underrepresented groups. Funding covers travel, accommodation, meals, and a stipend, making it an accessible option for aspiring scientists.

Maine Office of Community Affairs

The Maine Office of Community Affairs (MOCA) was established by the Maine State Legislature in 2024 as a one-stop-shop to assist municipalities, Tribal governments and regional planning organizations in building a more resilient future.

In spring 2025, MOCA introduced a newly established State Resilience Office and staff to lead cross-agency efforts to enhance climate resilience across the state, especially in communities with significant climate vulnerabilities impacting residents, infrastructure, and the environment.

Shore and Harbor Planning Grants

The Maine Office of Community Affairs’ Maine Coastal Program (MCP) and Municipal Planning Assistance Program (MPAP) are seeking applications for coastal planning grants totaling approximately $550,000. The two grants covered by this announcement are the Shore and Harbor Planning Grant and the Coastal Community Grant. Funding for these planning grants comes from the Maine Coastal Program’s annual grant from the National Oceanic and Atmospheric Administration (NOAA). 

Program Goals

The Shore and Harbor Planning Grant program provides resources on a competitive basis for shoreline access planning, waterfront and harbor planning, identification and resolution of waterfront use conflicts, and planning, feasibility, and design efforts for resilient waterfront infrastructure. Shore and Harbor Planning Grant projects are often well prepared to compete for construction funding through other sources.  

The Outreach and Restoration Grant Program, a collaboration of Chesapeake Bay Trust and various Maryland counties and cities, aims to fund projects that enhance community engagement and environmental stewardship. With funding tracks ranging from $50,000 to $125,000, it supports outreach, behavior change, and restoration initiatives to improve local green spaces and waterways. This program encourages residents to participate actively in restoring their natural resources, fostering a sense of community and responsibility.

Department of Health and Human Services

DHHS is the largest agency in New Hampshire state government, responsible for the health, safety and well-being of the citizens of New Hampshire. DHHS provides services for individuals, children, families and seniors, and administers programs and services such as mental health, developmental disability, substance misuse, and public health. This is accomplished through partnerships with families, community groups, private providers, other state and local government entities, and many citizens throughout the State who help make New Hampshire a special place in which to live.

RFP-2027-DPH-03-INSUR (DoIT #2026-047): Insurance Benefit and Medical Claims Management for Clients Living With Human Immunodeficiency Virus

The New Hampshire Department of Health and Human Services, Division of Public Health is seeking responses to this Request for Proposals (RFP) from qualified Vendors to provide insurance benefit and medical claim management services on behalf of individuals living with Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) who are enrolled in the New Hampshire CARE Program (NH CARE). 

The Green Acres State Land Acquisition Program, managed by the New Jersey Department of Environmental Protection, focuses on acquiring land for open space from property owners. It aims to preserve areas designated for recreation and conservation, integrating these lands into state parks, forests, and wildlife management areas. The program collaborates with various DEP divisions to ensure effective land management, and it accepts donations and bequests to enhance public access to natural resources.

The David Kelby Johnson Memorial Foundation offers grants to 501(c)(3) organizations focused on sight preservation, children's services, and environmental conservation, primarily in Utah. Established in memory of David Kelby Johnson, who tragically lost his life at a young age, the foundation aims to honor his legacy by supporting impactful charitable initiatives. Grants range from $5,000 to $100,000, with a commitment to improving communities both locally and globally.

The Liberty Mutual Foundation offers discretionary grants to 501(c)(3) organizations, focusing on those that empower low-income youth and young adults. The foundation prioritizes initiatives that align with its strategic framework and serves communities in Greater Boston and select areas in Washington State. Funding is not available for individuals, religious organizations, or those who have received support in the last 12 months, ensuring resources are directed towards impactful community-driven projects.

The Latin American Student Field Research Award, offered by the American Society of Mammalogists, supports graduate students conducting field research in Latin America. Eligible applicants must be citizens of Latin American countries and enrolled in a graduate program. Research areas include ecology, conservation, and wildlife biology. This award emphasizes the importance of field-oriented investigations, promoting a diverse range of studies aimed at enhancing our understanding of mammalian species and their habitats in the region.

New Mexico Department of Agriculture

NMDA is a producer-consumer service and regulatory department responsible for various statutes legislated since its inception. NMDA’s mandate has changed over the years in response to changes in population, the needs of agribusiness, and technological advancements. NMDA remains committed to serving its constituents by periodically reviewing statutes and fee structures, as well as offering compliance assistance and education in an effort to maintain a safe and secure food supply, promote a fair marketplace, and secure our natural resources.

Noxious Weed Management Grant

Purpose

The New Mexico Department of Agriculture (NMDA) will award competitive grants to eligible applicants for projects that improve the state’s economy and environment by managing noxious weeds in New Mexico. The grants are funded through New Mexico’s Land of Enchantment Legacy Fund to achieve the purposes of the New Mexico Noxious Weed Management Act. 

Grant funds will be awarded for the following activities, but must include activities in at least one of the first three bullets bolded below to be considered for funding:

• Surveying & Mapping
• Early Detection and Rapid Response (EDRR)
• Integrated Weed Management (On-the-Ground-Treatments)
• Education/Outreach
• Planning, Capacity Development, & Partnership Building

The CDBGPF Design, Engineering, and Environmental Clearance (DEEC) Grant, administered by the Colorado Department of Local Affairs, supports local governments in enhancing community infrastructure. This grant assists eligible applicants with vital design, engineering, and environmental clearance activities for projects that benefit low to moderate income communities. Projects can include water systems, community centers, and more, aimed at fostering development and addressing urgent community needs.

Iowa Department of Natural Resources

The Iowa Department of Natural Resources (DNR) manages fish and wildlife programs, ensures the health of Iowa’s forests and prairies, and provides recreational opportunities in Iowa’s state parks.

Just as importantly, the DNR carries out state and federal laws that protect air, land and water through technical assistance, permitting and compliance programs. The DNR also encourages the enjoyment and stewardship of natural resources among Iowans through outreach and education. Our mission is to conserve and enhance our natural resources in cooperation with individuals and organizations to improve the quality of life in Iowa and ensure a legacy for future generations.

Urban Forestry Development Grant

Through the USDA Forest Service Inflation Reduction Act, the Iowa Department of Natural Resources (DNR) is a pass-through partner for the Urban Forestry Development grants for communities.

The Urban Forestry Development Grant provides reimbursable grants to complete projects such as creating community forestry plans, building urban food forests, hosting educational programming, and workforce development through forestry internships. The grant is a two-year program.

The Urban Forestry Development grants are available to community governmental entities, volunteer organizations, and service organizations involved with local urban and community forest services, to improve management, care, and public engagement with trees growing in parks, natural areas, and along public rights-of-way. Grants will also support projects in Iowa communities through investments in community-identified urban forestry needs, advancing environmental or health benefits.

Fatherhood Request for Proposal (RFP)

This application packet contains guidelines for submitting an application to ADCANP for a performance-based contract to provide opportunities to families with custodial fathers and mothers. Activities (training, workshops, conferences, counseling, etc.) should encourage and facilitate active parenting by non-custodial fathers/mothers. The goals are to increase the parents’ involvement in their children’s lives, provide employment training and skills, and increase child support payments/collection. Federal Temporary Assistance for Needy Families (TANF) funds for this competitive selection process are provided to ADCANP through a partnership with the Alabama Department of Human Resources (DHR).

The target population for Fatherhood Programs should include (but are not limited to) non-custodial and custodial mothers and fathers who:

• Are unemployed or underemployed (income less than 200% of the federal poverty level)
• Lack a high school diploma or GED
• Lack the skills to obtain gainful employment
• Males or females over the age of 18 with children
• Reside in the state of Alabama

The TANF funds available for these initiatives will address the following goals:

• To gain employment skills and certifications that will allow participants to secure employment
• that can provide for the family and promote self-sufficiency
• To find and retain suitable employment
• To improve awareness of participants’ roles in the lives of their child(ren)
• To establish high-quality, emotionally supportive relationships with their children
• To pay child support and provide other financial support for their child(ren)
• To support Re-Entry services for formerly incarcerated parents

The Social & Economic Mobility Grant, offered by the Community Foundation of Broward, supports 501(c)(3) nonprofits providing services in Broward County. Eligible organizations must have a Gold Seal of Transparency from Candid. Grants are awarded twice a year across four focus areas, including Social & Economic Mobility. Specific areas, such as Strong Nonprofit Community, accept applications by invitation only. Detailed eligibility criteria can be found in the Focus Area Grant Guide.

The Fair Housing Initiatives Program (FHIP), established by Congress in 1988, aims to fund organizations to combat discriminatory housing practices. The Education and Outreach Initiative (EOI) educates stakeholders about their rights under fair housing laws. Key components include the National Media Campaign, which promotes fair housing awareness nationally, and local programs that support community-based outreach. HUD oversees the process, ensuring compliance and monitoring of funded initiatives to enhance fair housing practices.

The Columbus Realtors Foundation supports real estate-related initiatives in central Ohio through its community grants. With over $600,000 invested since 2008, the foundation aids organizations that address homelessness, repair homes for low-income families, and promote affordable housing. Established in 1991, it aims to enhance the real estate environment while empowering local nonprofits and government entities to foster healthy communities.

The County Forest Sustainable Grant, offered by the Wisconsin Department of Natural Resources, aims to support short-term projects that enhance sustainable forestry practices in counties with lands enrolled under the County Forest Law. Priority is given to urgent needs such as storm recovery and temporary staffing to address immediate workloads. This funding initiative seeks to improve forest management and ensure the long-term sustainability of Wisconsin's county forest resources.

Rhode Island Office of Energy Resources

The Rhode Island Office of Energy Resources’ (OER) mission is to lead the state toward a clean, affordable, reliable, and equitable energy future. OER develops policies and programs that respond to the state's evolving energy needs, while advancing environmental sustainability, energy security, and a vibrant clean energy economy. OER is committed to working with public- and private-sector stakeholders to ensure that all Rhode Islanders have access to cost-effective, resilient, and sustainable energy solutions.

Agricultural Energy Grant Program

The Rhode Island Office of Energy Resources (OER) and the Rhode Island Department of Environmental Management (DEM) request Rhode Island Agricultural Operations to submit applications seeking funding for energy projects in an effort to improve energy efficiency, promote renewable energy, and reduce greenhouse gas emissions. 

The following clean energy investments and technologies will be considered eligible for this program, so long as each proposed project meets all program requirements.

• Renewable Energy: Photovoltaics (PV); Small Scale Wind; Biomass; Energy Storage
• Energy Efficiency: Envelope Insulation; LED Lighting; HVAC Systems (especially heat pump technologies); Automatic Temperature Controls; Variable Speed Motors, Drives, & Pumps; Solar Thermal

This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.

The Edna E. Harrell Community Children’s Fund Grant, managed by The Oregon Community Foundation, supports programs enhancing the lives of underserved youth in Baker County and North Powder. Established in 2014, it provides funding for various enrichment activities, including summer camps, after-school programs, and arts initiatives. Eligible applicants include nonprofit organizations, churches, and schools, ensuring that children from financially constrained families have access to vital development opportunities.

The Aquatic Invasive Species Control Research & Demonstration program, supported by the Wisconsin Department of Natural Resources, aims to enhance water quality and protect ecosystems through collaborative initiatives. By providing cost-sharing funding for various activities, this program empowers eligible applicants, including local governments and educational institutions, to engage in effective water management practices. The initiative emphasizes sustainable stewardship of surface water resources, fostering partnerships to ensure long-term ecological health and community resilience in Wisconsin.