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Best Large Grants for Nonprofit Organizations

Get large grants for nonprofits scaling impact through capital projects, innovation, strategic growth, or infrastructure.

33,000+

Available grants

$8.25B

Total funding

$6K

Median grant

33,000+ grants
$8.25B total
$6K median

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32,595 Results based on applied filters

Herbert A. and Adrian W. Woods Foundation Grants

Herbert A. and Adrian W. Woods Foundation
Private
Missouri
Unspecified amount
The Herbert A. and Adrian W. Woods Foundation, founded in 1999, supports charitable organizations primarily in the greater St. Louis area. Funding interests focus on aiding abused children, the poor, the Episcopal Church and its affiliates, arts and culture, animal welfare, and victims of illness. The foundation accepts special project requests, capital campaigns, matching grants, and general operation funding, while multi-year grants and endowment funding are excluded.
Art & Culture Animal Welfare - General Disability Care & Services +6 more

PMCA Research and Conservation Grant

Purple Martin Conservation Association
Private
Americas
US $500 - US $2,500
The Purple Martin Conservation Association offers the PMCA Research and Conservation Grant to support research on Purple Martins. This grant aims to promote conservation efforts and may cover expenses such as travel and supplies, though it does not fund salaries or overhead. Eligible applicants include students and professionals engaged in Purple Martin research, with a focus on projects that enhance the species' habitat and well-being.
Ornithology Ornithological Conservation

H. Branch Howe Grant

Georgia Ornithological Society
Association/Society
Georgia (Country), North America +2 more
Up to US $15,000
The H. Branch Howe Grant, offered by the Georgia Ornithological Society, supports graduate students conducting ornithological research in Georgia. This grant encourages the scientific study of birds and conservation efforts, providing funding for research that enhances knowledge of avian life. Eligibility is limited to graduate students in Georgia, and preference is given to projects within state boundaries. The GOS aims to foster collaboration and knowledge sharing among those passionate about birds and nature.
Ornithology Ornithological Conservation

Worcester County Food Bank Fund to End Hunger Grant Program

Greater Worcester Community Foundation
Private
Worcester County, Massachusetts
Approximately US $3,000
The Worcester County Food Bank Fund to End Hunger, established in 2011, aims to support nonprofit organizations dedicated to eradicating hunger in Worcester County. It focuses on increasing access to healthy foods, enhancing the capacity of food-serving organizations, and advocating for policy changes that benefit marginalized communities. Eligible applicants include all 501(c)(3) nonprofits serving this area, while individuals and businesses are not supported. This grant encourages collaboration with the Hunger-Free Network.
Adult Education Workforce Preparation & Job Readiness Food Access & Hunger +2 more

Canadian Wildlife Habitat Conservation Stamp Program- Category #4: Newfoundland and Labrador Murre Conservation Fund Grants

Wildlife Habitat Canada
Private
Canada
Unspecified amount
The Canadian Wildlife Habitat Conservation Stamp Program's Category #4 grants focus on supporting Murre conservation efforts in Newfoundland and Labrador. These grants fund projects that assess Murre populations, promote hunting stewardship, and engage in habitat conservation. By leveraging funds from stamp sales and additional non-federal support, the program aims to enhance local wildlife habitats and contribute significantly to conservation initiatives across Canada.
Ornithology Ornithological Conservation

Emerging Contaminants / PFAS Funding

North Carolina Department of Environmental Quality
State/Local Government
North Carolina
Up to US $5,000,000
The North Carolina Department of Environmental Quality (NC DEQ) is offering funding for projects addressing PFAS contamination in water systems during its Fall 2023 funding round. Eligible applicants include local government units and non-profit water corporations. Funding supports both planning and construction efforts, enabling systems to assess and implement solutions for PFAS issues. This initiative aims to enhance water quality and public health by tackling emerging contaminants effectively.
Sanitation & Clean Drinking Water Water Resource Management

Reinberger Foundation: Education Grants

Reinberger Foundation
Private
Cuyahoga County, Ohio, Franklin County, Ohio +5 more
Unspecified amount
The Reinberger Foundation offers education grants to support underserved individuals in Northeast and Central Ohio. Priority is given to organizations with recent funding history. Eligible organizations must be 501(c)(3) non-profits serving low-income populations, including schools, adult education, and workforce development programs. The foundation focuses on Cuyahoga and Franklin Counties, with specific considerations for grant requests. Organizations should discuss their proposals with the foundation before submitting applications.
Workforce Preparation & Job Readiness Adult Education Education - K through 12 +2 more

Habitat Protection and Restoration Grants

Great Lakes Fisheries Trust
Private
Adams County, Wisconsin, Brown County, Wisconsin +40 more
Up to US $750,000
The Habitat Protection and Restoration grant by the Great Lakes Fisheries Trust aims to fund projects that protect and restore vital fish habitats in the Great Lakes region. Priorities include enhancing fish passage, supporting sustainable reproduction, and utilizing decision-support tools for project identification. Eligible applicants include non-profits and governmental organizations, focusing on projects within the Lake Michigan basin. This grant emphasizes community support and long-term management, ensuring impactful conservation efforts.
Habitat & Ecosystem Restoration Land / Habitat Conservation Fisheries

GCCF: Community Impact Grants - Youth and Education

Greenwood County Community Foundation
Corporate
Greenwood County, South Carolina
Up to US $5,000
The GCCF Community Impact Grants for Youth and Education aim to enhance the educational landscape in Greenwood County. These grants support initiatives that address educational attainment, reduce dropout rates, and foster early childhood development. Organizations with 501(c)(3) status can apply for up to $5,000 to fund specific programs that demonstrate collaboration and community value. This funding opportunity is vital for empowering youth and ensuring access to quality education for all residents.
Student Retention & Drop-Out Prevention Literacy Early Childhood Development +4 more

Sharon Center School Millennium Fund

The Berkshire Taconic Community Foundation
Private
Litchfield County, Connecticut
US $100 - US $1,000
The Sharon Center School Millennium Fund, supported by the Berkshire Taconic Community Foundation, aims to enrich the educational experiences of students and teachers at Sharon Center School. Established to foster excellence, the fund supports diverse projects such as independent studies, new programs, extracurricular activities, and professional development for teachers. It prioritizes proposals that engage volunteer efforts and demonstrate additional support, ensuring lasting impact within the community.
Academic Success & Enrichment After School / Summer Educational Programs Teacher Development & Training +4 more

The Research Foundation: Community Grants

The Research Foundation
Private
Jackson County, Missouri
Unspecified amount
The Research Foundation is launching community grants to enhance health access and equity in Kansas City, particularly for Jackson County residents. Eligible nonprofit organizations can receive support for programs that align with the foundation's priorities, including a 10% allowance for indirect costs. The focus is on health-centric missions, ensuring the funding promotes care access and workforce retention in the healthcare sector, while adhering to the foundation's guidelines.
Health Care Access & Delivery Health Disparities & Social Determinants of Health Epidemiology & Public Health +4 more

Catalyze Challenge Grant

Catalyze
Association/Society
United States
Up to US $300,000
The Catalyze Challenge Grant, managed by Catalyze, is an opportunity for organizations to receive funding for innovative solutions that enhance career-connected learning for youth aged 11-22. With over $4 million available in Round 5, finalists can secure up to $300,000 to implement their ideas. The grant seeks proposals that empower underserved learners through hands-on experiences and meaningful employer partnerships, ultimately impacting over 65,000 young people across the U.S.
Career / College Preparation Educational Access & Equity Academic Success & Enrichment +3 more

ABC Conservation Awards

African Bird Club
Private
Africa
Up to £3,000
The ABC Conservation Awards, funded by the African Bird Club, provide grants of up to £3,000 for conservation projects in Africa. Open to residents and institutions, these awards support diverse initiatives such as bird monitoring, educational programs, and local club support. With over £600,000 awarded since 1996, ABC has funded more than 300 projects across 50 countries, fostering significant contributions to the conservation of African birds and habitats.
Ornithology Ornithological Conservation

Water Quality Improvement Project (WQIP) Program

New York State Department of Environmental Conservation (DEC)
State/Local Government
New York
Unspecified amount

Water Quality Improvement Project (WQIP) Program

The Water Quality Improvement Project (WQIP) program is a competitive, statewide reimbursement grant program that funds projects that directly improve water quality or habitat, promote flood risk reduction, restoration, and enhanced flood and climate resiliency, or protect a drinking water source.

Sanitation & Clean Drinking Water Water Resource Management

Buell Foundation Grant

Temple Hoyne Buell Foundation
Private
Colorado
Unspecified amount
The Buell Foundation Grant supports organizations that enhance children's education and development in Colorado. Focused on underserved communities, it prioritizes early childhood programs, evaluations, and quality improvements. Grants typically range from $10,000 to $50,000, directing funds to those committed to impactful initiatives. Applicants must be 501(c)(3) organizations or government entities with a dedication to non-discrimination and community engagement. The foundation aims to create sustainable support for programs that foster positive outcomes for children.
Reproductive Education Early Childhood Development Education - Preschool / Early Learning +3 more

Maxinmotion Grants

Maxinmotion
Private
Arizona, California
Unspecified amount
MaxInMotion Grants provide essential financial support to youth sports organizations in Arizona and California, ensuring that financially challenged children can participate in sports programs. This funding not only promotes physical fitness but also fosters character development, teamwork, and academic excellence among youth. By prioritizing inclusivity, MaxInMotion aims to create equal athletic opportunities for all children, including those with special needs. The foundation is dedicated to combating the negative impacts of reduced sports access in low-income communities.
Sports & Athletics Diversity, Equity & Inclusion Hockey +4 more

Children’s Justice Act Grant (NM)

New Mexico Children, Youth, and Families Department
State/Local Government
New Mexico
Unspecified amount

New Mexico Children, Youth, and Families Department

CYFD believes that young people and their families are not simply clients. They are powerful catalysts for change – in their own lives and as partners in changing the systems that impact their lives.

This belief is operationalized through our core values about the young people we serve. 

Our Mission

  • Nurture the strength and resilience of families
  • Partner with children, families and communities based in trust and transparency
  • Serve by listening and learn from our diverse cultures to keep children, youth and families healthy, safe and thriving

Children’s Justice Act Grant

PURPOSE:

The New Mexico Children’s Justice Act Advisory Group (CJAAG) provides expert guidance and oversight for the distribution of federal Children’s Justice Act (CJA) funds managed by the New Mexico Children, Youth and Families Department (CYFD). Comprised of multidisciplinary leaders, including representatives from the courts, law enforcement, child welfare, and medical fields. CJAAG directs these resources to improve the investigation, prosecution, and judicial handling of child abuse and neglect cases.

The primary mission of the CJAAG is to foster a system that minimizes additional trauma for child victims, particularly in cases of sexual abuse, exploitation, fatalities, and cases involving children with disabilities. By leveraging these funds, the CJAAG ensures that New Mexico’s response to child maltreatment is coordinated, effective, and centered on the protection of the state’s most vulnerable citizens.

Child Abuse & Neglect Children With Disabilities Sexual Assault / Abuse +3 more

Prince George’s County Rain Check Rebate Grant

Chesapeake Bay Trust
Private
Prince George's County, Maryland
Up to US $20,000
The Prince George’s County Rain Check Rebate Grant offers property owners financial incentives for implementing approved stormwater management practices to enhance local waterways. Eligible participants include homeowners, businesses, and nonprofits, with rebates available for various practices such as rain barrels and green roofs. The program is currently open, operating on a first-come, first-served basis. Maximum lifetime rebates are $6,000 for residential and $20,000 for commercial properties, encouraging community engagement in sustainable practices.
Water Resource Management Environmental Stewardship

Bucks Innovative and Improvement Grants

Foundations Community Partnership
Private
Bucks County, Pennsylvania
Up to US $15,000
Bucks Innovative and Improvement Grants (BIIG) offer $10,000 to $15,000 to innovative projects enhancing the lives of children, youth, and families in Bucks County, PA. Applicants must demonstrate measurable outcomes and report progress after six and twelve months. The grant cycle includes applications due in October and April, with pre-grant meetings scheduled after letter of inquiry submissions. Only nonprofit organizations focused on special needs are eligible, ensuring that funds support impactful community initiatives.
Children With Disabilities Children’s Mental Health Youth Services +3 more

North Coast Seafood Extension Fellowship

California Sea Grant
State/Local Government
Del Norte County, California, Humboldt County, California +1 more
More than US $130,233
The North Coast Seafood Extension Fellowship, funded by California Sea Grant, aims to enhance seafood marketing and production opportunities in California's rural North Coast region. The fellowship will support collaboration among local partners to improve seafood availability and sales, strengthen marketing efforts, and develop infrastructure. The fellow will engage in training and educational initiatives for commercial fishers, facilitating connections between them and regional markets, all while promoting sustainable practices and community resilience.
Fisheries Food Security Aquaculture

Healthcare Workforce Development

Patterson Family Foundation
Private
Kansas, Missouri
Unspecified amount
The Patterson Family Foundation supports healthcare workforce development in rural communities across Kansas and western Missouri. The foundation encourages programs that enhance education, licensure, and retention of healthcare professionals. Organizations must register for grant consideration, and eligibility includes being a 501(c)(3) nonprofit or government entity. The foundation's mission focuses on strategic initiatives to ensure rural communities thrive, emphasizing collaboration and investment in essential services.
Health Policy & Advocacy Workforce Preparation & Job Readiness Health Care Access & Delivery +3 more

Development of Medications to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional) (358937)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $3,000,000
This NOFO invites applications for innovative research aimed at developing and implementing interventions to prevent and treat substance use disorders (SUDs) and overdose. It encourages studies that can rapidly advance candidate solutions towards regulatory approval or clinical use, while also addressing co-morbid SUDs. The initiative supports a wide range of research including basic, clinical, translational, and implementation strategies to tackle drug misuse and related health issues, such as HIV/AIDS.
Pharmacology Addiction & Substance Use Disorders Drug Use Disorder

Training Program in Neurodevelopmental Disabilities

The Childrens Hospital Of Philadelphia
Private
Pennsylvania
Unspecified amount
The Training Program in Neurodevelopmental Disabilities at The Children's Hospital of Philadelphia Research Institute offers advanced training for individuals pursuing careers in neuroscience and neurodevelopmental research. Established in 1998, it emphasizes the understanding of disabilities linked to chromosomal defects and trauma. Trainees engage in hands-on research, develop critical skills, and collaborate with esteemed scientists, aiming to become leaders in their field. The program actively encourages applications from underrepresented minority groups to foster diversity in scientific research.
Neuroscience Neurological Diseases & Disorders Learning Disabilities +3 more

Wirtanen Family Fund Grant

Boreal Waters Community Foundation
Private
Aitkin County, Minnesota, Ashland County, Wisconsin +8 more
Up to US $4,000
The Wirtanen Family Fund supports initiatives aimed at fostering community awareness of global interdependence, promoting social justice, and increasing democratic participation. It prioritizes projects addressing contemporary issues with regional impact, such as health care access and environmental preservation. Eligible organizations include those classified as charitable under IRS codes and serving specific counties in Minnesota and Wisconsin. The fund encourages co-sponsorship and highlights the importance of understanding diverse cultures and social systems.
Civic Affairs Social Justice / Human Rights Health Care Access & Delivery +6 more

Advanced and Specialized Course Access

Patterson Family Foundation
Private
Kansas, Missouri
US $50,000 - US $500,000
The Patterson Family Foundation offers funding for advanced and specialized course access, aiming to enhance educational opportunities for rural students in Kansas and western Missouri. Organizations can apply after registering through the Grants Portal. The foundation focuses on collaborative initiatives that ensure thriving rural communities by providing essential resources like dual-credit and STEM courses. Eligible applicants include 501(c)(3) organizations, school districts, or government entities, while projects outside the foundation's catchment area are ineligible.
STEM / STEAM Education Educational Access & Equity Education - High School +3 more

AISES Stellantis Scholarship

American Indian Science and Engineering Society (AISES)
Association/Society
United States
Up to US $20,000
The AISES Stellantis Scholarship aims to enhance the representation of Indigenous peoples in STEM fields. Funded by Stellantis, this scholarship offers $20,000 for full-time students enrolled in colleges with Mopar Career Automotive Programs. Eligible candidates must be current AISES members and either enrolled citizens or descendants of recognized Indigenous groups. The program not only supports education but also fosters a diverse and inclusive workforce within the automotive industry.
Education - Higher Education Diversity, Equity & Inclusion Educational Access & Equity +7 more

Knight Foundation Advised Fund

Central Carolina Community Foundation
Private
Richland County, South Carolina
Unspecified amount
The Knight Foundation Advised Fund supports innovative projects that enhance democracy and community engagement in Columbia, SC. With grant amounts typically not exceeding $75,000, it focuses on revitalizing downtown areas and riverfront development. Eligible organizations must be 501(c)(3) charities or similar entities serving Columbia or Richland County. The foundation prioritizes civic engagement, smart design, and the arts to foster inclusive public life, while avoiding funding for debt reduction, capital campaigns, or projects with discriminatory practices.
Civic Engagement & Education Parks & Public Spaces Community Development & Revitalization +7 more

Large Grants for Nonprofit Organizations Highlights

Large grants for nonprofit organizations provide significant funding to expand programs, enhance infrastructure, and scale operations. The following grants empower nonprofits to address large-scale challenges, foster sustainability, and create meaningful community impact.


Search Instrumentl's Large Grants for Nonprofit Organizations Database


Discover 8,000+ funding opportunities for nonprofits, with $3.43B available. Instrumentl connects nonprofits to tailored large-scale grants, offering tools for tracking deadlines, customized searches, and insights to achieve transformative growth.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Large Grants for Nonprofit Organizations

Grant Availability

How common are grants in this category?

Quite common — grants in this category are more prevalent than in others.

8,000+ Large Grants for Nonprofit Organizations grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

3,000+ Large Grants for Nonprofit Organizations over $25K in average grant size

3,000+ Large Grants for Nonprofit Organizations over $50K in average grant size

1,000+ Large Grants for Nonprofit Organizations supporting general operating expenses

7,000+ Large Grants for Nonprofit Organizations supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

600+ Grants on Instrumentl focused on Food Access & Hunger

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Large grants for Nonprofit Organizations?

Most grants are due in the first quarter.

Q1
29.8%
Q2
23.8%
Q3
23.9%
Q4
22.6%

Typical Funding Amounts

What's the typical grant amount funded for Large Grants for Nonprofit Organizations?

Grants are most commonly $34,887.

$0 $0 Min.
$34,887 $34.9 K Median
$655,609 $655.6 K Average
$188,250,000 $188.3 M Max.

Frequently asked questions

Nonprofits eligible for large grants typically have a proven track record of success and are ready to take on big projects with a lot of financial backing. Organizations with solid programs, strong financial management, and the ability to show long-term impact tend to receive these types of grants. Nonprofits working on large-scale initiatives in areas like healthcare, education, the environment, or economic growth are often prioritized. It’s important to show that your organization can handle the size of the project and funds required.

Based on Instrumentl’s live grant database for large grants, grant deadlines are most common in Q1, accounting for 29.8% of all submission dates. The slowest period for new grant opportunities in this category falls in Q4, making it a less competitive time for preparation and strategic planning.

Large grants exist to support projects that need significant financial resources. Funders want to invest in initiatives that lead to long-term impact, often focusing on areas like public health, education, climate action, and economic growth. The goal is to support projects that have the potential for wide reach, solve big problems, and continue making a difference long after initial funding runs out. Large grants focus on creating long-lasting, sustainable solutions.

Funding for large grants varies widely, with award amounts ranging from a minimum of $0 to a maximum of $188,250,000. Based on Instrumentl’s data, the median grant amount for this category is $34,887, while the average grant awarded is $655,609. Understanding these funding trends can help nonprofits set realistic expectations when applying.

Large grants are most commonly funded by government agencies, major foundations, and large corporate programs. Government agencies provide funding for public service projects in areas like healthcare, education, and infrastructure. Major foundations like the Bill & Melinda Gates Foundation and the Ford Foundation offer grants for projects focused on systemic change and social impact. Corporations also support large initiatives, especially those aligned with their corporate social responsibility (CSR) goals.

To improve the chances of receiving large grants, nonprofits should:

  • Create a detailed proposal – Make sure your proposal clearly outlines the project plan, timeline, and measurable results you expect to achieve.
  • Highlight past achievements – Give examples of how your organization has managed similar projects in the past and made a lasting difference.
  • Build partnerships – Collaborate with organizations or businesses that can help boost your project’s success and impact.
  • Have a clear long-term funding plan – Prove how you’ll sustain the project after initial grant funds run out, whether through partnerships, revenue, or other sources.

Need help writing a strong funding request? Follow our step-by-step guide to crafting compelling grant proposals.

Instrumentl simplifies the process of applying for large grants by offering an intuitive platform that helps nonprofits discover relevant funding opportunities, track deadlines, and analyze funder-giving patterns. The platform's automated alerts ensure users never miss a deadline, while detailed funder insights help organizations tailor their applications to align with grantor priorities.

See how Sleep in Heavenly Peace doubled their grant revenue from $1 million to $2 million within a year.