Best Large Grants for Nonprofit Organizations

The Brownson Memorial Fund Grants, established in 1985, have provided over $520,000 to nonprofit organizations in Mesa County, Colorado, focusing on substance abuse prevention and treatment. Affiliated with the Western Colorado Community Foundation since 2004, these grants support local initiatives aimed at improving community health and safety. Organizations must have IRS Tax Exempt status and comply with Colorado's Charitable Solicitations Law to be eligible for funding.

The New Mexico Children's Foundation (NMCF) offers annual grants aimed at supporting 501(c)(3) nonprofit organizations in New Mexico that serve children in underserved communities. This year, NMCF prioritizes programs that promote social-emotional development and enhance educational opportunities. Grants of up to $10,000 are available to programs that address unmet needs for children aged 18 and younger, particularly in rural areas. Operating expenses are also eligible for funding.

The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.

Alabama Rural Health Transformation Program: Maternal and Fetal Health Initiative

Program Overview

The Centers for Medicare and Medicaid Services (CMS) Rural Health Transformation (RHT) Program was authorized by Public Law 119-21 on July 4, 2025. The RHT Program is a $50 billion federal initiative planned to establish funding to strengthen rural hospitals and modernize the healthcare ecosystem for all 50 states. The RHT Program is designed to transform the rural healthcare ecosystem along five strategic axes: supporting rural health innovations, improving provider sustainability, developing the local healthcare workforce, expanding care delivery models, and testing technology-based solutions.

The Alabama Rural Health Transformation Program (ARHTP) is Alabama’s broader statewide framework for advancing the goals of the Rural Health Transformation (RHT) Program through coordinated, statedesigned strategies, initiatives, and investments intended to improve rural healthcare access, strengthen quality and delivery systems, support innovation, and promote long-term sustainability and accountability in rural communities. ARHTP is focused on transformational, practical approaches that strengthen provider networks, improve access to appropriate services closer to home, and support more resilient models of rural healthcare delivery across Alabama.

The Alabama Department of Economic and Community Affairs (ADECA), on behalf of the ARHTP, invites eligible applicants to apply for funding under the Maternal and Fetal Health Initiative. The purpose of this initiative is to improve maternal and fetal health outcomes in rural Alabama by addressing gaps in access to care and strengthening the capacity of healthcare systems to provide maternal and fetal health services. This includes connecting rural healthcare facilities to regional maternal and fetal referral hubs and expanding access to specialized imaging services and telerobotic ultrasound devices necessary to ensure healthcare facilities have the capacity, connectivity, and resources required to provide appropriate maternal and fetal care services. This NOFO establishes the application requirements, review framework, and award parameters for competitive funding designed to accomplish the purpose of the initiative as set forth above.

The Maternal and Fetal Health Initiative is intended to support practical, scalable strategies that strengthen maternal healthcare delivery systems across rural Alabama. Consistent with the State’s ARHTP framework, this initiative supports projects involving the establishment and enhancement of regional maternal and fetal referral hubs, the acquisition and deployment of telerobotic ultrasound equipment, and equipment upgrades and minor building renovations or alterations necessary to provide appropriate services under the defined strategy categories described below.

Projects funded under this NOFO must serve rural Alabama, align with at least one of the defined Maternal and Fetal Health Initiative strategy categories listed below, and clearly demonstrate how the proposed project advances one or more of the initiative goals identified in this section. Applicants do not need to be physically located in a rural area to apply; however, each proposal must clearly demonstrate that the project is specifically designed to provide a direct benefit to rural Alabama communities, expectant mothers, infants, healthcare providers, or facilities participating in regional referral networks.

Mission

The Foundation was established in December 2013 by Kathryn B. McQuade, after retiring from 33 years of working in the business community. I was blessed to have been born into a loving middle class family. My father worked very hard to insure that all of his children were given an opportunity for a good education and my mother, “a stay at home Mom’ was always there for us. My world was safe and comfortable. My life is in stark contrast to how much of the rest of the world lives. I continue to read of the terrible injustices waged against women and children globally and hope that this foundation can provide them the opportunity and resources to succeed. We will support organizations that help us achieve our goal of Striving to make sustainable improvements in women and children’s rights education and welfare.

Kathryn McQuade Foundation Grant

The Foundation will make timely decisions on your grant request and provide clear communications on our expectations of reporting progress.

Women

The Foundation’s goal is to provide women assistance and provide them an opportunity to succeed. Assistance can take many forms, however our goal is to help them become self sufficient and enable them to lift themselves out of poverty and provide for their children. Access to education, job training and professional skills, even access to capital in order to build a business are possible ways we will consider helping women to succeed. Grant requests should focus on enabling the women to sustain financial independence.

We look forward to hearing of the many creative ways organizations are working on helping women succeed through out the world. To help women is to help their children and the communities they live in.

Children

Too many children in the US and across the world live in poverty and lack the access to education. Education and/or appropriate skills training are necessary to break the cycle of poverty and crime. While the assistance to women may take many forms, the foundation’s focus for children will target education and/ or skills training. The Foundation is open to many ideas on how to accomplish this goal and look forward to receiving proposals to help all children achieve their potential.

The Katharine C. Pierce Trust Grant aims to enhance the lives of women in Massachusetts facing challenging circumstances. Focusing on health and human services, it supports nonprofit organizations providing essential services, including homecare and emergency assistance. The grant prioritizes program or capital requests, with a typical award of $10,000 for one year. Applications for direct service grants are due by May 1. Special consideration is given to initiatives benefiting elderly women.

The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.

The Alexander and Margaret Stewart Trust Grant supports innovative cancer research and enhances the quality of life for children and cancer patients in Washington, D.C. It funds non-profit organizations focused on pediatric care and cancer treatment, particularly for those in disadvantaged communities. The Trust prioritizes programs that provide compassionate care and support early-career scientists through its Pew-Stewart Scholars program, fostering breakthroughs in cancer research and treatment.

The Amboy Foundation Grant provides funding to tax-exempt organizations under Section 501(c)(3) of the Internal Revenue Code. With a minimum grant amount of $1,000 and a maximum typically not exceeding $10,000, the foundation supports community development, educational programs, and social welfare initiatives. Eligible organizations include those aiding low to moderate income populations and higher educational institutions focused on business programs. Applications are accepted year-round, with quarterly deadlines for review.

Who We Are

The Department of Energy and Environment (DOEE) is the leading authority on energy and environmental issues affecting the District of Columbia. Using a combination of regulations, outreach, education, and incentives, our agency administers programs and services to fulfill our mission. We work collaboratively with other government agencies, residents, businesses, and institutions to promote environmentally responsible behavior that will lead to a more sustainable urban environment.

RiverSmart Homes Landscaping Installation Program

The Department of Energy and Environment (DOEE) solicits grant applications from eligible entities (called “Applicant” or “Applicants”). The goal of this Request for Applications (RFA) is to mitigate the impact of nonpoint source pollution, reduce the volume of stormwater runoff, increase water conservation, and strengthen District residents' understanding of stormwater issues. 

Purpose of the Grant

The purpose of this grant is to mitigate stormwater pollution on the District's waterways through funding an incentivized voluntary landscaping installation program.

IDNR Mission Statement

To manage, conserve and protect Illinois' natural, recreational and cultural resources, further the public's understanding and appreciation of those resources, and promote the education, science and public safety of Illinois' natural resources for present and future generations.

Inflation Reduction Act Urban & Community Forestry Program 23-DG-11094200-327

Description 

To plan for, establish, manage and protect trees, forests, green spaces and related natural resources in and adjacent to cities and towns. The urban and community forestry program provides ecosystem services, social and economic benefits. It links these benefits to governmental, private and grassroots organizations and resources to improve the quality of life in these cities and towns.

Matching Requirement: Yes

The Gilmore Inclusive Arts Grant supports projects that engage individuals with disabilities in Northeast Indiana's arts communities. Annually, applications open in May and close in September, with funding up to $25,000. Organizations must be 501(c)(3) compliant, and priority is given to impactful projects. Collaboration is encouraged, ensuring diverse participation in the arts. This grant aims to foster inclusivity and enhance the cultural landscape by empowering individuals with disabilities.

The Birding For Everyone Fellowship, offered by the Golden Gate Bird Alliance, aims to empower BIPOC conservation leaders and promote diversity in the birding community. This fellowship provides free access to courses, networking opportunities, and field trips to reduce barriers for underrepresented groups. By nurturing diverse leadership, the program enhances community engagement and environmental stewardship in the Bay Area. With over 200 bird walks annually and a century of conservation efforts, the fellowship continues the legacy of inclusivity and education.

The Blue Impact Grant by Blue Cross and Blue Shield of Illinois supports community-based non-profit organizations focused on improving health equity in Illinois. This grant program emphasizes addressing social determinants of health, including economic opportunity, food access, and health outcomes. Eligible organizations must align with BCBSIL's mission and serve Illinois residents. Applications are welcomed from tax-exempt entities under section 501(c)(3), with a commitment to fostering sustainable community solutions.

The IA AmeriCorps Formula Grant, offered by Volunteer Iowa, aims to enhance community service and volunteering in underserved areas. This grant prioritizes projects that serve communities facing poverty, improve youth mental health access, support veterans, and promote environmental stewardship. Organizations that engage AmeriCorps members in these critical areas can receive funding to foster civic engagement and build resilient communities, ultimately contributing to national service efforts across the state.

The McKesson Foundation Grant provides funding above $25,000 to support health equity initiatives across North America. Founded in 1943, its mission focuses on removing barriers to quality healthcare for vulnerable communities. The foundation prioritizes projects that align with strategic pillars: reducing cancer burdens, preparing the healthcare workforce, and enhancing crisis response. Eligible organizations include national and local nonprofits. Funding is limited to specific regions and assessed based on demonstrated need and expected impact.

The H-E-B Tournament of Champions Grant, established in 1986, supports organizations benefiting Special Olympics Texas and educational initiatives. Over 37 years, it has raised over $145 million, promoting health, arts, and social services in Texas. Eligible applicants must be valid 501(c)3 non-profits, focusing on specific areas like disaster relief and education, and located near H-E-B regions. This grant fosters community engagement and enhances the quality of life for many Texans.

The L.B. Research and Education Foundation Grant Program supports U.S.-based nonprofits focusing on innovative education and health solutions for underserved populations. Eligible organizations can apply by submitting a 400-word concept paper, and selected applicants may receive funding ranging from $10,000 to $75,000. The Foundation prioritizes projects that foster critical thinking and creativity, address health disparities, and encourage collaboration. There are no application deadlines, promoting year-round engagement.

The Jack and Anne Glenn Foundation, established in 2004, aims to support disadvantaged youth and their families through program and project grants. With a grant range of $5,000 to $25,000, the foundation focuses on organizations that are 501(c)(3) exempt. The foundation prioritizes applicants providing guidance to those at risk of poor educational and social outcomes in communities including Metro Atlanta, GA, and Charleston, SC.

The Appalachian Regional Commission Federal Grant Program (ARC) supports economic development in West Virginia by providing federal grants for community-based projects. Prioritizing infrastructure improvements, particularly in distressed counties, ARC funds projects related to water, sewer, broadband, and job training. Applicants can request varying amounts based on the project's nature and location, with a focus on matching funds. This initiative fosters sustainable growth and revitalization in the region's economy.

The Great Lakes Protection Fund Grant aims to support projects that deliver significant ecological improvements to the Great Lakes region. The Fund seeks transformative initiatives that involve collaboration among diverse stakeholders and rely on scientific rigor. Eligible applicants include non-profits, universities, and businesses, and the projects must demonstrate a positive environmental impact on the Great Lakes ecosystem. Importantly, the Fund does not support advocacy or compliance-related activities.

About Us

A new name. The same dedication to service.

Ives Bank, formerly known as Savings Bank of Danbury, is a full-service Connecticut community bank rooted in history and positioned for the future.

Established in 1849 and headquartered at 220 Main Street in Danbury, Ives Bank is a mutual savings bank with assets in excess of $1.4 billion. We have 16 branch offices in Bethel, Brookfield, Danbury, New Fairfield, New Milford, Newtown, Norwalk, Southbury, Stamford and Waterbury. Stamford Mortgage Company, a division of Ives Bank, has a local office on Summer Street in Stamford.

We are about People Serving People.

We are committed to employing the best, motivated people who build relationships with our customers through highly personalized attention and customer service that is second to none.

Foundation

Contributing to the organizations that are essential parts of our daily lives.

We're a local community bank investing in the organizations that enrich our communities.

Mission

We help strengthen our local communities by providing grants to organizations that are vital to the well-being, growth and prosperity of the places where we live and work. The Foundation was established to provide grants to eligible 501(c)(3) tax-exempt organizations in five primary areas:

• Affordable Housing
• Arts & Culture
• Community & Economic Development
• Education
• Health & Human Services

The Foundation Grants Committee meets once a year to review requests. Awards are made to eligible 501(c)(3) tax-exempt organizations. Any organization interested in being considered should review the Foundation Guidelines and Instructions listed on the grant request form.

The Mayor's Matching Grant Program, initiated in 1994, supports Orange County Public Schools and nonprofit organizations by funding projects that enhance community engagement, education, and youth development. Grants ranging from $1,000 to $10,000 are available, requiring a dollar-for-dollar match from applicants. This initiative fosters collaboration among community members and organizations, aiming to create safe environments and improve academic outcomes for youth in Orlando.

The Alice Kleberg Reynolds Foundation supports qualified non-profit organizations in 50 counties of south and central Texas. Grants are focused on arts, culture, education, literacy, and medical/scientific purposes. Non-profits are encouraged to apply and share this opportunity with others. The Foundation does not fund capital campaigns, scholarships, or Type II/III Supporting Organizations. For detailed guidelines, visit the Foundation's FAQ page.

The New Hampshire Nita M. Lowey 21st Century Community Learning Centers (21st CCLC) Grant provides federal funding for academic enrichment and support services for students in high poverty schools. It aims to enhance student learning through tutoring, mentoring, and a range of extracurricular activities. Families also benefit from educational development opportunities. This initiative is part of the broader effort to meet educational standards and improve outcomes for youth in the state.

The Bridge Association of REALTORS Community Foundation Grants aims to financially support vital community programs that promote housing, youth opportunities, and diversity. The foundation focuses on Youth Arts and Education, Senior Services, and Workforce Housing, providing grants to non-profits in Albany, Berkeley, Emeryville, Kensington, Oakland, and Piedmont. With an emphasis on specific projects, eligible organizations must have tax-exempt status and demonstrate a commitment to addressing pressing community needs.

The Community Benefit Initiative Reinvestment (CBIR) Grant supports innovative projects aimed at improving healthcare access for EOCCO members. Grants of up to $50,000 fund one-year initiatives that foster collaborations, enhance telehealth, and address health disparities. Eligible organizations include healthcare providers and community groups in Eastern Oregon. Successful projects may inspire replication in other regions, ultimately benefiting underserved populations and improving health outcomes across the service area.