Best Operating Grants for Nonprofits

The Small Projects and Community Events (SPACE) Grants support local groups in funding short-term, community-led initiatives that protect natural resources and promote conservation education. These grants aim to be accessible and prioritize projects benefiting Black and Indigenous communities, communities of color, and low-income groups. Eligible projects include native plantings, community gardens, and conservation workshops. Applications are accepted on a rolling basis and should be submitted at least 45 days prior to the event.

The Forest Restoration and Wildfire Risk Mitigation Grant Program, established by the Colorado State Forest Service, aims to reduce wildfire risk to communities in the wildland-urban interface. Since its inception in 2017, the program has expanded to support projects that enhance forest health and promote the use of woody materials for energy. Eligible applicants must collaborate with local entities to ensure community-wide benefits and address wildfire threats effectively.

The Grable Foundation is dedicated to enhancing the lives of children in the Pittsburgh area by supporting early learning, public education, out-of-school programs, and community resources. By investing in innovative educational initiatives and family-friendly activities, the foundation strives to create an environment where children can thrive, explore, and reach their full potential. Their work fosters collaboration among educators, families, and community organizations to ensure every child has access to high-quality learning experiences and support.

The Long Island Sound Futures Fund (LISFF) is offering approximately $12 million in grants to enhance the health and living resources of Long Island Sound. Managed by the National Fish and Wildlife Foundation (NFWF) in collaboration with the U.S. EPA and the Long Island Sound Study (LISS), this initiative seeks innovative proposals to support environmental restoration efforts, leveraging major funding from various agencies and foundations.

The Roy J. Carver Charitable Trust provides grants primarily to 501(c)(3) tax-exempt organizations in Iowa and parts of Illinois. Focused on enhancing educational opportunities, the Trust supports projects in elementary and secondary education, higher education, medical research, youth services, and recreation. By funding innovative initiatives, it aims to improve access to educational resources and foster scientific advancement, while also addressing the recreational needs of youth and supporting community development.

The BGCF365 Grants, initiated by the Blue Grass Community Foundation, empower emerging philanthropists to collectively fund nonprofit projects that dismantle barriers to employment, transportation, and housing for families in Fayette County. In 2024, grants will focus on enhancing resilience among youth aged 0-22. Members contribute $365 annually, pooling resources to award $30,000 to selected organizations. This initiative fosters community engagement and aims to improve living conditions for all in Lexington.

The Area Development Grant Program, managed by the Appalachian Regional Commission (ARC), supports economic growth in Appalachia through investments in critical infrastructure and workforce development. Targeting 423 counties across 13 states, the program encourages local communities to collaborate with state governments to identify and implement impactful projects. Key focus areas include enhancing utilities, promoting entrepreneurship, and strengthening local leadership. This initiative aims to uplift the 26 million residents of Appalachia, fostering sustainable economic opportunities.

The Joseph and Elaine Malama Vierra Scholarship Fund, established in 2016, supports Hawaii residents pursuing degrees in conservation and environmental sciences. Applicants must demonstrate financial need, maintain a minimum GPA of 3.0, and attend an accredited four-year institution. Preference is given to past recipients who continue to meet eligibility requirements. This fund encourages the study of vital fields, including Conservation Biology and Marine Sciences, contributing to the sustainability of Hawaii's natural resources.

About PCORI

PCORI funds patient-centered comparative clinical effectiveness research (CER).

Our Mission

PCORI helps people make informed healthcare decisions, and improves healthcare delivery and outcomes, by producing and promoting high-integrity, evidence-based information that comes from research guided by patients, caregivers, and the broader healthcare community.

Broad Pragmatic Studies PCORI Funding

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA), seeking to fund patient-centered comparative clinical effectiveness research (CER) projects. 

Research Initiative Highlights

CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences.

Special Areas of Emphasis

For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAE) within the BPS funding opportunity. The purpose of identifying these SAEs is to encourage submissions to these areas, rather than limiting submissions to these topics. Applicants addressing one of the below SAEs should identify the area that is best associated with their research approach:  

• Addressing Obesity
• Diabetes Prevention, Care and Treatment
• Management of Urogynecological and Pelvic Pain
• Pain Management for Individuals Living With Sickle Cell Disease

In PCORI-funded research, patients and other research partners are expected to meaningfully contribute their lived experience or professional expertise to ensure studies are patient-centered, relevant and useful for healthcare decision making. Applicants must address PCORI’s Foundational Expectations for Partnerships in Research — an evidence-based framework supported by tools and resources to guide effective engagement strategies. Applicants are also strongly encouraged to consider the inclusion of a broad range of patient-centered burdens and economic outcomes. 

Broad Pragmatic Studies PFA: Category 1, Category 2 and Category 3 Study Specifications

PCORI will commit up to $120 million in direct costs through this funding opportunity. This funding opportunity contains three categories for funding:

• Category 1: Category 1 will support research projects with direct costs up to and including $5 million.

• Category 2: Category 2 will support research projects with direct costs greater than $5 million and up to a maximum of $12 million. Applications for funding under Category 2 will be required to provide additional information in the Letter of Intent (LOI) and application to justify the size and scope of the proposed research projects and to explain how additional funds are necessary with respect to the scale, scope and complexity of personnel and material resources needed to address the research question.

• Category 3: Category 3 will support research projects with direct costs up to $12 million that utilize PCORnet® to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet Studies® must include two or more Clinical Research Networks and share study progress, performance metrics and best practices with the network to promote continuous learning and improvement. PCORnet Studies® will leverage the PCORnet Common Data Model® as appropriate. Additional details about Category 3 can be found on the PCORI website.  

The Marine Mammal Commission is inviting proposals aimed at developing innovative tools and methods for enhancing marine mammal stock assessments. This initiative focuses on creating cost-effective strategies to estimate population sizes and assess human-caused mortality. Applicants can be from within or outside the U.S., and projects must contribute to science-based management. The funding limit is set at $75,000, encouraging novel approaches to improve the reliability of critical data in marine conservation.

The Patient-Centered Outcomes Research Institute (PCORI) intends to issue a Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) on Aug. 4, 2026, seeking to fund high-impact, patient-centered comparative clinical effectiveness research (CER) projects. This preannouncement provides potential applicants additional time to identify collaborators; obtain patient and stakeholder input on potential studies; and develop responsive, high-quality applications. 

Patient-centered CER compares at least two available health treatments, services or care delivery strategies. PCORI seeks proposals that compare clinical interventions (e.g., pharmacological and nonpharmacological treatments, screening and diagnostic approaches) and healthcare delivery system interventions (e.g., workforce, technologies, healthcare service delivery designs) to evaluate potential benefits and harms of different treatment and care delivery options, thus generating evidence that empowers patients, caregivers and the broader healthcare community with information to make informed choices that reflect their needs and preferences. 

The England Family Foundation Grant aims to amplify local solutions for inclusive prosperity in Washington, DC. It welcomes 501(c)(3) organizations to apply for general operating grants that align with its strategic priorities, including economic justice and community safety. The foundation prioritizes funding for organizations addressing systemic inequalities and fostering leadership among youth. Grants are awarded twice a year, with a commitment to reducing gun violence and supporting vulnerable communities. Interested applicants can submit inquiries via an online portal.

The Sacramento District California In-Lieu Fee Program, established by the National Fish and Wildlife Foundation, offers a mitigation option for permittees to compensate for authorized impacts to aquatic resources in California. Approved by multiple agencies, this program facilitates the purchase of mitigation credits to meet compensatory mitigation requirements. It employs a watershed approach to evaluate wetland threats, prioritize restoration, and implement mitigation projects, ensuring effective management of aquatic resources across designated service areas.

Service Objects In-Kind Grants support non-profit organizations dedicated to environmental conservation and sustainability. By leveraging their data validation services, they aim to assist projects that promote ecological health and responsible resource management. The program prioritizes applications with clear, measurable objectives and impactful outcomes within one to three years. Organizations with 501(c)(3) status in the U.S. are eligible, while initiatives lacking detailed plans or focusing on generalized education will not qualify. This grant fosters community involvement in environmental stewardship.

The Deluxe Corporation Foundation's ERG Grant Program supports diverse and inclusive initiatives by empowering employee resource groups (ERGs) to partner with nonprofits addressing relevant social issues. Each of the ten ERGs will award a $25,000 grant to a selected organization, fostering community impact and collaboration. The foundation, established in 1954, has invested over $109 million in charitable causes, focusing on financial literacy, education, and community support to enhance lives and promote entrepreneurship.

The Community Impact Grants by the United Way of Martin County support local programs focusing on health, education, and financial stability. These grants aim to enhance community well-being by funding organizations that demonstrate measurable outcomes and align with the United Way's mission. Eligible programs must be 501(c)(3) entities, serve Martin County residents, and have a track record of at least two years. A review panel of community leaders evaluates applications to ensure impactful funding.

The Kirkpatrick Foundation Small Grants program supports diverse initiatives in arts, culture, education, animal wellbeing, environmental conservation, and historic preservation, primarily in Central Oklahoma. With no specific deadlines and monthly reviews, the foundation aims to enhance the quality of life through strategic funding. Organizations that qualify as 501(c)(3) nonprofits and serve the local community are encouraged to apply. This program reflects the foundation's commitment to fostering a vibrant and sustainable environment for all citizens.

About the Montana Department of Commerce

Every day, staff at Commerce work alongside private industry and local organizations to create jobs, grow businesses, provide affordable housing and improve community infrastructure.

The economy of the Treasure State continues to grow and diversify. Studies rank Montana as the number one place in the country to start a business. Plus, our workforce has earned some of the highest rankings in both trade and technical skills by having one of the highest STEM (science, technology, engineering and mathematics) concentrations in the country.

Public and Community Facilities

Public and Community Facility Grants

Montana's CDBG Public and Community Facilities grants help local governments fund construction or rehabilitation of infrastructure and facilities that primarily benefit low- to moderate-income (LMI) Montanans, i.e. individuals earning less than 80% of the area median income. These projects can target LMI residents and provide direct benefits by improving or creating access to suitable living environments or necessary services, or these projects can provide an area-wide benefit to the entire community as long as at least 51% of the project’s beneficiaries are determined to be LMI. 

Certain projects such as senior centers, food banks, homeless shelters, youth homes, or head start centers are presumed to serve a limited clientele that is primarily LMI. Therefore, determining exactly what percent of project beneficiaries qualify as LMI is not required. Other projects, such as a wastewater improvements or water treatment improvements provide benefits to the entire community and are considered to have area-wide benefit because both LMI and non-LMI residents are served. Therefore, applicants must document at least 51% of the project’s beneficiaries qualify as LMI for projects considered to have an area-wide benefit.

The Children's Guild Foundation Grant supports non-profit organizations in Western New York that cater to children with special needs. The Foundation, operational for over a century, focuses on funding impactful programs addressing developmental, medical, intellectual, behavioral, and mental health challenges. By forming partnerships and advocating for systemic change, the Foundation aims to enhance the lives of these children and their families, ensuring their needs are met effectively and efficiently.

The Robinson-Broadhurst Foundation, established in 1984, is dedicated to enhancing the quality of life for residents in Stamford and Worcester, New York, and Winchendon, Massachusetts. By funding charitable 501(c)(3) organizations, the foundation supports various initiatives, including community health services, historical preservation, education, and public safety. Organizations aligned with these goals are encouraged to apply for grants to foster community spirit and cooperation.

The Delta Foundation, established by CFD Research Corporation in 2021, aims to enhance community well-being through collective employee-owner contributions. By funding local non-profit organizations, the Foundation supports vital initiatives in arts, mental health, and basic needs, ensuring that every dollar directly benefits the Huntsville area. The Foundation prioritizes organizations that align with its mission to improve quality of life, fostering impactful change through collaboration and community engagement.

Major Grant Fund

Apply for $50,000 to $200,000 per year, renewable up to two times for a total of three years of funding. Funds may support health-related direct service delivery or advocacy efforts. New for 2026, Major Grant funds can also support evaluation projects.

Funding Principles

Projects funded by the Health Equity Fund should align with the following funding principles:

Improving health outcomes and access

for communities and populations experiencing the deepest and most persistent health and economic disparities in King County.

Actively addressing the issues of systemic, structural, and institutional barriers

including racism, sexism, homophobia, transphobia, income inequality, and other forms of oppression or discrimination that negatively impact healthcare delivery and health outcomes.

Partnering or collaborating with other organizations

to enhance the impact of addressing health disparities.

Building capacity and empowerment

for communities addressing health disparities.

Funding for service delivery is limited to King County. There are no geographic restrictions on the residence of clients served or advocacy efforts, as long as the program can demonstrate the use of funds addressing disparities in health among residents of the Puget Sound region (King, Snohomish, Pierce, and Kitsap counties).

Organizations may not receive two PHPDA grants in the same year for the same project. Applicants can request grant funds for a different project as long as the time period covered by funding ends by the new contract period.

Organizations may only submit one application.

Focus Areas

Specific populations are facing heightened threats to their safety, security, and access to care, and the organizations that support them are experiencing drastic funding cuts. Our Major Grant program aims to support these organizations who are facing disproportionate burdens to their wellbeing. This year, Major Grants will be limited to organizations with projects in one or more of these three focus areas:

• Gender Affirming Care and/or HIV Prevention and Care for LGBTQIA2S+ Communities
• Barrier-Reducing Healthcare Delivery for Immigrant and Refugee Populations that is Responsive to Community Concerns 
• Access to Birth Control and Abortion Care

The Joseph B. Whitehead Foundation supports various initiatives in metro Atlanta, focusing on early childhood education, K-12 education, human services, health, and youth development. The foundation seeks to enhance educational opportunities and improve quality of life for vulnerable populations. Through collaborations with established organizations, it aims to address community needs and invest in proven solutions that empower children and families, ultimately fostering economic opportunities and health improvements in the region.

The IMPLICIT Grant, funded by the Minnesota Department of Health, aims to enhance maternal and perinatal care by implementing the IMPLICIT model in at least five clinics over three years. This initiative addresses critical factors such as smoking and maternal depression to reduce birth defects. A total funding of $130,000 is available, providing annual stipends of $18,000 to participating clinics, which will also receive essential training and support to ensure sustainable healthcare improvements.

The Louisville Water Foundation aims to enhance community health by ensuring access to safe water through various initiatives. Grants are available to 501c3 organizations within the Louisville service areas for projects that provide drinking water solutions, educational programs, and watershed protection efforts. The application deadline for the water access projects is September 15, encouraging impactful contributions to local water-related challenges.

The Great Apes and Gibbons Program Grant, administered by the Arcus Foundation, supports conservation efforts for great apes and gibbons across 24 priority landscapes in Africa and Asia. The program emphasizes sustainable coexistence between humans and wildlife, having awarded over 2,000 grants to more than 500 organizations globally. Funding is not available for individuals or specific lobbying activities, ensuring resources are directed towards impactful conservation initiatives.

The Monmouth County Community Grant, offered by the Community Foundation of New Jersey, invites nonprofit organizations to submit proposals addressing diverse community needs. Prioritizing initiatives that emphasize diversity, equity, and inclusion, this grant supports programs in education, healthcare, and food security, among others. With funding up to $10,000 per organization, the grant aims to foster collaborative partnerships and address systemic issues affecting underserved populations in Monmouth County.