Best Large Grants for Nonprofit Organizations

The New England BioLabs Foundation Grant focuses on supporting nonprofit organizations that enhance biocultural diversity and ecosystem services in regions such as Central America and West Africa. Projects should aim to conserve biological diversity, sustain traditional knowledge, and promote local economic vitality. The foundation prioritizes community-led initiatives, especially in coastal communities along Massachusetts' North Shore. Those interested must first submit a letter of inquiry, adhering to specific guidelines before proceeding with full proposals.

The Trio Foundation of St. Louis Grant aims to enhance community well-being and promote equity through its new funding framework. Established over two decades ago, the foundation focuses on empowering marginalized groups, particularly those facing discrimination based on race, gender, and socioeconomic status. The grant supports initiatives in women's economic empowerment, arts accessibility, and environmental justice, fostering authentic relationships with community partners to create lasting impact in the St. Louis region.

The Huntington Impact Investment Philanthropy Grant Program aims to strengthen communities by supporting nonprofit organizations that enhance self-sufficiency and social equality. With a focus on areas such as community revitalization, affordable housing, and economic development, the program prioritizes initiatives that serve low- and moderate-income individuals. Organizations with IRS tax-exempt status can apply for funding to address critical community needs, fostering a more equitable environment for all.

The NACD Technical Assistance Grants program, in partnership with NRCS, has been enhancing conservation district support since 2018. By funding staff hires, it aims to improve service for agricultural producers and address conservation workload challenges. The initiative focuses on outreach, education, and civic engagement to empower local communities, promote sustainability, and support historically underserved producers in implementing conservation practices, thereby fostering both individual and community resilience.

The Ashden International Award celebrates innovative climate solutions, supporting businesses and organizations that promote social justice and reduce emissions. This year, the awards focus on climate innovators enhancing job roles and skills for a low-carbon future. Winners receive grants, essential publicity, and connections with climate experts, fostering impactful change in the UK and low-income nations. Join Ashden in recognizing pioneers who are transforming the green job landscape and leading the way in climate action.

The Securian Foundation focuses on enhancing community well-being through financial stability, youth education, and vibrant communities. They aim to empower families by supporting initiatives that ensure equitable access to basic needs, promote financial literacy, and encourage community engagement in arts and culture. The foundation prioritizes funding for food security, housing, workforce development, educational programs, and civic opportunities, while maintaining a commitment to serving underrepresented populations.

About

Together we can strengthen our communities.

ServeWyoming is our State’s center for volunteerism and national service. We exist to help implement and coordinate the AmeriCorps programs, as well as build, maintain and mobilize the volunteer infrastructure we believe necessary to address the critical needs in our State. We also collaborate with other AmeriCorps and AmeriCorps Seniors programs such as AmeriCorps*VISTA and AmeriCorps Seniors*RSVP and VGF*Service Learning.

Our Mission

ServeWyoming is our State’s commission on national and community service.

We exist to help implement and coordinate the AmeriCorps programs, as well as build, maintain and mobilize the volunteer infrastructure we believe necessary to address the critical needs in our State. We also collaborate with other AmeriCorps and AmeriCorps Seniors programs such as AmeriCorps*VISTA, AmeriCorps*VGF (Service Learning) and AmeriCorps Seniors*RSVP.

Notice of Funding Opportunity

If you are interested in applying to be a new program, please reach out to ServeWyoming staff at ACProgram@servewyoming.org before proceeding. ServeWyoming requires that new programs submit a Concept Paper. 

Concept Paper

The ServeWyoming AmeriCorps application process begins with the Concept Paper; to succinctly and precisely identify the proposed project, the needs it addresses, the activities members will be engaged in and the number of members requested. The Concept Paper process is designed as a “qualifying” round.

The New Mexico Clean and Beautiful Grant Program, administered by the New Mexico Tourism Department, aims to foster community beautification, reduce waste, and eliminate litter across the state. This initiative supports municipalities, counties, and Tribal Governments by providing financial assistance and technical guidance to promote litter control and enhance recycling efforts. The program empowers local organizations, aiming to create a cleaner and more beautiful environment for all New Mexicans.

Aid to Agencies

About the Program

The Arapahoe County Aid to Agencies (A2A) Program provides financial support to nonprofit organizations delivering essential services to Arapahoe County residents. Established in 2008 by the Arapahoe County Board of County Commissioners, the program was created to address critical community needs through strategic partnerships with local nonprofit providers.

Since its inception, the program has awarded more than $30 million to nonprofits serving residents across the county. 

For the 2026–2027 funding cycle, approximately $3,079,500 in General Fund support will be available, including designated allocations for safety net providers. 

In 2025, the program framework was updated to align with Arapahoe Forward and strengthen transparency, accountability, measurable outcomes, and alignment with community-identified needs. The updated framework prioritizes investments that address documented service gaps and improve quality of life for Arapahoe County residents.

Safety net providers are nonprofit organizations that deliver essential services to vulnerable or underserved populations. These organizations are typically distinguished by one or more of the following: 

• Serving as the sole or primary provider of a critical service  
• Offering services that do not duplicate existing County programs  
• Addressing high-need and high-impact service areas with demonstrated community demand  

Organizations currently designated as safety net providers: 

• Three Birds Alliance (formerly Gateway Domestic Violence Services)  
• Aurora Mental Health Center & Recovery – Detox Services  

These organizations receive direct base funding outside of the competitive application pool.

The Sudbury Foundation's Youth Emotional Well-Being Grant Program aims to enhance emotional health supports for children and youth, particularly underserved populations. Nonprofits in the Sudbury area are invited to apply for funding to develop or expand programs addressing issues like stress, anxiety, and grief. The foundation prioritizes organizations with a strong youth development focus and encourages innovative programming that fosters long-term relationships between youth and caring adults. A virtual information session will be held on February 1, 2024.

The Conservation Stewardship Program (CSP) in Mississippi, administered by the USDA Natural Resources Conservation Service, offers agricultural producers the opportunity to enhance their conservation practices and earn payments based on performance. By developing tailored conservation plans, the program supports landowners in achieving sustainable management goals, improving productivity, and increasing resilience against market and environmental challenges. Participants benefit from additional payments for adopting innovative practices that contribute to healthier ecosystems and land management.

The Levin Family Foundation Grant supports nonprofits focused on critical issues in Montgomery County, Ohio, such as the opiate epidemic, human trafficking, anti-bullying, and suicide prevention. Established in 1996, the foundation has invested over $12 million globally, emphasizing projects that align with its mission. Eligible organizations must be IRS 501(c)(3) tax-exempt. Priority is given to initiatives in the Greater Dayton Area, fostering positive community impact.

The GPOA Foundation Grant supports programs for children in Orleans Parish, Louisiana, with a focus on kindergarten readiness, reading proficiency by third grade, and equipping at-risk youth for independence. The foundation accepts concept papers biannually and encourages collaborative requests. Eligible organizations include nonprofits serving children and youth, while ineligible programs include those outside Orleans Parish or unrelated to children. Funding can cover operational costs and multi-year requests, fostering impactful educational initiatives.

The MainStreet Foundation Quarterly Grant, initiated by Androscoggin Bank, focuses on supporting at-risk youth in Maine by funding essential programs related to food, security, shelter, and education. Grants of up to $5,000 are awarded quarterly to nonprofits that effectively address the needs of vulnerable children. By emphasizing community involvement and sustainable practices, the Foundation aims to create a supportive environment for youth development, ultimately enhancing their well-being and future prospects.

The Knapp Community Care Foundation Grant supports organizations in the Mid-Valley region that enhance health and wellness. Since 2013, the foundation focuses on projects addressing the Social Determinants of Health, including economic stability and healthcare access. Eligible organizations must be recognized 501(c)(3) entities and demonstrate innovative programs that positively impact the community. The foundation encourages partnerships and evidence-based initiatives to leverage additional funding and improve health outcomes for vulnerable populations.

The Delaware County Foundation's Community Grants program aims to strengthen communities through charitable giving. Since its inception in 1995, the foundation has provided over $18 million in funding to support various nonprofit organizations in Delaware County, focusing on areas such as animal welfare, arts and culture, basic needs, education, economic opportunity, and environmental sustainability. Organizations addressing these critical areas are encouraged to apply for funding to enhance community well-being.

The Community Foundation of Fort Dodge and United Way offer Special Project Grants aimed at enhancing community life through charitable projects. Focused on economic growth, education, and well-being, these grants support 501(c)(3) organizations dedicated to public service. Priority areas include youth development, health, and community betterment. By investing in local nonprofits, the foundation aims to uplift the Fort Dodge area, ensuring a vibrant and sustainable community for all residents.

The Ecolab St. Paul, MN Area NPO Grant Program supports 501(c)(3) organizations that focus on youth development, community and civic engagement, environmental conservation, and arts education. Grants are available to current grantees in the St. Paul area, with applications opening on September 8, 2025. This initiative aims to enhance health, sustainability, and operational efficiency in local communities, aligning with Ecolab's mission of protecting people and the planet.

The Kentucky Nita M. Lowey 21st CCLC Grant aims to support local school districts and community organizations in developing effective out-of-school programs to enhance student achievement and social development. With an award amount of $150,000, this grant focuses on providing academic, artistic, and cultural enrichment for students from high-poverty schools, ensuring they meet state academic standards through engaging and comprehensive programming.

The Biodiversity Fund Grant, offered by the Boreal Waters Community Foundation, aims to enhance biodiversity in the Duluth-Superior region. It supports projects focused on habitat restoration, species protection, and addressing climate change impacts. Eligible applicants include charitable organizations that serve specific counties in Wisconsin and Minnesota. This initiative seeks to promote ecological health and engage local communities in conservation efforts, ensuring the preservation of vital ecosystems for future generations.

The United Way of Greater St. Louis Targeted Funding aims to provide flexible, one-year grants to nonprofits addressing urgent community needs through emergency, emergent, or innovative approaches. Funding will focus on basic needs, health and wellness, crisis response, and more across 16 counties. Priority will be given to areas identified as having the greatest needs based on recent assessments, ensuring that support is directed where it is most needed.

Tempe Community Council 

Serving the community since 1972, Tempe Community Council (TCC), a 501(c)(3) nonprofit, is committed to addressing immediate and long-term human service needs in Tempe. A nonpartisan organization, TCC serves as a means for individuals and organizations to work together to identify and plan for needed human service programs in our community. Our unique model of including residents to make decisions is an example of what makes Tempe a great city.

Mission Statement: TCC’s mission is to connect those in need with those who care. TCC does this by convening community, conducting research, determining priorities, implementing effective programs and exemplifying prudent stewardship of resources.

Annual Agency Review Human Services Funding

An annual funding process known as Agency Review provides an opportunity for nonprofit human services providers to apply for available human services funding from City of Tempe and Tempe Community Council. Learn more..

For over 40 years, Tempe Community Council (TCC) has expertly administered and managed the distribution of human services funds on behalf of the City of Tempe, along with community donations, through a process known as “Agency Review.”  

What makes this process unique – and truly a community effort – is TCC’s involvement of community members who live or work in Tempe. Their participation brings a personal, human touch to Agency Review, making it much more than just a grant process.

Funding Human Services for Tempe

For Fiscal Year 2026-27, Tempe’s City Council approved $1.136 million in funding to support agencies offering 35 different services and programs, addressing a wide range of needs Tempe residents may be facing. The primary funding source comes from City of Tempe tax dollars, specifically allocated to support human services. Additional funds come from Together Tempe donations, collected through City of Tempe utility bills and direct contributions to Tempe Community Council (TCC).

Each year, this funding process is administered by TCC. The selected programs and services help individuals and families move from crisis to stability, and in some cases, toward self-sufficiency. These services address critical areas of need, including aging, homelessness, poverty, disabilities, abuse, addiction, youth support, food security, isolation, mental health, and shelter.

The Kosciuszko Foundation offers Tuition Scholarships for American students of Polish descent pursuing graduate studies in the U.S. Scholarships can provide up to $12,000 for full-time studies, including master's and Ph.D. programs. Eligible applicants must be U.S. citizens or legal residents with Polish heritage and maintain a minimum GPA of 3.0. This program aims to foster educational exchanges and cultural understanding between the U.S. and Poland, supporting various fields of study.

The Bailey Research Fellowship offers a unique opportunity for graduate students to conduct research in the renowned Rocky Mountain National Park. Funded by the Leslie Fidel Bailey Charitable Trust, this fellowship encourages the exploration of diverse topics, including ecology, geology, and wildlife management. Selected fellows will collaborate with park staff for three to four months, receiving housing and a stipend of $12,000, plus potential additional funds for research-related expenses.

The Old National Bank Foundation offers grants to nonprofit organizations for community impact initiatives across Indiana, Illinois, Kentucky, Tennessee, Michigan, Minnesota, Iowa, and Wisconsin. Focused on four key areas—Affordable Housing, Workforce Development, Economic Development, and Financial Empowerment—the foundation prioritizes programs that support underrepresented communities. Organizations must have 501(c)(3) status and align with the foundation’s funding priorities to qualify for grants, which can be applied for every two years.

The Westchester Community Foundation Grant Program offers competitive grants to public charities and groups providing programs in Westchester County. The foundation prioritizes initiatives in human justice, human services, workforce development, youth development, arts, social justice, and technical assistance. This support aims to enhance the lives of residents through diverse projects that address civil rights, economic stability, youth empowerment, and cultural access. Funding fosters community engagement and innovative solutions to local challenges.

The Nature in Neighborhoods Capital Grants, provided by Metro, support diverse community projects aimed at enhancing local parks, restoring streams, and promoting nature education. These grants prioritize projects led by community organizations and local governments, focusing on publicly owned capital projects that advance racial equality and climate resilience. With funding available for land acquisition and urban transformations, the program seeks to engage communities and foster connections with nature throughout the greater Portland area.