Best South Dakota Grants for Nonprofits

Society of Hospital Medicine (SHM)

The Society of Hospital Medicine (SHM) is dedicated to promoting high-value care and achieving optimal outcomes for acutely ill patients. As part of this mission, SHM seeks to address inequities in acute patient care and contribute to a greater dialogue on this important issue. As the home for hospitalists, SHM activates and engages our community to

• Advocate for our specialty, our members, and the diverse patients we serve.
• Promote high-value care and optimal outcomes for acutely ill patients.
• Meet the evolving educational needs of a dynamic specialty.
• Cultivate an inclusive community for hospitalists and support career growth and wellbeing.
• Advance the research and innovation of healthcare delivery, quality, safety, and experience across the care continuum.

Society of Hospital Medicine Travel Grant

The SHM Global and Rural Health Foundation brings our mission directly to patients in rural and underserved regions of the United States and abroad by offering small travel grants to hospital-based clinicians and practice administrators involved in this work. The Foundation also aims to amplify the stories of inequitable patient care and celebrate hospital medicine professionals enhancing outcomes.

The SHM Global and Rural Health Foundation awards travel grants of up to $2,000 per person for travel to qualifying relief programs. Travel grants will be awarded to support travel for work conducted through established nonprofits, such as Doctors Without Borders, or a program run by a nonprofit academic health center.

PetSmart Charities

We’re proud to celebrate over 30 years of being the leading funder of animal welfare in communities across North America. Since 1994, we’ve granted over $600 million to change-making organizations that help transform the lives of pets and those who love them.

Our Mission: We make the world a better place for pets by investing in community partners that advocate and care for the well-being of pets and all who love them.

Adoption Growth Grants 

Purpose

Adoption Growth grants drive lifesaving outcomes by supporting successful, sustainable in-store adoption programs, events, and results in partnership with PetSmart stores.

Funding Support

Funding may be used for costs associated with building or enhancing your organization’s adoption program in partnership with PetSmart stores, including:

• Staff positions supporting in-store adoption programs and events.
• Marketing and advertising for in-store adoption programs.
• Volunteer or foster support, incentives, and recruitment related to in-store adoption events.
• Event supplies, including containment and enrichment materials.
• Shelter software and technology needs.
• Vehicle repairs or transportation to adoption events.
• Innovative in-store adoption ideas and pilot programs.
• Other costs directly associated with facilitating PetSmart adoptions and in-store events.

There are two Cohorts under this funding: Cohort 1-  Accelerating in-store adoptions; and Cohort 2: Capacity Building.

Cohort 2: Capacity Building

Applicants must have completed at least one adoption in a PetSmart store within the last 12 months.

Preference will be given to organizations seeking to build a consistent, sustainable in-store adoption program. Applications should include a clear plan, with examples, for sustaining the program over time.

Four Required Steps

Applicants must complete all four required steps below before submitting a grant application:

• Step 1 - Watch the kick-off video and complete the Adoption Accessibility Questionnaire
• Step 2 - Confirm eligibility and connect with your Adoptions Grant Manager: After completing the questionnaire, you will receive an email confirming your eligibility. Eligible partners will be invited to a call with their Adoptions Grant Manager to discuss the grant opportunity, expectations, and potential fit.
• Step 3 - Engage your PetSmart store partners: Discuss your intent to apply, align on goals, and gain their commitment to support the success of your in-store adoption program.
• Step 4-  Submit your application.

About Us

For over three decades, the Hamilton Education Foundation (HEF) has been sparking innovation and expanding horizons within our classrooms. Since 1991, this community-powered non-profit has channeled more than $2.5 million from passionate individuals, local businesses, and forward-thinking organizations directly into the hands of Hamilton’s students and teachers. 

By funding transformative workshops, creative projects, and classroom grants, HEF doesn't just support education—it inspires students to dream bigger, rewards academic excellence, and builds a stronger, more vibrant community.

Our Vision

The vision of the Hamilton Education Foundation is to assist in achieving creative and academic excellence for the 21st Century through funding activities and projects for students and educators in the Hamilton School District.

Our Mission

Our mission, in partnership with the community, is to fund, Enhanced, Extended, and Enriched learning opportunities for students and educators in the Hamilton School District.

Teacher Grants

Educator Enrichment Grant

The Educator Enrichment Grant funds teacher participation in off-campus professional development, including seminars, workshops, conferences, and externships. 

About Us

For over three decades, the Hamilton Education Foundation (HEF) has been sparking innovation and expanding horizons within our classrooms. Since 1991, this community-powered non-profit has channeled more than $2.5 million from passionate individuals, local businesses, and forward-thinking organizations directly into the hands of Hamilton’s students and teachers. 

By funding transformative workshops, creative projects, and classroom grants, HEF doesn't just support education—it inspires students to dream bigger, rewards academic excellence, and builds a stronger, more vibrant community.

Our Vision

The vision of the Hamilton Education Foundation is to assist in achieving creative and academic excellence for the 21st Century through funding activities and projects for students and educators in the Hamilton School District.

Our Mission

Our mission, in partnership with the community, is to fund, Enhanced, Extended, and Enriched learning opportunities for students and educators in the Hamilton School District.

Student Grants

Evaluation Factors

Applications are reviewed based on:

The AACR June L. Biedler Prize for Cancer Journalism

Prize Summary

The AACR June L. Biedler Prize for Cancer Journalism was established by the AACR in 2015 to raise awareness of the critical role that the media play in educating the public about cancer and cancer research.

Funded by a major bequest to the AACR from cancer research pioneer Dr. June L. Biedler, a scientist, mentor, and former member of the AACR Board of Directors, this prize showcases outstanding examples of cancer journalism and recognizes individual professional journalists who have produced accurate, informative, and compelling stories that enhance the public’s understanding of cancer, cancer research, cancer advocacy, or cancer policy.

The prize provides an unrestricted cash award of $5,000 and a commemorative award.

Categories

Each submission may be considered for only one category, as selected by the candidate on the application form.

Applicants may submit in any of the following categories:

Prize Acceptance

Awardees will be able to accept the prize during the AACR Annual Meeting 2027 in Orlando, April 2-7, 2027.

Edward E. Ford Foundation

The Edward E. Ford Foundation seeks to improve secondary education by supporting U.S. independent schools and encouraging promising practices. 

• We make Traditional Grants to eligible schools and Associations to help them grow and develop in pursuit of their own missions.
• We make Educational Leadership Grants to eligible schools or groups of schools that consist of larger dollar awards to fewer recipients.
• We encourage collaboration with others in both grant cycles.
• Occasionally, we may make larger, multi-­year Collaborative Innovation Grants in support of projects that have the potential to influence secondary education more broadly and positively affect our democratic society.
• Beyond grant-making, we share what we learn, sponsor strategic meetings, and work with others to identify and respond to the most pressing challenges facing the field of secondary education.

Traditional Grant for Associations

These grants are made in response to requests that can range from $25,000 to $100,000 and that must be matched by additional funds raised by the association at least 1:1.

Associations seeking placement on a Traditional Grant Agenda should be prepared to specify the anticipated dollar value of their proposal when they request placement. This can be months in advance of the date the final version of the proposal will be due, depending on the length of the queue. 

Traditional Grants are awarded based on the quality of the proposal and other considerations in terms of the association’s operation, but it does not identify certain areas of independent school work as favored. That is, you can seek guidance as to what sort of proposals have been funded in the past but association should identify their own greatest institutional need that they think the Foundation can help address.

Step-by-Step Process

• Request Agenda Placement — Please fill out the Agenda Placement form to tell the Foundation a bit more about your association and to help us determine if it is eligible for EE Ford funding.

• Agenda Placement Phone Call — If your association is eligible for Agenda Placement, we will schedule a phone call between your association’s Executive Director and the Executive Director of the EE Ford Foundation. This phone call will serve as an informal introduction and it will determine if Agenda placement is right for your association. No proposal can be considered from associations that have not reserved a place on an upcoming Agenda. If your association is placed on an Agenda, you will receive an Agenda Placement Confirmation email with further instruction.

• Executive Director Meeting — Schedule a 2-3 hour meeting between your association’s Executive Director and our foundation’s Executive Director to be held in our Brooklyn office. The Preliminary Materials will be due one week prior to this meeting (see “Preliminary Materials” under "Required Materials"). 

• Final Submission — Deadline for submission of final materials is January 30 for the April Agenda or April 1 for the June Agenda. When the Board makes its decision about a proposal, the Executive Director communicates this decision within days.

The BJS FY 2026 National Criminal History Improvement Program (NCHIP) Training and Technical Assistance aims to enhance the accuracy and accessibility of criminal history records. By providing direct technical assistance to states, territories, and tribal jurisdictions, the program ensures compliance with FBI standards and promotes the use of advanced technologies. This initiative supports the DOJ’s objective to reduce violent crime and improve public safety through effective criminal background checks and information sharing.

The BJS FY 2026 Consolidated National Criminal History Improvement Program is designed to enhance the quality and accessibility of criminal history records, ensuring effective background checks for both criminal and non-criminal justice purposes. With significant funding allocated to programs like NCHIP and NARIP, the initiative aims to bolster public safety by improving the accuracy of background information and supporting state and tribal updates to the FBI's National Instant Criminal Background Check System.

The Substance Abuse Prevention, Treatment, and Aftercare program aims to combat substance abuse in American Indian and Alaska Native populations. It focuses on enhancing care coordination, expanding culturally competent behavioral health services, and implementing early intervention strategies for at-risk youth. By supporting Tribal and community-led initiatives, the program fosters collaboration among families, youth, and community partners to create effective prevention, treatment, and recovery solutions.

The Healthy Lifestyles in Youth program, funded by the Indian Health Service, aims to empower Tribes and Tribal Organizations to deliver essential public health services. This new cohort of NPHR awards supports initiatives that foster healthier lifestyles among youth in Indigenous communities, addressing critical health disparities and promoting well-being through culturally relevant programs and services.

The Zero Suicide Initiative aims to enhance suicide prevention within Indian health systems by implementing the Zero Suicide framework. This program focuses on culturally informed strategies to empower Tribal health systems, fostering leadership, workforce development, and effective suicide risk identification. It emphasizes timely engagement and evidence-based treatment, ensuring continuity of care and quality improvement, ultimately enhancing outcomes for American Indian and Alaska Native individuals at risk for suicide.

The Behavioral Health Integration Initiative aims to enhance the health of American Indian and Alaska Native individuals by expanding access to integrated behavioral health care. It supports Tribal and Urban Indian Organization health systems in providing culturally responsive and trauma-informed services. The initiative focuses on improving care coordination, promoting early identification of mental health issues, and integrating various health services to improve overall health outcomes and quality of life for AI/AN communities.

American Academy of Family Physicians Foundation

The AAFP Foundation focuses on improving health for everyone, and your support makes an immediate impact on the good work we do—from leadership development and education scholarships to funding social and health care services.

The AAFP Foundation strives to create a sense of belonging through an inclusive environment that embraces the family medicine community by recognizing individual uniqueness and contributions to family medicine.

Richard D. Feldman, M.D. Student and Resident Essay Contest

Each year, the Center for the History of Family Medicine (CHFM) sponsors a contest to encourage medical students and family medicine residents to write scholarly essays relevant to the history of family medicine in the United States. The first-place winner will receive $2,000 and the second-place winner will receive a $1,000 award.

We encourage all to apply and are committed to developing scholarly essays relevant to the history of Family Medicine in the United States by medical students and residents who reflect the rich diversity of the specialty and the patients served.

American Brain Foundation

The American Brain Foundation funds research across the spectrum of the brain and nervous system, because it is our best hope for improving treatments, advancing prevention strategies, and discovering cures. Brain diseases, disorders, and injuries are interconnected. When we cure one, we will cure many.

Next Generation Research Grants

The American Brain Foundation’s Next Generation Research Grants (NGRGs) support early career investigators conducting high-quality research aimed at better understanding, treating, and curing brain diseases. These grants are offered in collaboration with disease-focused partner organizations and reflect ABF’s Cure One, Cure Many research philosophy: the belief that breakthroughs in one area of research accelerate progress across many others.

McKnight Clinical Translational Research Scholarship in Cognitive Aging and Age-Related Memory Loss

This award aims to support young investigators in clinical studies relevant to age-related cognitive decline and memory loss. The award also recognizes the importance of rigorous training in clinical research and encourages young investigators to seek opportunities to establish future careers in the area of human cognitive aging.

Please Note: The focus should NOT be on a neurodegenerative dementia (e.g., Alzheimer’s disease); however, proposals that focus on the combined study of cognitive aging and neurodegenerative cognitive changes may be considered.

For the purpose of this scholarship, research is defined as patient-oriented research conducted with human participants, or translational research specifically designed to develop treatments or enhance identification of age-related cognitive decline and memory changes. These may include epidemiologic or behavioral studies, clinical trials, studies of disease mechanisms, the development of new technologies, and health outcomes research. Disease-related studies not directly involving humans are also encouraged if the primary goal is the development of therapies, diagnostic tests, or tools to mitigate age-related cognitive decline and memory loss.

About Father John Foundation GrantIn 1997 Monsignor John P. Hourihan established this perpetual charitable foundation for the purpose of funding care for the homeless and people with disabilities, especially the deaf and hard of hearing. The purpose of the Foundation is to financially assist churches and other non-profit organizations, that do not take more than insubstantial government funding, in administering their programs. Our giving focus is broad and considers programs that are: religious, educational, rehabilitational, social, and/or vocational. A priority is given to the deaf and homeless. All funding is given regardless of nationality, race or religion. The Foundation will continue its dedication to raising and distributing grants to be used by charities devoted to providing care and services to the homeless and disabled.

American Brain Foundation

The American Brain Foundation funds research across the spectrum of the brain and nervous system, because it is our best hope for improving treatments, advancing prevention strategies, and discovering cures. Brain diseases, disorders, and injuries are interconnected. When we cure one, we will cure many.

Next Generation Research Grants

The American Brain Foundation’s Next Generation Research Grants (NGRGs) support early career investigators conducting high-quality research aimed at better understanding, treating, and curing brain diseases. These grants are offered in collaboration with disease-focused partner organizations and reflect ABF’s Cure One, Cure Many research philosophy: the belief that breakthroughs in one area of research accelerate progress across many others.

Lawrence M. Brass, MD Clinical Research Training Scholarship in Stroke

This award aims to recognize the importance of good clinical research and to encourage early career investigators in clinical studies related to stroke, vascular neurology, and neurocritical care.

For the purpose of this scholarship, research is defined as “patient-oriented research conducted with human participants, or translational research specifically designed to develop treatments or enhance diagnosis of neurological disease. These areas of research include epidemiologic or behavioral studies, clinical trials, studies of disease mechanisms, the development of new technologies, and health services and outcomes research.” Disease-related studies not directly involving humans or human tissue are also encouraged if the primary goal is the development of therapies, diagnostic tests, or other tools to prevent or mitigate neurological diseases.

Agnes McCarthy Caregiver Foundation

The Agnes McCarthy Caregiver Foundation is a 501(c)(3) not-for-profit charity that provides hope and relief to caregivers who care for a loved one with mental health conditions.

Caregiver Grant

Family caregiving has become a public health issue that receives inadequate recognition in our country. While it can be rewarding to care for our loved ones, it often comes with significant physical, emotional and financial costs to the caregiver. On average, caregivers spend over 25% of their own income to support their loved one and provide 32 hours a week in unpaid care.

AMCF currently offers a $500 financial relief grant to assist family members with unexpected expenses due to their caregiving role. If you are a family caregiver to someone living with a mood or psychiatric condition like depression, anxiety, PTSD, bipolar, schizophrenia, or other mental health/co-occurring conditions, you are not alone, and we welcome you to apply for a caregiver grant today.

Additional Information

• To ensure our limited funds reach families with the greatest need, grants may require documentation confirming a diagnosed serious mental illness (SMI).  

• The $500 grant is limited to one award per household within a 12-month period.

• Applications are generally reviewed by our Board of Directors, with decisions made within 30 days of receipt.

T7 Social Impact GrantsThe T.D. Jakes Foundation (TDJF), in partnership with Wells Fargo, is proud to launch the Social Impact Grant Challenge, a transformative funding opportunity designed to identify, support, and amplify nonprofit organizations creating meaningful change in communities across the United States.

Designed around the T.D. Jakes Foundation's pillars of service (Educational Access & Workforce Readiness, financial inclusion, and community transformation and well-being), the Challenge seeks innovative nonprofit organizations that are addressing critical social issues through impactful, scalable, and sustainable solutions.

Finalists selected through this process will have the opportunity to showcase their organization through a live presentation at the inaugural Thriving Seven (T7) Summit, taking place November 12 –14 in Atlanta, Georgia. In addition to competing for grant funding, finalists will gain national visibility for their work and connect with nonprofit leaders, funders, and changemakers from across the country.Grant Funding: A total of $1,500,000 in grant funding is anticipated to be awarded: 

• One (1) - $500,000 grant
• One (1) - $250,000 grant
• Two (2) - $100,000 grant
• Eleven (11) - $50,000 grant

About Panorama GlobalPanorama Global is a social impact nonprofit that empowers changemakers through radical collaboration. We help our partners navigate the winding path from vision to impact. 

What We Do

• Collaboratives - Hosting and supporting collaborative efforts to achieve common goals.
• Fiscal Sponsorship - Financial and administrative support providing lean operating models to jumpstart projects.
• Funds - Philanthropic vehicles to manage and distribute funds that fuel global initiatives.

About  Innovative Postsecondary Models Fund

The Innovative Postsecondary Models (IPM) Fund supports innovative postsecondary education models that are rethinking how education is designed, delivered, financed, and assessed for learners in the United States.

The Fund is interested in innovations that benefit all learners, but especially learners whom the data show encounter the greatest obstacles to opportunity. The goal of this Fund is not only to provide funding to innovative models, but also to learn from selected grantees on how to reduce barriers to postsecondary access and increase student success outcomes to help inform the role philanthropy can play in supporting higher education innovation.

What We're Funding

We are seeking innovative postsecondary education models that demonstrate, or have the potential to demonstrate, meaningful improvements in how learners access, experience, and benefit from postsecondary education. We seek approaches with the potential to scale, influence the field, and inform how postsecondary education evolves nationally.

To help illustrate the types of innovations we hope to support, we have organized this opportunity around four broad themes. These themes reflect key dimensions of postsecondary innovation that have the potential to improve learner outcomes and inform broader systems change.

All four themes are grounded in a shared principle: student-centeredness. Truly innovative postsecondary models must be designed around learner needs, especially the needs of learners whom the data show face the greatest barriers to access and success in traditional postsecondary education.

Applicants are not expected to address all four themes, but should demonstrate strong alignment with at least one of the following:

Reimagining Instructional Design, Delivery, Assessment, and Student Support

• What success might look like:
  • Innovative instructional models improve student persistence, completion, and post-completion success, particularly for historically underserved learners, while maintaining or reducing costs.
  • Learners benefit from personalized, adaptive instruction and competency-based assessments that enable them to demonstrate and document skills in ways that are recognized by employers and other educational institutions.

Advancing Affordability and Financial Sustainability

• What success might look like:
  • Learners spend less overall, face reduced financial risk, and access high-quality education pathways that lead to credentials supporting economic mobility.
  • Successful models demonstrate affordability not only through reducing costs for learners, but also by maintaining or reducing the cost of delivering high-quality education through sustainable, efficient approaches.

Career and Workforce Alignment

• What success might look like:
  • Work and learning are more demonstrably connected and flexible, with evidence that skills are more directly tied to credentials and real career opportunities.

Removing Barriers for Underserved Learners

• What success might look like:
  • More learners from backgrounds and communities who the data show have faced the greatest barriers to accessing postsecondary education are able to access, complete, and benefit from high-quality credentials.

Rare Diseases Clinical Research Network

The RDCRN was established by Congress under the Rare Diseases Act in 2002. The network is an initiative of the National Institutes of Health (NIH), led by the National Center for Advancing Translational Sciences through is Division of Rare Diseases Research Innovation (formerly the Office of Rare Diseases Research). It is funded by collaborating NIH institutes, centers, and offices.

Now in its fifth funding cycle, RDCRN supports 20 rare disease research groups (consortia) that partner with 127 affiliated patient advocacy groups. In total, 180 diseases are currently being studied at 273 active clinical sites, both in the United States and internationally.

Pilot Grant in Pediatric Fungal Disease

Goal

Invites applications for one-year pilot projects that establish feasibility, refine the analytic design, or generate preliminary data to support future studies addressing critical knowledge gaps or improving patient-centered outcomes for pediatric invasive fungal diseases.

Objectives

• Establish feasibility of proposed pediatric IFD studies
• Refine study design or analytic approaches
• Generate preliminary data to strengthen future large-scale research
• Expand and support a diverse investigator community in pediatric IFD research
• Encourage multi-site collaboration and incorporation of patient/caregiver perspectives

Award Description

Awards will provide up to $30,000 (inclusive of direct and indirect costs) for a one-year period. Applicants are encouraged to pursue co-sponsorship with institutional partners, research networks, industry collaborators, or other stakeholders to expand available resources. To receive the award, investigators must submit their full study protocol for approval by the RDCRN. Award recipients will be offered a project management team that meets quarterly to help ensure that progress is consistent with timelines and benchmarks. Funded investigators will also be required to submit quarterly progress reports and an end-of-project report to be reviewed by the Pilot Project Committee.

The NSF Expeditions in Computing program aims to foster transformative research in computer and information science. By funding projects up to $15 million over seven years, it encourages multidisciplinary teams to tackle ambitious research agendas that redefine the future of computing. The program supports innovative areas such as new architectures for intelligence, advanced robotics, and next-generation communication, emphasizing the importance of collaboration across various fields to achieve groundbreaking advancements.

The Emerging Frontiers in Research and Innovation (EFRI) program by the NSF aims to support transformative research in wave-based computing, fostering significant advancements in foundational engineering knowledge. With funding opportunities including EAGER awards and four-year grants up to $2 million, EFRI-WBC encourages interdisciplinary collaboration and innovative approaches to address strategic technology priorities. Proposals should articulate their potential long-term impacts on national science and technology missions, promoting a new era in computing methodologies.

The NSF MPS Chemistry Research Programs support groundbreaking research in chemical sciences, encompassing areas such as chemical catalysis, measurement, imaging, and theory. This initiative encourages innovative proposals that can lead to transformative advancements, without the necessity of immediate commercial applications. Researchers interested in exploring foundational concepts that could shape the future of chemistry are invited to submit their ideas for funding.

The National Science Foundation's Engineering Directorate (NSF ENG) promotes groundbreaking research in chemical, bioengineering, energy, and transport systems. Key programs include Chemical Process Systems, Engineering Biological and Biomedical Systems, Energy, Water, and Resource Engineering, and Transport Phenomena. NSF ENG seeks innovative, transformative proposals that push the boundaries of foundational research, regardless of immediate commercial applications, and emphasizes diverse funding opportunities based on availability.

The MPS Materials Research Programs, funded by the National Science Foundation, aim to enhance the understanding of materials and their diverse applications. These programs cover areas such as biomaterials, ceramics, condensed matter physics, and electronic materials. With an emphasis on transformative research, NSF MPS encourages proposals that are innovative and foundational, without the necessity for immediate commercial outcomes, fostering long-term advancements in materials science.

The BJA FY 2026 Kevin and Avonte Program aims to reduce the injuries and fatalities of individuals with dementia and developmental disabilities who wander from safe environments. This funding opportunity supports law enforcement and public safety agencies in implementing locative technologies to track missing individuals and develop programs that enhance safety and facilitate rescues, ultimately ensuring the well-being of vulnerable populations.

The ADCMS Competitive Grant Program, administered by the DOT Federal Highway Administration, aims to incentivize eligible State Departments of Transportation and partners to implement innovative technology in construction projects. This initiative promotes collaboration among various entities, including local governments and private industries, with a required cost share of 20% to enhance project viability and effectiveness. The program encourages joint applications to maximize the impact of technological advancements in the construction sector.