Skip to main content
Main content

Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

9,297 Results based on applied filters

Nutrition Education Program

Ann B Zekauskas Family Foundation Inc
Private
United States
Unspecified amount

Ann B. Zekauskas Family Foundation

Empowerment through Food Awareness, Access, and Education

We are a private, family-directed, not-for-profit philanthropic organization, established through the estate of Ann B. Zekauskas. We are dedicated to educating students, families, and communities, especially the underserved, on producing, preparing, and eating healthy foods, and to supporting organizations focused on hunger relief and careers in the culinary arts.

We perform our mission through collaborations with and support of approved non-profit organizations within these key areas of giving: nutrition education, food access, and culinary arts training.

Nutrition Education

Ann B. Zekauskas believed that individuals of all ages — especially school-aged children and their families — should be provided with an education to understand how food makes its way from seed to plate —from planting and growing, to harvesting and sourcing, to cooking and serving.

Nutrition education empowers people with the knowledge, skills, and confidence needed to make healthy food choices, promoting overall mental well-being and physical wellness.

In carrying out Ann’s legacy, we work with schools, community groups, and other like-minded organizations across the country, supporting their programs that encourage a lifelong practice of healthy eating.

Request a Grant

The Ann B. Zekauskas Family Foundation is committed to supporting qualified 501(c)(3) organizations that align with our mission and values. We welcome grant requests from nonprofit organizations seeking to make a meaningful impact in their communities in the areas of nutritional education, food access, or the advancement of cuilnary arts careers.

Nutrition & Healthy Eating School Health Educational Access & Equity

Middle Ground Program Grant

National Congress of Parents & Teachers
Corporate
United States
Up to US $3,501

National PTA® is the oldest and largest child advocacy association in America. For 125 years, PTA has worked with school communities and decision makers to solve the toughest problems in our nation’s history.

PTA is a network of millions of families, students, teachers, administrators, and business and community leaders devoted to the educational success of children and the promotion of family engagement in schools.

PTA is a registered 501(c)(3) nonprofit association that prides itself on being a powerful voice for all children, a relevant resource for families and communities, and a strong advocate for public education.

The Middle Ground Program Grant

National PTA, in collaboration with the New York Life Foundation, is offering grants of up to $3,500 to support middle school PTAs in creating The Middle Ground—a dedicated, supportive space for students experiencing grief and loss with opportunities for peer connection, creative expression, storytelling and support.

Education - Middle School Bereavement / Grief Services Academic Success & Enrichment

Presidential Pathology Scholarship

College Of American Pathologists Foundation
Private
United States
US $500 - US $1,500

Who We Are - CAP Foundation

Mission

Our mission is to improve people’s health by:

  • Developing tomorrow’s pathology leaders through awards for advanced training, research, and education.
  • Mobilizing pathologists to expand health equity in medically underserved communities within the US and globally.

Vision

Our vision is that pathologists are equipped to bridge health disparities and enhance outcomes globally.

CAP Foundation History

For over 50 years, the CAP Foundation has granted millions of dollars to support pathology education, research, training, and travel grants, with the purpose to:

  • Enhance the role of the pathologist in the provision of medical care.
  • Advance pathology through the education of the medical community.
  • Encourage the clinical application of research developments.

Our Core Values

  • Advancement: We are committed to pushing the boundaries of pathology and patient care through scholarships, grants, and educational programs.
  • Collaboration: Through effective partnerships, we significantly enhance our capacity to fulfill our mission.
  • Excellence: We are dedicated to achieving the highest standards in pathology education, research, and community service.
  • Service: Service reflects our core mission of improving health equity by providing access to healthcare and pathology expertise, particularly in underserved communities.

Presidential Pathology Scholarship

This scholarship allows the sitting CAP President to personally support educational creativity, expand awareness of pathology, and connect communities through the CAP Foundation’s mission to develop tomorrow’s pathology leaders. This scholarship is established in honor of each sitting CAP President, as a commitment to the CAP Foundation’s efforts to advance the specialty by supporting creative projects that encourage interest in or expand the reach of pathology. Up to two scholarships will be supported each year. Ranging from $500-$1,500 per awardee, to be used toward the selected project(s).

Each year the sitting CAP President will select a focus area to support based on at least one of the CAP Foundation’s Five (5) Pillars. CAP Foundation Five Pillars:

  • Global: Expands global pathology access, capacity, training, and equity.
  • Future Leaders: Builds pipeline through learning, leadership, mentorship, and awards.
  • Ethics, Research, Innovation: Advances ethical practice, discovery, innovation, and diagnostic excellence.
  • Advanced Training: Delivers specialized skills through grants, workshops, and roundtables.
  • Community Engagement: Increases visibility and connection with patients, partners, and the public.

Education - K through 12 STEM / STEAM Education Academic Scholarship Programs +2 more

ASEEES Internship Program

Association for Slavic, East European, and Eurasian Studies (ASEEES)
Private
United States
Unspecified amount

ASEEES Internship Grant Program

Funded by an external grant, ASEEES’s Internship Grant Program provides incoming, current, and recent (i.e. those who have graduated no more than two years prior to the competition deadline) MA, PhD, and professional school students with grants that make it possible for them to accept unpaid or underpaid internships in areas broadly related to Russia, including Russia’s relations with other regions/countries.

The grant offers $2,000 a month, to be paid directly to the grantee (intern) during their internship. In the case of underpaid internships, ASEEES will work with the host institutions and the grantees to make sure the grantee receives a combined stipend of $2,000 per month or has an extended duration for the internship.

Apprenticeship & Internship Programs International / Foreign Affairs

LaFrancine Stallings Math & Science College Scholars

United Negro College Fund Inc
Private
United States
Up to US $6,375

LaFrancine Stallings Math & Science College Scholars

The LaFrancine Stallings Math & Science College Scholarship will provide renewable need-based scholarships of up to $6,375 to undergraduate juniors enrolled full-time pursuing a Science Technology Engineering Mathematics (STEM) major at any four-year accredited HBCU in the 2026-2027 school year.

Education - Higher Education STEM / STEAM Education

ASTS-iMDx Research Grant for Understanding the Health Economics of in-house vs send-out diagnostics

American Society Of Transplant Surgeons
Private
Canada, United States
US $100,000

ASTS-iMDx Research Grant for Understanding the Health Economics of in-house vs send-out diagnostics

As new diagnostics become available to the transplant community, the development of in-house expertise and infrastructure vs send out testing becomes a critical decision. In-house diagnostic testing provides faster results, improving immediate patient care and reducing follow-up visits, while send-out testing (reference labs) is better for complex, rare, or high-volume specialized tests. This grant will support health econometric research projects comparing in-house vs outsourced testing and the potential impact on patient care. The output of this research would show a model of the costs and benefits of diagnostic testing in transplantation to educate transplant centers and labs on their choice of assays.

Amount:

  • $100,000 fpr 12 months.

Funds Support:

No more than 25% of grant can go towards the individual applicant’s salary; no indirect costs, but salary support for post-docs and collaborators are permitted at the NIH cap. Funds for this grant are being supplied by Insight Molecular Diagnostics (iMDx).

Surgery Organ And Tissue Banks

Bernie Smillie Memorial Scholarship - Medical

Saginaw Community Foundation
Private
United States
Unspecified amount

The Bernie Smillie Memorial Scholarship was established in 2010, in memory of Freeland resident and business owner Bernie Smillie. Bernie passed away in 2000, due to complications from a lung transplant he had received in 1994. In 2005, family and friends of Bernie established the Bernie Smillie Memorial Golf Outing. Proceeds of this outing has helped to promote organ donor support and awareness and establish this scholarship fund.

Bernie Smillie Memorial Scholarship - Medical

Evaluation Criteria

  • Leadership ability
  • Financial need
  • Academic performance
  • Standardized test scores
  • Special skills
  • Awards and honors
  • Community service
  • Work experience
  • Extracurricular school activities
  • Overall involvement
  • Career goals as demonstrated in essay
  • Letter of recommendation.
Education - Higher Education Medical Education & Professional Training

Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) (359650)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
The National Institute of Environmental Health Sciences (NIEHS) invites applications for the Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional). This program supports interdisciplinary research centers focused on biomedical and environmental science. Eligible institutions must be accredited higher education establishments. Applications are due by 5:00 PM local time, and successful submissions will undergo a rigorous peer-review process to ensure quality and relevance in addressing hazardous substance issues.
Environmental Chemistry & Toxicology Environmental Health

Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research (U42 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $212,004 - US $2,725,311
This funding opportunity aims to advance HIV/AIDS research by implementing human new approach methodologies (NAMs) to reduce the reliance on specific pathogen free (SPF) animal models. It emphasizes the integration of NAMs-enabled frameworks for in vitro testing while supporting essential SPF colony resources. The initiative seeks to enhance research rigor and reproducibility through innovative strategies that prioritize human-relevant models, ultimately improving HIV research outcomes and facilitating collaborative development in the field.
HIV / AIDS

Bernie Smillie Memorial Scholarship - Michigan Resident

Saginaw Community Foundation
Private
United States
Unspecified amount

The Bernie Smillie Memorial Scholarship was established in 2010, in memory of Freeland resident and business owner Bernie Smillie. Bernie passed away in 2000, due to complications from a lung transplant he had received in 1994. In 2005, family and friends of Bernie established the Bernie Smillie Memorial Golf Outing. Proceeds of this outing has helped to promote organ donor support and awareness and establish this scholarship fund.

Bernie Smillie Memorial Scholarship - Michigan Resident

Evaluation Criteria

  • Financial need (20)
  • Work experience (20)
  • Overall involvement at work, school and community activities (20)
  • Career goals as demonstrated in essay (20)
  • Letters of recommendation
Education - Higher Education Computer Science & Engineering Career / College Preparation +1 more

Yellow Dog Studio Memorial Scholarship

Saginaw Community Foundation
Private
United States
Unspecified amount

Yellow Dog Studio Memorial Scholarship

The Yellow Dog Studios Memorial Scholarship was established in memory of Mari Zimmerman-Thompson and Christopher Thompson. Mari and Chris became husband and wife in May of 2002. They lived their remaining years together as kindred spirits until July 2, 2015 when a tragic automobile accident took them from their family and friends.

Evaluation Criteria

  • Special skills/interests (30)
  • Career goals (20)
  • Essay (15)
  • Letters of recommendation (15)
  • Extracurricular activities (5)
  • Awards and honors (5)
  • Overall involvement in work, school and community activities (5)
  • Academic performance (5)
Education - Higher Education Career / College Preparation Photography

Women of Colors Scholarship

Saginaw Community Foundation
Private
United States
Unspecified amount

Women of Colors Scholarship

Women of Colors (WOC) was founded in 1993 by a group of women that believed it would take a cooperative effort of women of all nationalities, ages and socioeconomic status to address issues plaguing the Saginaw Community. The founders believed that women should take a more active role in addressing issues of crime, blight and poverty. WOC began by providing support, community outreach services and facilitating discussions within the community. WOC’s mission promotes multi-cultural diversity and enhances community relations in Saginaw County by performing community service, mentoring youth, and collaborating with other organizations.

The Women of Colors Scholarship will be awarded each year to a Great Empowering Motivational Sessions (GEMS) member that is an area high school senior actively involved in efforts to empower young women and in activities that address issues affecting young women in the Saginaw Community. If no GEMS members are high school seniors, applications will be accepted from non-GEMS applicants.

Education - Higher Education Career / College Preparation Computer Science & Engineering +1 more

Connor Arthur Lynskey Memorial Academic Award for Oneida/Herkimer Counties

The Community Foundation of Herkimer & Oneida Counties
Private
United States
Unspecified amount

About The Community Foundation

The Community Foundation of Herkimer and Oneida Counties is a community-based social impact investor whose mission is to engage, invest, and lead—working toward a vision of community vibrancy with opportunity for all. Our team of experienced staff and dedicated trustees is committed to boldly leading and supporting transformational community investments. We channel charitable contributions from donors through nonprofit partners that are meeting current community needs and steward community resources responsibly to ensure greater capacity for the future.

Connor Arthur Lynskey Memorial Academic Award for Oneida/Herkimer Counties

This scholarship fund was created in memory of Connor Arthur Lynskey (18 years old) of Hinckley, New York. Connor aspired to be a rural physician and attended premedical school at Siena College. His dream was to practice medicine in an underserved area in order to help residents receive adequate health care.

Connor had an extraordinary way about himself for someone his age. He was God-inspired, loved everyone as he loved himself, and cared deeply about his family and friends. He had a mysterious ability to consistently make lemonade out of lemons. Everyone loved him when they met him. He was truly an inspiration to friends, family and clergy members alike, who now all suffer an enormous heart-wrenching void due to a careless and reckless drunk driver that took his life on August 11, 2018.

Education - Higher Education

Connor Arthur Lynskey Memorial Athletic/Character Award for Oneida/Herkimer Counties

The Community Foundation of Herkimer & Oneida Counties
Private
United States
Unspecified amount

About The Community Foundation

The Community Foundation of Herkimer and Oneida Counties is a community-based social impact investor whose mission is to engage, invest, and lead—working toward a vision of community vibrancy with opportunity for all. Our team of experienced staff and dedicated trustees is committed to boldly leading and supporting transformational community investments. We channel charitable contributions from donors through nonprofit partners that are meeting current community needs and steward community resources responsibly to ensure greater capacity for the future.

Connor Arthur Lynskey Memorial Athletic/Character Award for Oneida/Herkimer Counties

This scholarship fund was created in memory of Connor Arthur Lynskey (18 years old) of Hinckley, New York. Connor aspired to be a rural physician and attended premedical school at Siena College. His dream was to practice medicine in an underserved area in order to help residents receive adequate health care.

Connor had an extraordinary way about himself for someone his age. He was God-inspired, loved everyone as he loved himself, and cared deeply about his family and friends. He had a mysterious ability to consistently make lemonade out of lemons. Everyone loved him when they met him. He was truly an inspiration to friends, family and clergy members alike, who now all suffer an enormous heart-wrenching void due to a careless and reckless drunk driver that took his life on August 11, 2018.

Education - Higher Education

Boule' Foundation Scholarship

United Negro College Fund Inc
Private
United States
US $7,000

United Negro College Fund

“A mind is a terrible thing to waste.”®

For more than seven decades, this principle has remained at the heart of UNCF, enabling us to raise more than $5 billion and help more than 500,000 students and counting not just attend college, but thrive, graduate and become leaders.

We do this in three ways: By awarding more than 12,000 students scholarships, worth more than $65 million, each year. By providing financial support to 37 historically Black colleges and universities (HBCUs). And by serving as the nation’s leading advocate for the importance of minority education and community engagement.

The Boulé Foundation Scholarship

The Boule' Foundation in conjunction with the United Negro College Fund, will provide annual merit-based scholarships to entering college freshmen students (Fall 2026) attending four-year, accredited non-profit degree-granting colleges and universities of their choice.

Education - Higher Education

Don & Mary Hamerski Memorial Scholarship Fund

Community Foundation of Central Wisconsin
Private
United States
Unspecified amount

Community Foundation of Central Wisconsin

The Community Foundation of Central Wisconsin gives everyone the opportunity to make significant and lasting gifts to their community. We manage over 320 funds that enhance Portage and Waushara counties. Together with our generous donors, we create a strong culture of philanthropy in Central Wisconsin.

We are a tax-exempt, 501(c)(3) public charity founded in 1982 to provide scholarships and grants to organizations and projects that improve the quality of life in Portage and Waushara counties.

Scholarships

The Community Foundation proudly supports students in Portage and Waushara counties with over $325,000 in scholarships annually, thanks to the generosity of local individuals and families. Award amounts range from $500 to $40,000, opening doors to educational opportunities.

Whether you're a student seeking financial support or a donor looking to grow a scholarship fund, we invite you to explore available opportunities and learn how you can be involved.

Don & Mary Hamerski Memorial Scholarship Fund

Qualifications: Graduating High School seniors from a Central Wisconsin high school.

Education - Higher Education Agriculture

Joey Trzebiatowski Memorial Scholarship

Community Foundation of Central Wisconsin
Private
United States
Unspecified amount

Community Foundation of Central Wisconsin

The Community Foundation of Central Wisconsin gives everyone the opportunity to make significant and lasting gifts to their community. We manage over 320 funds that enhance Portage and Waushara counties. Together with our generous donors, we create a strong culture of philanthropy in Central Wisconsin.

We are a tax-exempt, 501(c)(3) public charity founded in 1982 to provide scholarships and grants to organizations and projects that improve the quality of life in Portage and Waushara counties.

Scholarships

The Community Foundation proudly supports students in Portage and Waushara counties with over $325,000 in scholarships annually, thanks to the generosity of local individuals and families. Award amounts range from $500 to $40,000, opening doors to educational opportunities.

Whether you're a student seeking financial support or a donor looking to grow a scholarship fund, we invite you to explore available opportunities and learn how you can be involved.

Joey Trzebiatowski Memorial Scholarship

Qualifications: Graduating senior from Central Wisconsin, or UWSP or UW-Madison student planning to study business.

Education - Higher Education

AHA/CHF Congenital Heart Defect Research Awards: Predoctoral Fellowship

The Childrens Heart Foundation
Private
United States
More than US $29,364

About The Children’s Heart Foundation

The Children’s Heart Foundation (CHF) is the country’s leading national organization solely dedicated to funding congenital heart defect (CHD) research. The mission of The Children’s Heart Foundation is to fund the most promising research to advance the diagnosis, treatment, and prevention of congenital heart defects. Since its inception, CHF has funded millions of dollars of CHD research across the U.S. and Canada. 

AHA/CHF Congenital Heart Defect Research Awards

The Children’s Heart Foundation partners with the American Heart Association to fund Congenital Heart Defect Research Awards. This collaborative investment of funds provides support for investigators who are actively conducting research directly related to advancing the prevention, diagnosis, and treatment of CHDs, which directly aligns with The Children's Heart Foundation's mission. 

Congenital Heart Defect Funding Opportunities

A multi-year commitment between the American Heart Association (AHA) and Children’s Heart Foundation (CHF) jointly supports Predoctoral Fellowship or Postdoctoral Fellowship investigators actively conducting basic, clinical, population, or translational congenital heart defects research.

Predoctoral Fellowship

Purpose

To enhance the integrated research and clinical training of promising students who are matriculated in pre-doctoral or clinical health professional degree training programs and who intend careers as scientists, physician-scientists or other clinician-scientists, or related careers aimed at improving global cardiovascular, cerebrovascular and brain health.

  • AHA research awards are limited to U.S.-based non-profit institutions, including medical, osteopathic, and dental schools, veterinary schools, schools of public health, pharmacy schools, nursing schools, universities and colleges, public and voluntary hospitals and others that can demonstrate the ability to conduct the proposed research.
  • Applicants must be AHA Professional Members at the time of proposal submission. The AHA expects all mentors associated with training/mentored research awards to maintain active AHA membership, as well.
  • This award is not for individuals of faculty/staff rank.

Applicants are not required to reside in the United States for any period before applying for American Heart Association funding. However, applicants must have one of the following designations at the time of proposal submission – not award start date, depending on career stage and each individual’s situation. An awardee must maintain one of the designations listed below throughout the duration of the award. Please consult with your institution’s grant officer.

  • U.S. citizen
  • Permanent resident
  • Pending permanent resident (must have filed Form I-485 for permanent resident status and obtained an I-797C 3 Notice of Action that the application has been received by USCIS and case is pending)
  • E-3 Visa - specialty occupation worker
  • F-1 Visa – student (for predoctoral and postdoctoral fellows only)
  • G-4 Visa - family member of an international organization employee
  • H1-B Visa - temporary worker in a specialty occupation
  • J-1 Visa - exchange visitor (pre- and postdoctoral fellowships only; all other awardees must obtain an H-1B or equivalent by the award activation date)
  • O-1 Visa - temporary worker with extraordinary abilities in the sciences
  • TN Visa - NAFTA Professional
  • DACA - Deferred Action for Childhood Arrivals
Cardiovascular Diseases & Systems Neurological Diseases & Disorders

AHA/CHF Congenital Heart Defect Research Awards: Postdoctoral Fellowship

The Childrens Heart Foundation
Private
United States
More than US $63,480

About The Children’s Heart Foundation

The Children’s Heart Foundation (CHF) is the country’s leading national organization solely dedicated to funding congenital heart defect (CHD) research. The mission of The Children’s Heart Foundation is to fund the most promising research to advance the diagnosis, treatment, and prevention of congenital heart defects. Since its inception, CHF has funded millions of dollars of CHD research across the U.S. and Canada. 

AHA/CHF Congenital Heart Defect Research Awards

The Children’s Heart Foundation partners with the American Heart Association to fund Congenital Heart Defect Research Awards. This collaborative investment of funds provides support for investigators who are actively conducting research directly related to advancing the prevention, diagnosis, and treatment of CHDs, which directly aligns with The Children's Heart Foundation's mission. 

Congenital Heart Defect Funding Opportunities

A multi-year commitment between the American Heart Association (AHA) and Children’s Heart Foundation (CHF) jointly supports Predoctoral Fellowship or Postdoctoral Fellowship investigators actively conducting basic, clinical, population, or translational congenital heart defects research.

Postdoctoral Fellowship

Purpose

To enhance the training of postdoctoral applicants who are not yet independent. The applicant must be embedded in an appropriate investigative group with the mentorship, support, and relevant scientific guidance of a research mentor. Recognizing the unique challenges that clinicians, in particular, experience in balancing research and clinical activity, this award mechanism aims to be as flexible as possible to enable applicants to develop academic careers in research alongside fulfilling clinical service commitments.

The trainee and mentor should collaboratively provide a thoughtfully planned, systematic proposal aimed at clearly answering an investigative question in cardiovascular, cerebrovascular or brain health research

  • AHA research awards are limited to U.S.-based non-profit institutions, including medical, osteopathic, and dental schools, veterinary schools, schools of public health, pharmacy schools, nursing schools, universities and colleges, public and voluntary hospitals andothers that can demonstrate the ability to conduct the proposed research.
  • Applicants must be AHA Professional Members at the time of proposal submission. The AHA expects all mentors associated with training/mentored research awards to maintain active AHA membership, as well.
  • This award is not intended for individuals of faculty rank.

Applicants are not required to reside in the United States for any period before applying for American Heart Association funding. However, applicants must have one of the following designations at the time of proposal submission – not award start date, depending on career stage and each individual’s situation. An awardee must maintain one of the designations listed below throughout the duration of the award. Please consult with your institution’s grant officer.

  • U.S. citizen
  • Permanent resident
  • Pending permanent resident (must have filed Form I-485 for permanent resident status and obtained an I-797C 3 Notice of Action that the application has been received by USCIS and case is pending)
  • E-3 Visa - specialty occupation worker
  • F-1 Visa – student (for predoctoral and postdoctoral fellows only)
  • G-4 Visa - family member of an international organization employee
  • H1-B Visa - temporary worker in a specialty occupation
  • J-1 Visa - exchange visitor (pre- and postdoctoral fellowships only; all other awardees must obtain an H-1B or equivalent by the award activation date)
  • O-1 Visa - temporary worker with extraordinary abilities in the sciences
  • TN Visa - NAFTA Professional
  • DACA - Deferred Action for Childhood Arrivals
Cardiovascular Diseases & Systems Neurological Diseases & Disorders

DoW Peer Reviewed Cancer, Idea Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
The FY26 Peer Reviewed Cancer Research Program's Idea Award promotes innovative, high-risk cancer research initiatives. It supports groundbreaking concepts that advance cancer knowledge, patient care, and treatment options within the Military Health System. Projects must demonstrate creativity and innovation, avoiding incremental advancements. Notably, the Early Career Investigator Option is available to foster the growth of promising new investigators early in their careers. This award aims to make significant contributions to cancer research for Service Members and Veterans.
Cancer / Oncology

DoW Peer Reviewed Cancer, Clinical Trial Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $4,500,000
The DoW Peer Reviewed Cancer Clinical Trial Award supports the rapid initiation of clinical trials aimed at significantly improving cancer treatment. Projects may range from small pilot studies to large-scale phase III trials, focusing on innovative products, drugs, or devices. This award mandates the inclusion of patient advocates and prohibits animal studies, ensuring that all preclinical work is completed prior to the award start date. Regulatory applications must be submitted if required for the proposed trials.
Cancer / Oncology

DoW, Peer Reviewed Cancer, Impact Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
US $1,500,000 - US $2,000,000
The FY26 Peer Reviewed Cancer Research Program Impact Award promotes significant research aimed at enhancing clinical cancer care. It requires preliminary data to ensure feasibility and emphasizes projects with a strong potential for immediate impact. This funding supports clinical trials and allows for either a single Principal Investigator or a duo of partnering PIs, ensuring that both can contribute distinct aspects of the research. Applications must be carefully coordinated to avoid withdrawal risks.
Cancer / Oncology

DoW Traumatic Brain Injury and Psychological Health, Clinical Trial Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
US $2,100,000 - US $4,100,000
The FY26 Traumatic Brain Injury and Psychological Health Research Program's Clinical Trial Award aims to fund impactful clinical trials that address psychological health issues and traumatic brain injury (TBI). This award supports a variety of interventions, requires preliminary data, and mandates community-based participatory research approaches. It offers two research levels: one for pilot studies and early trials, and another for larger, advanced trials assessing effectiveness in relevant populations.
Brain Injuries

DoW Traumatic Brain Injury and Psychological Health, Health Services Research Award

US DOD: U.S. Army Medical Command
Federal Government
American Samoa, Guam +4 more
Up to US $4,000,000
The FY26 Traumatic Brain Injury and Psychological Health Research Program (TBIPHRP) aims to support impactful health services research that connects research, practice, and policy. It emphasizes building real-world evidence for interventions and clinical guidelines tailored to specific populations. Key features include requirements for clinical trials, preliminary data, and community-based participatory research approaches. The program also offers an Early-Career Investigator Partnering Option to foster collaboration between seasoned and emerging researchers.
Brain Injuries

NCI Research Specialist (Clinician Scientist) Award (R50 Clinical Trial Not Allowed) (362277)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NCI Research Specialist Award (R50) supports clinician scientists involved in NCI-funded clinical trials. This funding opportunity encourages the development of stable research careers by providing salary support and autonomy, allowing clinician scientists to contribute to national clinical trial development and implementation. They play a critical role in sustaining the NCI clinical trials network without serving as principal investigators. This award aims to ensure continuity in cancer research careers.
Cancer / Oncology

NCI Research Specialist Award for Core and Laboratory-based Scientists (R50 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NCI Research Specialist Award (R50) supports non-tenure track scientists in cancer research who provide essential contributions within laboratories and core facilities. This award aims to enhance research careers for skilled scientists who do not seek independent investigator funding. Eligible candidates must possess an advanced degree, have at least two years of contribution to NCI-funded research, and dedicate a significant portion of their time to this work. The R50 offers salary support and travel funds to recognize and stabilize these vital roles in cancer research.
Cancer / Oncology

Research Resource for a National Swine Resource and Research Center (U42 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $960,898 - US $1,008,943
The National Swine Resource and Research Center (NSRRC) is a pivotal resource that enhances biomedical research by providing genetically modified models. This centralized facility reduces variability and costs for researchers, allowing them to focus on scientific discovery. NSRRC offers breeding, cryopreservation, and genotyping services, ensuring consistent access to high-quality models. By consolidating these resources, it promotes reproducibility and supports the development of innovative methodologies in research, ultimately advancing our understanding of human health and disease.
Livestock & Ranching Farms & Farming

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

Browse South Dakota Grants by Focus Area

Filter South Dakota Grants by Location

Browse Grants by Counties within South Dakota

Browse Grants by Major US Cities within South Dakota

Explore Grants Outside of South Dakota

Browse Grants by Other States or Regions