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Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

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9,246 Results based on applied filters

Elroy Webster Cooperative Studies (EWCS) Scholarships

Ralph K. Morris Foundation
Association/Society
United States
US $1,000 - US $2,500
The Elroy Webster Cooperative Studies Scholarships support graduate and law students in agricultural cooperative programs. Up to two EWCS Fellows can receive $2,500 each year, while up to three EWCS Scholars may receive $1,000. Applicants must demonstrate how their studies benefit the agricultural cooperative industry. The program promotes inclusivity, welcoming candidates without regard to race or background, and encourages attendance at related events to enhance networking and recognition.
Academic Scholarship Programs Agricultural Education Education - Higher Education

VFW Student Fellowship

Veterans Of Foreign Wars Of
Private
United States
Unspecified amount
The VFW Student Fellowship, hosted by the Veterans of Foreign Wars and Student Veterans of America, empowers student veterans to advocate for their community on Capitol Hill. Running from October 2025 to March 2026, this program offers selected fellows the chance to collaborate on policy priorities, attend leadership training, and participate in significant conferences, ensuring their voices are heard among 500 advocates at the VFW Washington Conference. Travel expenses are fully covered.
Military & Veterans Services Academic Scholarship Programs Education - Higher Education

Peyronie's Disease Fund

Healthwell Foundation
Private
United States
Up to US $5,600
The Peyronie's Disease Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from Peyronie's disease. This condition involves the formation of fibrous scar tissue in the penis, leading to painful erections and erectile dysfunction. The fund provides financial assistance for prescription drugs and related healthcare costs, ensuring that patients receive necessary treatment without the stress of high out-of-pocket expenses. HealthWell is committed to improving access to essential healthcare for America’s underinsured population.
Chronic Illnesses Health Care Access & Delivery Reproductive Health

BRAID (Bridgebuilders Relating Across Interfaith Differences) Fellowship

Interfaith America
Private
United States
More than US $3,000
The BRAID Fellowship, initiated by Interfaith America, addresses rising prejudice in higher education by fostering a national network of undergraduate student leaders. This program empowers students to promote respect and cooperation across diverse backgrounds. Each fellow receives a $1,000 project award and a $2,000 stipend, along with opportunities for specialized training and community engagement. Through this initiative, Interfaith America commits to cultivating a diverse cohort that represents a wide range of religious and ideological perspectives.
Interfaith Cooperation / Religious Freedom

AΩA Fellows in Leadership Program

Alpha Omega Alpha Honor Medical Society
Private
United States
US $30,000
The AΩA Fellows in Leadership Program, established by the Alpha Omega Alpha Honor Medical Society, aims to cultivate leadership skills among mid-career medical professionals. Recipients receive $30,000 to develop a year-long project focused on enhancing their leadership capabilities. This initiative emphasizes servant leadership and innovative thinking, addressing the increasing complexities in healthcare. The program seeks to empower leaders who can effectively navigate the evolving landscape of medicine while promoting the core values of the AΩA society.
Medical Education & Professional Training

Community Engagement Committee- Sponsorships

Us Venture Schmidt Family Foundation Inc
Private
United States
Up to US $35,000
U.S. Venture Sponsorships, supported by the Us Venture Schmidt Family Foundation, aim to enhance community engagement by addressing the root causes of poverty through collaboration and social innovation. Grants typically do not exceed $10,000, ensuring that eligible public charities, especially those with 501(c)(3) status, can benefit. Each organization can receive one sponsorship grant annually, reflecting U.S. Venture's commitment to giving back and fostering meaningful partnerships.
Poverty Alleviation & Services

Annual Feline Proposals: Feline Health Fellowship Training Award

Morris Animal Foundation
Private
United States
Up to US $145,000
The Morris Animal Foundation invites proposals for the Feline Health Fellowship Training Award, aimed at advancing the health and welfare of domesticated cats. This program supports new investigators by providing salary funds in a mentoring environment. Proposals should focus on hypothesis-driven research with high scientific merit, targeting community and pet cats (Felis catus). The maximum award duration is 24 months, with budgets not exceeding $145,000. Join us in making impactful contributions to feline health.
Animal Welfare - Domestic Animals & Pets

Annual Feline Proposals: Feline Health Established Investigator Award

Morris Animal Foundation
Private
United States
Approximately US $100,000
The Morris Animal Foundation offers the Annual Feline Proposals: Feline Health Established Investigator Award to support research aimed at improving the health and welfare of domesticated cats. Established in 1948, the foundation funds innovative, hypothesis-driven studies that demonstrate high scientific merit. This grant encourages collaboration between academia and industry and has a maximum project duration of 36 months, with average awards around $100,000. Eligible proposals should focus solely on domesticated cats, excluding other feline species.
Animal Welfare - Domestic Animals & Pets

Annual Feline Proposals: Feline Health Pilot Study Award

Morris Animal Foundation
Private
United States
Up to US $20,000
The Morris Animal Foundation offers the Annual Feline Health Pilot Study Award to support innovative research that enhances the health and welfare of domesticated cats. This funding is aimed at proof-of-concept studies, advancing animal health research through collaborative projects. With a maximum funding of $20,000 for a 12-month duration, the foundation seeks proposals that have a significant impact on both scientific and community stakeholders, ensuring a healthier future for feline populations.
Animal Welfare - Domestic Animals & Pets

Feline Annual: Feline Health First Award

Morris Animal Foundation
Private
United States
Up to US $120,000
The Morris Animal Foundation is dedicated to improving the health of animals through scientific research and funding. With a focus on domesticated cats, the Feline Health First Award supports innovative research that addresses the welfare of both community and pet cats. Grants are available for projects lasting up to 24 months, with a maximum budget of $120,000. This initiative encourages collaborations that translate research findings into practical applications for veterinarians and cat caretakers.
Animal Welfare - Domestic Animals & Pets

Alzheimer’s Association Research Grant For All (AARGA) Program

Alzheimer's Association
Private
United States
US $70,000 - US $200,000
The Alzheimer’s Association Research Grant For All (AARGA) Program supports early-career investigators in their first seven years as independent researchers. This grant aims to fund projects that develop preliminary data and test new hypotheses in Alzheimer’s and related dementia research. Areas of interest include disease mechanisms, biomarker development, and health equity. Applications are welcome from both U.S. and international researchers, fostering innovation and collaboration in the fight against dementia.
Dementia & Alzheimer’s Disease

Waldenstrom Macroglobulinemia Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Waldenstrom Macroglobulinemia Fund provides crucial financial assistance to underinsured patients suffering from this rare blood cancer. Through the HealthWell Foundation, the fund helps cover prescription copays, insurance premiums, and treatment-related costs, ensuring access to necessary medical care. With over $1.2 billion in grants awarded, the program has supported more than 1.1 million patients since its inception in 2004. Its mission is to alleviate financial barriers to essential healthcare, allowing patients to focus on their treatment and recovery.
Cancer / Oncology Immune System Diseases Health Care Access & Delivery

Systemic Sclerosis with Interstitial Lung Disease Fund

Healthwell Foundation
Private
United States
Up to US $9,000
The Systemic Sclerosis with Interstitial Lung Disease Fund, managed by the HealthWell Foundation, aims to reduce financial barriers for underinsured patients suffering from systemic sclerosis. This rare autoimmune disease leads to excessive collagen production, causing serious health issues. The fund assists with prescription copays and insurance premiums to ensure patients receive necessary treatments. In 2024, HealthWell awarded over $1.2 billion in grants, supporting more than 1.1 million patients in accessing vital healthcare services.
Cardiovascular Diseases & Systems Neurological Diseases & Disorders Multiple Sclerosis +3 more

Porphyrias Fund

Healthwell Foundation
Private
United States
Up to US $4,000
The Porphyrias Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from porphyrias, a group of eight disorders characterized by the accumulation of porphyrins in the body. The fund assists with prescription drug copays and insurance premiums, offering up to $4,000 in financial aid. Established to ensure no patient lacks necessary treatment due to costs, the foundation has awarded over $1.2 billion since 2004, supporting more than 1.1 million patients.
Health Care Access & Delivery Endocrine & Metabolic Diseases Rare Diseases

ACS - Fanconi Cancer Foundation Discovery Boost Grant

American Cancer Society
Association/Society
United States
More than US $135,000
The ACS - Fanconi Cancer Foundation Discovery Boost Grant invites innovative proposals for translational cancer research addressing the challenges faced by individuals with Fanconi anemia (FA). This grant supports high-risk, high-reward projects aimed at improving detection, prevention, or treatment of FA-related cancers. With funding of up to $135,000 per year for two years, it encourages research in early detection technologies, prevention mechanisms, and therapeutic strategies tailored to the unique sensitivities of the FA population.
Cancer / Oncology

Metabolic Dysfunction-Associated Steatohepatitis Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Metabolic Dysfunction-Associated Steatohepatitis Fund, established by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients facing chronic illnesses. It provides critical support for expenses related to prescription copays, insurance premiums, and transportation for treatment. With a maximum award of $8,000, the fund ensures that individuals can access necessary healthcare services without financial strain. This initiative emphasizes the commitment to improving health outcomes for those affected by metabolic dysfunction-associated steatohepatitis.
Health Care Access & Delivery Liver Disease Cystic Fibrosis +1 more

Mantle Cell Lymphoma Fund

Healthwell Foundation
Private
United States
Up to US $8,500
The Mantle Cell Lymphoma Fund, managed by the HealthWell Foundation, provides financial assistance to underinsured patients diagnosed with Mantle Cell Lymphoma. The fund covers prescription drug copays and Medicare Part B premiums, with a maximum award of $8,500. Eligible patients must have insurance that covers their medication and meet specific income guidelines. The foundation aims to reduce financial barriers to essential treatments, ensuring that patients receive necessary care without undue financial strain.
Health Care Access & Delivery Lymphoma Cancer / Oncology

Inborn Metabolic or Genetic Bile Acid Deficiency Vitamins and Supplements Fund

Healthwell Foundation
Private
United States
Up to US $1,000
The HealthWell Foundation's Inborn Metabolic or Genetic Bile Acid Deficiency Vitamins and Supplements Fund provides essential financial assistance for individuals facing significant health challenges. By covering copays, deductibles, and related expenses, the fund aims to alleviate the financial burden on underinsured patients. With a commitment to enhancing healthcare access, the Foundation has awarded over $1.2 billion since its inception, ensuring that vital treatments remain accessible to those in need.
Endocrine & Metabolic Diseases Health Care Access & Delivery Genetic Conditions & Birth Defects

The Schneider Electric SkillPointe Scholarship

SKILLED Nation
Association/Society
United States
US $3,000
The Schneider Electric SkillPointe Scholarship aims to close the skills gap in America by providing $3,000 scholarships to individuals pursuing careers in building automation and related fields. Funded by the SkillPointe Foundation, this initiative is designed for students enrolled in relevant training programs who are passionate about energy and sustainability. With a proven success rate of 95% in training completion and 97% employment, this scholarship empowers workers to thrive in high-demand industries without requiring a four-year degree.
Energy Artificial Intelligence (AI)

The Niagara Cares SkillPointe Scholarship

SKILLED Nation
Association/Society
United States
US $1,000 - US $3,000
The Niagara Cares SkillPointe Scholarship offers $1,000 to $3,000 for individuals pursuing high-demand careers in manufacturing. Administered by the SkillPointe Foundation, this initiative addresses the skills gap by funding vocational training for candidates enrolled in post-secondary institutions. With over 1,000 scholarships awarded and a 97% employment rate among recipients, this program empowers workers and strengthens the economy by promoting essential skills without requiring a four-year degree.
Vocational & Trade Education Manufacturing Engineering

The Gunther & Lee Weigel Medical School Scholarship

Elks National Foundation Inc
Private
United States
Unspecified amount
The Gunther & Lee Weigel Medical School Scholarship is an exclusive opportunity for current and former Elks National Foundation scholarship recipients pursuing medical or osteopathic degrees. This scholarship, established in memory of Gunther Weigel, aims to support Elks scholars entering their first year of medical school. The number and amount of scholarships vary annually, reflecting the Foundation's commitment to healthcare education.
Academic Scholarship Programs Health & Medicine

The Gates Scholarship (TGS)

Gates Foundation
Private
United States
Unspecified amount
The Gates Scholarship (TGS) is a prestigious last-dollar scholarship launched by the Gates Foundation in 2017, aimed at empowering high school seniors from low-income backgrounds. By covering financial barriers, it supports exceptional student leaders in pursuing their college education. The program not only provides funding but also engages scholars with resources and services throughout their academic journey, fostering their growth into future leaders. TGS exemplifies the Foundation's commitment to educational equity and student success.
Education - Higher Education Academic Scholarship Programs Civic Leadership Development

U.S. Venture Program Grants

Us Venture Schmidt Family Foundation Inc
Private
United States
Unspecified amount
The U.S. Venture/Schmidt Family Foundation supports initiatives that drive self-sufficiency and community enrichment for vulnerable populations. With over $4.31 million awarded last year, the foundation prioritizes projects that demonstrate measurable impact and foster stronger communities. Eligible organizations include those designated as public charities by the IRS. The foundation emphasizes collaboration with other funders, avoiding sole financial support to ensure comprehensive community development.
Community Development & Revitalization Nonprofit Growth & Development Basic Human Needs

DTA Foundation: Dental Hygiene Scholarship

Dental Trade Alliance Foundation
Private
United States
Unspecified amount
The DTA Foundation: Dental Hygiene Scholarship, in partnership with the Benco Family Foundation, provides up to $10,000 to dental hygiene students from underrepresented backgrounds. This initiative honors Lawrence and Sally Cohen's contributions to the field. With a generous $1M endowment, the scholarship aims to support aspiring dental hygienists, ensuring increased accessibility to the profession and recognizing those who demonstrate passion and commitment to dental care.
Dental Health

Ordóñez Family Scholarship

Community Foundation for Southeast Michigan
Private
United States
Up to US $5,000
The Ordóñez Family Scholarship aims to support graduates from Detroit Public Schools or accredited private high schools in southwest Detroit. This renewable scholarship offers $1,250 annually for up to four years, totaling $5,000. Applicants must have resided in southwest Detroit throughout high school and maintain a minimum 2.5 GPA in college. Renewal is contingent upon reapplication and meeting academic criteria, ensuring continued support for eligible students.
Career / College Preparation Academic Scholarship Programs

Common Ground Scholarship

Foundation for Rural Service
Private
United States
US $9,000
The Common Ground Scholarship, awarded by the Foundation for Rural Service, supports high school seniors from rural communities across America with two $9,000 scholarships. Preference is given to students pursuing studies in environmental sustainability, social justice, telecommunications, or economic development. This initiative has provided over $1 million in scholarships, empowering rural students to enhance their communities with vital skills and experiences, thus fostering future leaders in various fields.
Career / College Preparation Academic Scholarship Programs

nccPA Health Foundation: Oral Health - Research Integration Grant

nccPA Health Foundation
Association/Society
United States
Up to US $3,500
The nccPA Health Foundation offers the Oral Health - Research Integration Grant to support PAs in integrating oral health into their curriculum or clinical practice. With grants of up to $3,000 available, this initiative aims to enhance the skills and knowledge of PAs, ensuring that oral health is recognized as a critical component of overall health care. Applications are accepted year-round, encouraging innovative strategies to improve access and reduce disparities in oral health.
Dental Health Medical Education & Professional Training

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

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