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Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

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9,242 Results based on applied filters

The Shawn Carter Scholarship Fund (SCSF)

Shawn Carter Scholarship Fund
Private
United States
Unspecified amount
The Shawn Carter Scholarship Fund (SCSF) supports motivated individuals in need by providing financial assistance for education. Aimed at underserved youth and young adults, the SCSF helps cover tuition and related expenses, ensuring access to higher education. Eligible candidates include high school seniors, GED holders, and undergraduate students with a minimum GPA of 2.0. The program encourages community service, fostering a spirit of giving back among its scholars.
Academic Scholarship Programs

Urology Care Foundation Bridge Award

American Urological Association Inc
Private
United States
US $60,000
The Urology Care Foundation Bridge Award, supported by Dornier MedTech, aims to assist established urology researchers facing financial challenges. It provides up to $60,000 over a 12-month period to sustain vital urologic projects at risk due to funding gaps or setbacks. This unrestricted funding targets independent researchers who are no longer under formal mentorship, ensuring that those actively engaged in research receive timely support to maintain their competitiveness in the field.
Urology

Abbott Professional Medical Education Grants

Abbott Fund
Private
United States
Unspecified amount
The Abbott Professional Medical Education Grants provide funding to healthcare institutions and education providers for independent medical education events. Established by the Abbott Fund, these grants aim to enhance scientific knowledge and patient wellness, focusing on areas such as cardiovascular diseases and heart therapies. Grants cover general expenses like accreditation and marketing, but do not support speaker fees or travel costs. Applications must be submitted at least 45 days prior to the event.
Medical Education & Professional Training Cardiovascular Diseases & Systems

Abbott Fellowship Program Grants

Abbott Fund
Private
United States
Unspecified amount
The Abbott Fellowship Program Grants, established by the Abbott Fund, aim to enhance medical education and patient wellness. Through these grants, medical institutions can develop fellowship programs focusing on critical areas such as cardiovascular disease, electrophysiology, and heart failure. The initiative seeks to foster innovation in healthcare by enabling organizations to support the training of fellows and advance scientific knowledge, ultimately improving patient outcomes and community health.
Cardiovascular Diseases & Systems Medical Education & Professional Training

Shell Creek Watershed Scholarship

Lower Platte North Natural Resources District (LPNNRD)
State/Local Government
United States
US $1,000
The Shell Creek Watershed Scholarship, offered by the Lower Platte North Natural Resources District, awards three $1,000 scholarships to graduating seniors from specific high schools in the Shell Creek Watershed Monitoring Program. Eligible students must have completed at least one year in the program and plan to pursue studies in science or natural resources. The scholarship is disbursed in two installments, contingent upon maintaining a GPA of at least 3.0 in college.
Career / College Preparation Academic Scholarship Programs

Mantle Cell Lymphoma Fund

Healthwell Foundation
Private
United States
Up to US $8,500
The Mantle Cell Lymphoma Fund, managed by the HealthWell Foundation, provides financial assistance to underinsured patients diagnosed with Mantle Cell Lymphoma. The fund covers prescription drug copays and Medicare Part B premiums, with a maximum award of $8,500. Eligible patients must have insurance that covers their medication and meet specific income guidelines. The foundation aims to reduce financial barriers to essential treatments, ensuring that patients receive necessary care without undue financial strain.
Health Care Access & Delivery Lymphoma Cancer / Oncology

Inborn Metabolic or Genetic Bile Acid Deficiency Vitamins and Supplements Fund

Healthwell Foundation
Private
United States
Up to US $1,000
The HealthWell Foundation's Inborn Metabolic or Genetic Bile Acid Deficiency Vitamins and Supplements Fund provides essential financial assistance for individuals facing significant health challenges. By covering copays, deductibles, and related expenses, the fund aims to alleviate the financial burden on underinsured patients. With a commitment to enhancing healthcare access, the Foundation has awarded over $1.2 billion since its inception, ensuring that vital treatments remain accessible to those in need.
Endocrine & Metabolic Diseases Health Care Access & Delivery Genetic Conditions & Birth Defects

Hyperoxaluria Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Hyperoxaluria Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from hyperoxaluria, a condition characterized by excessive oxalate in urine. This fund assists with prescription drug copays and insurance premiums, providing vital support for treatments. In 2024 alone, HealthWell allocated over $1.2 billion in grants, ensuring access to essential medications for those in need. The organization is committed to improving healthcare access and reducing disparities for affected individuals.
Health Care Access & Delivery Kidney Diseases Genetic Conditions & Birth Defects

Emergency/Medical Workers Behavioral Health Fund

Healthwell Foundation
Private
United States
Up to US $2,000
The Emergency/Medical Workers Behavioral Health Fund aims to support emergency workers facing trauma and anxiety due to their roles. Established by the HealthWell Foundation, it provides financial assistance for treatment-related costs, including copayments for prescription drugs, counseling, and transportation. In 2024, the Foundation awarded over $1.2 billion to underinsured patients, ensuring no one is denied essential healthcare due to financial barriers. This initiative helps address the critical mental health needs of those who serve on the front lines.
Crisis Intervention Emergency Medical Care & Services Public Transportation & Mass Transit Systems +4 more

Dupuytren’s Disease Fund

Healthwell Foundation
Private
United States
Up to US $3,500
The Dupuytren’s Disease Fund, managed by the HealthWell Foundation, aims to reduce financial barriers for underinsured patients suffering from Dupuytren's Disease. This fund provides assistance for prescription drug copays and insurance premiums related to treatment. With an average grant utilization of $1,650 over a 12-month period, the fund ensures that essential medications and therapies are affordable. HealthWell Foundation, a private non-profit, has helped over 1.1 million patients since 2004, demonstrating its commitment to healthcare access.
Health Care Access & Delivery Skin Diseases & Dermatology

Cushing's Disease or Cushing's Syndrome Fund

Healthwell Foundation
Private
United States
Up to US $10,000
The Cushing's Disease or Cushing's Syndrome Fund, operated by the HealthWell Foundation, provides vital financial assistance to underinsured patients facing high medical costs associated with these conditions. The fund covers co-payments, insurance premiums, and necessary treatments, ensuring that patients receive the care they need without financial burden. With an average grant utilization of $3,000 over twelve months, this fund aims to alleviate the challenges of treatment accessibility, supporting both physical and mental health for those affected.
Health Care Access & Delivery Endocrine & Metabolic Diseases

Congenital Sucrase-Isomaltase Deficiency Fund

Healthwell Foundation
Private
United States
Up to US $10,000
The Congenital Sucrase-Isomaltase Deficiency Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients suffering from this genetic disorder. By providing assistance with prescription drugs and treatment costs, the fund ensures that vital medications are accessible, allowing patients to manage their condition effectively. In 2024, the Foundation is expected to award over $1.2 billion in grants, showcasing its commitment to enhancing healthcare access for those in need.
Health Care Access & Delivery Endocrine & Metabolic Diseases Diabetes +1 more

Chronic Lymphocytic Leukemia Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Chronic Lymphocytic Leukemia Fund, managed by the HealthWell Foundation, aims to alleviate financial burdens for underinsured patients battling chronic lymphocytic leukemia (CLL). This fund provides essential support for prescription copays and premiums, ensuring that patients can access necessary treatments without the stress of financial constraints. Since its inception, the foundation has awarded over $1.2 billion in grants, helping more than 1.1 million patients. The initiative emphasizes the importance of accessible healthcare and aims to improve the quality of life for those affected by this condition.
Cancer / Oncology Leukemia Health Care Access & Delivery +1 more

Cancer-Related Behavioral Health Fund

Healthwell Foundation
Private
United States
Up to US $2,000
The Cancer-Related Behavioral Health Fund, established by the HealthWell Foundation, provides financial assistance to individuals diagnosed with cancer for behavioral health treatments. This fund covers costs associated with prescription drugs, counseling services, and transportation. Aiming to alleviate financial burdens, it ensures that underinsured patients can access necessary care without delay. In 2024, the foundation awarded over $1.2 billion, emphasizing its commitment to improving health outcomes for cancer patients across the United States.
Cancer / Oncology Crisis Intervention Health Care Access & Delivery +2 more

Blepharitis Fund

Healthwell Foundation
Private
United States
Up to US $3,500
The Blepharitis Fund, managed by the HealthWell Foundation, aims to alleviate financial barriers for underinsured patients suffering from blepharitis, an inflammatory condition of the eyelids. This program assists with prescription drug copays and insurance premiums, covering up to $3,500 annually for treatments. With a mission to ensure no patient is deprived of necessary healthcare due to financial constraints, the HealthWell Foundation has provided over $1.2 billion in grants, supporting more than 1.1 million patients since its inception.
Health Care Access & Delivery Eye Diseases & Disorders

ANCA-Assoc Vasculitis and Granulomatosis with Polyangiitis Fund

Healthwell Foundation
Private
United States
Up to US $6,000
The ANCA-Assoc Vasculitis and Granulomatosis with Polyangiitis Fund, established by the HealthWell Foundation, aims to reduce financial barriers for underinsured patients suffering from this rare and serious condition. The fund assists with copays, premiums, and out-of-pocket expenses related to treatment, ensuring that affected individuals have access to necessary medications. With over $1.2 billion in grants awarded since 2004, the foundation has helped over 1.1 million patients access critical healthcare services.
Health Care Access & Delivery Rare Diseases Heart Disease

Amyotrophic Lateral Sclerosis Fund

Healthwell Foundation
Private
United States
Up to US $15,000
The Amyotrophic Lateral Sclerosis Fund, managed by HealthWell Foundation, aims to alleviate financial barriers for underinsured patients battling ALS, a progressive neurodegenerative disease. The fund provides financial assistance for prescription copays, insurance premiums, and related healthcare expenses, ensuring patients can access vital treatments. With an average grant utilization of $3,000 over twelve months, the fund exemplifies HealthWell's commitment to ensuring no patient is denied necessary healthcare due to cost. Since 2004, HealthWell has awarded over $1.2 billion in grants, supporting more than 1.1 million patients.
Health Care Access & Delivery Amyotrophic Lateral Sclerosis (ALS) Neurological Diseases & Disorders

Amyloidosis Fund

Healthwell Foundation
Private
United States
Up to US $8,000
The Amyloidosis Fund, managed by the HealthWell Foundation, provides essential financial assistance to underinsured patients facing treatment costs for Amyloidosis. The program covers prescription copays, insurance premiums, and related expenses, ensuring that patients can access necessary medications without financial strain. With a maximum award of $8,000, the fund aims to alleviate the burden of healthcare costs for those diagnosed with this complex disease, promoting better health outcomes and quality of life for patients across the United States.
Health Care Access & Delivery Cancer / Oncology Endocrine & Metabolic Diseases

Alagille Syndrome Vitamins and Supplements Fund

Healthwell Foundation
Private
United States
Up to US $1,500
The Alagille Syndrome Vitamins and Supplements Fund, managed by the HealthWell Foundation, offers financial assistance to patients suffering from Alagille Syndrome. This fund helps cover the costs of essential vitamins and supplements needed for treatment. With a maximum award of $1,500, the program aims to reduce financial barriers for underinsured individuals, ensuring they receive the necessary support to manage their health, thereby enhancing their quality of life.
Rare Diseases Health Care Access & Delivery Liver Disease

Philip J. Wyatt Award in Analytical Chemistry

American Chemical Society
Association/Society
United States
Up to US $7,500
The Philip J. Wyatt Award in Analytical Chemistry, established in 1947 and endowed by the Wyatt Family Foundation in 2026, recognizes outstanding contributions to analytical chemistry. Offered by the American Chemical Society, the award includes a $5,000 prize and a certificate, with up to $2,500 for travel expenses to the award presentation meeting. This award supports diversity and inclusion by being available regardless of race, gender, or background, promoting a global community in the field of chemistry.
Chemistry

Rural Health Fellows Leadership Program

National Rural Health Association
Private
United States
Unspecified amount
The Rural Health Fellows Leadership Program, offered by the National Rural Health Association (NRHA), is an intensive yearlong initiative aimed at cultivating a diverse network of rural health leaders. Selected participants engage in leadership training, policy advocacy, and collaborative projects. The program includes monthly virtual sessions, in-person meetings at key conferences, and opportunities for financial support, thereby empowering fellows to make a significant impact on rural healthcare.
Health Disparities & Social Determinants of Health

L.L.Bean Charitable Donations

L.L. Bean
Corporate
American Samoa, Guam +4 more
Unspecified amount
L.L.Bean Charitable Donations supports outdoor initiatives that bring communities together. The program encourages partnerships with inspiring individuals and organizations. To apply, ensure requests are made at least eight weeks before the event. Please note that the program does not fund individuals, advertising, specific schools, or projects outside the U.S. For more information, visit their website to learn how to get involved.
Outdoor Recreation Outdoor Equity

Don Rossi Scholarship

Coastal Community Foundation of South Carolina
Private
United States
Approximately US $1,000
The Don Rossi Scholarship, established by the National Golf Course Owners’ Association in 1993, supports college juniors and seniors majoring in Sports Administration or related fields. This scholarship aims to foster careers in golf-related industries, encouraging students nationwide to pursue their aspirations. Funded by the Coastal Community Foundation, it reflects a commitment to education and community growth, ensuring that financial barriers do not hinder talented individuals from achieving their goals.
Academic Scholarship Programs Golf

E.B. Henderson Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The E.B. Henderson Award, presented by SHAPE America, honors minority members who have demonstrated exceptional commitment to scholarship, mentorship, and advocacy for ethnic minorities within health and physical education. Established in 1885, SHAPE America serves over 200,000 professionals, promoting high-quality education standards. The award recognizes individuals who have significantly contributed to increasing the participation of underserved populations in the field. Limited to two awards annually, it highlights the importance of diversity and inclusion in health education.
Diversity, Equity & Inclusion Educational Access & Equity Black American Services +9 more

Curriculum and Instruction Honor Award

Society Of Health And Physical Educators
Private
United States
Unspecified amount
The Curriculum and Instruction Honor Award, presented by SHAPE America, recognizes outstanding contributions to health and physical education curriculum research. This prestigious award highlights the importance of effective instructional practices that prepare students for active and healthy lives. Award recipients are selected based on their scholarship in health education and physical education, demonstrating commitment to excellence since the organization's founding in 1885. SHAPE America advocates for quality education and promotes the well-being of preK-12 students across the United States.
Kinesiology & Sports Medicine Education - K through 12 Dance +3 more

Elroy Webster Cooperative Studies (EWCS) Scholarships

Ralph K. Morris Foundation
Association/Society
United States
US $1,000 - US $2,500
The Elroy Webster Cooperative Studies Scholarships support graduate and law students in agricultural cooperative programs. Up to two EWCS Fellows can receive $2,500 each year, while up to three EWCS Scholars may receive $1,000. Applicants must demonstrate how their studies benefit the agricultural cooperative industry. The program promotes inclusivity, welcoming candidates without regard to race or background, and encourages attendance at related events to enhance networking and recognition.
Academic Scholarship Programs Agricultural Education Education - Higher Education

VFW Student Fellowship

Veterans Of Foreign Wars Of
Private
United States
Unspecified amount
The VFW Student Fellowship, hosted by the Veterans of Foreign Wars and Student Veterans of America, empowers student veterans to advocate for their community on Capitol Hill. Running from October 2025 to March 2026, this program offers selected fellows the chance to collaborate on policy priorities, attend leadership training, and participate in significant conferences, ensuring their voices are heard among 500 advocates at the VFW Washington Conference. Travel expenses are fully covered.
Military & Veterans Services Academic Scholarship Programs Education - Higher Education

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

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