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Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

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9,242 Results based on applied filters

Art Bridges Cohort Program

Art Bridges
Private
United States
Unspecified amount
The Art Bridges Cohort Program aims to enhance access to American art by fostering multi-year partnerships among museums across the U.S. This initiative creates sustainable art-sharing ecosystems that promote collaboration and community engagement. The program supports museums through funding for various phases, including research, small art shares, and large art shares, ensuring resources for travel, exhibition design, and educational opportunities. Eligibility includes a strong commitment to community engagement and existing art collections.
Art & Culture Community Culture & Heritage

Center for the History of Family Medicine Oral History Grant

American Academy of Family Physicians Foundation
Corporate
United States
Up to US $3,000
The AAFP Foundation's Center for the History of Family Medicine Oral History Grant offers up to $3,000 annually for oral history interviews in family medicine. Aimed at researchers, physicians, and students, it encourages the documentation of family medicine's history in the U.S. The grant supports travel and research expenses to enhance the oral history collection, ensuring a diverse representation of experiences and perspectives in the field.
Historical Records & Archives History Of Science

American Indian Services: Trade Scholarship

AMERICAN INDIAN SERVICES
Private
United States
Up to US $2,500
The American Indian Services: Trade Scholarship offers financial support for American Indian and Alaska Native students pursuing trade education. Since its inception over 40 years ago, the program has awarded scholarships to more than 35,000 Native students. Eligible applicants can receive up to $2500, with distinct deadlines for January and September awards. This initiative aims to empower Native students by facilitating access to trade school opportunities.
Vocational & Trade Education Native American Services

AWS Welding Workforce Grant

American Welding Society Inc
Private
United States
Up to US $50,000
The AWS Welding Workforce Grants aim to enhance welding programs by providing up to $50,000 for essential resources such as new equipment and training. This initiative addresses the growing demand for skilled welders while supporting educational institutions. Eligible applicants include secondary schools, community colleges, and post-secondary programs. Preference is given to proposals that significantly increase welding graduates and address geographic areas with high needs. Note: Applications are currently closed and will reopen in January 2026.
Workforce Preparation & Job Readiness

Andrew Burgin Charitable Trust Grant

Andrew Burgin Charitable Trust
Private
United States
US $5,000 - US $20,000
The Andrew Burgin Charitable Trust Grant supports organizations that are exempt under Section 501(c)(3) and focuses on charitable, educational, religious, and scientific purposes. With grant sizes ranging from $5,000 to $20,000 and an annual budget of approximately $55,000, the trust primarily serves Alabama organizations. Applications are accepted year-round, but must meet specific deadlines for review. This grant offers opportunities across diverse areas such as arts, education, health, and human services.
Art & Culture Humanities & Social Science Education +6 more

AWI Implementing Refinement Grant

Animal Welfare Institute
Private
Canada, United States
Up to US $8,000
The AWI Implementing Refinement Grant, offered by the Animal Welfare Institute, aims to enhance the welfare of animals in experimentation. Grants up to $8,000 support equipment purchases or staff training for implementing proven refinements. Eligible applicants must be from the U.S. or Canada, and projects should be completed within a year. The grant focuses on improving animal lives beyond basic needs, ensuring no funds are misused for indirect costs or basic care.
Animal Welfare - General

James B and Lois R Archer Charitable Foundation Large Grant

James B And Lois R Archer Charitable Foundation
Private
United States
More than US $10,000
The James B and Lois R Archer Charitable Foundation offers Large Grants for requests exceeding $10,000. Focused on fostering positive change, the foundation supports initiatives in Arts and Culture, Civic Engagement, Education, Health, and Human Services. Eligibility includes 501(c)(3) organizations, while restrictions apply to consecutive grant cycles and non-qualifying purposes such as endowments and fundraising events. Organizations are encouraged to apply for various projects to enhance community well-being.
Art & Culture Civic Engagement & Education Human & Social Services +2 more

James B and Lois R Archer Charitable Foundation Smaller Grant

James B And Lois R Archer Charitable Foundation
Private
United States
Up to US $10,000
The James B and Lois R Archer Charitable Foundation offers Smaller Grants of $10,000 or less to support initiatives in Arts and Culture, Civic Engagement, Education, Health, and Human Services. Organizations must have 501(c)(3) status and comply with eligibility criteria, including a one-year waiting period for reapplications. The foundation aims to have a significant impact on communities, especially in West Texas, while avoiding funding for specific exclusions such as endowments and fundraising events.
Art & Culture Civic Engagement & Education Human & Social Services +2 more

AMVETS Veteran, Active Duty & Guard/Reserve Scholarship

Amvets National Service Foundation
Private
United States
Up to US $12,000
The AMVETS Veteran, Active Duty & Guard/Reserve Scholarship provides financial assistance up to $12,000 for qualified U.S. Veterans and active military members pursuing undergraduate degrees. This scholarship is designed to bridge the financial gap after all other federal and state aid has been utilized. Eligibility includes being an honorably discharged veteran or active service member, enrolled in an accredited institution, and demonstrating financial need. AMVETS is dedicated to serving those who have served our country.
Military & Veterans Services Academic Scholarship Programs

AMVETS Spouse Scholarship

Amvets National Service Foundation
Private
United States
Unspecified amount
The AMVETS Spouse Scholarship offers financial support to the spouses of honorably discharged veterans and active military personnel, including National Guard and Reserves. This scholarship aims to bridge financial gaps after other federal and state resources have been exhausted. Eligible applicants must be U.S. citizens enrolled in accredited undergraduate programs, demonstrate financial need, and not be in default on federal student loans. AMVETS stands committed to empowering military families through education.
Military & Veterans Services Academic Scholarship Programs

AMVETS Children and Grandchildren Scholarship

Amvets National Service Foundation
Private
United States
US $4,000
The AMVETS Children/Grandchildren Scholarship supports the educational aspirations of children and grandchildren of honorably discharged U.S. veterans and active military. This scholarship aims to bridge financial gaps after all federal and state assistance has been utilized. Eligible applicants must be U.S. citizens, high school seniors, and demonstrate financial need while enrolled in accredited four-year universities. Incomplete applications will be disqualified, ensuring that the award goes to deserving candidates committed to their education.
Military & Veterans Services Academic Scholarship Programs

The Anna Fuller Fund Grant

The Anna Fuller Fund
Association/Society
Countries
US $75,000 - US $150,000
The Anna Fuller Fund Grant provides year-round support for organizations dedicated to alleviating suffering caused by cancer. Established in memory of Egbert C. Fuller’s wife, the fund prioritizes applications that focus on cancer research and education initiatives. Eligible applicants must be 501(c)(3) organizations or equivalent charities outside the U.S. Grant funds cannot be used for direct treatment, ensuring that resources are allocated to research and public education.
Cancer / Oncology Preventative Healthcare

The Fox Family Foundation Grant

Robert A Fox Family Charitable Foundation
Private
United States
Unspecified amount
The Fox Family Foundation Grant focuses on empowering individuals with disabilities through workforce development, education, and advocacy. By promoting accessibility and inclusion, the foundation creates opportunities for differently-abled individuals to thrive in their careers. With a commitment to innovative programs and partnerships, it seeks to bridge the gap in funding for disability initiatives, ensuring equitable access to meaningful careers and education for all.
Disability Care & Services Educational Access & Equity

Frederic C. Collin Trust Grant

COLLIN FREDERIC C TUW
Private
United States
US $2,000 - US $3,800
The Frederic C. Collin Trust Grant supports 501(c)(3) organizations in promoting polo and tennis, especially among youth. Established under Frederic C. Collin's will, it offers grants ranging from $2,000 to $3,800, with an annual total giving of approximately $9,000. Applications are accepted year-round for consideration during the annual grant meeting. This initiative aims to enhance participation in these sports, fostering talent and interest among young players.
Tennis Equestrian Sports

Opportunities for Collaborative Research at the NIH Clinical Center

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Opportunities for Collaborative Research at the NIH Clinical Center aims to foster high-quality translational research partnerships between NIH intramural and extramural investigators. This program supports projects that bridge basic biological discoveries with clinical applications, ultimately enhancing patient-centric research. By facilitating collaborations, the program seeks to accelerate scientific advancements leading to improved health outcomes through innovative therapeutic interventions and diagnostic strategies.
Biology Health & Medicine

David and Jacquie Clark Family Fund Grant

David And Jacquie Clark Family Fund
Private
United States
Unspecified amount
The David and Jacquie Clark Family Fund, established in 2017, aims to support individuals with special needs and their families through grants to nonprofits. With a focus on Ohio organizations, the fund seeks to ensure equitable opportunities for these individuals, fostering their success and well-being. Since its inception, the fund has provided assistance to over 30 nonprofits across the U.S., enhancing programs that promote learning and growth outside traditional educational settings.
Intellectual / Developmental Disabilities Academic Success & Enrichment

Ruth Danley and William Enoch Moore Charitable Fund Grant

The Ruth Danley And William Enoch Moore Fund
Private
United States
Approximately US $77,000
The Ruth Danley and William Enoch Moore Charitable Fund Grant is a private foundation based in Pittsburgh, established in 1992. It focuses on philanthropy, specifically supporting K-12 education for Native American children living on reservations. The foundation directs its grants primarily to regions preferred by donors, including several states in the Northeast and Midwest, aiming to improve educational opportunities and foster community development in underserved populations.
Education - K through 12 Native American Services Educational Access & Equity

Andrea-Mennen Family Foundation Grant

The Andrea-Mennen Family Foundation
Private
United States
Unspecified amount
The Andrea-Mennen Family Foundation Grant aims to enhance the quality of life for children and young adults facing mental and physical challenges. By supporting registered charitable organizations that align with its mission, the foundation seeks to ensure that 100% of grant funds directly benefit those in need within the US. Emphasizing immediate results and proven success, the foundation is dedicated to making a positive impact in the lives of future generations.
Youth Services Children’s Mental Health Child Welfare Services +5 more

The James Paul Sutton Medical Research Fund Grant

James Paul Sutton Medical
Private
United States
Approximately US $15,000
The James Paul Sutton Medical Research Fund Grant supports non-profit organizations engaged in cancer and medical research, established through a trust by the Sutton family. Eligible organizations must be 501(c)(3) exempt. Preference is given to cancer research initiatives, while grants are not available for individuals, political groups, or for-profit entities. This fund aims to sustain medical research efforts for the long term, continuing the legacy of the Sutton family.
Cancer / Oncology

Animal Food Regulatory Program Standards Implementation Development and Maintenance, with Mutual Reliance Initiatives Clinical Trials Not Allowed

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
Up to US $300,000
The Animal Food Regulatory Program Standards Implementation Development and Maintenance initiative aims to enhance the national animal food safety system. This funding opportunity supports state regulatory programs in achieving and sustaining the Animal Food Regulatory Program Standards (AFRPS) within five years. By fostering collaboration with the FDA and standardizing regulatory processes, this initiative seeks to improve food safety, promote compliance, and mitigate foodborne illnesses, ultimately creating a more integrated food safety framework.
Animal Food & Drug Safety

Notice of Intent to Publish a Funding Opportunity Announcement for HIV Pediatric, Adolescent and Maternal Clinical Trials

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $30,000,000
The US Dept. of Health & Human Services, through the Eunice Kennedy Shriver National Institute of Child Health and Human Development, is set to announce a funding opportunity focused on HIV research for pediatric and maternal populations. This initiative aims to foster innovative clinical trials addressing critical research areas in HIV, inviting collaborations from experts in various fields. Applications are not currently solicited, but potential applicants are encouraged to prepare for this opportunity.
Infectious & Parasitic Diseases HIV / AIDS Chronic Illnesses

MCSF- Career & Technical Education Scholarship

Marine Corps Scholarship Foundation
Private
United States
US $2,500 - US $10,000
The MCSF Career & Technical Education Scholarship supports children of Marines pursuing non-degree certificate programs. It offers financial assistance to eligible applicants based on need, helping cover tuition, fees, and associated educational costs. With a minimum GPA requirement of 2.00 and a family income cap of $123,000, this scholarship ensures that all qualifying students have access to vocational training at accredited institutions. Applications are accepted year-round, providing flexibility for students.
Workforce Preparation & Job Readiness Vocational & Trade Education

Earth Rising Foundation Grants

Earth Rising Foundation
Private
United States
US $200 - US $20,000
The Earth Rising Foundation Grants provide financial support ranging from $200 to $20,000 for grassroots climate initiatives. The foundation emphasizes empowering Indigenous communities, advocating for sustainable agricultural practices, and addressing social justice issues linked to climate change. By fostering youth involvement and supporting innovative projects, the foundation aims to create a vision for a sustainable future that respects both people and the planet. Applications must be submitted through a US-based nonprofit organization.
Youth Services Climate Change Resilience & Equity Diversity, Equity & Inclusion +3 more

Sensata Foundation Grant

Sensata Technologies Foundation Inc
Private
United States
US $5,000 - US $25,000
The Sensata Foundation, established in 2017, is a 501(c)(3) nonprofit supporting community development and STEM education across the U.S. With a focus on improving access to STEM resources and empowering youth, the Foundation partners with nonprofits to address food insecurity, homelessness, and environmental sustainability. By fostering community partnerships and providing financial support, Sensata Foundation aims to inspire future leaders and enhance the quality of life for all, particularly in underserved areas.
Homelessness Services Environment Food Security +3 more

David Kelby Johnson Memorial Foundation Grants

David Kelby Johnson Memorial Foundation
Private
United States
US $5,000 - US $100,000
The David Kelby Johnson Memorial Foundation offers grants to 501(c)(3) organizations focused on sight preservation, children's services, and environmental conservation, primarily in Utah. Established in memory of David Kelby Johnson, who tragically lost his life at a young age, the foundation aims to honor his legacy by supporting impactful charitable initiatives. Grants range from $5,000 to $100,000, with a commitment to improving communities both locally and globally.
Eye Diseases & Disorders Vision Impairment Care & Services Senior Services +4 more

McMillen Foundation Grants Program

The Robert B Mcmillen Foundation
Private
United States
Unspecified amount
The McMillen Foundation Grants Program supports research in cardiology, lipids, and organ transplant, along with educational initiatives and social services in Washington and Alaska. With a single grant cycle annually, nonprofits certified under 501(c)(3) can apply for funding, preferably those benefiting children and promoting equity. The foundation emphasizes programs that leverage the arts to foster social change, impacting youth and disadvantaged communities. Applications must be submitted by July 31 to be considered for the current cycle.
Space Physiology & Health Cardiovascular Diseases & Systems Organ And Tissue Banks +6 more

One Hive Foundation Grant

One Hive Foundation
Private
Canada, Connecticut +8 more
Up to US $75,000
The One Hive Foundation Grant focuses on promoting pollinator health and ecologically responsible agriculture through funding research and nonprofit initiatives. Launched in 2022, the grant supports diverse projects aimed at enhancing environmental data, public education, and scientific collaboration. Targeting verified 501c3 organizations, the foundation emphasizes ecological practices and community engagement in Vermont and beyond, with grants of up to $75,000 available to eligible applicants.
Science Communications Food Security Agricultural Pest Management +5 more

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

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