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Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

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Filters

9,242 Results based on applied filters

CF Foundation/NIH K-Unfunded Award

Cystic Fibrosis Foundation
Private
United States
Up to US $125,000
The CF Foundation/NIH K-Unfunded Award aims to support exceptional research projects in cystic fibrosis (CF) that have been approved by the NIH but lack funding. This award provides temporary financial assistance of up to $80,000 per year for two years to ensure that promising CF research continues without interruption. The initiative focuses on fostering a new generation of researchers dedicated to advancing CF studies while encouraging the NIH to provide long-term support.
Cystic Fibrosis

CFF/NIH R01-Unfunded Award

Cystic Fibrosis Foundation
Private
United States
Up to US $125,000
The CFF/NIH R01-Unfunded Award, offered by the Cystic Fibrosis Foundation, supports exceptional CF-related research projects that have been submitted to NIH but lack funding. This program aims to bridge the gap for meritorious projects, providing up to $125,000 per year for two years. By facilitating research in cystic fibrosis, the foundation helps ensure that innovative ideas can continue to progress toward improving care and outcomes for individuals affected by this disease.
Cystic Fibrosis

ASF Family Fund Grant

Angelman Syndrome Foundation
Private
United States
Up to US $5,000
The ASF Family Fund Grant, offered by the Angelman Syndrome Foundation, provides crucial financial assistance to families of individuals with Angelman syndrome. This rare neuro-genetic disorder affects approximately 500,000 people globally. The fund aims to enhance the quality of life for affected individuals, allowing caregivers to apply for up to $5,000 to cover essential needs. Limitations include restrictions on certain expenses and prior grant awards. This initiative aims to support families through education and necessary resources.
Family Services Disability Care & Services Intellectual / Developmental Disabilities

James Madison Graduate Fellowship

James Madison Memorial Fellowship Program
Federal Government
United States
Up to US $24,000
The James Madison Graduate Fellowship supports U.S. citizens pursuing master's degrees focused on the Constitution, enhancing their constitutional knowledge for teaching. Fellows are required to teach American history, government, or civics at the secondary level for one year per funding year. Financially, the fellowship awards up to $24,000, covering tuition and fees, and must be repaid if fellowship conditions are unmet. This program ensures future educators embody constitutional principles in their teaching.
Education American History Civic Affairs

Valley Hospital Auxiliary Scholarships

The Valley Hospital Inc
Private
United States
Unspecified amount
The Valley Hospital Auxiliary has been supporting future healthcare professionals since 1961 by providing scholarships to high school seniors and undergraduate students. In 2025, they awarded $30,000 to 21 exceptional students who have shown academic excellence and a commitment to healthcare. This initiative not only benefits the recipients but also contributes to the community by nurturing the next generation of medical leaders. Eligible high school students can reapply throughout their college years, ensuring continuous support for their educational journeys.
Academic Scholarship Programs College Success / Persistence

VFW's Sport Clips Help A Hero Scholarship

Veterans Of Foreign Wars Of
Private
United States
Up to US $5,000
The VFW's Sport Clips Help A Hero Scholarship offers financial support of up to $5,000 to eligible veterans and service members pursuing their educational goals. This initiative, backed by the Veterans of Foreign Wars organization, aims to alleviate the burden of student debt for those who have served our country. By partnering with Student Veterans of America and Sport Clips, the VFW ensures that veterans receive the assistance they deserve to succeed in their academic endeavors.
Military & Veterans Services Educational Access & Equity Education - Higher Education

The Truman Scholarship

HARRY S TRUMAN SCHOLARSHIP FOUNDATION DEVELOPMENT FUND
Private
United States
Up to US $30,000
The Truman Scholarship, established by the Truman Foundation, supports college juniors committed to public service. It offers up to $30,000 for graduate studies, alongside mentoring and career development opportunities. Ideal candidates demonstrate leadership, a strong commitment to public service, and the potential for success in graduate school. This prestigious award aims to cultivate future leaders dedicated to making a positive impact in their communities and beyond.
Education - Higher Education Civic Leadership Development Academic Scholarship Programs

PCORI Call for Proposals for HSII Implementation Projects

Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $2,500,000
The PCORI Call for Proposals for HSII Implementation Projects invites innovative approaches to address barriers in healthcare settings. These projects should enhance practice change through active, multi-component strategies and include rigorous evaluations to measure implementation effectiveness. While developing tools to support these strategies is permitted, it should not be the main focus. Successful proposals will demonstrate their potential impact on healthcare outcomes and patient experiences.
Medical Education & Professional Training Cardiovascular Diseases & Systems

Ollie Hinkle Heart Foundation: Technology Grant

Ollie Hinkle Heart Foundation
Private
United States
Unspecified amount
The Ollie Hinkle Heart Foundation's Technology Grant aims to improve pediatric heart care outcomes through innovative collaborations. By focusing on predictive technologies for early recognition, precision for personalized care, and preventive measures for quality of life, the foundation seeks to transform care for heart children and their families. Their mission emphasizes community support, education, and advocacy to ensure no family faces unmet needs alone, creating a legacy of love and courage in the heart community.
Cardiovascular Diseases & Systems Children’s Health & Pediatrics Medical Technology, Devices, and Equipment

Limited Competition PCORI Funding: Implementation Awards -- Cycle 3 2026

Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $2,500,000
The Implementation Awards by PCORI aim to fund projects that translate patient-centered research into real-world practices. With budgets up to $2.5 million for implementation projects lasting up to 48 months, applicants must present a clear plan for broad evidence uptake. Additionally, those proposing implementation projects need an accepted Draft Final Research Report related to their original PCORI-funded research to qualify for funding.
Patient Care & Services

Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases (R01 Clinical Trials Optional)

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
American Samoa, Guam +4 more
Up to US $600,000
This funding opportunity aims to enhance the development of medical products in rare diseases through innovative natural history studies. By generating high-quality data, the FDA seeks to bridge critical knowledge gaps and eliminate barriers in rare disease research. The initiative focuses on diseases with unmet needs, fostering significant impacts for those affected and facilitating the development of effective therapeutic solutions.
Rare Diseases Manufacturing Engineering Pharmacology +1 more

St. Baldrick’s Foundation Summer Fellowship Award

St Baldricks Foundation Inc
Private
United States
US $5,000
The St. Baldrick’s Foundation Summer Fellowship Award provides funding for undergraduate, graduate, or medical students to gain hands-on experience in pediatric oncology. With a stipend of $5,000 awarded to the mentor's institution, this fellowship supports the next generation of researchers dedicated to finding cures for childhood cancers. Since its inception, the foundation has mobilized volunteers through various fundraising events, fostering a community committed to transforming lives and advancing cancer research.
Academic Success & Enrichment After School / Summer Educational Programs College Success / Persistence

St. Baldrick's Foundation Scholar (Career Development) Award

St Baldricks Foundation Inc
Private
United States
Up to US $330,000
The St. Baldrick's Foundation Scholar (Career Development) Award supports early-career researchers dedicated to childhood cancer research. This three-year award, which can be extended for two additional years based on progress, provides up to $110,000 per year. Founded in 2000, the foundation has mobilized volunteers worldwide to raise funds through head-shaving events and various activities, all aimed at finding cures and improving survivors' lives.
Children’s Health & Pediatrics Pediatric Cancers

St. Baldrick’s Foundation Research Grant Award

St Baldricks Foundation Inc
Private
United States
Up to US $200,000
The St. Baldrick’s Foundation Research Grant Award supports innovative research aimed at curing childhood cancers. With funding of $100,000 per year for two years, this grant is designed for hypothesis-driven projects that can be laboratory, clinical, or epidemiological in nature. Established through community-driven fundraising events, the foundation empowers volunteers and donors to make a significant impact in the fight against cancer, ensuring a brighter future for young survivors.
Pediatric Cancers

St. Baldrick’s Foundation Fellowship Award

St Baldricks Foundation Inc
Private
United States
Up to US $195,000
The St. Baldrick’s Foundation Fellowship Award supports pediatric oncology training through a two-year fellowship, with a potential third year based on need and achievements. This initiative, powered by community fundraising events, aims to advance research for childhood cancer cures. The award provides a salary capped at $97,500 per year, covering salary and benefits for fellows. This fellowship not only fosters professional growth but also contributes significantly to the fight against childhood cancers.
Pediatric Cancers

Numotion Foundation Grants

Numotion Foundation
Private
United States
US $500 - US $10,000
The Numotion Foundation Grants aim to enhance the lives of individuals with mobility disabilities by supporting IRS-designated 501(c)(3) nonprofit organizations. By fostering partnerships with various charities, including national and local organizations, the foundation raises awareness and funds for necessary research and support services. Contributions are made for each new wheelchair sold, ensuring a coordinated approach to charitable giving while prioritizing programs that specifically assist those with mobility-related challenges.
Disability Care & Services Children With Disabilities Physical Disabilities

Tipgoomoogus Memorial Trust Grant

1992 Tipgoomoogus Memorial Trust
Private
United States
US $5,000 - US $10,000
The Tipgoomoogus Memorial Trust Grant supports organizations dedicated to the care and comfort of small household pets, including dogs, cats, and birds. Founded by Thomas and Ellen Fallon, the trust primarily funds New Jersey-based charities that qualify as 501(c)(3) organizations. Applications are accepted year-round, with a submission deadline of April 30 for annual review. The foundation prefers to assist animal shelters and dog pounds, while excluding funding for salaries or animals raised for commercial or research purposes.
Animal Welfare - Domestic Animals & Pets

Harry Kramer Memorial Fund Grant

Harry Kramer Memorial Fund
Private
Israel, United States
US $10,000 - US $25,000
The Harry Kramer Memorial Fund Grant supports U.S. charitable organizations that assist individuals and institutions in Israel, focusing on welfare, healthcare for the sick and aged, and education in South Florida. Founded by Harry A. Kramer, a successful entrepreneur and veteran, the fund reflects his deep commitment to charitable causes. Organizations must qualify under Section 501(c)(3) and meet specific eligibility criteria to apply for funding, ensuring that aid reaches those in need.
Jewish Culture Senior Services Religion & Spirituality +4 more

Downing-Nix Trust Grant

Frances Downing Nix 1013002741
Private
United States
US $6,000 - US $12,000
The Downing-Nix Trust Grant provides funding for organizations engaged in research on muscular dystrophy, maintaining treatment wards in Atlanta hospitals, offering veterinary medicine scholarships, and supporting shelters for small animals. Organizations must qualify as 501(c)(3) charities. Applications are accepted year-round, but submissions by April 15 are required for annual meeting reviews. Priority may be given to hospitals and veterinary schools within Atlanta, GA.
Muscular Dystrophy Health Facilities & Clinics Veterinary Science & Services +2 more

Howe Foundation Grant

Howe Foundation 45871100
Private
United States
Approximately US $5,000
The Howe Foundation, established by Thomas E. Howe in Clark County, Nevada, supports U.S. charitable organizations focused on education, medical advancements, and game hunters associations. Grants are administered by Wells Fargo Bank, with applications reviewed annually in September. Eligible organizations must be 501(c)(3) exempt under the Internal Revenue Code, ensuring support for meaningful community initiatives.
Education Health & Medicine Wildlife Management +1 more

Hunger to Health Collaboratory (H2HC) 2026 Prizes for Innovation

Newmans Own Foundation
Corporate
United States
Up to US $100,000
The Hunger to Health Collaboratory (H2HC) 2025 Prizes for Innovation aim to enhance health equity for youth through innovative funding in three categories: Food and Nutrition Policy, Nutrition Education & School Food, and Indigenous Food Justice. Supported by Newman’s Own Foundation, these prizes include $100K grants for policy work and $25K grants for education and justice initiatives. Winners will participate in the H2HC Fall Summit in Boston, fostering collaborative solutions to food challenges.
Food Access & Hunger Youth Services Indigenous Sovereignty & Rights +2 more

George William Groh Trust Grant

Groh George W Tr FBO Med Research
Private
United States
US $11,500
The George William Groh Trust Grant supports medical research initiatives by providing funding to organizations that qualify as exempt under Section 501(c)(3) of the Internal Revenue Code. Applications are accepted year-round, with a deadline of May 1 for consideration at the annual grant meeting. The foundation aims to enhance medical research efforts and contribute to advancements in healthcare.
Health & Medicine

Elizabeth Hurlock Beckman Award Trust Grant

The Elizabeth@Hurlock Beckman Award Trust
Private
United States
More than US $25,000
The Elizabeth Hurlock Beckman Award Trust Grant honors educators who inspire students to create impactful organizations or movements. Established in 2008, the trust has awarded over $3.5 million to 148 professors across the U.S. The grant primarily supports those teaching in psychology, medicine, or law, emphasizing the importance of community contribution. Eligibility is limited to U.S. citizens or permanent residents who have inspired their former students to make a difference.
Law Health & Medicine Psychology +1 more

Undergraduate Development Program Student Travel Award

Society of Toxicology
Association/Society
United States
Unspecified amount
The Undergraduate Development Program Student Travel Award offers undergraduate science majors a unique opportunity to attend the Society of Toxicology Annual Meeting from March 21–23, 2026. The program aims to inspire students pursuing research careers in toxicology and related biomedical sciences. Participants will engage with professionals, attend sessions, and explore various educational and career paths. SOT emphasizes inclusiveness, encouraging diverse perspectives to enhance innovation in the field.
Biomedical informatics Environmental Chemistry & Toxicology Education - Higher Education

Undergraduate Development Program Advisor Travel Award

Society of Toxicology
Association/Society
United States
Unspecified amount
The Undergraduate Development Program Advisor Travel Award, hosted by the Society of Toxicology, enables faculty advisors to attend the Undergraduate Development Program from March 21-23, 2026. This initiative aims to familiarize advisors with toxicology and encourage them to guide students toward careers in biomedical sciences. Recipients of the award will participate in educational sessions, networking opportunities, and receive support for travel-related expenses, fostering diversity and innovation within the field.
Environmental Chemistry & Toxicology Biomedical informatics

UPMC Microvascular Reconstructive Fellowship

Upmc
Private
United States
Unspecified amount
The UPMC Microvascular Reconstructive Fellowship offers a one-year clinical program designed for qualified surgeons, focusing on mentorship in microsurgical techniques and comprehensive patient care. Participants will gain hands-on experience in reconstructive surgeries, including extremity trauma and facial reanimation, while also engaging in multidisciplinary cancer treatment. The fellowship emphasizes both clinical and didactic learning, with opportunities for research in renowned laboratories, ensuring fellows acquire a deep understanding of the field.
Medical Education & Professional Training Reconstructive Surgery

Joan M Wismer Foundation Grant

Joan M Wismer Foundation
Private
United States
US $2,500 - US $25,000
The Joan M. Wismer Foundation, established in 2001, honors the legacy of Joan Marilynn Wismer, who was dedicated to charitable work and community service. The foundation focuses on improving lives through education, youth development, safety, humanitarian services, and medical research. It primarily supports IRS-recognized 501(c)(3) organizations, schools, and churches, while emphasizing the importance of sustainable funding and effective financial management in its grant-making process.
Education Youth Services Art & Culture +4 more

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

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