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Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

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9,242 Results based on applied filters

Local Shelter/Agency Support Grant

Ms Molly Foundation
Private
United States
Unspecified amount
The Ms. Molly Foundation provides essential support for domestic violence victims through the Local Shelter/Agency Support Grant. Established in 1996, the foundation aims to raise awareness and assist local agencies committed to helping victims find safety and empowerment. Eligible applicants include 501(c)(3) nonprofit shelters that partner with Molly Maid franchises. By addressing the cycle of violence, the foundation strives to create healthier family environments and restore hope to those affected.
Domestic Violence

The Andy Warhol Foundation- Arts Writers Grant

Andy Warhol Foundation for the Visual Arts
Private
United States
US $15,000 - US $50,000
The Andy Warhol Foundation's Arts Writers Grant supports writers engaging with contemporary visual art through various formats, including articles, books, and short-form writing. Grants range from $15,000 to $50,000, catering to both emerging and established writers. Eligible applicants must be individuals over 25, U.S. citizens or residents, and published authors. This initiative encourages critical discourse and interdisciplinary approaches in arts writing, particularly related to post-World War II visual art and its diverse contexts.
Performing Arts Visual Arts Art History

NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens (360006)

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
American Samoa, Guam +4 more
Up to US $200,000
The NARMS Cooperative Agreement Program aims to enhance antibiotic resistance surveillance in retail food specimens. Funded by the FDA, this initiative strengthens the National Antimicrobial Resistance Monitoring System established in 1996. By improving detection methods and expanding sampling sites, the program seeks to protect public health and align with NARMS objectives, ultimately combating the growing threat of antibiotic resistance in food commodities.
Drug-Resistant Bacteria Epidemiology & Public Health

Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01 Clinical Trials Required)

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
American Samoa, Guam +4 more
Up to US $900,000
The RFA-FD-23-001 funding opportunity aims to support clinical trials for orphan products targeting rare diseases. It focuses on evaluating the efficacy and safety of treatments to address unmet medical needs. By promoting innovative and collaborative trial designs, the FDA seeks to enhance the approval rates of effective therapies for rare conditions, ultimately benefiting patients and advancing drug development in this critical area.
Rare Diseases Medical Ethics Human Genome & Genetics

Yéigo Action Grant

First Peoples Fund
Private
United States
Up to US $2,500
The Yéigo Action Grant, provided by the First Peoples Fund, offers financial support ranging from $100 to $2,500 for Native artists and culture bearers facing hardships that affect their creative practices. This grant aims to assist artists with specific professional opportunities, such as workshops or emergencies. By honoring the spirit of encouragement embodied in the Diné word 'yéigo', the grant helps ensure that artists can continue their vital work within their communities.
Art & Culture Indigenous Services Emergency Medical Care & Services +1 more

Rooted Pathways Program

First Peoples Fund
Private
American Samoa, Guam +4 more
Up to US $55,000
The Rooted Pathways Program, initiated by First Peoples Fund, offers essential support to Native-led arts organizations, fostering their growth and stability. This funding empowers these organizations to thrive in their missions, providing unrestricted operating support and participation in a Learning Cohort. Eligible applicants include Native nonprofits and collectives with budgets under $500,000, and the program aims to uplift artists from U.S. federally recognized tribes. This initiative is part of the Wallace Foundation's broader commitment to enhancing well-being in the arts.
Artist Training & Development Community Culture & Heritage Arts / Culture Access & Participation +2 more

Rotary Works Foundation Grant

Rotary Works Foundation Inc.
Private
La Crosse County, Wisconsin, United States
US $500 - US $5,000
The Rotary Works Foundation Grant supports charitable projects primarily focused on children, youth, and families, emphasizing active Rotarian involvement. Grants range from $500 to $5,000, awarded prior to events. Eligible applicants include 501(c)(3) or 501(c)(1) organizations. Preference is given to projects engaging Rotarians. The application deadline is the 2nd Wednesday of each month, and all grantees must report outcomes post-project.
Youth Services Youth Development & Leadership Youth Involvement in the Arts +2 more

Native Performing Arts Live Production Grant (LPG)

First Peoples Fund
Private
United States
US $30,000
The Native Performing Arts Live Production Grant (LPG) supports Native artists and organizations in staging live performances, fostering cultural expression. With a $30,000 grant for one year, this initiative prioritizes projects that actively engage Native performers, enhancing their artistic skills and community connections. By addressing the unique needs of Native creators, the program aims to empower them with resources, mentorship, and equitable opportunities in the performing arts landscape.
Music Theater Dance +1 more

Native Performing Arts Fellowship (NPA) Fellowship

First Peoples Fund
Private
United States
Up to US $10,000
The Native Performing Arts Fellowship (NPA) supports Native artists in enhancing their craft through grants of up to $10,000. This fellowship prioritizes personal artistic development over project-based funding, encouraging applicants to focus on growth through classes, workshops, and professional mentorship. Eligible candidates must be U.S.-based, 18 years or older, and enrolled members of recognized tribes. The program emphasizes Indigenous values in performing arts, fostering resilience and cultural expression.
Performing Arts Native American Culture & Heritage Arts / Culture Access & Participation

Jennifer Easton Community Spirit Award

First Peoples Fund
Private
United States
Up to US $50,000
The Jennifer Easton Community Spirit Award honors Native artists who have dedicated their lives to sharing cultural knowledge and ancestral gifts. With a grant of $50,000, this award supports artists deeply rooted in their communities, fostering healing and resilience. Nominations are open for practicing artists across various mediums, including music, dance, and storytelling, ensuring the continuation of Indigenous traditions and the enrichment of Native culture.
Native American Culture & Heritage Arts / Culture Access & Participation Folk Art / Traditional Art

Cultural Capital (CC) Fellowship

First Peoples Fund
Private
United States
US $10,000
The Cultural Capital Fellowship offers $10,000 grants to Native artists and culture bearers dedicated to community outreach and cultural preservation. This fellowship strengthens the Collective Spirit of First Peoples artists, emphasizing the importance of passing on ancestral knowledge and maintaining cultural sharing. Eligible applicants must have strong ties to their Native community and be committed to sustaining cultural practices. The fellowship aims to support those who promote generosity, wisdom, and integrity within their communities.
Community Culture & Heritage Folk Art / Traditional Art Native American Culture & Heritage

Artist in Business Leadership (ABL) Fellowship

First Peoples Fund
Private
United States
US $10,000
The Artist in Business Leadership (ABL) Fellowship supports Native artists in building sustainable art-centered businesses. This yearlong program provides $10,000 in funding along with professional development and networking opportunities. Eligible applicants must be 18 years or older, reside in the U.S., and be enrolled in or have lineage from a federally recognized tribe. The fellowship aims to empower artists to thrive within their communities while honoring their cultural heritage.
Art & Culture Native American Culture & Heritage Business Development

MASOT Conney W. Berger Jr., PhD, DABT, Memorial Graduate Student Award

Society of Toxicology
Association/Society
United States
Unspecified amount
The MASOT Conney W. Berger Jr. Memorial Graduate Student Award, established in honor of a dedicated toxicologist, supports doctoral students in toxicology/pharmacology. Eligible candidates must present at the MASOT meeting and meet specific criteria, including GPA requirements and MASOT membership. This award, valued at $500, encourages academic excellence and is made possible through the generous support of SafeBridge Consultants, Inc.
Environmental Chemistry & Toxicology

Jeanette Zaichkin NRP Nursing Grant for Excellence and Innovation in NRP Education

American Academy Of Pediatrics
Private
Canada, United States
Up to US $10,000
The Jeanette Zaichkin NRP Nursing Grant for Excellence and Innovation in NRP Education supports nurses dedicated to enhancing neonatal resuscitation training. This grant, offered by the American Academy of Pediatrics, provides up to $10,000 for innovative projects addressing key gaps in transitional physiology and evidence-based practices. Eligible applicants must be current NRP Instructors and work in neonatal care settings. The initiative aims to empower nurses in teaching essential skills for successful newborn resuscitation.
Nursing Obstetrics & Neonatal Care Medical Education & Professional Training +1 more

NRP Young Investigator Award

American Academy Of Pediatrics
Private
Canada, United States
Up to US $15,000
The NRP Young Investigator Award is designed to support research on optimizing newborn care during delivery using Neonatal Resuscitation Program (NRP) techniques. This grant encourages innovative projects addressing gaps in transitional physiology and resuscitation practices. Eligible applicants include researchers from Canadian and US institutions, particularly those in training or within four years of completing medical training. Awardees may receive up to $15,000 to enhance their skills and knowledge, ultimately improving neonatal outcomes.
Obstetrics & Neonatal Care Medical Education & Professional Training Human Physiology +3 more

William Coon Jr. Scholarship

United States Adult Cystic Fibrosis Association (USACFA)
Association/Society
United States
US $2,500
The William Coon Jr. Scholarship, offered by the USACFA, provides four $2,500 awards annually for students with cystic fibrosis pursuing degrees in various fields. Applications require transcripts, proof of enrollment, and essays, focusing on financial need and academic performance. Winners receive full or half awards based on their enrollment status. This scholarship honors Bill Coon Jr.'s legacy, supporting individuals facing similar health challenges and promoting their educational aspirations.
Academic Scholarship Programs Cystic Fibrosis

What’s Your Gap Grant

BreatheStrong CF
Association/Society
United States
Unspecified amount
The What’s Your Gap Grant, provided by BreatheStrong CF in partnership with the Closing the Gap Foundation, supports teens and adults living with cystic fibrosis. This grant alleviates financial barriers, allowing recipients to pursue health and wellness opportunities tailored to their individual goals. It aims to empower applicants who envision a healthier lifestyle but face challenges in achieving it, serving as a catalyst for positive change in their lives.
Cystic Fibrosis Wellness & Healthy Living

Loretta Morris Memorial Grants

BreatheStrong CF
Association/Society
United States
Up to US $750
The Loretta Morris Memorial Grants support individuals with cystic fibrosis in California who wish to engage in physical activities such as swimming, horseback riding, dance, or golf. Established in memory of Loretta Morris, this fund aims to help recipients enjoy the benefits of an active lifestyle. Applications are welcomed from both children and adults, promoting inclusivity and well-being within the CF community. Note that certain items, like memberships or accessories, are not eligible for funding.
Dance Cystic Fibrosis Swimming +2 more

NESOT Fall Meeting Student Poster Awards

Society of Toxicology
Association/Society
United States
US $125 - US $750
The NESOT Fall Meeting Student Poster Awards, presented by the Society of Toxicology, recognize outstanding student presentations at the Northeast Regional Chapter Fall Meeting. Eligible candidates include undergraduate, graduate, and post-baccalaureate students who are NESOT members. Awards include $750 for 1st place, $500 for 2nd, and $250 for 3rd, along with a separate $125 award for an undergraduate poster presentation, fostering engagement and excellence in the field of toxicology.
Environmental Chemistry & Toxicology

Path to a Cure (PTAC) - Postdoc-to-Faculty Transition Award

Cystic Fibrosis Foundation
Private
United States
Up to US $86,000
The Path to a Cure (PTAC) - Postdoc-to-Faculty Transition Award by the Cystic Fibrosis Foundation supports postdoctoral fellows in advancing their research careers in cystic fibrosis. This program offers up to five years of funding, including 3 years for research training and 2 years for transitioning to an independent faculty position, with a maximum support of $110,000 per year. It aims to foster innovative research that develops new therapies for cystic fibrosis.
Cystic Fibrosis

Harry Shwachman Clinical Investigator Award

Cystic Fibrosis Foundation
Private
United States
Up to US $133,000
The Harry Shwachman Clinical Investigator Award, offered by the Cystic Fibrosis Foundation, supports clinically trained physicians transitioning to independent researchers in cystic fibrosis. It provides up to $133,000 per year for three years to facilitate research tailored to individual interests. The funding covers personnel costs and supplies, promoting a strong mentorship during this critical stage of their academic careers.
Cystic Fibrosis

Cystic Fibrosis Foundation: Travel Award Supplement

Cystic Fibrosis Foundation
Private
United States
Up to US $3,000
The Cystic Fibrosis Foundation offers a Travel Award Supplement aimed at supporting Ph.D. students, postdoctoral fellows, and junior faculty. This funding of up to $3,000 enables trainees to participate in off-site workshops or training programs to enhance their research skills. Eligible applicants must be active researchers in CF projects, with a minimum of one year of experience. The program excludes conference attendance and for-profit entities, ensuring focused support for advancing cystic fibrosis research.
Cystic Fibrosis

Cystic Fibrosis Foundation: Student Traineeship Award

Cystic Fibrosis Foundation
Private
United States
Up to US $4,000
The Cystic Fibrosis Foundation's Student Traineeship Award supports students in engaging with cystic fibrosis research through hands-on projects. With a maximum funding of $4,000 for one year, the program aims to inspire students to pursue careers in CF research or care. Eligible applicants must be enrolled in a degree program and collaborate with a faculty mentor on a relevant project. This initiative also emphasizes the importance of maintaining interest in CF-related research among new generations.
Cystic Fibrosis

Cystic Fibrosis Foundation: Screening Improvement Program (SIP) Award

Cystic Fibrosis Foundation
Private
United States
Up to US $75,000
The Cystic Fibrosis Foundation's Screening Improvement Program (SIP) Award aims to enhance early diagnosis of cystic fibrosis (CF) through improved newborn screening processes. This initiative emphasizes equitable screening practices for diverse populations and seeks innovative approaches to strengthen communication with primary care providers. Grants of up to $75,000 per year for two years are available to support projects that focus on algorithm transformation and best practices in screening, without funding clinical trials.
Cystic Fibrosis Genetic Conditions & Birth Defects

Cystic Fibrosis Foundation: Program for Adult Care Excellence (PACE)

Cystic Fibrosis Foundation
Private
United States
Up to US $36,000
The Cystic Fibrosis Foundation's Program for Adult Care Excellence (PACE) aims to enhance adult care for cystic fibrosis patients by recruiting and training physicians. With an increasing life expectancy for CF patients, the program addresses the need for specialized adult caregivers. Physicians can apply for funding up to $38,435 per year for three years, enabling them to develop expertise in adult CF care. This initiative supports both the medical community and the CF population significantly.
Cystic Fibrosis Medical Education & Professional Training

AO North America: VET Preceptorships Program

Ao North America Inc
Private
United States
US $2,750
The AO North America VET Preceptorships Program offers surgical residents from the American College of Veterinary Surgeons the chance to enhance their skills in Veterinary Trauma and Orthopedics through a structured training experience. Participants can receive up to four weeks of advanced training in AO techniques at designated surgical centers, with funding available for housing and travel expenses, totaling up to $2,750. This initiative aims to foster professional development and improve patient care outcomes.
Veterinary Science & Services Orthopedics

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

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