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Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

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9,242 Results based on applied filters

Stephen J. White Prize

American Philosophical Association Inc
Private
United States
US $1,000
The Stephen J. White Prize, established by the American Philosophical Association, honors the late Dr. Stephen J. White and is awarded biennially to the best published paper by a junior philosopher. It focuses on themes central to Professor White's work, such as moral responsibility and practical reasoning. The winner receives a $1,000 monetary award and a symposium at an APA divisional meeting, recognizing significant contributions in philosophy.
Philosophy

Indigenous Tomorrows Fund Grant

Native Americans In Philanthropy
Private
United States
Unspecified amount
The Indigenous Tomorrows Fund (ITF) is a youth-led initiative by Native Americans in Philanthropy aimed at supporting Indigenous youth leadership and community-driven solutions. In its 2025 pilot year, ITF will award up to 24 grants of $30,000 each to projects that enhance cultural continuity and sustainable futures. Priorities include promoting food justice, advancing community health, and strengthening cultural connections, particularly those addressing inequity and fostering long-term healing.
Food Access & Hunger Indigenous Services Wellness & Healthy Living

Tuttleman Foundation Grants

Tuttleman Foundation
Private
United States
US $1,000 - US $250,000
The Tuttleman Foundation, established in Philadelphia in 2003, provides grants ranging from $1,000 to $250,000 to 501c3 organizations. Guided by the legacy of Stanley and Edna Tuttleman, the foundation focuses on areas such as education, community building, health care, arts and museums, basic human services, and spirituality. Their engaged philanthropy aims to support enduring benefits for the communities they serve, reflecting the founders' commitment to impactful giving.
Museums & Cultural Institutions Basic Human Needs Religion & Spirituality +1 more

Murray Watson, Jr. Scholarship

Brazos Higher Education Service
Private
United States
US $5,000
The Murray Watson, Jr. Scholarship offers a $5,000 award each month to Texas students. Funded by Brazos Higher Education, this scholarship aims to support students in achieving their college dreams, whether they are high school seniors or current college attendees. Eligibility includes being a Texas resident with a minimum GPA of 3.3. This initiative is part of Brazos' commitment to making education more accessible and affordable for Texas families.
Academic Scholarship Programs

BHT Community Sponsorship

Better Health Together
Private
United States
Up to US $5,000
Better Health Together (BHT) is committed to enhancing community wellness through sponsorships. By collaborating with over 100 organizations in eastern Washington, BHT addresses critical health issues and supports events that elevate community voices. Organizations seeking funding should submit applications at least 6–8 weeks prior to their event to ensure timely review. BHT values partnerships that align with its mission and aims to invest in innovative solutions for community health challenges.
Community Services Community Health Education Physical Fitness

Merkin Peripheral Neuropathy and Nerve Regeneration Center: Seed Grants

Johns Hopkins
Private
United States
Up to US $150,000
The Johns Hopkins Merkin Peripheral Neuropathy and Nerve Regeneration Center offers Seed Grants for innovative research on peripheral neuropathy and nerve regeneration. These grants support high-risk, high-reward pilot projects addressing axon degeneration and Schwann cell dysfunction. Researchers may apply for funding of up to $75,000 per year for one or two years. The initiative aims to foster novel ideas and successful transitions to external funding, enhancing scientific understanding and therapeutic development.
Neurological Diseases & Disorders

Financial Assistance & Scholarships for Education

Pizza Hut Foundation
Private
United States
US $500 - US $5,000
The Pizza Hut Foundation is offering scholarships for students demonstrating financial need and community leadership. Eligible applicants must be U.S. residents aged 17-26, enrolled in accredited post-secondary education for Spring 2026, and maintain a minimum GPA of 2.5. Scholarship amounts range from $500 to $5,000, with distribution to be made in Spring 2026. The application period runs from July 8 to September 5, 2025, with notifications for recipients by November 17, 2025.
Vocational & Trade Education Academic Scholarship Programs College Success / Persistence

Clinical & Translational Science Award TL1 Postdoc Fellowship Training Grant

National Center for Advancing Translational Sciences (NCATS)
Federal Government
United States
Unspecified amount
The Clinical & Translational Science Award TL1 Postdoc Fellowship Training Grant offers comprehensive support for biomedical researchers at Vanderbilt University. This program empowers scholars through career development tools, mentoring opportunities, and participation in national Translational Science meetings. Trainees must hold a doctoral degree and be committed to translational research while pursuing full-time training. This fellowship fosters innovation and collaboration among researchers, enhancing their contributions to the field.
Human Physiology Health & Medicine

Gerald & Sybil Cohen Family Foundation Scholarship

Gerald & Sybil Cohen Family Foundation
Association/Society
United States
More than US $2,500
The Gerald & Sybil Cohen Family Foundation Scholarship aims to ease the financial burden of college costs for students pursuing education in STEM fields. Open to U.S. citizens aged 18 and older with a minimum GPA of 3.5, the scholarship is available for public colleges and universities. Preference is given to dependents of former employees of Information Builders, Inc. Awards are not guaranteed and may vary in amount.
Academic Scholarship Programs College Success / Persistence

Path to a Cure (PTAC) - Postdoctoral Research Fellowship Award

Cystic Fibrosis Foundation
Private
United States
Up to US $76,000
The Cystic Fibrosis Foundation offers the Path to a Cure (PTAC) Postdoctoral Research Fellowship Award to support innovative research training in cystic fibrosis (CF). Aimed at enhancing scientific knowledge and facilitating the transition to independent careers, this program funds projects targeting the development of new therapies for CFTR variants. Awards can reach up to $75,000 in the first year and $76,000 in the second year, fostering foundational research that could lead to breakthroughs in CF treatment.
Cystic Fibrosis

NRP Research Grant Program

American Academy Of Pediatrics
Private
Canada, United States
Up to US $50,000
The NRP Research Grant Program offers up to $50,000 for healthcare professionals to explore optimal neonatal resuscitation methods. It encourages innovative research addressing gaps in transitional physiology and effective teaching of resuscitation skills. Applications must focus on evidence-based practices and demonstrate potential for meaningful impact in delivery room care. Researchers from Canadian and US institutions are eligible, though applications primarily focused on quality improvement without a research emphasis will not be considered.
Cognitive Science Obstetrics & Neonatal Care Maternal And Perinatal Health +3 more

Robert J. Keown Trust Grant

KEOWN ROBERT J TUW
Private
United States
US $10,000 - US $20,000
The Robert J. Keown Trust, established in 1934, provides financial assistance to needy Christians through grants to charitable organizations. Managed by Wells Fargo Bank N.A., the trust focuses on supporting organizations that benefit residents of Los Angeles County. Eligible organizations must be 501(c)(3) exempt. Preference is given to requests aiding needy Christians and elderly women. The trust awards an average of four grants per year, fostering community support and outreach.
Senior Services Basic Human Needs Christianity +2 more

Jennie K. Scaife Charitable Foundation Grant

Jennie K Scaife Charitable Foundation Inc
Private
United States
Unspecified amount
The Jennie K. Scaife Charitable Foundation Grant focuses on enhancing family support, women's and children's health, and animal welfare. It aims to fund programs that promote beneficial human-animal interactions and early intervention in addiction prevention. Eligible organizations must have a valid 501(c)(3) designation. Grants align with at least one of the foundation's focus areas, ensuring impactful contributions to community welfare and well-being.
Children’s Health & Pediatrics Women & Girl Services Addiction & Substance Use Disorders +2 more

Campership Grant

Colburn-Keenan Foundation
Private
United States
Up to US $500
The Campership Grant, offered by the Colburn-Keenan Foundation, aims to support children affected by chronic inherited bleeding disorders by providing up to $500 for camp attendance. This initiative is designed to help families send their children to specialized camps, fostering community and support. Eligible applicants include children under 18 with chronic illnesses and those whose siblings or parents are affected. The program emphasizes the importance of community engagement and aims to alleviate financial burdens for families.
Summer Camps

Camp Equipment & Capital Improvement Grant Program

Colburn-Keenan Foundation
Private
United States
Unspecified amount
The Camp Equipment & Capital Improvement Grant Program, established by the Colburn-Keenan Foundation, aims to enhance the experiences of children with chronic inherited bleeding disorders. This initiative provides funding to camps for acquiring new equipment or improving facilities, emphasizing the importance of a supportive environment for these children. Eligible camps must serve at least 25% of participants affected by such disorders, ensuring that the assistance directly impacts those in need.
Summer Camps

Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
US $2,500,000
The National Institutes of Health is launching a funding opportunity to explore the mechanisms of skin injuries caused by toxic chemicals. This initiative aims to understand the common pathways of injury from various harmful substances, facilitating the discovery of therapeutic targets. Researchers are encouraged to collaborate and apply their expertise in cutaneous wound healing. The goal is to develop broad-spectrum medical countermeasures for mass casualty events involving toxic exposures, enhancing public health safety.
Cell Biology Environmental Chemistry & Toxicology Wounds & Injuries +1 more

Maximizing Investigators' Research Award

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $750,000
The Maximizing Investigators' Research Award (MIRA) program, established by NIGMS, aims to enhance research funding efficiency by providing stable financial support to investigators. This allows for greater scientific flexibility and encourages innovative studies. MIRA is pivotal for distributing funding among promising researchers, fostering groundbreaking research. The program invites applications from eligible NIGMS-funded and NIH-defined New Investigators, as well as current MIRA grantees seeking renewal, ensuring a broad and inclusive approach to advancing science.
Biology Biochemistry Medical Education & Professional Training

Peter Chortek Leadership Award

Jewish Community Foundation Of San Diego
Private
United States
Up to US $9,540
The Peter Chortek Leadership Award honors Jewish high school students in San Diego who demonstrate outstanding leadership and commitment to community service through tikkun olam. Awardees receive a $9,000 stipend, $540 to set up a Donor Advised Fund, and a professional video showcasing their project. This award encourages students to create or enhance community initiatives, fostering engagement in social justice and service projects.
Community Development & Revitalization

Delta Scholarship

Jewish Community Foundation Of San Diego
Private
United States
Up to US $40,000
The Delta Scholarship aims to support college-bound minority students in San Diego County who are dedicated to pursuing higher education. Established in memory of Jim Lewis, a passionate community leader, this scholarship offers up to $10,000 per student annually for four years, based on financial need. Eligible applicants must be graduating high school seniors with a minimum GPA of 3.0, planning to attend an accredited college or university.
Education - Higher Education Career / College Preparation Academic Scholarship Programs

College Now Greater Cleveland Manufacturing Scholarship

College Now Greater Cleveland
Association/Society
United States
Up to US $2,000
The College Now Greater Cleveland Manufacturing Scholarship offers financial assistance to high school graduates pursuing training in manufacturing. Awarded funds, up to $2000, are sent directly to educational institutions for related expenses. Applicants must reside in specific Ohio counties and be enrolled in eligible programs. This scholarship aims to support individuals seeking vocational training, certifications, or degrees within a two-year timeframe, fostering career development in the manufacturing sector.
Vocational & Trade Education

Cardiothoracic Surgical Trials Network (CTSN) Linked Clinical Research Centers

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NHLBI is set to release a NOFO aimed at enhancing an international research platform for cardiac surgery. This initiative will integrate various research areas, including mechanistic science and implementation science, to advance innovative techniques and improve health outcomes for adults with cardiovascular disease. Furthermore, the platform will serve to train future clinical trialists. Potential applicants are encouraged to start forming collaborations and preparing their proposals, as applications are not yet being solicited.
Bioengineering Pharmacology Cardiovascular Diseases & Systems +1 more

Forecast to Publish a Notice of Funding Opportunity for Paul Calabresi Career Development Award in Clinical Oncology (K12 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Cancer Institute (NCI) plans to issue a Notice of Funding Opportunity (NOFO) for the Paul Calabresi Career Development Award in Clinical Oncology (K12). This program aims to enhance training for clinician-scientists in cancer research, fostering their career development and collaboration with basic research scientists. It mandates diverse oncology specialties in faculty, individualized career development plans, and mentorship, supporting Scholars for up to three years to promote their research initiatives in clinical trials.
Cancer / Oncology Biotechnology Health Policy & Advocacy +1 more

EA Funds : EA Infrastructure Fund Grant

Centre For Effective Altruism Usa Inc
Private
Countries
US $10,000 - US $300,000
The EA Infrastructure Fund Grant supports projects that enhance effective altruism by improving access to talent, capital, and knowledge. With grants typically ranging from $5,000 to $200,000, it welcomes applications from individuals, nonprofits, and academic institutions worldwide. However, individuals must ensure their projects conclude by August 31, 2025. The fund aims to amplify the impact of direct charitable work and foster a community committed to effective altruism principles.
Volunteerism & Philanthropy Nonprofit Growth & Development Community Services +1 more

EA Funds: Animal Welfare Fund Grant

Centre For Effective Altruism Usa Inc
Private
Countries
Up to US $200,000
The EA Funds: Animal Welfare Fund Grant aims to enhance the welfare of nonhuman animals globally through strategic grants. It focuses on neglected regions, innovative research, and impactful advocacy, particularly for farmed and wild animals. The fund supports projects that alleviate suffering, promote alternatives to factory farming, and engage in policy advocacy. By contributing to this grant, you can help create a significant positive impact on animal welfare and support initiatives that are often overlooked.
Animal Welfare - General Animal Welfare - Domestic Animals & Pets Farms & Farming +2 more

William C. Risser Charitable Trust Grants

William C Risser Irrev Trust 1865-4019875730
Private
United States
US $25,000 - US $55,000
The William C. Risser Charitable Trust Grants support mental health research, particularly in Schizophrenia. This private foundation assists 501(c)(3) nonprofit organizations across the U.S. with grants typically ranging from $25,000 to $55,000. Administered by Wells Fargo, the Trust awards 1-2 grants annually, focusing on program support for scientific and educational research. Eligible organizations must meet IRS exemption requirements.
Schizophrenia

Age-Friendly Health Systems Cohort Scholarships for the AHA Next Generation Leaders Fellowship

John A Hartford Foundation
Private
United States
US $13,995
The John A. Hartford Foundation offers scholarships for the Age-Friendly Health Systems Cohort as part of the AHA Next Generation Leaders Fellowship. This initiative targets healthcare leaders aiming to implement the 4Ms Framework, enhancing care for older adults. Selected fellows will receive a program fee scholarship of $13,995, enabling them to focus on transformation efforts in health systems. This fellowship seeks diverse leaders to address critical healthcare challenges and improve quality, safety, and affordability.
Senior Services Aging / Gerontology Patient Care & Services +5 more

Anna B. Glauser Trust Grants

Anna B Glauser Trust Will Nect
Private
United States
US $2,500 - US $5,000
The Anna B. Glauser Trust Grants provide financial support to organizations aiding physically handicapped individuals, particularly blind residents in Delaware County, PA. Established in memory of Willis K. Glauser, the trust awards 1-2 grants annually, ranging from $2,500 to $5,000. Eligible organizations must be 501(c)(3) certified, while funding for salaries is typically excluded. This initiative reflects Anna Glauser's lifelong commitment to assisting the visually impaired community.
Vision Impairment Care & Services Physical Disabilities

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

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