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Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

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9,246 Results based on applied filters

Strategic Projects: Capital Grants

M J Murdock Charitable Trust
Private
United States
More than US $100,000
The Strategic Projects: Capital Grants by the M J Murdock Charitable Trust offer vital funding opportunities for nonprofit organizations in the Pacific Northwest. These grants support transformative projects that enhance community well-being through construction, renovation, and infrastructure investments. Eligible entities include 501(c)(3) nonprofits and government entities. The Trust emphasizes projects that demonstrate strong community impact and funding diversification, ensuring sustainable growth and lasting benefits for the communities served.
Nonprofit Growth & Development Art & Culture Education +6 more

Strategic Projects: Equipment & Technology Grants

M J Murdock Charitable Trust
Private
United States
More than US $50,000
The M J Murdock Charitable Trust offers Strategic Projects: Equipment & Technology Grants to nonprofits in the Pacific Northwest. These grants focus on capacity-building projects and essential equipment, requiring recipients to cover at least 50% of costs. Eligible organizations include 501(c)(3) nonprofits and tribal entities. Priority is given to projects enhancing community services, education, and environmental stewardship, supporting initiatives that foster human flourishing and demonstrate diversified funding.
Art & Culture Education Community Services +6 more

Bridging Investments in Abortion and Contraception Research Grant

Society Of Family Planning
Private
United States
Up to US $100,000
The Society of Family Planning is offering the Bridging Investments in Abortion and Contraception Research Grant to support the completion of NIH grants focused on abortion and contraception. This funding aims to mitigate the impact of recent funding terminations by ensuring that vital research continues, promoting equitable access to reproductive health. Proposals can request up to $100,000 and must detail their alignment with the Society's mission, planned activities, and budget within a 24-month timeline.
Reproductive Health Women's Health Reproductive Rights

The Slomo and Cindy Silvian Foundation Grant

Slomo And Cindy Silvian Foundation Inc
Private
United States
Unspecified amount
The Slomo and Cindy Silvian Foundation Grant supports a range of subjects including education, children's welfare, medical care, medical research, and Jewish philanthropic endeavors. Established in honor of Cindy Silvian, the foundation has awarded over $30 million since 2008. Applications are by invitation only, and organizations must meet specific eligibility criteria to be considered for funding. This year, the foundation allocated over $2.4 million to more than 110 organizations, highlighting its commitment to impactful philanthropy.
Education Health & Medicine Child Welfare Services +5 more

Avant Garde Award for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $350,000 - US $700,000
The Avant Garde Award supports innovative research on HIV and substance use disorders, encouraging creative scientists to explore high-risk, high-reward approaches. While applications are not currently being accepted, this initiative by the National Institute on Drug Abuse (NIDA) aims to stimulate collaborations and impactful research. Early-stage investigators are particularly encouraged to consider this opportunity as they develop their proposals for future funding. The program uses the DP1 activity code, fostering transformative advancements in biomedical and behavioral science.
HIV / AIDS Addiction & Substance Use Disorders

NIH Science Education Partnership Award (SEPA)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Science Education Partnership Award (SEPA) fosters innovative educational initiatives aimed at pre-college students, promoting their interest in STEM fields, especially in biomedical and behavioral sciences. This program supports both classroom projects and informal science education activities, such as after-school programs and library events. Emphasizing the development of quantitative and computational skills, SEPA seeks to inspire the next generation of scientists and thinkers through engaging educational experiences.
STEM / STEAM Education Education - K through 12 Biology

Charles Lathrop Parsons Award

American Chemical Society
Association/Society
United States
Up to US $7,500
The Charles Lathrop Parsons Award, presented by the American Chemical Society, honors exceptional public service by ACS members. This prestigious award includes a $5,000 monetary prize and a certificate. Up to $2,500 can be reimbursed for travel expenses related to the award ceremony. It is awarded every two years, although the interval may be shortened at the discretion of the ACS Board for deserving nominees. All eligible members are encouraged to apply.
Chemistry Volunteerism & Philanthropy

Hovland Scholarship

Sioux Falls Area Community Foundation
Private
United States
Unspecified amount
The Hovland Scholarship, offered by the Sioux Falls Area Community Foundation, supports college students of Norwegian descent. Eligible applicants must be full-time students entering their third year at an accredited four-year institution in the U.S., maintain a GPA of 2.0 or higher, and demonstrate financial need. Multiple renewable scholarships are available, contingent upon meeting requirements and funding availability. This scholarship aims to enrich the quality of life through education and philanthropy.
Education - Higher Education

JPF Principal Grant Program RFP

Jacques Pepin Foundation
Private
United States
Up to US $10,000
The Jacques Pepin Foundation (JPF) is dedicated to advancing culinary arts education by supporting community kitchens that provide culinary training to individuals facing employment barriers. Grants of up to $10,000 are available for nonprofits to enhance their culinary programs, including operating costs and facility improvements. Eligibility extends to organizations funded in prior cycles, those that applied but were not funded, and newcomers to JPF funding. This initiative aims to empower underserved communities through culinary skills.
Workforce Preparation & Job Readiness Culinary Arts

Spirit of Sioux Falls Scholarship

Sioux Falls Area Community Foundation
Private
United States
Unspecified amount
The Spirit of Sioux Falls Scholarship supports college students pursuing business degrees while emphasizing community engagement and academic excellence. Eligible applicants must reside in Lincoln or Minnehaha County, South Dakota, and maintain full-time enrollment in appropriate programs. The scholarship aims to inspire philanthropy and improve local quality of life through educational advancement. Notably, previous recipients are ineligible for reapplication, ensuring fresh opportunities for new candidates. Multiple awards are available, promoting further education in the business field.
Education - Higher Education Business Education

Waneta Drake Miller Edmison Non-Traditional Student Scholarship

Sioux Falls Area Community Foundation
Private
United States
Unspecified amount
The Waneta Drake Miller Edmison Non-Traditional Student Scholarship is designed to support individuals aged 24 and older from Minnehaha, Lincoln, Turner, or McCook counties in South Dakota who are pursuing further education. Applicants must be enrolled in at least twelve credit hours at an accredited institution and have completed at least six credit hours in a degree program. This scholarship exemplifies the commitment to lifelong learning and community enrichment.
Education - Higher Education

Worden Christian Youth Ministry Scholarship

Sioux Falls Area Community Foundation
Private
United States
Unspecified amount
The Worden Christian Youth Ministry Scholarship supports full-time students entering their third or fourth year at an accredited four-year college or university, who plan to pursue a career in youth ministry. Candidates must demonstrate financial need and engage in school and community activities. Preference is given to those intending to serve as youth ministers in the Sioux Falls area, ensuring that the scholarship aligns with the mission of enriching local lives through philanthropy.
Education - Higher Education Religious / Theological Education

Good Neighbor Firefighter Safety Program Grant

National Volunteer Fire Council Inc
Private
United States
US $10,000
The Good Neighbor Firefighter Safety Program Grant, initiated by State Farm and the National Volunteer Fire Council, aims to support volunteer fire departments in acquiring critical safety equipment. In 2025, the program will award $1.5 million in grants, providing $10,000 each to 150 eligible departments. This initiative not only enhances firefighter safety and operational efficiency but also fosters community service, ensuring that these departments are well-equipped to respond effectively to emergencies.
Firefighting & Fire Prevention

Strategic Impact Grant

Bertin Family Foundation
Private
Countries
Unspecified amount
The Bertin Family Foundation Grants support 501(c)(3) public charities that align with the foundation's mission of community strengthening and compassion. Grant requests are accepted annually from July 1 to August 31, focusing on program or project support rather than general endowment. The foundation values measurable outcomes and responsible stewardship, and gives preference to organizations with Gold or Platinum status on Candid.
Disaster Relief / Humanitarian Aid Community Development & Revitalization Human & Social Services +3 more

Store-Based Giving Program Grant

Ross Stores Foundation
Private
United States
US $300 - US $500
The Store-Based Giving Program by Ross Stores Foundation supports socioeconomically disadvantaged youth by providing gift cards for school or professional clothing. Organizations must be federal tax-exempt and serve at least 60% low-income youth. Eligible programs include academic achievement and life skills initiatives. Award amounts typically range from $300 to $500, depending on budget and mission alignment. Applications are not accepted from organizations that have received donations within the past 12 months.
Youth Services Financial Literacy Career / College Preparation +2 more

CHEST Travel Grant

American College Of Chest Physicians
Private
United States
US $1,000
The CHEST 2025 Travel Grant aims to foster inclusivity in chest medicine by supporting diverse healthcare professionals. Recipients receive complimentary registration and $1,000 for attending the CHEST Annual Meeting in Chicago. Open to CHEST members from historically excluded backgrounds, the grant enhances professional growth and engagement in the field. With a focus on diversity and equity, the program also offers opportunities for mentorship, contributing to the development of future leaders in chest medicine.
Community Services Medical Education & Professional Training Health Policy & Advocacy

Peer Education Grant

Organization For Autism Research
Private
United States
US $500 - US $10,000
The Peer Education Grant, offered by the Organization for Autism Research, aims to enhance autism acceptance among children by providing educational resources and funding for initiatives. Grants of up to $10,000 support school-wide projects, with smaller grants available for other activities. Eligible applicants include educators and community organization leaders focused on autism awareness, particularly in low-income areas. This initiative fosters inclusive relationships and understanding between children and their autistic peers.
Autism

Founders’ Award

SAX LLP
Corporate
United States
Up to US $20,000
The Founders’ Award by SAX LLP honors nonprofit organizations demonstrating perseverance in their mission. With a rich history since 1956, SAX aims to empower nonprofits through a $20,000 unrestricted gift for the first place, alongside additional support for second and third places. Eligible applicants must hold a 501(c)(3) tax exemption and attend the awards ceremony if selected among the Top 75. This initiative reflects SAX's commitment to advancing impactful nonprofits in their communities.
All fields of work

Open Ocean Research Grant Program

Global Fishing Watch Inc
Private
Algeria, Andorra +155 more
Up to US $20,000
The Open Ocean Research Grant Program, funded by Global Fishing Watch Inc, aims to enhance ocean governance through data sharing on human activity at sea. It invites researchers to improve technologies for better governance, offering up to $10,000 for individuals and $20,000 for small groups. This initiative strengthens the community of practice and optimizes Global Fishing Watch datasets to maximize their impact on ocean conservation efforts.
Oceanography Marine / Ocean Conservation Marine Biology

USA Football’s Flag Equipment Grant

USA Football
Association/Society
United States
Unspecified amount
USA Football’s Flag Equipment Grant supports youth organizations and schools in need of flag belts and footballs for girls flag football programs. Eligible applicants include legally designated non-profits in good standing with USA Football. The grant provides USA Football-branded equipment, with quantities determined by the application responses. Organizations are unable to select items from a catalog, as awards are issued directly from warehouse partners, ensuring accessibility for participants.
Youth Services Football

AED Grants

USA Football
Association/Society
United States
Unspecified amount
The AED Grant, offered by USA Football, supports youth organizations, middle schools, and high school girls flag football programs in acquiring essential Automated External Defibrillators (AEDs). This initiative ensures that lifesaving equipment is readily available during emergencies. Recipients receive specific AED models, comprehensive training, and certification to guarantee proper usage. Eligible applicants must be non-profits in good standing with USA Football, promoting safety and preparedness on the field.
Youth Services Football

Elisabeth Severance Prentiss Foundation Grant

E S Prentiss Foundation
Private
United States
Unspecified amount
The Elisabeth Severance Prentiss Foundation Grant supports healthcare initiatives in the greater Cleveland area, focusing on medical research, public health promotion, and assistance to local hospitals. The foundation prioritizes grant requests from private sector organizations and favors projects with a duration of three years or less. It does not fund national campaigns, individual scholarships, or endowment contributions. Eligible projects must align with the foundation's commitment to enhancing health services for all, particularly low-income populations.
Health & Medicine Epidemiology & Public Health Surgery +2 more

ASTRO-AstraZeneca SCLC Therapy Challenge RFP

American Society For Radiation Oncology
Association/Society
United States
US $175,000 - US $375,000
The ASTRO-AstraZeneca SCLC Therapy Challenge RFP aims to enhance research on limited-stage small cell lung cancer (LS-SCLC) through innovative combination therapies, particularly integrating immunotherapy with advanced radiation techniques. Proposals are encouraged to explore various aspects, including care patterns, treatment workflows, prognostic biomarkers, and toxicity management. The target budget for projects ranges from $175,000 to $375,000, with consideration given to higher requests based on scientific merit, fostering significant advancements in radiation oncology.
Cancer / Oncology Lung Cancer

CSA Stanley V. and Mary G. Mahalick Scholarship

Center for Scholarship Administration (CSA)
Private
United States
Unspecified amount
The Stanley V. and Mary G. Mahalick Scholarship is a one-year award for deserving students from Mahanoy Area High School or Marian Catholic High School. Funded by the Center for Scholarship Administration, this scholarship supports students with a minimum GPA of 2.5 who demonstrate financial need and good moral character. Recipients may reapply for additional funding up to four years, provided they maintain full-time enrollment in an accredited college or university.
Career / College Preparation Academic Scholarship Programs

McKnight Clinical Translational Research Scholarship in Cognitive Aging and Age-Related Memory Loss

American Academy Of Neurology Institute
Private
United States
Up to US $150,000
The McKnight Clinical Translational Research Scholarship supports young investigators focusing on cognitive aging and age-related memory loss. Funded by the McKnight Brain Research Foundation, this scholarship offers $65,000 annually for two years, plus an education stipend. Eligible applicants should have completed their PhD or residency within the last five years and conduct their research in accredited U.S. institutions. The award emphasizes rigorous training and aims to foster careers in human cognitive aging research.
Neurological Diseases & Disorders Cognitive Science Aging / Gerontology

Dr. Patricia L. Austin Family Physicians of Tomorrow Scholarship

American Medical Association Foundation
Private
United States
US $10,000
The Dr. Patricia L. Austin Family Physicians of Tomorrow Scholarship offers $10,000 in tuition assistance to medical students entering their final year. Sponsored by the AMA Foundation, this program supports a diverse group of students, including those of Eastern European descent and first-generation students. All applicants must be enrolled in accredited U.S. medical schools, ensuring equitable opportunities in pursuing their medical careers, while fostering representation in the field.
Medical Education & Professional Training Academic Scholarship Programs

Pathway to Stop Diabetes Initiator Award (INI)

American Diabetes Association Inc
Private
United States
Up to US $325,000
The Pathway to Stop Diabetes Initiator Award (INI) aims to support early career researchers in diabetes research by providing funding and mentorship. With a focus on innovative and transformational ideas, this initiative encourages researchers to develop groundbreaking solutions for diabetes prevention and management. The award offers up to $100,000 annually in Phase 1 and $325,000 in Phase 2, fostering a new generation of leaders committed to improving the lives of those affected by diabetes.
Diabetes

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

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