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Best South Dakota Grants for Nonprofits

Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.63B

Total funding

$5K

Median grant

9,000+ grants
$2.63B total
$5K median

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9,246 Results based on applied filters

Pathway to Stop Diabetes Accelerator Award (ACE)

American Diabetes Association Inc
Private
United States
Up to US $325,000
The Pathway to Stop Diabetes Accelerator Award supports innovative early-career researchers tackling diabetes-related challenges. It offers flexible funding up to $325,000 annually for transformative research. Candidates must have independent faculty status and demonstrated productivity in diabetes research. The program aims to inspire groundbreaking discoveries by providing essential resources and mentorship, thereby improving the lives of those affected by diabetes. Nominations focus on translational research that bridges basic science with practical benefits for patients.
Diabetes

Collaborative Capacity Program - Standard Grant: Community Partner Applicants

National Forest Foundation (NFF)
Private
United States
US $10,001 - US $75,000
The National Forest Foundation’s Collaborative Capacity Program offers financial awards to enhance collaboration among communities, tribes, and the Forest Service. Aimed at improving wildfire resilience and forest health, these grants support efforts that lead to long-term stewardship outcomes. Funding ranges from $10,001 to $75,000, with a 20% match required. The program seeks to empower local partners to develop strategic plans and strengthen collaborative initiatives, ultimately benefiting National Forest System lands.
Recreation Forestry Fire Ecology +1 more

Collaborative Capacity Program - Standard Grant: Tribal Applicants

National Forest Foundation (NFF)
Private
United States
US $20,000 - US $50,000
The National Forest Foundation’s Collaborative Capacity Program offers financial support to enhance collaboration among local communities and partners, focusing on improving wildfire resilience and forest health. Grants range from $10,001 to $75,000, with a 20% cash or in-kind match requirement. The program aims to foster long-term stewardship outcomes for National Forest System lands, ensuring benefits to both forests and local economies through collaborative efforts.
Recreation Forestry Fire Ecology +1 more

Forecast for Clinical Trial Readiness for Rare Diseases, Disorders, and Syndromes (R21 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
The Forecast for Clinical Trial Readiness for Rare Diseases (R21) aims to enhance the development and testing of diagnostics and therapeutics for rare diseases. This funding opportunity invites researchers to facilitate clinical trial readiness by developing rigorous biomarkers and clinical outcome measures. Through collaborative efforts with various stakeholders, NCATS seeks to improve the efficiency of moving candidate therapeutics towards clinical trials, ultimately increasing the likelihood of successful treatments for rare diseases.
Rare Diseases

NIA Expanding Research in AD/ADRD (ERA) Postbaccalaureate Research Education Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $400,000
The NIA Expanding Research in AD/ADRD Postbaccalaureate Research Education Program aims to enhance the research workforce by providing intensive research experiences for recent graduates. This initiative supports early-stage investigators in Alzheimer's Disease and related dementias, addressing a critical shortage of researchers in the field. Participants engage in independent research, mentorship, and professional development, equipping them with skills necessary for advanced degrees and research careers in aging and dementia. The program fosters innovation and interdisciplinary collaboration essential for advancing AD/ADRD research.
Aging / Gerontology Dementia & Alzheimer’s Disease Medical Education & Professional Training

Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,300,000
This funding opportunity supports the establishment of Animal and Biological Material Resource Centers to enhance biomedical research through the provision of specialized laboratory animals and related resources. It seeks to promote scientific rigor and reproducibility by facilitating the development of new methodologies that complement traditional research. Centers must align with multiple NIH Institutes and focus on integrating innovative approaches like cell culture and computational models, fostering collaboration and advancement in human disease modeling.
Biology

Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $500,000
The NIH invites applications for research projects focusing on developing and enhancing models for studying human health and diseases. Projects must demonstrate broad applicability across multiple NIH Institutes, addressing diseases that impact various organ systems. Successful proposals will outline the need for resources and their potential impact on diverse scientific disciplines. Applications targeting specific diseases or with limited NIH relevance will not be accepted. Deadline for submission is 5:00 PM local time.
Medical Technology, Devices, and Equipment Biomedical informatics Diseases & Conditions

NIA Expanding Research in AD/ADRD (ERA) Summer Research Education Program

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $200,000
The NIA Expanding Research in AD/ADRD Summer Research Education Program supports the recruitment of early-stage investigators and aims to provide hands-on research experiences in Alzheimer's Disease and related dementias. Targeting high school students, undergraduates, and science teachers, the program enhances STEM education through authentic research opportunities and educational activities. By fostering early exposure to research, it aims to stimulate interest in AD/ADRD careers and address workforce shortages in this critical field.
Dementia & Alzheimer’s Disease STEM / STEAM Education

Carnegie-Whitney Grant

American Library Association (ALA)
Association/Society
United States
Up to US $5,000
The Carnegie-Whitney Grant, established by Andrew Carnegie in 1902, supports the creation of bibliographical aids for American libraries. Grants cover the preparation costs of reading lists and indexes, enhancing access to library resources. Eligibility requires projects to stimulate library use and be broadly appealing, with a focus on national distribution. Notably, completed works and projects under contract are ineligible. The fund encourages innovation in library resource development, welcoming applications from individuals and organizations.
Library & Information Science Library Services

Baker and Taylor YALSA Conference Grant

American Library Association (ALA)
Association/Society
United States
US $1,000
The Baker and Taylor YALSA Conference Grant provides two $1,000 awards to librarians working with young adults, enabling them to attend the Annual Conference for the first time. One grant supports a school librarian, while the other is for a public library librarian. Applicants must be current members of ALA/YALSA, with prior membership preferred for at least two years, and must have between one to ten years of experience working with teenagers.
Library Services

Implementing Shared Decision Making in Hemophilia Patient Care

Pfizer, Inc.
Corporate
United States
Up to US $30,000
The Shared Decision Making in Hemophilia Patient Care grant program, funded by Pfizer, aims to enhance patient outcomes through Quality Improvement projects that integrate shared decision-making tools into hemophilia care. This initiative encourages multidisciplinary collaboration to address healthcare disparities and empower patients in their disease management. Eligible organizations include healthcare institutions and professional schools, fostering innovative approaches to improve care for individuals living with hemophilia.
Hematological Systems

Jason Reynolds / Simon & Schuster Travel Grant

American Library Association (ALA)
Association/Society
United States
Up to US $3,000
The Jason Reynolds / Simon & Schuster Travel Grant supports five black/African American youth and teen services librarians annually. Each grant, ranging from $1500 to $3000, covers expenses for travel, housing, registration, and attendance at the ALA Annual Conference, including the Coretta Scott King Awards Breakfast. This initiative aims to empower underrepresented librarians in their professional development and community engagement.
Library Services Black American Services

Clinical Research Training Scholarship in Parkinson's Disease

American Academy Of Neurology Institute
Private
Countries, United States
Up to US $150,000
The Clinical Research Training Scholarship in Parkinson's Disease, funded by the Parkinson's Foundation and the American Brain Foundation, supports young investigators in clinical studies related to Parkinson's disease. Offering $65,000 annually for two years, plus an additional $10,000 for education and research costs, this award aims to foster rigorous clinical research. Eligible applicants must have an MD, PhD, or equivalent degree and be AAN members, focusing on patient-oriented research with human subjects.
Neurological Diseases & Disorders Parkinson’s Disease

Center for the History of Family Medicine Oral History Grant

American Academy of Family Physicians Foundation
Corporate
United States
Up to US $3,000
The AAFP Foundation's Center for the History of Family Medicine Oral History Grant offers up to $3,000 annually for oral history interviews in family medicine. Aimed at researchers, physicians, and students, it encourages the documentation of family medicine's history in the U.S. The grant supports travel and research expenses to enhance the oral history collection, ensuring a diverse representation of experiences and perspectives in the field.
Historical Records & Archives History Of Science

American Indian Services: Trade Scholarship

AMERICAN INDIAN SERVICES
Private
United States
Up to US $2,500
The American Indian Services: Trade Scholarship offers financial support for American Indian and Alaska Native students pursuing trade education. Since its inception over 40 years ago, the program has awarded scholarships to more than 35,000 Native students. Eligible applicants can receive up to $2500, with distinct deadlines for January and September awards. This initiative aims to empower Native students by facilitating access to trade school opportunities.
Vocational & Trade Education Native American Services

Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
This funding opportunity aims to support innovative research projects targeting previously undruggable classes of proteins associated with challenging human diseases. By encouraging early-stage exploratory projects, it seeks to foster the development of novel methods and agents that can selectively modulate these hard-to-target proteins, ultimately advancing therapeutic strategies and improving patient outcomes.
Pharmacology Rare Diseases

Greenpoint Foundation Grant

Greenpoint Foundation Inc.
Private
United States
Unspecified amount
The Greenpoint Foundation Grant aims to enhance community life by supporting organizations that focus on agriculture, food security, education, and community enhancement. Established in 2022, the Foundation accepts grant applications year-round for both general operating budgets and specific projects. Priority is given to 501(c)(3) organizations and local government entities, while faith-based programs are considered on a case-by-case basis. Grant recipients must submit impact reports to ensure continued support.
Education Agriculture Food Security +2 more

AFS Travel Grant

Austin Film Society
Private
Africa, Americas +4 more
US $500 - US $1,000
The AFS Travel Grant, offered by the Austin Film Society, supports Texas-based filmmakers by covering travel costs to competitive film festivals worldwide. Since its inception, the grant has provided crucial financial assistance, enabling filmmakers to gain exposure and foster industry connections. Eligible applicants can receive up to $1,500 for travel, helping them navigate the financial challenges of festival participation. This initiative strengthens the local creative community and promotes diverse storytelling in the film industry.
Film

Strategic Projects: Program & Staff Grants

M J Murdock Charitable Trust
Private
United States
More than US $50,000
The M J Murdock Charitable Trust offers the Strategic Projects: Program & Staff Grants to support nonprofits in the Pacific Northwest. These grants focus on capacity-building for mission-driven projects and infrastructure investments. Eligible organizations must demonstrate a commitment to community flourishing, with funding available for new programs or expansion of existing ones. The Trust prioritizes initiatives that align with its strategic goals, fostering sustainable nonprofit growth and impact in the region.
Art & Culture Education Community Services +6 more

Christina Sue Lilja Resource Grants

American Farm Bureau Federation
Association/Society
United States
US $100
The Christina Sue Lilja Resource Grants support agricultural literacy by providing funds for educators to purchase resources from the Ag Foundation store. In 2025, 100 educators will receive $100 in store credits, selected randomly if applications exceed this number. This initiative, backed by the CSL Foundation, honors Christy Lilja's legacy of advocating for agricultural education. The grants aim to enhance classroom resources and improve students' understanding of agriculture, ensuring access to accurate information.
Agriculture Agricultural Education Education - K through 12

The XENO PRIZE for Artists’ Books

Franklin Furnace Fund
Private
United States
US $5,000
The XENO PRIZE for Artists’ Books offers a $5000 grant to support the publication of an artist's book addressing the themes of book banning and burning. Open to independent artists in the U.S., the prize will be awarded based on submissions to be accepted starting March 1, 2025. A minimum of 100 copies must be printed, with winners announced in September 2025. This initiative aims to highlight and preserve avant-garde art forms and their cultural significance.
Art & Culture Art Education Cross-Cultural Understanding & Exchanges +1 more

AE Foundation Community Grants

AE FOUNDATION
Private
Canada, United States
Up to US $10,000
The AE Foundation Community Grants aim to support US and Canadian non-profit organizations focused on enhancing the mental health and well-being of young people. By funding local programs, the AE Foundation empowers teens and young adults to embrace authenticity and build a brighter future. Eligible organizations must be certified 501(c)3 non-profits or registered charities, and grant funding should be utilized within 365 days of receipt. This initiative reinforces the importance of mental health in today's society.
Mental Health & Psychiatric Diseases Youth Services Wellness & Healthy Living

Garden Club of Houston Grant

Garden Club Of Houston
Private
United States
Unspecified amount
The Garden Club of Houston, established in 1924, promotes gardening and environmental conservation through various community initiatives. Their funding supports nonprofit organizations and government entities, focusing on projects that enhance public landscapes, educational resources, and community gardens. Grants are not awarded for operating funds or endowments, with preference given to projects within the greater Houston area. This commitment to civic improvement underscores their mission to foster a love of gardening and environmental stewardship.
Horticulture & Gardening Greening & Beautification Parks & Public Spaces

Staff Research Program (359236)

US DOD: U.S. Army Materiel Command
Federal Government
United States
US $200,000 - US $10,000,000
The Staff Research Program, initiated by the ARO, aims to enhance the professional skills of its scientific staff through collaborative basic research with external institutions. This program encourages hands-on scientific investigations in various fields, including engineering and life sciences, while ensuring the integrity of the ARO's mission. ARO scientists will not act as principal investigators on proposals but will contribute to research outcomes and educational activities, fostering knowledge advancement and collaboration.
STEM / STEAM Education Military Operations Emerging Technology Development

Illuminations Grant for Black Trans Women Visual Artists

Queer Art
Private
American Samoa, Guam +4 more
US $10,000
The Illuminations Grant for Black Trans Women Visual Artists, a $10,000 annual grant, supports early-career Black trans women artists in the U.S. whose contributions to visual arts are often overlooked. Established in partnership with notable figures, this grant not only provides funding but also offers professional development resources. In its fifth year, it aims to address systemic barriers and enhance representation in the arts, with additional awards for finalists to further their artistic journeys.
Visual Arts

Alfred H. and Janet L. Lander Family Charitable Foundation Grant

Alfred H Lander and Janet L Lander Family Charitable Foundation
Private
United States
Unspecified amount

We support community programs that promote health, education, and human dignity.

The Alfred H. Lander and Janet L. Lander Family Charitable Foundation is a qualified 501(c)(3) private operating foundation that conducts charitable work that meets our mission statement. The Foundation seeks to uplift individuals and families through community programming in the following three areas:

  • Programs promoting and supporting the physical and mental health of the community through fitness opportunities and access to services, resources, and qualified care providers.
  • Educational programs providing a strong foundation for learning at all ages and levels, including those that improve workforce placement and success.
  • Programs assisting individuals and families in meeting basic needs and include a pathway for upward mobility.
Basic Human Needs Poverty Alleviation & Services Workforce Preparation & Job Readiness +6 more

World Trade Center Scholarship (NJ)

New Jersey Higher Education Student Assistance Authority
State/Local Government
New Jersey, United States
Unspecified amount
The World Trade Center Scholarship in New Jersey provides financial support to dependent children and surviving spouses of residents who lost their lives in the September 11 attacks. Administered by HESAA, this scholarship covers tuition, fees, and other educational costs at eligible institutions. Applicants must be full-time students and maintain satisfactory academic progress. The award amount varies each year based on funding and need, ensuring that assistance is available to those who have lost financial support due to these tragic events.
Education - Higher Education

South Dakota Grants for Nonprofits Highlights

South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.


Search Instrumentl's South Dakota Grants Database


Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : South Dakota Grants for Nonprofits

Grant Availability

How common are grants in this category?

Uncommon — grants in this category are less prevalent than in others.

100+ South Dakota grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

30 South Dakota grants for nonprofits over $25K in average grant size

23 South Dakota grants for nonprofits over $50K in average grant size

23 South Dakota grants for nonprofits supporting general operating expenses

91 South Dakota grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?

Most grants are due in the first quarter.

Q1
34.7%
Q2
24.6%
Q3
19.8%
Q4
21.0%

Typical Funding Amounts

What's the typical grant amount funded for South Dakota Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$89,650 $89.7 K Average
$1,250,000 $1.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.

Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:

  • State & Local Government: The state of South Dakota offers over 29 grants. Many of these funding opportunities focus on agriculture.
  • Private Foundations: Around 43 private foundation grants are available in the state of South Dakota, with focus areas ranging from rural development to health and medicine.
  • Corporate Funders: There are around 17 open corporate grants. These grants mainly focus on agriculture and human and social services.

Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.

The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.

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