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Find nonprofit grants in South Dakota, including opportunities in Sioux Falls, Rapid City, and Aberdeen. Updated listings for 501(c)(3) organizations statewide.
9,000+
Available grants
$2.63B
Total funding
$5K
Median grant
Skip the search. Get matched with grants that fit your non-profit.
Smart recommendations based on your profile — in minutes.
Cures Within Reach
Cures Within Reach is the philanthropic leader in drug, device and nutraceutical repurposing research, which has the potential to transform the lives of patients with unsolved diseases by delivering treatments that can be used in the near-term. Our focus: we find and fund proof-of-concept clinical trials that, once successful, de-risk and catalyze follow-on funding, building the clinical evidence required for regulatory approval or to support off-label use by patients everywhere.
Clinical Repurposing Research to Impact US Veterans/Military
This Request for Proposals (RFP) from Cures Within Reach (CWR) is seeking clinical repurposing trials from US-based research institutions using already approved treatments to address unmet and high-priority medical needs of US veterans and/or active US military, such as mental health, post-traumatic stress disorder (PTSD) and brain injuries. Our strongest preference is for proof of concept, pivotal, Phase I or Phase IIA clinical repurposing trials. Eligible trials may be conducted at accredited US-based academic, nonprofit and governmental research institutions and/or health systems involved with medical research, including Veterans Administration (VA) health systems and hospitals.
Repurposed therapies must be approved and/or generally recognized as safe for human use by some regulatory agency, such as the US Food and Drug Administration, European Medicines Agency, Health Canada or Japan’s Pharmaceuticals and Medical Devices Agency, and may include drugs, devices, nutraceuticals or diagnostics, as well as combination therapies. These repurposed therapies must be tested in a new indication for which they are not already approved or used widely in clinical practice as standard of care. Repurposed therapies also may be added to current standard of care to improve patient outcomes and/or quality of life.
American Chemical Society
The American Chemical Society (ACS) is a non-profit organization founded in 1876 and chartered by the U.S. Congress. ACS is committed to improving all lives through the transforming power of chemistry. Our mission is to advance scientific knowledge, empower a global community, and champion scientific integrity. Our vision is a world built on science.
What We Do
More than 145 years after our founding, we remain a champion for chemistry, its practitioners and our global community of members.
We’re recognized as a leading publisher of authoritative scientific information. Our 80+ peer-reviewed journals are ranked the “most-trusted, most-cited and most-read.”
We empower our members to advance chemistry, elevate their career potential, expand their networks, inspire future generations, collaborate globally and build communities that provide scientific solutions.
We provide broader networks that facilitate connections and open doors in a way no other professional organization can match!
ACS Award in Industrial Chemistry
Purpose
To recognize outstanding contributions to chemical research in the industrial context. Significant creative contribution to chemistry in any field of chemical, chemical engineering, pharmaceutical, or biochemical research is appropriate.
The award consists of $5,000 and a certificate. Up to $2,500 for travel expenses to the meeting at which the award will be presented will be reimbursed.
Community Foundation of the Holland/Zeeland Area
Our Mission
The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.
Scholarships
CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.
All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.
The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.
Angie Van Hoven Nursing Scholarship
Community Foundation of the Holland/Zeeland Area
Our Mission
The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.
Scholarships
CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.
All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.
The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.
DeLong and Brower, P.C. Scholarship
Community Foundation of the Holland/Zeeland Area
Our Mission
The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.
Scholarships
CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.
All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.
The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.
Franz Family International Adoption Scholarship
Community Foundation of the Holland/Zeeland Area
Our Mission
The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.
Scholarships
CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.
All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.
The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.
Franz Family Scholarship for Families Impacted by Cancer
Community Foundation of the Holland/Zeeland Area
Our Mission
The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.
Scholarships
CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.
All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.
The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.
Fraternal Order of Police Lodge 104 Undergraduate Studies Scholarship
Community Foundation of the Holland/Zeeland Area
Our Mission
The Community Foundation of the Holland/Zeeland Area seeks to ensure that our community thrives today, tomorrow, and forever by building our Community’s Endowment to support high impact charitable projects, helping donors achieve their charitable goals, and leading and partnering in community-level initiatives.
Scholarships
CFHZ awards over $1 million in scholarships each year for students to attend schools of higher education throughout the nation. Our scholarships are possible thanks to the generosity of donors who invest in our community’s future by furthering the education of others.
All Holland/Zeeland area individuals interested in post-secondary education are encouraged to apply for CFHZ scholarships.
The Foundation proudly administers over 100 scholarships, each with unique eligibility criteria that must be met before a candidate can be considered.
Global Concepts Enterprise, Inc. Founders’ Scholarship
Ann Query Scholarship
Graduating senior who attends public, private, or home school and resides in the Zeeland Public School District area (student does not have to attend Zeeland Public Schools to be eligible)
Alice O. Rydell Interior Design Scholarship
Graduating senior or graduating early college student who attends public, private, or home school in the primary service area of the Community Foundation.
South Dakota grants for nonprofits provide funding to support rural development, education, public health, and cultural preservation initiatives. The following grants help organizations address community challenges, foster sustainability, and enhance quality of life across South Dakota.
Find 106 funding opportunities for nonprofits in South Dakota, with $6.4M available. Instrumentl streamlines the funding process by offering grant-matching tools, deadline alerts, and key insights to help organizations achieve their missions.
How common are grants in this category?
Uncommon — grants in this category are less prevalent than in others.
Over the past year, when are grant deadlines typically due for South Dakota grants for Nonprofits?
Most grants are due in the first quarter.
What's the typical grant amount funded for South Dakota Grants for Nonprofits?
Grants are most commonly $10,000.
A wide variety of funding sources for nonprofits are available in South Dakota. Currently, 100+ are available, totaling $6,365,150. For organizations interested in pursuing grant funding in South Dakota, the median grant size is $10,000. Among these grants, 23 grants support general operating expenses while 91 grants fund projects and programs specifically.
Various organizations and institutions provide grants for the state of South Dakota, including government agencies, private foundations, associations, and more. Here’s a breakdown of where you'll find the most grants available:
Whether you go after government grants or foundation grants depends on your grant readiness. Keep in mind that government grants often have large awards but equally large compliance requirements.
Based on the data we have now, the best time to apply for grants in South Dakota is in Q1, which is when about 34.7% of grant deadlines fall. This period offers nonprofits the most opportunities to secure funding. Comparatively, Q3 has the least activity, with only 19.8% of deadlines. To maximize your chances of securing funding, be aware of the peak fundraising periods.
The nonprofit funding landscape throughout South Dakota has shown significant activity over the past several years. Based on the funding reports sent to the IRS, overall grant funding reached $481,503,794 in 2021 and then rose to $619,327,674 in 2022, an increase of about 28.62%. Among all the grants awarded in South Dakota, the most popular focus areas for funding were single-organization support from private grantmaking, single-organization support, professional societies, associations and research institutes, and/or public policy analysis. Likewise, the top counties that received the most funding were Pennington County, Minnehaha County and Todd County.
If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within South Dakota for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.
With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in South Dakota. Learn more about Instrumentl’s powerful grant platform.