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Best Alabama Grants for Nonprofits

Find nonprofit grants in Alabama, including opportunities in Birmingham, Montgomery, and Mobile. Updated listings for 501(c)(3) organizations statewide.

9,000+

Available grants

$2.61B

Total funding

$5K

Median grant

9,000+ grants
$2.61B total
$5K median

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9,364 Results based on applied filters

Annual Artist Grant Program - Even Year Focus

Puffin Foundation Ltd
Private
United States
Up to US $3,500
The Puffin Foundation's Annual Artist Grant Program focuses on supporting artists and organizations that are often marginalized. In even years, proposals are accepted in fine arts, music, and photography. With a maximum grant size of $3,500, it aims to empower individuals and groups with limited resources to flourish creatively. This initiative reflects the Foundation's commitment to ensuring diverse artistic expressions thrive in society. Applicants must be U.S. citizens or residents, and only one proposal is permitted per year.
Music Fine Art Photography

NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
Unspecified amount
The NARMS Cooperative Agreement Program aims to enhance antibiotic resistance surveillance in retail food specimens, building on the National Antimicrobial Resistance Monitoring System initiated by the FDA in 1996. This program seeks to improve detection of antibiotic-resistant bacteria in food commodities and expand sampling sites. By strengthening monitoring efforts, it aims to protect public health and achieve measurable outcomes aligned with NARMS objectives, contributing to national efforts against antibiotic resistance.
Veterinary Science & Services Animal Food & Drug Safety

Bolger Foundation Grant

Bolger Foundation
Private
United States
US $10,000 - US $250,000
The Bolger Foundation Grant is dedicated to supporting capital projects that enhance tangible property for 501(c)(3) nonprofit organizations. Grants range from $10,000 to $250,000, with a maximum project budget of $2.5 million. The foundation focuses on community empowerment through conservation, health, and education, while excluding revenue-generating and operational costs. Eligible organizations must adhere to strict compliance with federal tax regulations. The mission is to inspire and empower nonprofits to better serve their communities.
Environmental Conservation Health & Medicine Community Services +1 more

HVAC Skills Lab Grant - New Skills Lab

Explore The Trades
Private
Canada, United States
Up to US $25,000
The HVAC Skills Lab Grant aims to support middle and high schools in the U.S. and Canada by providing equipment and resources to establish plumbing and HVAC skills labs. With a growing demand for skilled trades, this program encourages educational institutions to equip students with vital trade skills. Grant recipients will receive $25,000 worth of products and equipment, along with access to SkillCat's technical training platform, fostering a new generation of skilled professionals.
Vocational & Trade Education Workforce Preparation & Job Readiness

HVAC Skills Lab Grant - Refurbish an Existing Plumbing or HVAC Skills Lab

Explore The Trades
Private
Canada, United States
Up to US $10,000
The HVAC Skills Lab Grant aims to refurbish existing plumbing and HVAC skills labs in middle and high schools across the U.S. and Canada. With a focus on preparing students for vital trade careers, the grant provides $10,000 in equipment to enhance hands-on learning. This initiative supports schools with technical training resources, promoting the growth of skilled labor in these essential fields. Schools that have not received a Skills Lab award in the past 24 months are eligible to apply.
Workforce Preparation & Job Readiness Vocational & Trade Education

Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed) (357004)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Stimulating Hematology Investigation: New Endeavors (SHINE) program aims to enhance nonmalignant hematology research aligned with the goals of the NIDDK, NIA, and NHLBI. It invites R01 grant applications focused on innovative and early translational hematology topics, fostering growth in this critical research area. Key deadlines for applications span from February 2025 to October 2027, allowing for both standard and renewal submissions.
Aging / Gerontology Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases +6 more

NIA Academic Leadership Career Award (K07 Independent Clinical Trial Not Allowed) (357000)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $150,000
The NIA Academic Leadership Career Award (K07) provides funding for established investigators to strengthen research capacity in aging and Alzheimer's Disease. The program supports the development of educational infrastructure, mentorship, and career development activities. Key deadlines for applications include February 12, June 12, and October 12 from 2025 to 2027. This award is specifically for research not involving independent clinical trials, allowing applicants to gain experience in trials led by others.
Aging / Gerontology Dementia & Alzheimer’s Disease

Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional) (357003)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional) aims to enhance cancer treatment by integrating imaging and liquid biopsy assays. This initiative, led by the National Cancer Institute (NCI), encourages grant applications focused on assessing therapy responses and resistance emergence in patients. Key deadlines for submissions span from February 2025 to January 2028, providing ample opportunities for researchers to contribute to this vital area of cancer research.
Cancer / Oncology Biomedical Imaging

Molecular Imaging of Inflammation in Cancer (R01 Clinical Trial Not Allowed) (357002)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
This funding opportunity invites applications for R01 grants focused on molecular imaging methods to explore cancer inflammation in vivo. It aims to enhance understanding of dynamic interactions between inflammation and cancer through innovative imaging techniques. The initiative encourages collaborations between cancer researchers and imaging scientists to leverage molecular imaging for identifying cellular physiology changes in response to treatment. Deadline dates for applications range from February 2025 to October 2027, emphasizing timely submission for prospective researchers.
Cancer / Oncology Biomedical Imaging

Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional) (357011)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Research With Activities Related to Diversity (ReWARD) program by the NIH aims to enhance research diversity and inclusion across the United States. It supports scientists contributing to Diversity, Equity, Inclusion, and Accessibility (DEIA) who lack current NIH funding. The program funds both scientific research and DEIA activities, addressing the needs of various NIH Institutes and Centers to foster a more diverse biomedical research landscape.
Biology Health & Medicine Diversity, Equity & Inclusion

Igor Gorin Memorial Award

Community Foundation for Southern Arizona
Private
United States
Up to US $12,000
The Igor Gorin Memorial Award, established in 1993 by the Community Foundation for Southern Arizona, honors the legacy of Igor Gorin by supporting aspiring vocalists. With $382,000 awarded to 49 young talents, this fund provides unrestricted financial assistance for coaching, travel, and auditions. The 2026 award offers up to $12,000, aimed at those overcoming financial barriers to pursue operatic careers, ensuring that exceptional vocalists can thrive in their artistic journeys.
Opera

Community Collaboration Challenge

National Partnership for Student Success
Association/Society
United States
US $5,000 - US $10,000

Community Collaboration Challenge

Applications for the 2026 Community Collaboration Challenge are now open! With support from the Leon Lowenstein Foundation, the Challenge provides $5,000 – $10,000 awards to communities and is designed to support collaboration that expands and pilots evidence-based K-12 student supports in the form of high-impact tutoring, mentoring, student success coaching, postsecondary transition coaching, and/or wraparound/integrated student supports.

Tutoring & Mentoring College Success / Persistence

Smart Family Fund

Smart Family Fund
Private
United States
US $25,000 - US $100,000
The Smart Family Fund is a private foundation dedicated to supporting early-stage non-profits that demonstrate the potential for scalable, positive impact. With grants ranging from $25,000 to $100,000, they aim to assist organizations in refining their models and preparing for larger investments. The foundation, guided by three brothers, focuses on mentoring and backing social entrepreneurs facing challenges in securing funding for innovative yet untested ideas, fostering a brighter future for communities.
All fields of work Nonprofit Growth & Development

The Rona Jaffe Foundation Fellowship

Fine Arts Work Center in Provincetown
Private
United States
More than US $2,500
The Rona Jaffe Foundation Fellowship supports emerging women writers with a fully funded 7-month residency at the Fine Arts Work Center. Established by the Rona Jaffe Foundation, it includes a $2,500 prize to assist with travel and living expenses. Eligible candidates must be U.S. residents, at least 18 years old, and not enrolled in a degree program during the fellowship year. This prestigious fellowship aims to nurture exceptional literary talent.
Writing & Literature

Limited Competition: Renewal of Existing NINDS-Supported Clinical Trial Cooperative Agreement Awards (U01 - Clinical Trials Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This funding opportunity invites renewal applications for existing NINDS-supported clinical trial cooperative agreements (U01) that require additional time and resources. The National Institute of Neurological Disorders and Stroke (NINDS) expects applicants to request only what is necessary for trial completion, without introducing new aims. Discussions with NINDS prior to submission are encouraged. Eligible applications must be renewals of previously approved cooperative agreements under specified NIH funding announcements.
Neuroscience Neurological Diseases & Disorders Stroke

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) (356879)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.
Human Genome & Genetics Rare Diseases

Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This Funding Opportunity Announcement (FOA) aims to advance the identification and evaluation of candidate biomarkers for neurological and neuromuscular disorders. By facilitating the clinical development of neurotherapeutics, the FOA encourages research that includes both animal studies and preliminary human evaluations. The ultimate goal is to produce biomarkers ready for rigorous analytical and clinical validation, enhancing the effectiveness of treatments in clinical practice.
Biomedical informatics Neurological Diseases & Disorders Musculoskeletal Diseases

Limited Competition: Basic Instrumentation Grant (BIG) Program (S10 Clinical Trial Not Allowed) (356887)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The Limited Competition: Basic Instrumentation Grant (BIG) Program offers funding to NIH-supported researchers for purchasing specialized instruments or integrated systems, with minimum awards of $25,000 and maximum awards reaching $350,000. Eligibility is restricted to institutions that have not received significant S10 funding in recent years. This program aims to enhance research capabilities by providing access to essential technology, thereby fostering scientific innovation and collaboration within the NIH community.
Biology Health & Medicine Medical Technology, Devices, and Equipment

Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed) (356886)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The Shared Instrumentation Grant (SIG) Program supports NIH-funded investigators in acquiring high-cost, specialized instruments, with a minimum award of $50,000 and a maximum of $750,000. Eligible instruments include light microscopes, mass spectrometers, and DNA sequencers, among others. This program aims to enhance research capabilities by enabling the purchase or upgrade of essential equipment for scientific advancement.
Biology Health & Medicine Medical Technology, Devices, and Equipment

High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed) (356883)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $5,000,000
The High-End Instrumentation (HEI) Grant Program, offered by the NIH, invites applications for purchasing or upgrading high-end, specialized instruments, with a minimum award of $750,001 and a maximum of $2,000,000. This program supports NIH investigators aiming to enhance their research capabilities through advanced technologies such as mass spectrometers and electron microscopes. Applications must be submitted by 5:00 pm local time of the applicant organization.
Medical Technology, Devices, and Equipment Health & Medicine Biotechnology +1 more

Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed) (356888)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.
Biomedical informatics Epidemiology & Public Health Health Information Technology

Reboot Representation Grant

Reboot Representation Tech Coalition
Association/Society
United States
Unspecified amount
The Reboot Representation Tech Coalition aims to significantly increase the number of Black, Latina, and Native American women earning computing bachelor’s degrees. They invite qualified organizations to submit grant inquiries focused on recruiting and retaining these women in tech. Programs that leverage existing resources and operate across multiple regions will be prioritized, and the Coalition seeks initiatives backed by substantial research and community trust.
Computer Science & Engineering Diversity, Equity & Inclusion Women's Rights & Equality +4 more

Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program, funded by the NIH, aims to enhance the biomedical research landscape by supporting resource-limited organizations. It targets domestic institutions with limited research resources and few doctoral students in biomedical fields, promoting broader participation in research and boosting administrative capacities for sponsored programs. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submissions.
Biology Health & Medicine

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) (356925)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
This grant opportunity from the NIH aims to enhance mechanistic research on precision probiotic therapies through a biphasic R61/R33 award mechanism. It encourages innovative studies to identify specific biological factors influencing probiotic responses, thereby improving clinical outcomes. The program supports up to five years of research, with the initial phase focused on discovering unique host characteristics and the second phase assessing improvements in probiotic efficacy through rigorous studies.
Integrative & Alternative Health Microbiomes

Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional) (356927)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,400,000
This funding opportunity aims to advance mechanistic research for precision probiotic therapies. It invites R33 applications focused on characterizing individual differences in probiotic responses, identifying responder subgroups, and enhancing clinical outcomes. The goal is to develop strategies addressing barriers to effective probiotic use, accounting for human variability. Proposals should include innovative studies using animal models or human subjects, supported by preliminary data to test biological patterns and their effects on health outcomes.
Biology Microbiology Microbiomes

Extramural Discovery Science Accelerator Award

American Cancer Society
Association/Society
United States
Up to US $75,000
The Extramural Discovery Science Accelerator Award supports the commercialization of ongoing cancer research projects, focusing on experiments that facilitate technology validation and de-risking. Applications are accepted on a rolling basis, with a budget of up to $75,000 for one year. This award encourages independent investigators at any career stage to advance their technologies, with a strong emphasis on commercial viability and collaboration within a learning community.
Cancer / Oncology Medical Technology, Devices, and Equipment

Leukemia Exploration and Prevention Grant Program (LEAP) - Team Award

American Cancer Society
Association/Society
United States
Up to US $1,720,000
The Leukemia Exploration and Prevention Grant Program (LEAP) aims to advance cancer interception and prevention for patients with RUNX1 familial platelet disorder (RUNX1-FPD). This program supports interdisciplinary research teams investigating the mechanisms of leukemogenesis and innovative treatment strategies. With funding of up to $430,000 per year, LEAP encourages projects focused on both understanding clonal evolution and developing novel therapeutic approaches. The initiative seeks to bridge critical knowledge gaps and provide urgent interventions for high-risk populations.
Leukemia

Alabama Grants for Nonprofits Highlights

Alabama grants for nonprofits provide funding to support diverse programs in education, health, and community development. The following grants help organizations address local needs, empower underserved communities, and foster growth across the state of Alabama.


Search Instrumentl's Alabama Grants Database


Discover 151 funding opportunities for nonprofits in Alabama, with $47.5M available. Instrumentl connects local organizations with funding sources, offering deadline tracking, grant-matching tools, and insights to create lasting impact in Alabama communities.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Alabama Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Alabama grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

35 Alabama grants for nonprofits over $25K in average grant size

25 Alabama grants for nonprofits over $50K in average grant size

26 Alabama grants for nonprofits supporting general operating expenses

100+ Alabama grants for nonprofits supporting programs / projects

1,000+ Grants on Instrumentl focused on Workforce Preparation & Job Readiness

2,000+ Grants on Instrumentl focused on Art & Culture

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Alabama grants for Nonprofits?

Most grants are due in the second quarter.

Q1
20.7%
Q2
28.0%
Q3
27.0%
Q4
24.3%

Typical Funding Amounts

What's the typical grant amount funded for Alabama Grants for Nonprofits?

Grants are most commonly $10,000.

$250 $250 Min.
$10,000 $10 K Median
$522,234 $522.2 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

A wide variety of funding sources for nonprofits are available in Alabama. Specifically, there are over 200+ individual grants totaling $47,523,252. If you're thinking about pursuing grant funding in Alabama, know that the median grant size is $10,000. Among these grants, 26 grants support general operating expenses, while 100+ grants fund projects and programs.

In Alabama, grants come from different funders, including government agencies, private foundations, corporate funders, and more. Here’s a breakdown of each:

  • Private Funders: There are 75 grants right now from private funders in Alabama. When filtering for these grants, you'll see that many focus on education and healthcare.
  • Corporate Foundations: There are currently 23 active grants from corporate foundations in Alabama. Many of these grants focus on education, the environment, and children's well-being.
  • State / Local Funders: There are a moderate number of grants available from state and local agencies in Alabama. Around 38 grants are currently listed in our database. These grants largely focus on the environment and community services.

When considering the type of grants to go after, keep in mind that government grants often have large awards but equally large compliance requirements.

Based on the data we have now, the best time to apply for grants in Alabama is in Q2, which is when about 28.0% of deadlines for grants land. However, Q3 has a similar amount of grant deadlines, with 27.0%. These periods offer the most opportunities to secure funding. Comparatively, Q1 is the grant period with the least activity, coming in at 20.7%. To maximize your odds of winning grant funding, be aware of these peak fundraising periods.

The nonprofit funding landscape throughout Alabama has shown large activity over the past several years. Based on the funding reports sent to the IRS, total grant funding reached up to ~$1.3 billion in 2021 and then rose up to ~$1.4 billion in 2022, a growth of about 12%. Among all the grants awarded in Alabama during this time, the most popular focus areas for funding were single-organization support from private foundations, professional societies, and associations. Likewise, the top counties that received the most funding were Jefferson County, Montgomery County, and Mobile County.

If you want to start finding more grants, Instrumentl simplifies the entire grant process. You can find grants within Alabama for your nonprofit while also researching funders, managing deadlines, and keeping on top of everything in our all-in-one platform.

With Instrumentl, you'll get access to over 20,000 live grants and 400,000 funders beyond what you see here in Alabama. Learn more about how Instrumentl helps nonprofits streamline their grant process.

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