Best Massachusetts Grants for Nonprofits

The MPS Astronomical Sciences Research Programs, funded by the National Science Foundation, support innovative research in astronomical sciences. These initiatives aim to enhance our understanding of the universe through core research, technological advancements, and instrumentation. Topics include solar storm prediction, the discovery of exoplanets, and the study of black holes. Proposals should reflect ambitious, transformative ideas that may not require immediate practical outcomes, fostering long-term scientific exploration.

The NSF Expeditions in Computing program aims to foster transformative research in computer and information science. By funding projects up to $15 million over seven years, it encourages multidisciplinary teams to tackle ambitious research agendas that redefine the future of computing. The program supports innovative areas such as new architectures for intelligence, advanced robotics, and next-generation communication, emphasizing the importance of collaboration across various fields to achieve groundbreaking advancements.

The Emerging Frontiers in Research and Innovation (EFRI) program by the NSF aims to support transformative research in wave-based computing, fostering significant advancements in foundational engineering knowledge. With funding opportunities including EAGER awards and four-year grants up to $2 million, EFRI-WBC encourages interdisciplinary collaboration and innovative approaches to address strategic technology priorities. Proposals should articulate their potential long-term impacts on national science and technology missions, promoting a new era in computing methodologies.

The NSF MPS Chemistry Research Programs support groundbreaking research in chemical sciences, encompassing areas such as chemical catalysis, measurement, imaging, and theory. This initiative encourages innovative proposals that can lead to transformative advancements, without the necessity of immediate commercial applications. Researchers interested in exploring foundational concepts that could shape the future of chemistry are invited to submit their ideas for funding.

The National Science Foundation's Engineering Directorate (NSF ENG) promotes groundbreaking research in chemical, bioengineering, energy, and transport systems. Key programs include Chemical Process Systems, Engineering Biological and Biomedical Systems, Energy, Water, and Resource Engineering, and Transport Phenomena. NSF ENG seeks innovative, transformative proposals that push the boundaries of foundational research, regardless of immediate commercial applications, and emphasizes diverse funding opportunities based on availability.

The MPS Materials Research Programs, funded by the National Science Foundation, aim to enhance the understanding of materials and their diverse applications. These programs cover areas such as biomaterials, ceramics, condensed matter physics, and electronic materials. With an emphasis on transformative research, NSF MPS encourages proposals that are innovative and foundational, without the necessity for immediate commercial outcomes, fostering long-term advancements in materials science.

The OVW Fiscal Year 2026 Electronic Service Protection Order Court Pilot Program supports state and Tribal courts in implementing electronic communication methods for serving protection orders. This initiative, part of the Violence Against Women Act, aims to enhance the efficiency and effectiveness of protection order enforcement, ensuring safety for victims of domestic violence, sexual assault, and stalking. Applications are due by October 8, 2026, at 4:59 pm through JustGrants.

Mission: A non-profit, charitable, Private Foundation established in 1959 by the Long family to support local charities, schools, education events and general community needs.

Grants

Our approach to grant requests focuses on fostering local neighborhood vitality and excellence. The John F. Long Foundation supports local non-profit organizations that promote this objective. The Foundation looks for groups who are working to help themselves, help their own communities, and help others like themselves through self-empowering, community organizing efforts. To be eligible for consideration, the grant request must meet the following criteria:

• Funds’ use must have measurable benefits
• Your organization must have good management, a solid financial background, well-established administration policies and Board of Directors
• The grant request must be precise and complete, providing necessary detail
• The Foundation Questionnaire is to be completed in its entirety
• The grant request amount and time frame must be clearly communicated, i.e. one-time grant, ongoing support, or special project
• If your request is for a particular event or program, providing a budget is always helpful
• Requests for grants of $1,000.00 or more, as well as groups we have not funded within the past two years, must: (i) Provide financial reports/statements for past and current fiscal year; (ii) Provide a list of past donors going back no more than two years.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Shelter Grants

Critical Shelter Infrastructure

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Shelter Grants

Strengthening Shelter Essentials

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Spay/Neuter Grants

Increasing Spay/Neuter Surgeries

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

2026 ASPCA Grants for Shelters and Spay/Neuter Clinics

The American Society for the Prevention of Cruelty to Animals® (ASPCA®) is offering up to $14 million in grants to support shelters and spay/neuter clinics in meeting the needs of vulnerable animals throughout the United States, including addressing the shortfall in available spay/neuter surgeries. We will fund qualified proposals that support:

• Critical shelter infrastructure
• Strengthening shelter essentials
• Increasing the number of spay/neuter surgeries year-over-year 
• Major capital projects that increase spay/neuter capacity
• Special projects that increase spay/neuter capacity

Spay/Neuter Grants

Spay/Neuter Major Capital Projects

Only one application per agency/organization will be considered. 

Applicants may choose only one of the five funding categories. Our interest is in meeting your most pressing needs in one of the offered categories; we do not have our own preference for funding one category over another. We will fund the most compelling proposals, regardless of category chosen.

The ASPCA is offering up to $14 million in Spay/Neuter Grants for shelters and clinics across the U.S. to enhance spay/neuter services for vulnerable animals. Proposals can address critical infrastructure needs and major capital projects to increase spay/neuter capacity. Only one application per organization is permitted, and applicants must choose one funding category. The focus is on compelling proposals that meet the most urgent needs.

The Amy Adina Schulman Memorial Fund

The Amy Adina Schulman Memorial Fund is a Princeton, New Jersey-based endowment fund providing grants to individuals, young adults who volunteer or intern for progressive social action projects or programs in an area of their interest and commitment. The Amy Adina Fund also sponsors a lecture each year on a relevant and timely topic related to its educational mission.

The Amy Adina Schulman Memorial Fund was started in 1987 one year after Amy Adina, 20, died suddenly while a student and activist at Rutgers University. It is a realization of her family and her communities’ desire to celebrate her life, to fulfill her dreams and her potential. Since its inception, almost 1,500 grants have been awarded for work in Africa, Asia, Latin America, the Middle East, and the United States—nearly $1,000,000 in total. The Amy Adina Schulman Memorial Fund is a 501(c)3 nonprofit organization.

About Our Grants

Small grants (depending on length of service), are awarded to as many applicants as possible rather than giving larger amounts to fewer individuals. The number of awards has grown each year thanks to annual contributions as well as to gifts sent to the Fund to honor special occasions and life cycle events.

Charles Hayden Foundation

The Charles Hayden Foundation is committed to expanding opportunities for young people and helping them build the knowledge, skills, experiences, and relationships they need to thrive in school, work, and life.

We support youth-serving nonprofit organizations and public district, charter, Catholic, and independent schools, as well as organizations that strengthen the capacity of those serving young people. Our grantmaking spans academic success, social and emotional development, post-secondary pathways, and career-connected learning, with an emphasis on programs and organizations that create meaningful opportunities and demonstrate positive outcomes for young people.

The Foundation primarily supports young people from low-income communities in New York City and Boston, with some grantmaking in Newark, New Jersey.

Our Grantmaking

The Foundation focuses its grantmaking in the following areas:

• Academic Readiness: Programs and initiatives that strengthen young people’s academic skills and provide access to educational, enrichment, and other learning opportunities that prepare them for future educational and career pathways.
• Social, Emotional, and Practical Skills: Programs and services that help young people develop the social, emotional, and practical skills they need to thrive in school, work, and life.
• Post-Secondary Success: College access and persistence efforts that prepare young people to pursue post-secondary opportunities, matriculate, persist, and successfully graduate.
• Career-Connected Learning: Opportunities that enable young people to explore their interests, gain exposure to careers, build real-world skills and experiences, and pursue meaningful career pathways.
• Organizational Capacity Building: Support for organizations that strengthen youth-serving nonprofits and schools through technical assistance, training, and other capacity-building services. This may include support in areas such as program quality and improvement, leadership and staff development, organizational strategy, data and evaluation, infrastructure, and other areas that strengthen organizational effectiveness and improve outcomes for young people.

Multi-Year Grant Opportunity: Supporting Strategic Plan Implementation

The Charles Hayden Foundation is launching a Multi-Year Grant Opportunity to help strengthen organizations and improve outcomes for young people in New York City and Boston. Through this opportunity, the Foundation anticipates inviting up to 10 organizations to receive multi-year project grants over a two- to three-year period to support strategic initiatives identified as priorities in their current strategic plans.

Proposed initiatives may build upon or enhance an existing Charles Hayden Foundation-supported program, such as hiring additional program staff to expand or strengthen services, or focus on an organizational capacity-building effort, such as implementing a new data and evaluation system.

Organizations selected for a Multi-Year Grant will receive a two- to three-year award that will replace their annual Charles Hayden Foundation grant for the duration of the grant period. Current annual grant funding will continue as part of the multi-year award, along with additional funding awarded to support the proposed strategic initiative. Organizations that are not selected will remain eligible to apply through the Foundation’s annual grantmaking process.

Project Criteria

Proposed projects should represent strategic investments that strengthen an organization’s ability to serve young people over the long term. Examples of eligible projects include:

• Hiring key leadership or program staff
• Expanding or enhancing existing programs
• Strengthening organizational capacity
• Building evaluation, learning, or data systems
• Technology or infrastructure improvements
• Other strategic initiatives identified in the organization’s strategic plan

The Foundation anticipates providing partial support for proposed initiatives and generally will not fund the full cost of a project. Award amounts will be determined based on the scope of the proposed initiative and the resources required for successful implementation. Because these grants support strategic initiatives over a two-to-three-year period, the Foundation anticipates that most requests will exceed an organization’s current annual Charles Hayden Foundation grant.

The Fiscal Year 2027 AmeriCorps Seniors RSVP Competition invites communities to apply for funding aimed at engaging adults aged 55 and older in addressing pressing local needs. Through national service and volunteerism, AmeriCorps strengthens communities and fosters civic engagement. This open competition spans all states and territories, encouraging organizations to harness the skills and expertise of older adults to enhance community well-being and promote a culture of service.

The OVC FY 2026 Services for Victims of Human Trafficking aims to enhance victim service programs across the United States. This initiative supports victims by providing critical services to address their diverse needs, including mental health support and assistance with legal challenges. By funding comprehensive programs, the Office for Victims of Crime seeks to combat human trafficking effectively and promote recovery for affected individuals, ensuring their rights and well-being are prioritized.

The OVC FY 2026 Preventing Trafficking of Girls program aims to provide crucial prevention and early intervention services for girls at risk of human trafficking. This initiative, backed by the US DOJ's Office of Justice Programs, supports efforts to protect vulnerable populations, including young women up to age 25, from both sex and labor trafficking. Applicants are encouraged to outline their strategies to effectively serve survivors and address diverse needs in their proposals.

The OVC FY 2026 grant aims to improve outcomes for child and youth victims of human trafficking by integrating policies at state and Tribal levels. This funding opportunity focuses on developing strategic plans to address the challenges faced by minor victims, enhance coordination among systems like child welfare and juvenile justice, and ensure effective identification and prosecution of traffickers. By fostering multidisciplinary approaches, the program seeks to provide comprehensive support and services to these vulnerable populations.

The Agriculture Risk Management Education Partnerships Competitive Grants Program (ARME) aims to educate agricultural producers on various risk management activities, including crop insurance, debt reduction, and market assessment. Emphasizing farm viability, the program seeks to provide technical assistance and outreach to farmers and ranchers to improve their risk management strategies, as outlined in the Agriculture Risk Protection Act of 2000. This initiative is funded by the USDA's National Institute of Food and Agriculture (NIFA).

The FY26 Breast Cancer Research Program's Clinical Research Extension Award aims to enhance breast cancer clinical studies by extending data collection and follow-up. This funding mechanism emphasizes the importance of patient participation and addresses challenges from early trial terminations. Notably, applications must include two breast cancer consumer advocates and can feature either a single Principal Investigator or a duo. This initiative seeks to improve outcomes through comprehensive data analysis and patient engagement.

The FY26 Breast Cancer Research Program's Breakthrough Award supports transformative research aimed at significant advancements in breast cancer treatment. This award offers various funding levels, including Population Science Studies, allowing for innovative approaches that can lead to clinical applications. Each application must align with overarching BCRP challenges, ensuring a focus on impactful research. The program acknowledges both individual and collaborative Principal Investigators, emphasizing the importance of timely submissions to avoid administrative issues.

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is set to renew a Notice of Funding Opportunity (NOFO) focused on advancing translational research in maternal and pediatric pharmacology. This initiative aims to enhance precision medicine by developing innovative tools and therapeutics for pregnant and lactating women, infants, and children. The goal is to improve the safety and efficacy of medications while ensuring effective patient-provider communications. Applications are not currently being solicited.

The Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) program is designed to enhance research on muscular dystrophy through a collaborative, center-based approach. By fostering interdisciplinary projects and providing essential training for emerging scientists, the MDSRCs aim to drive innovation in both basic and clinical research. Engaging patient and advocacy communities is a key component, ensuring research is patient-centered and informed by real-world needs. This initiative is supported by various legislative authorities.

The National Institutes of Health is funding a groundbreaking project to enhance our understanding of Type 1 diabetes (T1D) through multimodal AI. This initiative aims to integrate diverse datasets to explore the interactions of biological processes in T1D development. By leveraging advanced AI models, the research will uncover critical insights, identify biomarkers, and pave the way for personalized medicine approaches, ultimately improving prevention and treatment strategies for this complex disease.

The Substance Abuse Prevention, Treatment, and Aftercare program aims to combat substance abuse in American Indian and Alaska Native populations. It focuses on enhancing care coordination, expanding culturally competent behavioral health services, and implementing early intervention strategies for at-risk youth. By supporting Tribal and community-led initiatives, the program fosters collaboration among families, youth, and community partners to create effective prevention, treatment, and recovery solutions.

The Healthy Lifestyles in Youth program, funded by the Indian Health Service, aims to empower Tribes and Tribal Organizations to deliver essential public health services. This new cohort of NPHR awards supports initiatives that foster healthier lifestyles among youth in Indigenous communities, addressing critical health disparities and promoting well-being through culturally relevant programs and services.