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Best Massachusetts Grants for Nonprofits

Find nonprofit grants in Massachusetts, including opportunities in Boston, Worcester, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.66B

Total funding

$5K

Median grant

10,000+ grants
$2.66B total
$5K median

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9,975 Results based on applied filters

Therapeutic Giving: Neuroscience: Local & Regional Organizations

Johnson & Johnson Innovative Medicine
Corporate
United States
Unspecified amount
The Therapeutic Giving program from Johnson & Johnson Innovative Medicine aims to support local and regional organizations focused on improving patient access to treatment and advancing health equity. Eligible applicants include 501(c)(3) nonprofit organizations, with funding preferences for programs that address significant healthcare disparities, mental health initiatives, and innovative solutions with measurable outcomes. The application period for local organizations runs from March 1 to May 31, while national organizations can apply in September.
Wellness & Healthy Living Preventative Healthcare Health Disparities & Social Determinants of Health +7 more

Therapeutic Giving: Neuroscience: National Organizations

Johnson & Johnson Innovative Medicine
Corporate
United States
Unspecified amount
The Therapeutic Giving initiative by Johnson & Johnson focuses on funding programs in neuroscience aimed at enhancing patient access to treatments and promoting health equity. Nonprofit organizations classified as 501(c)(3) can apply for support from March 1 to May 31. The initiative emphasizes innovative, measurable programs in areas like Alzheimer’s disease and mental health, prioritizing those that address healthcare disparities and improve quality of life for affected individuals.
Neuroscience Mental Health & Psychiatric Diseases Crisis Intervention +7 more

NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required) (352165)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
The NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award supports investigator-initiated clinical trials of natural products, including botanicals and dietary supplements. This funding opportunity aims to validate the pharmacokinetics and bioavailability of these products over three years in a phased approach. Successful trials will provide crucial data for further development and clinical application, emphasizing the importance of scientifically driven research in natural product efficacy.
Food Safety Drug Safety Integrative & Alternative Health

ASTRO-AAPM Physics Resident/Post-Doctoral Fellow Seed Grant (1 year)

American Society For Radiation Oncology
Association/Society
United States
Up to US $100,001
The ASTRO-AAPM Physics Resident/Post-Doctoral Fellow Seed Grant supports early-career scientists in radiation oncology physics research. Jointly funded by AAPM and ASTRO, this grant aims to foster innovation in the field, with up to two awards of $50,000 each available. Eligible applicants include medical physics residents and post-doctoral fellows who are active members of ASTRO and AAPM. This initiative strives to enhance the next generation of researchers, ensuring a commitment to advancing radiation oncology.
Cancer / Oncology Physics

Exceptional Project Grants

Breast Cancer Alliance Inc
Private
United States
US $100,000
The Breast Cancer Alliance offers Exceptional Project Grants aimed at enhancing survival rates and quality of life for individuals affected by breast cancer. This grant, amounting to $100,000 over one year, supports innovative research and projects in the contiguous United States. Eligible applicants include clinical doctors and research scientists at any career stage. The funding covers salary and project costs, with indirect costs capped at 8% of direct costs, ensuring comprehensive support for impactful research.
Breast Cancer

Young Investigator Grants

Breast Cancer Alliance Inc
Private
United States
US $125,000
The Young Investigator Grants, offered by the Breast Cancer Alliance, aim to support early-career researchers focused on breast cancer. This two-year grant provides up to $125,000 in funding, split across the duration, to facilitate independent research projects. Applicants must be affiliated with U.S. institutions and should not have held major grant support previously. This initiative fosters innovation in breast cancer research, ultimately enhancing survival rates and quality of life for affected individuals.
Breast Cancer

Boehringer Ingelheim: External Collaborative Research (ECR)

Boehringer Ingelheim Pharmaceuticals, Inc.
Corporate
United States
Unspecified amount
The External Collaborative Research (ECR) program by Boehringer Ingelheim invites academic and community scientists to propose collaborative studies aimed at protocol development and result publication. This program offers potential drug and financial support, excluding direct salary for the Principal Investigator. Budgets must represent fair market value and will be negotiated further. Research interests span therapeutic areas including Cardio-Renal-Metabolic, Mental Health, Dermatology, and Oncology, encouraging innovative solutions to unmet medical needs.
Skin Diseases & Dermatology Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases +7 more

Clinician Scientist Development Awards

National Multiple Sclerosis Society
Association/Society
United States
Unspecified amount
The National MS Society's Clinician Scientist Development Awards aim to cultivate promising young investigators in multiple sclerosis research. This program supports postdoctoral fellows with three years of comprehensive training in academic medicine focused on MS. Applicants must hold a clinical degree and be licensed in the U.S. The Society prioritizes research that aligns with its Pathways to Cures Roadmap, which emphasizes stopping disease progression, restoring function, and preventing MS.
Multiple Sclerosis

National MS Society: Harry Weaver Scholar Awards

National Multiple Sclerosis Society
Association/Society
United States
Unspecified amount
The National MS Society offers Harry Weaver Scholar Awards to support emerging researchers in multiple sclerosis. This prestigious award honors Dr. Harry Weaver's legacy and aims to facilitate independent research careers. Eligible candidates must have a doctoral degree and relevant postdoctoral training. The funding is designed to provide salary and grant support for five years, allowing awardees to establish competence in their research area. Applications should align with the Society's Pathways to Cures Roadmap.
Multiple Sclerosis

Search Team Grant

National Disaster Search Dog Foundation
Private
United States
Up to US $1,000
The Search Team Grant, established by the National Disaster Search Dog Foundation, provides financial assistance to active handlers of live-find and human remains detection canines. This program helps cover out-of-pocket expenses for training and equipment, enabling handlers to remain deployment-ready. Over 17 years, it has supported specialized training and essential gear purchases, ensuring that canine teams can effectively assist communities in need during emergencies.
Search & Rescue Service Animals

National MS Society: MS Clinical Mentorships: Medical Student Mentorship Program

National Multiple Sclerosis Society
Association/Society
United States
US $5,000
The National Multiple Sclerosis Society offers a Medical Student Mentorship Program that provides a four-week clinical experience for medical students who have completed at least one year of school. This program aims to raise awareness about the challenges faced by individuals with MS and generate interest in careers focused on MS care. Students gain hands-on experience under the guidance of MS specialists, enhancing their understanding of the disease and its management.
Multiple Sclerosis

National MS Society: Sylvia Lawry Physician Fellowships

National Multiple Sclerosis Society
Association/Society
United States
Up to US $225,000
The National Multiple Sclerosis Society offers the Sylvia Lawry Physician Fellowships to support MDs in acquiring essential clinical trial training. This fellowship aims to enhance expertise in conducting complex trials for MS therapies, fostering skills in protocol design, patient recruitment, and data analysis. Applicants must have relevant medical training and be engaged in ongoing MS clinical research. The program is vital for addressing the increasing demand for trained professionals in MS clinical trials, contributing to advancements in treatment.
Multiple Sclerosis

Bay Area Lyme Foundation: Emerging Leader Award

Bay Area Lyme Foundation
Private
United States
Unspecified amount
The Bay Area Lyme Foundation's Emerging Leader Award supports innovative research in Lyme disease, offering two $150,000 grants to post-doctoral and early-career scientists. Applicants are encouraged to propose proof-of-concept projects that enhance diagnostics or therapeutics. The award seeks to attract talent and foster scientific leadership in biomedical sciences. Evaluation criteria include the potential for novel therapies, scientific rationale, and support from institutions. This opportunity is ideal for those new to tickborne disease research.
Lyme Disease

Stanford Medicine Children’s Health Center for IBD and Celiac Disease Postdoctoral and Early Career Support Award

Stanford Health Care
Private
United States
Up to US $200,000
The Stanford Medicine Children’s Health Center for IBD and Celiac Disease offers funding for postdoctoral fellows and instructors to conduct innovative research focused on pediatric IBD and celiac disease. This initiative aims to nurture future researchers and prepare them for independent funding opportunities. Eligible research includes basic, clinical, epidemiological, and health policy studies related to maternal and child health. Funding supports substantial salary and benefits, ensuring commitment to impactful research in this critical area.
Digestive System Health & Diseases Children’s Health & Pediatrics Maternal And Perinatal Health

NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required) (352061)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $3,600,000
The NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44) invites small businesses to submit applications for investigator-initiated clinical trials. This program particularly supports high-risk, hypothesis-driven studies that may involve non-routine interventions or unlicensed products. Letters of Intent are encouraged and due 30 days prior to the full proposal deadline. All applications must be submitted by 5:00 PM local time of the applicant organization.
Allergies & Allergic Diseases Infectious & Parasitic Diseases Immune System Diseases

Stanford Childern's Health Center for IBD and Celiac Disease - Intramural Seed Grants Research Program

Stanford Health Care
Private
United States
Up to US $200,000
The Stanford Children's Health Center for IBD and Celiac Disease offers Intramural Seed Grants to promote innovative research in pediatric diseases. This program supports high-risk, high-reward projects, encouraging multi-PI collaborations across disciplines. Awards of up to $100,000 per year for two years are available, aimed at generating preliminary data for future funding applications. Eligible applicants include Stanford faculty holding specific university positions. Proposals should focus on advancing understanding of pediatric IBD and celiac disease through various research approaches.
Digestive System Health & Diseases Maternal And Perinatal Health Children’s Health & Pediatrics

Melanoma Research Resident and Fellowship Grant

Melanoma Research Foundation
Private
United States
Up to US $10,000
The Melanoma Research Resident and Fellowship Grant offers $10,000 to support early-career residents and fellows in conducting clinical or laboratory research focused on melanoma. This grant encourages innovative approaches to understanding prevention, detection, and treatment of melanoma, including special emphasis on ocular melanoma. Eligible candidates must have a qualified mentor and conduct research at a U.S. institution. This initiative aims to enhance the landscape of melanoma research and foster the next generation of researchers.
Cancer / Oncology Skin Diseases & Dermatology Eye Diseases & Disorders +1 more

Celiac Disease Foundation: Jocelyn Silvester Rising Villus Student Research Award

Celiac Disease Foundation
Private
Canada, Mexico +1 more
Up to US $6,000
The Celiac Disease Foundation offers the Jocelyn Silvester Rising Villus Student Research Award to encourage medical students and residents to pursue celiac disease research. This prestigious award provides a $5,000 stipend for a 10-week mentored research experience across North America, honoring Dr. Jocelyn Silvester's contributions to the field. Recipients must secure a mentor and maintain good standing in their academic programs, ensuring a commitment to advancing celiac disease research.
Celiac Disease

National MS Society: Institutional Clinician Training Award

National Multiple Sclerosis Society
Association/Society
United States
Approximately US $225,000
The National MS Society's Institutional Clinician Training Award supports the training of neurologists and physiatrists in comprehensive MS care. This program enhances the skills of postdoctoral fellows through mentorship and specialized training, ensuring they are equipped to provide personalized, high-quality care. The Society aims to foster a community of leaders in MS clinical practice, encouraging active participation in research and volunteer opportunities to improve outcomes for individuals with MS.
Multiple Sclerosis Medical Education & Professional Training

Multiple Sclerosis Clinical Care Physician Fellowship: Adult Care

National Multiple Sclerosis Society
Association/Society
United States
US $75,000
The Multiple Sclerosis Clinical Care Physician Fellowship is a one-year program by the National Multiple Sclerosis Society aimed at training neurologists and physiatrists in specialized clinical care for MS patients. Eligible candidates include PGY3 or PGY4 residents from U.S. programs. The fellowship focuses on supervised patient care, multidisciplinary team activities, and professional development, preparing fellows to provide high-quality care and to engage as future leaders in the MS community.
Medical Education & Professional Training Multiple Sclerosis

Multiple Sclerosis Clinical Care Physician Fellowship: Pediatric Care

National Multiple Sclerosis Society
Association/Society
United States
US $75,000
The Multiple Sclerosis Clinical Care Physician Fellowship: Pediatric Care, offered by the National Multiple Sclerosis Society, aims to enhance the training of physicians in providing specialized care for pediatric patients with MS. This one-year post-residency program emphasizes direct patient care and multidisciplinary collaboration. Participants will learn under the supervision of MS specialists, gaining essential skills to improve clinical practices and contribute to the MS community, ultimately leading to better outcomes for those affected by this condition.
Children’s Health & Pediatrics Multiple Sclerosis Medical Education & Professional Training

MRF Breakthrough Consortium (MRFBC) Young Investigator Team Award to Advance the Field of Translational Immuno-Oncology

Melanoma Research Foundation
Private
United States
Up to US $150,000
The MRFBC Young Investigator Team Award supports innovative research in immuno-oncology for melanoma, offering up to $150,000 annually for two years. This funding targets U.S.-based researchers aiming to enhance clinical outcomes for melanoma patients or deepen the scientific understanding of immuno-oncology. The MRF collaborates with key institutions to address challenges in melanoma research, fostering partnerships that maximize research potential and impact.
Cancer / Oncology Skin Diseases & Dermatology Pediatric Cancers

HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $140,000
The HEAL Initiative's Career Development Awards aim to empower early career researchers and clinicians in implementation science. By providing training and funding, this initiative seeks to address substance use prevention and treatment through research projects that align with the HHS Overdose Prevention Strategy. Focused on vital areas such as opioid prescribing, OUD treatment, and recovery support, the program aspires to cultivate a new generation of experts who will significantly impact addiction clinical practices and mentorship.
Drug Use Disorder Addiction & Substance Use Disorders

SBB Research Group Grant

SBB Research Group Foundation
Private
United States
US $1,000 - US $5,000
The SBB Research Group Grant offers $5,000 to 501(c)(3) organizations with a focus on addressing unmet needs through sustainable strategies. The application process is streamlined, consisting of just ten questions. The evaluation includes a review by the Philanthropy Committee, which selects nominees for interviews and finalists for presentations. Winners receive funding and further opportunities, while all finalists receive $1,000. This grant aims to empower organizations with 5 to 49 full-time employees.
Community Services

Teiger Foundation Single Project Grant

Teiger Foundation
Private
American Samoa, Guam +4 more
Up to US $250,000
The Teiger Foundation Single Project Grant supports innovative visual arts projects at non-profit exhibition spaces with annual budgets exceeding $3 million. Focused on curatorial practices, the grant encourages experimentation and creativity, aiming to drive positive structural change in contemporary art. Eligible expenses include artist fees, publication costs, and coalition-building efforts. The next Call for Proposals opens in Fall 2026, with funding of up to $150,000 available for selected projects.
Visual Arts

Teiger Foundation Programming Grant

Teiger Foundation
Private
American Samoa, Guam +4 more
US $75,000 - US $150,000
The Teiger Foundation Programming Grant supports innovative visual arts projects led by curators at smaller non-profit organizations with budgets under $3.5 million. Grants of up to $150,000 are available for three years, funding development, realization, and documentation of exhibitions and related programs. The foundation emphasizes community engagement, racial justice, and artistic experimentation while encouraging collaboration with other cultural institutions. Note: The next Call for Proposals opens in Fall 2026.
Visual Arts

Teiger Foundation: Hosting Grant

Teiger Foundation
Private
American Samoa, Guam +4 more
Up to US $75,000
The Teiger Foundation's Hosting Grant provides up to $75,000 for US-based curators or artistic directors to present contemporary visual art exhibitions that originated in different contexts. This grant encourages resource-sharing and collective learning, allowing institutions to expand their programming sustainably. It prioritizes projects affiliated with established non-profits, fostering community-building and positive change in the field of visual art while addressing issues of racial justice and climate crisis.
Visual Arts

Massachusetts Grants for Nonprofits Highlights

Massachusetts grants for nonprofits provide funding to support innovation in education, technology, and public health. The following grants help organizations tackle challenges, promote sustainability, and enhance quality of life for communities across the state.


Search Instrumentl's Massachusetts Grants Database


Find 241 funding opportunities for nonprofits in Massachusetts, with $67.8M available. Instrumentl provides nonprofits with deadline management tools, customized grant searches, and strategic insights to support impactful projects across the state.

Grant Insights : Massachusetts Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Massachusetts grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

95 Massachusetts grants for nonprofits over $25K in average grant size

75 Massachusetts grants for nonprofits over $50K in average grant size

60 Massachusetts grants for nonprofits supporting general operating expenses

200+ Massachusetts grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Massachusetts grants for Nonprofits?

Most grants are due in the first quarter.

Q1
32.0%
Q2
24.4%
Q3
18.8%
Q4
24.8%

Typical Funding Amounts

What's the typical grant amount funded for Massachusetts Grants for Nonprofits?

Grants are most commonly $26,875.

$250 $250 Min.
$26,875 $26.9 K Median
$413,560 $413.6 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

According to data from the IRS, funding for nonprofits in Massachusetts increased drastically from 2021 to 2022. The 20.67% increase saw funding amounts jump from $11.7B in 2021 to $14.1B in 2022. The most common grant focus areas in Massachusetts during this time were professional societies, associations, research institutes and/or public policy analysis, and alliance/advocacy organizations. Suffolk County, Middlesex County, and Norfolk County received the most funding across the state.

Instrumentl is the only complete grant solution that allows nonprofits to discover opportunities, cultivate relationships, apply for grants, streamline the application process, and report on grant management.

Learn more about how to find grants for your nonprofit.

When applying for funding, nonprofits in Massachusetts should be aware that of the available grants, 32.0% are due in Q1, while 24.8% are due in Q4. Fewer application deadlines fall in Q2 and Q3 as 24.4% and 18.8%, respectively, are due during these periods.

There are more than 200+ grants with a total of $67,823,884 in funding available to Massachusetts nonprofits. These grants, which have a median funding amount of $26,875, support organizations that address everyday challenges, promote sustainability, and enhance the quality of life for communities across the state.

The majority of grants available to Massachusetts nonprofits are funded by private organizations. State and local governments and corporations also provide funding for grants.

  • Private Organizations: Private organizations provide 124 grant opportunities that support causes such as environmental conservation, sustainability, and health and medicine.
  • State and Local Government: State and local government agencies support 72 grants and provide funding for agriculture, museums and cultural institutions, and homeland security.
  • Corporations: Corporations fund 22 grants for Massachusetts nonprofits that support homelessness services, entrepreneurship, affordable housing, and more.
    • Be sure to review all grant application requirements and deadlines to improve your chances of securing funding.

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