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Best Massachusetts Grants for Nonprofits

Find nonprofit grants in Massachusetts, including opportunities in Boston, Worcester, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$3.29B

Total funding

$5K

Median grant

10,000+ grants
$3.29B total
$5K median

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9,781 Results based on applied filters

Resident Clinical Research Award

American College Of Gastroenterology Inc
Private
Canada, United States
US $10,000
The Resident Clinical Research Award, supported by the ACG Institute and the American College of Gastroenterology, fosters original clinical research by medical residents in gastroenterology and hepatology. This award encourages promising trainees to undertake a mentored research project, with funding for diverse studies and reimbursement for travel to the ACG Annual Scientific meeting. Since 1994, over $31.9 million has been awarded to more than 745 recipients, promoting careers in clinical research.
Digestive System Health & Diseases

Medical Student Research Award

American College Of Gastroenterology Inc
Private
Canada, United States
US $5,000
The Medical Student Research Award, funded by the American College of Gastroenterology, offers U.S. and Canadian medical students a unique opportunity for summer research experiences in gastroenterology and hepatology. This award promotes interest in these fields through mentored projects, covering living expenses and travel to the ACG Annual Scientific meeting. Since 1994, over $31.89 million has been awarded, supporting more than 745 recipients, making it a vital program for aspiring researchers.
Digestive System Health & Diseases Medical Education & Professional Training

Veterans United Foundation Scholarship

Veterans United Foundation
Private
United States
Unspecified amount
The Veterans United Foundation Scholarship supports the educational aspirations of military families by providing financial assistance to eligible applicants. This scholarship is open to veterans with service-related disabilities, surviving spouses, and children of deceased servicemembers. Since its inception in 2012, over $1 million has been awarded, making a significant impact on the education of those who serve our country. The application process requires proof of eligibility and documentation to ensure support for education-related expenses.
Military & Veterans Services Academic Scholarship Programs

Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders (U01 - Clinical Trial Optional) (357817)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The U.S. Department of Health & Human Services, through the NIH, invites applications for the U01 grant aimed at advancing gene-based therapies for ultra-rare neurological and neuromuscular disorders. This initiative focuses on IND-enabling studies and supports the development of innovative therapeutics with proven biological rationale. Applications must include robust data and compelling justification for the proposed clinical candidates, targeting a specific patient population to facilitate IND filing and subsequent clinical trials.
Neurological Diseases & Disorders Rare Diseases Genetics & Genomics +2 more

Special Needs Grant

Coast Guard Mutual Assistance
Private
United States
Up to US $3,000
The Special Needs Grant, provided by Coast Guard Mutual Assistance (CGMA), offers financial support to Active Duty members facing increased financial demands due to dependents in the Coast Guard Special Needs Program. Eligible members can receive up to $3,000 every 60 months for various services and resources tailored for special needs, including adaptive equipment and membership fees for relevant organizations. This grant aims to enhance the quality of life for families with exceptional needs.
Disability Care & Services

ABMS Research and Education Foundation Grants

American Board of Medical Specialties
Association/Society
United States
Up to US $75,000
The ABMS Research and Education Foundation grants support innovative research aimed at enhancing healthcare quality through board certification. By encouraging collaborations among ABMS Member Boards, the program seeks original studies that inform improvements in certification processes. Proposals are reviewed based on relevance to the ABMS mission, research novelty, methods, team composition, and potential impact. Applications from diverse health organizations are welcomed, provided the principal investigator is unaffiliated with ABMS.
Epidemiology & Public Health Health Care Access & Delivery

Music Therapy Grants

Music Movement
Association/Society
United States
US $1,500 - US $2,500
Music Movement offers grants for music therapy aimed at children and young adults with Autism Spectrum Disorder (ASD) and other developmental challenges. Grants typically range from $1,500 to $2,500, providing financial relief to families seeking therapeutic resources. Eligible applicants include legal guardians of children in the U.S. who select qualified therapists. The organization focuses on enhancing communication, social skills, and emotional well-being through music, benefiting diverse communities and promoting personal growth.
Autism Children With Disabilities Music Education

Partnership Grants

Music Movement
Association/Society
United States
US $2,500 - US $5,000
The Partnership Grants, offered by Music Movement, provide funding between $2,500 and $5,000 for eligible entities such as academies, public schools, hospitals, and non-profit organizations within the United States. Applications are reviewed semi-annually, and existing non-profits must submit their 501(c)(3) TIN. Grants can be resubmitted for reconsideration annually, but international applications are not accepted.
Music

Wireless Family Fund

Music Movement
Association/Society
United States
US $1,500 - US $2,500
The Wireless Family Fund, supported by Music Movement, provides financial aid to families in the Wireless and Tech Industries, focusing on living expenses, medical bills, and educational support. Grants typically range from $1,500 to $2,500 and are available to families within the United States. Music Movement enriches the lives of individuals with Autism and other developmental differences through music-centric programs that enhance communication, social skills, and emotional expression.
Music Family Services Health & Medicine

AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer (Fund B)

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer provides $100,000 annually for three years to early-career faculty in digestive disease research. This award aims to support independent careers in pancreatic cancer research by protecting a significant portion of the recipient's time for research activities. Eligible applicants must hold an MD, PhD, or equivalent and work at a North American institution, with AGA membership required. Strong encouragement is given to underrepresented groups.
Pancreatic Cancer

AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer (Fund A)

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Bern Schwartz Family Fund Research Scholar Award in Pancreatic Cancer provides $100,000 annually for three years to early-career faculty focused on independent research in pancreatic cancer. This award aims to protect at least 50% of the recipient's time for research activities. Eligible applicants must hold an MD or PhD and be classified as early-career. The award encourages physician-scientists and underrepresented groups in biomedical research to apply, supporting innovative research that can lead to significant advancements in understanding pancreatic cancer.
Pancreatic Cancer

AGA-Gastric Cancer Foundation Ben Feinstein Memorial Research Scholar Award in Gastric Cancer

American Gastroenterological Association
Association/Society
North America
US $300,000
The AGA-Gastric Cancer Foundation Ben Feinstein Memorial Research Scholar Award provides $100,000 annually for three years to early-career faculty dedicated to gastric cancer research. Eligible candidates must have an MD, PhD, or equivalent and a full-time faculty position in North America. The award supports research in various areas related to gastric cancer, ensuring a minimum of 50% time commitment to the project, thus fostering independent careers in digestive diseases.
Gastrointestinal Cancers

Postdoctoral Fellowships

American Diabetes Association Inc
Private
American Samoa, Guam +4 more
US $84,008 - US $252,024
The American Diabetes Association's Postdoctoral Fellowship Awards aim to foster emerging leaders in diabetes research. With a focus on innovative research, these fellowships provide up to three years of funding, including a stipend and allowances. Eligible applicants must hold a recent advanced degree and conduct research at U.S. affiliated institutions. This initiative not only supports career development but also contributes significantly to the mission of preventing and curing diabetes.
Diabetes

Zuckerman Postdoctoral Scholars Program: Joint North American-israel Postdoc Track

Mortimer B Zuckerman Foundation
Private
Canada, Israel +1 more
Up to US $126,000
The Zuckerman Postdoctoral Scholars Program fosters collaboration between leading scientific institutions in the U.S. and Israel by attracting top postdoctoral researchers. With a focus on STEM leadership, this program offers a unique two-year scholarship, allowing scholars to conduct research at participating Israeli universities and North American institutions. The initiative aims to strengthen academic ties, enhance research capabilities, and support the return of talented Israeli scholars to their home institutions, ultimately enriching the global scientific community.
Engineering Mathematics Science +1 more

Tides Stronger Together Fund Grant

Tides Foundation
Private
United States
Unspecified amount
The Tides Stronger Together Fund, under the Tides Foundation, provides essential support grants to fiscally sponsored partners focused on historically underserved communities. By building organizational capacity and leadership, the fund empowers community changemakers to address inequities and enhance sustainability. With a pooled funding model, it directly responds to the needs of over 120 partners, ensuring resources are effectively allocated where they are most impactful, ultimately fostering long-term community resilience.
Community Services

Goldman Fund: Democracy & Civil Liberties

Lisa & Douglas Goldman Fund
Private
United States
Unspecified amount
The Lisa and Douglas Goldman Fund, established in 1992, supports charitable organizations that enhance society, focusing on democracy and civil liberties. The fund prioritizes projects that ensure equal citizen participation in the democratic process and protect civil liberties, especially those implemented nationally or across multiple states. It operates by invitation only and emphasizes flexible, informed grantmaking to qualified projects that align with its mission and values.
Governance & Democracy Civic Engagement & Education Gun Violence Prevention +1 more

HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) (357655)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
The HEAL Initiative aims to identify new druggable targets for pain within the understudied proteome. This funding opportunity invites applications for pilot projects that generate preliminary data and tools for exploring these targets. The initiative seeks to enhance research on understudied proteins related to pain management, providing essential funding for biochemical and biological work. This NOFO is part of the NIH's broader effort to develop novel medications that address various aspects of opioid addiction and its consequences.
Chronic / Acute Pain Anesthesia and Pain Medicine Drug Use Disorder +1 more

Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional) (357667)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $3,250,000
The Limited Competition: Clinical and Translational Science Award (CTSA) Program's Collaborative and Innovative Acceleration Award aims to enhance translational research by fostering collaboration in developing and implementing innovative solutions. This funding opportunity invites applications focused on new approaches and technologies that will improve research impact across various diseases and expedite treatment availability. Eligible applicants include organizations with active CTSA hub prime or partnering awards.
Health & Medicine Pharmacology Biomedical informatics +4 more

Outdoor Recreation Legacy Partnership Program (ORLP) Recurring Notice 5 Year

US Department of the Interior: National Park Service (NPS)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $15,000,000
The Outdoor Recreation Legacy Partnership Program (ORLP) is a competitive grant initiative by the National Park Service, aimed at enhancing parks and recreational opportunities in urban, underserved communities. This program supports the acquisition, development, and renovation of outdoor recreation areas through federal funding, addressing the needs of community organizations, local governments, and recognized tribes. Applications are accepted twice a year, before June 1 and November 1.
Parks & Public Spaces Outdoor Recreation Outdoor Equity

Improving Methods for Conducting Patient - Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement - Cycle 1

Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $750,000
The Patient-Centered Outcomes Research Institute (PCORI) Funding Announcement aims to enhance methods for conducting patient-centered comparative clinical effectiveness research. This initiative seeks to address critical methodological gaps, focusing on improving the use of artificial intelligence in clinical research, study design, data research networks, and ethical protections in patient-centered CER. With a budget of up to $750,000, successful proposals will contribute to the quality and strength of evidence generated in CER studies.
Medical Ethics Artificial Intelligence (AI) Health & Medicine

Improving Methods for Conducting Patient - Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement - Cycle 2

Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $750,000
The Patient-Centered Outcomes Research Institute (PCORI) is offering funding up to $750,000 for studies aimed at addressing critical methodological gaps in patient-centered comparative clinical effectiveness research. This initiative focuses on enhancing the quality of evidence in clinical research by prioritizing areas such as artificial intelligence, study design improvements, support for data research networks, and ethical considerations. Successful proposals will contribute to advancing research methodologies and improving patient outcomes.
Medical Ethics Artificial Intelligence (AI) Health & Medicine

Improving Methods for Conducting Patient - Centered Comparative Clinical Effectiveness Research PCORI Funding - Cycle 3

Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $750,000
The Patient-Centered Outcomes Research Institute (PCORI) is funding Cycle 3 to enhance patient-centered comparative clinical effectiveness research (CER). This initiative targets critical methodological gaps, focusing on improving the use of artificial intelligence, study design, data research networks, and ethical protections. By addressing these areas, PCORI aims to strengthen the quality of evidence in CER, thus promoting better outcomes in healthcare decision-making.
Health & Medicine Medical Ethics Artificial Intelligence (AI)

Risk and Protective Factors of Family Health and Family Level Interventions (R01 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Risk and Protective Factors of Family Health initiative invites research proposals to explore family health and resilience, addressing health disparities in minority communities. Key submission deadlines are set for various dates from February 2025 to February 2027. This program is supported by the National Institutes of Health, highlighting the importance of family well-being as a critical area for advancing health equity. Proposals should focus on interventions that improve family health outcomes.
Family Services Minority Services Health Disparities & Social Determinants of Health

ASTS: Veloxis Fellowship in Transplantation Grant

American Society Of Transplant Surgeons
Private
North America
US $85,000
The ASTS: Veloxis Fellowship in Transplantation Grant offers $42,500 per year for two years to support clinical training in solid organ transplantation. This grant is aimed at current transplant surgery trainees who have completed their surgical residency and are committed to the field. Awardees must attend the ASTS Award Ceremony and complete their fellowship at the same institution for the duration of the award, ensuring a focused and comprehensive training experience.
Surgery Organ And Tissue Banks

Caroline and Martin Gross Fellowship

New Hampshire Charitable Foundation
Private
Middlesex County, Massachusetts
Unspecified amount
The Caroline and Martin Gross Fellowship honors outstanding public service work in New Hampshire. Established in memory of Caroline and Martin Gross, it provides funding for individuals in elected or appointed positions to attend a three-week seminar at Harvard's Kennedy School of Government. Candidates are evaluated based on their public service experience, capacity to benefit from the program, and commitment to improving decision-making processes. Self-nominations are discouraged, ensuring a focus on merit.
Civic Leadership Development Governance & Democracy

Toward Translation of Nanotechnology Cancer Interventions (TTNCI; R01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,900,000
The National Cancer Institute (NCI) invites applications for the Toward Translation of Nanotechnology Cancer Interventions (TTNCI) program. This funding opportunity focuses on advanced pre-clinical research aimed at developing nanotechnology-based cancer diagnostics and therapeutics. TTNCI awards will support the maturation of innovative nanomedicines using nanoparticles and nano-devices, enhancing cancer treatment efficacy. Successful projects will progress towards further NCI translational programs, such as the NExT initiative.
Cancer / Oncology Nanomaterials & Nanotechnology

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional) (357744)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
This funding opportunity supports exceptionally promising Early Stage Investigators in genomics, encouraging innovative research across various fields such as genomic sciences and medicine. Applicants must submit their proposals by 5:00 PM local time of their organization. The initiative, led by the US Dept. of Health & Human Services through the NIH, aims to foster long-term career development in genomic research while addressing its ethical, legal, and social implications.
Genetics & Genomics Medical Ethics

Massachusetts Grants for Nonprofits Highlights

Massachusetts grants for nonprofits provide funding to support innovation in education, technology, and public health. The following grants help organizations tackle challenges, promote sustainability, and enhance quality of life for communities across the state.


Search Instrumentl's Massachusetts Grants Database


Find 247 funding opportunities for nonprofits in Massachusetts, with $68.5M available. Instrumentl provides nonprofits with deadline management tools, customized grant searches, and strategic insights to support impactful projects across the state.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Massachusetts Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Massachusetts grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

96 Massachusetts grants for nonprofits over $25K in average grant size

77 Massachusetts grants for nonprofits over $50K in average grant size

59 Massachusetts grants for nonprofits supporting general operating expenses

200+ Massachusetts grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Massachusetts grants for Nonprofits?

Most grants are due in the first quarter.

Q1
31.6%
Q2
25.7%
Q3
18.6%
Q4
24.1%

Typical Funding Amounts

What's the typical grant amount funded for Massachusetts Grants for Nonprofits?

Grants are most commonly $27,500.

$250 $250 Min.
$27,500 $27.5 K Median
$410,471 $410.5 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

According to data from the IRS, funding for nonprofits in Massachusetts increased drastically from 2021 to 2022. The 20.67% increase saw funding amounts jump from $11.7B in 2021 to $14.1B in 2022. The most common grant focus areas in Massachusetts during this time were professional societies, associations, research institutes and/or public policy analysis, and alliance/advocacy organizations. Suffolk County, Middlesex County, and Norfolk County received the most funding across the state.

Instrumentl is the only complete grant solution that allows nonprofits to discover opportunities, cultivate relationships, apply for grants, streamline the application process, and report on grant management.

Learn more about how to find grants for your nonprofit.

When applying for funding, nonprofits in Massachusetts should be aware that of the available grants, 31.6% are due in Q1, while 25.7% are due in Q2. Fewer application deadlines fall in Q4 and Q3 as 24.1% and 18.6%, respectively, are due during these periods.

There are more than 200+ grants with a total of $68,548,642 in funding available to Massachusetts nonprofits. These grants, which have a median funding amount of $27,500, support organizations that address everyday challenges, promote sustainability, and enhance the quality of life for communities across the state.

The majority of grants available to Massachusetts nonprofits are funded by private organizations. State and local governments and corporations also provide funding for grants.

  • Private Organizations: Private organizations provide 124 grant opportunities that support causes such as environmental conservation, sustainability, and health and medicine.
  • State and Local Government: State and local government agencies support 77 grants and provide funding for agriculture, museums and cultural institutions, and homeland security.
  • Corporations: Corporations fund 22 grants for Massachusetts nonprofits that support homelessness services, entrepreneurship, affordable housing, and more.
    • Be sure to review all grant application requirements and deadlines to improve your chances of securing funding.

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