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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,702 Results based on applied filters

ASTRO-LUNGevity Residents/Fellows in Radiation Oncology Seed RFA

American Society For Radiation Oncology
Association/Society
United States
Up to US $50,000
The ASTRO-LUNGevity Residents/Fellows in Radiation Oncology Seed Grant aims to advance the research careers of residents and fellows focusing on radiation oncology and its impact on lung cancer treatment. This $50,000 award supports innovative basic, translational, and clinical research projects. A no-cost extension may be granted at ASTRO and LUNGevity's discretion, but the total project duration cannot exceed two years.
Lung Cancer

ASTRO-AAPM Physics Resident/Post-Doctoral Fellow Seed Grant (1 year)

American Society For Radiation Oncology
Association/Society
United States
Up to US $100,001
The ASTRO-AAPM Physics Resident/Post-Doctoral Fellow Seed Grant supports early-career scientists in radiation oncology physics research. Jointly funded by AAPM and ASTRO, this grant aims to foster innovation in the field, with up to two awards of $50,000 each available. Eligible applicants include medical physics residents and post-doctoral fellows who are active members of ASTRO and AAPM. This initiative strives to enhance the next generation of researchers, ensuring a commitment to advancing radiation oncology.
Cancer / Oncology Physics

Exceptional Project Grants

Breast Cancer Alliance Inc
Private
United States
US $100,000
The Breast Cancer Alliance offers Exceptional Project Grants aimed at enhancing survival rates and quality of life for individuals affected by breast cancer. This grant, amounting to $100,000 over one year, supports innovative research and projects in the contiguous United States. Eligible applicants include clinical doctors and research scientists at any career stage. The funding covers salary and project costs, with indirect costs capped at 8% of direct costs, ensuring comprehensive support for impactful research.
Breast Cancer

Young Investigator Grants

Breast Cancer Alliance Inc
Private
United States
US $125,000
The Young Investigator Grants, offered by the Breast Cancer Alliance, aim to support early-career researchers focused on breast cancer. This two-year grant provides up to $125,000 in funding, split across the duration, to facilitate independent research projects. Applicants must be affiliated with U.S. institutions and should not have held major grant support previously. This initiative fosters innovation in breast cancer research, ultimately enhancing survival rates and quality of life for affected individuals.
Breast Cancer

Boehringer Ingelheim: External Collaborative Research (ECR)

Boehringer Ingelheim Pharmaceuticals, Inc.
Corporate
United States
Unspecified amount
The External Collaborative Research (ECR) program by Boehringer Ingelheim invites academic and community scientists to propose collaborative studies aimed at protocol development and result publication. This program offers potential drug and financial support, excluding direct salary for the Principal Investigator. Budgets must represent fair market value and will be negotiated further. Research interests span therapeutic areas including Cardio-Renal-Metabolic, Mental Health, Dermatology, and Oncology, encouraging innovative solutions to unmet medical needs.
Skin Diseases & Dermatology Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases +7 more

Clinician Scientist Development Awards

National Multiple Sclerosis Society
Association/Society
United States
Unspecified amount
The National MS Society's Clinician Scientist Development Awards aim to cultivate promising young investigators in multiple sclerosis research. This program supports postdoctoral fellows with three years of comprehensive training in academic medicine focused on MS. Applicants must hold a clinical degree and be licensed in the U.S. The Society prioritizes research that aligns with its Pathways to Cures Roadmap, which emphasizes stopping disease progression, restoring function, and preventing MS.
Multiple Sclerosis

National MS Society: Harry Weaver Scholar Awards

National Multiple Sclerosis Society
Association/Society
United States
Unspecified amount
The National MS Society offers Harry Weaver Scholar Awards to support emerging researchers in multiple sclerosis. This prestigious award honors Dr. Harry Weaver's legacy and aims to facilitate independent research careers. Eligible candidates must have a doctoral degree and relevant postdoctoral training. The funding is designed to provide salary and grant support for five years, allowing awardees to establish competence in their research area. Applications should align with the Society's Pathways to Cures Roadmap.
Multiple Sclerosis

National MS Society: MS Clinical Mentorships: Medical Student Mentorship Program

National Multiple Sclerosis Society
Association/Society
United States
US $5,000
The National Multiple Sclerosis Society offers a Medical Student Mentorship Program that provides a four-week clinical experience for medical students who have completed at least one year of school. This program aims to raise awareness about the challenges faced by individuals with MS and generate interest in careers focused on MS care. Students gain hands-on experience under the guidance of MS specialists, enhancing their understanding of the disease and its management.
Multiple Sclerosis

Drug Delivery Faculty Starter Grant

Pharmaceutical Research And Manufacturers Of America Fnd Inc (PhRMA)
Private
United States
US $100,000
The Drug Delivery Faculty Starter Grant from the PhRMA Foundation supports early-career researchers in drug delivery, providing $100,000 for one year. Eligible applicants include full-time faculty at accredited U.S. universities within their first five years of independent status. The grant emphasizes innovative research that enhances drug transport and dosage forms. Recipients must notify the Foundation of any external funding exceeding $250,000. This initiative aims to foster scientific independence and collaboration in biopharmaceutical innovation.
Pharmacology

SUS: Mid Career Award

Society of University Surgeons
Private
Canada, United States
US $40,000
The SUS Mid Career Award offers $40,000 for one year to SUS members in the US or Canada with prior research funding, supporting their ongoing work in surgical sciences. Eligible applicants must have experience as a principal investigator on independent or smaller grants, or hold a career development award. This award serves as bridge funding for those who have recently applied for independent grants but were not funded, fostering continued research and innovation.
Surgery

SUS: Resident Research Scholar Award

Society of University Surgeons
Private
Canada, United States
US $30,000
The SUS Resident Research Scholar Award offers $30,000 for one year to surgical residents engaged in basic or translational research. Eligible candidates must have completed two years of training and commit to full-time research with an SUS member. Notably, applicants must avoid mentors on the exclusion list, ensuring a fair and competitive application process. This funding promotes innovative surgical research and supports the development of future leaders in the field.
Surgery Bioengineering Health Information Technology +1 more

American Surgical Association: Surgical Leaders Fellowship Grant

American Surgical Association
Private
United States
US $5,000
The American Surgical Association's Surgical Leaders Fellowship Grant aims to develop future academic surgical leaders while promoting diversity in leadership roles. The program includes shadowing experiences and skill development, allowing fellows to assess their readiness for leadership positions in surgery. Each fellowship provides $5,000 in funding for visits to two academic institutions, enhancing professional growth through mentorship with established leaders in the field.
Surgery

FFAR Fellows: Stipend + Professional Development Category

Foundation for Food and Agriculture Research (FFAR)
Private
Canada, United States
Up to US $148,500
The FFAR Fellows Program offers professional development and leadership training for PhD students in food and agriculture sciences across the U.S. and Canada. Led by North Carolina State University, the program includes in-person meetings, virtual sessions, and mentorship opportunities. Students receive a combined stipend of $65,000 annually, with a minimum of 50% sponsorship from non-academic sources. The program emphasizes interdisciplinary collaboration, career exploration beyond academia, and the development of essential skills for future leaders in the field.
Agriculture

FFAR Fellows: Professional Development Category

Foundation for Food and Agriculture Research (FFAR)
Private
Canada, United States
US $15,000 in in-kind support
The FFAR Fellows Program, led by North Carolina State University, provides PhD students in food and agriculture sciences with essential leadership and professional development training. Over three years, fellows engage in in-person meetings, virtual sessions, and mentorship opportunities, enhancing their skills and networking. Applicants must be enrolled in a PhD program, have a confirmed financial sponsor, and demonstrate readiness to participate. This initiative promotes interdisciplinary collaboration and broadens career pathways beyond academia.
Agriculture

ASES Research Grant

Ases Foundation
Private
North America
Up to US $20,000
The ASES Research Grant, provided by the ASES Foundation, offers up to $20,000 for innovative shoulder and elbow research projects. It invites applications from principal investigators who are orthopaedic surgeons working in North America. The funding supports projects lasting between 12 to 24 months and aims to foster advancements in patient care through research. Applications are limited to one per principal investigator per year, promoting focused and impactful research initiatives.
Kinesiology & Sports Medicine Orthopedics Physical Therapy +1 more

Veterans and Nature Grant

National Environmental Education Foundation
Private
United States
Up to US $10,000
The Veterans and Nature Grant, offered by the National Environmental Education Foundation (NEEF) in partnership with the U.S. Forest Service, aims to engage veterans in outdoor activities that promote physical and mental health. With a funding pool of $100,000, grants of up to $10,000 are available for projects focused on outdoor recreation and wellness activities. Eligible applicants include 501(c)(3) entities partnered with public land organizations, fostering environmental awareness and community involvement.
Military & Veterans Services Outdoor Recreation Parks & Public Spaces

High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,500,000
The High Priority HIV and Substance Use Research funding opportunity aims to support innovative research that addresses the intersection of HIV and substance use. Researchers are encouraged to submit proposals that include a detailed research plan and preliminary data, exploring new avenues for prevention, treatment, and potential cures for HIV among people who use drugs. Applications are due by 5 PM local time, with optional Letters of Intent recommended 30 days prior.
HIV / AIDS Addiction & Substance Use Disorders Drug Use Disorder

Changing Aging (CA) Grant

Next50 Foundation
Private
United States
Unspecified amount
The Changing Aging (CA) Grant supports innovative projects aimed at enhancing economic opportunities for older adults and combating ageism. Priorities include advancing digital equity and promoting aging in place for marginalized communities. Funded by Next50, the grant encourages collaboration among nonprofits and requires an equity-focused approach to project design. Organizations may apply for up to three years of funding, with no maximum request limit, although a pre-application call is necessary for larger requests.
Aging / Gerontology Senior Services Social Isolation

Growing Convergence Research

National Science Foundation (NSF)
Federal Government
United States
US $1,200,000 - US $3,600,000
The Growing Convergence Research (GCR) initiative by the National Science Foundation (NSF) promotes innovative solutions to complex societal and scientific challenges through multidisciplinary collaboration. By integrating diverse expertise, GCR aims to address specific problems and foster new research paradigms. Proposals must outline a five-year plan, divided into two phases, with budgets not exceeding $1.2 million for Phase I and $2.4 million for Phase II. Successful projects are expected to lead to transformative advances in science and technology.
Cognitive Science Biological Anthropology Engineering +5 more

Amazon Literary Partnership Grant: US

Amazon, Inc.
Corporate
United States
US $5,000 - US $20,000
The Amazon Literary Partnership Grant supports nonprofit organizations in the U.S. that empower diverse and marginalized writers. Since 2009, it has provided over $17 million to various literary groups, fostering emerging talent across genres. Eligible organizations must focus on developing writers, celebrating storytelling, and connecting them with audiences. By funding innovative initiatives, Amazon helps ensure that underrepresented voices are heard in the literary community, contributing to a rich and diverse narrative landscape.
Writing & Literature

CURE Childhood Cancer: Translation to CURE award (T2C)

Cure Childhood Cancer Inc
Private
United States
Up to US $330,000
The CURE Childhood Cancer: Translation to CURE (T2C) award provides funding for groundbreaking research to improve outcomes for children with cancer. Offering up to $150,000 per year for two years, this grant supports innovative projects led by full-time faculty at nonprofit institutions. The initiative seeks to foster collaboration among researchers at all career stages, ensuring that promising ideas can take root and flourish, ultimately driving advancements in pediatric oncology.
Cancer / Oncology Children’s Health & Pediatrics

CURE Childhood Cancer: Early Investigator award (EI)

Cure Childhood Cancer Inc
Private
United States
Up to US $220,000
The CURE Childhood Cancer Early Investigator Award supports emerging scientists in the fight against pediatric cancer. This grant offers up to $150,000 per year for two years, totaling $330,000. It is designed for early-career researchers at US-based nonprofit institutions, particularly those at the Instructor or Assistant Professor level. The award aims to foster innovative research that can lead to effective treatments for childhood cancer, emphasizing the importance of collaboration and scientific advancement.
Cancer / Oncology Children’s Health & Pediatrics

2026-2027 AHA Predoctoral Fellowships

Autism Speaks
Private
United States
US $80,000
The Autism Speaks Predoctoral Fellowship aims to support early career autistic scientists in their research endeavors. By providing a two-year fellowship that includes a $40,000 annual award, the program seeks to enhance research training opportunities for promising candidates. Fellows will collaborate with leading mentors in autism research, ensuring that individuals with both academic expertise and lived experience can significantly contribute to advancements in the field. This initiative underscores Autism Speaks' commitment to fostering inclusivity and innovation in autism research.
Autism

Hanna H. Gray Fellows Program: Postdoctoral Training Phase

Howard Hughes Medical Institute
Private
Puerto Rico, United States
US $130,000 - US $154,382
The Hanna H. Gray Fellows Program, funded by the Howard Hughes Medical Institute, aims to enhance diversity in the scientific community by supporting early-career researchers. The program provides funding for postdoctoral training and early faculty years, promoting an inclusive academic culture. Fellows receive an initial salary of $80,000 and a $20,000 annual expense allowance. This initiative helps develop future leaders in biological and biomedical sciences, ensuring equitable opportunities for all backgrounds.
Medical Education & Professional Training Science Health & Medicine

EPSCoR Research Infrastructure Improvement (RII): EPSCoR Research Fellows

National Science Foundation (NSF)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The EPSCoR Research Infrastructure Improvement (RII): EPSCoR Research Fellows program, funded by the National Science Foundation (NSF), aims to enhance research capacity and workforce development in STEM. This initiative fosters collaborations between underrepresented researchers and leading institutions, providing essential resources and support. With two tracks available—one focusing on NSF and the other on NASA—this program uniquely positions Fellows to leverage transformative research experiences and contribute to sustainable advancements in their respective fields.
Economics Sociology Mathematics +10 more

Hanna H. Gray Fellows Program: Faculty Phase

Howard Hughes Medical Institute
Private
Puerto Rico, United States
Up to US $1,080,000
The Hanna H. Gray Fellows Program, supported by the Howard Hughes Medical Institute, aims to enhance diversity in the academic research community. It provides funding of $250,000 and a $20,000 annual expense allowance for early-career researchers committed to fostering an inclusive scientific culture. Eligible applicants must hold a PhD or MD, commit to at least 75% research effort, and have no more than 24 months of postdoctoral experience. This initiative empowers fellows to become leaders in science.
Science Health & Medicine Medical Education & Professional Training

El Dorado Springs Affiliate Grantmaking Program

Community Foundation of the Ozarks Inc.
Private
Cedar County, Missouri
US $2,500
The El Dorado Springs Affiliate Grantmaking Program, managed by the Community Foundation of the Ozarks, supports 501(c)(3) organizations and IRS-approved entities serving Cedar County. With a funding limit of $3,000, this program addresses vital community needs through flexible grantmaking. The foundation prioritizes projects that enhance the lives of local residents while ensuring non-discrimination in funding use. Applications are accepted periodically, reflecting the community's most pressing requirements.
Community Services Health & Medicine Human & Social Services +7 more

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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