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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,702 Results based on applied filters

PERF: Career Development Grants - CNS Elterman Research Grant

Pediatric Epilepsy Research Foundation
Private
Canada, United States
US $150,000
The PERF: Career Development Grants - CNS Elterman Research Grant, established by the Pediatric Epilepsy Research Foundation in partnership with the Child Neurology Society, supports early-stage investigators in pediatric neurology. Eligible candidates can receive $150,000 over two years to conduct clinical or basic science research. This initiative aims to foster the development of researchers focused on pediatric epilepsy and related conditions, enhancing the field through innovative studies and collaboration.
Children’s Health & Pediatrics Epilepsy Neurological Diseases & Disorders +1 more

Indian Environmental General Assistance Program

Environmental Protection Agency
Federal Government
United States
Unspecified amount
The Indian Environmental General Assistance Program (GAP), administered by the U.S. Environmental Protection Agency (EPA), provides crucial funding to tribal governments and intertribal consortia for developing environmental protection programs. Since 1992, GAP has focused on remediation of pollutants and, more recently, supports climate adaptation initiatives. The program emphasizes tribal sovereignty while aiding in capacity building, policymaking, and establishing joint EPA-Tribal Environmental Plans to effectively address environmental challenges faced by tribal communities.
Indigenous Sovereignty & Rights Environmental Conservation Waste Management +2 more

SBB Research Group Foundation Grant

SBB Research Group Foundation
Private
United States
US $1,000 - US $5,000
The SBB Research Group Foundation Grant supports 501(c)(3) organizations addressing unmet needs through sustainable strategies. Winners are selected monthly, receiving $5,000, while other finalists are awarded $1,000. The foundation collaborates with various partners and has a strong commitment to community service. Organizations are encouraged to apply early, as prior applicants can be reconsidered in subsequent months. This initiative aims to empower impactful initiatives across diverse sectors.
Community Services

Providing Research Education Experiences to Enhance Inclusivity for a Diverse Substance Use and Addiction Scientific Workforce (R25 Clinical Trials Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,250,000
The NIH R25 program aims to enhance inclusivity in research education by supporting activities that encourage individuals from diverse backgrounds to pursue careers in substance use and addiction sciences. This initiative focuses on skills development courses and research experiences, particularly targeting underrepresented groups in biomedical and behavioral sciences. Applications are due by 5:00 PM local time of the applicant organization, with optional Letters of Intent encouraged 30 days prior to the full proposal deadline.
Addiction & Substance Use Disorders STEM / STEAM Education Biology +3 more

Allergic Respiratory Diseases Award

American Lung Association
Private
United States
Up to US $150,000
The Allergic Respiratory Diseases Award, supported by the American Lung Association and the American Academy of Allergy, Asthma & Immunology, aims to bolster research in allergic respiratory diseases. Designed for faculty in Clinical Allergy and Immunology at academic medical centers, this award offers $75,000 annually for up to two years. It seeks to empower researchers at pivotal points in their careers, enhancing understanding and treatment of these conditions while promoting lung health.
Respiratory Diseases & Systems Allergies & Allergic Diseases Immune System Diseases

Catalyst Award

American Lung Association
Private
United States
Up to US $100,000
The Catalyst Award, offered by the American Lung Association, supports innovative research on lung disease and biology. This mentored grant provides $50,000 annually for up to two years, prioritizing novel projects with collaborative training plans. The American Lung Association aims to improve lung health and prevent diseases through research, education, and advocacy, focusing on defeating lung cancer and fostering a tobacco-free future.
Lung Cancer Respiratory Diseases & Systems

Dalsemer Interstitial Lung Disease Award

American Lung Association
Private
United States
Up to US $100,000
The Dalsemer Interstitial Lung Disease Award, funded by the American Lung Association, provides $50,000 per year for two years to support junior investigators researching interstitial lung disease. This award aims to foster independence in early-career scientists while building on the Association's 120-year legacy of improving lung health through innovative research and advocacy efforts, ultimately enhancing the lives of those affected by lung disease.
Interstitial Lung Disease

Emerging Respiratory Pathogen Award

American Lung Association
Private
United States
Up to US $200,000
The Emerging Respiratory Pathogen Award, offered by the American Lung Association, aims to enhance our understanding of respiratory infections' pathobiology and their implications. This award supports innovative research addressing the biology of respiratory viruses, host response factors, community spread dynamics of COVID-19, and long-term effects of viral infections. With a funding of $100,000 per year for two years, this initiative encourages groundbreaking studies to improve lung health and disease outcomes.
Respiratory Diseases & Systems Epidemiology & Public Health

Hasting Innovation Award for Interstitial Lung Disease

American Lung Association
Private
United States
Up to US $75,000
The Hasting Innovation Award for Interstitial Lung Disease, offered by the American Lung Association, provides $75,000 annually for up to two years to support early-career researchers. This award targets investigators with proven excellence and a track record of accomplishment, aiming to advance lung disease science. Successful candidates must have held a K or R type award within the last three to five years, fostering innovation and discovery in lung health.
Interstitial Lung Disease

Innovation Award

American Lung Association
Private
United States
Up to US $150,000
The Innovation Award by the American Lung Association offers $75,000 annually for up to two years, aimed at supporting promising investigators in lung disease research. With a legacy of over 120 years, the Association seeks to fund innovative projects that can significantly impact lung health. Eligible candidates must demonstrate prior excellence in their careers and have held a K or R type award within the last three to five years. This initiative fosters groundbreaking advancements in lung disease science.
Lung Cancer Respiratory Diseases & Systems

Lung Cancer Discovery Award

American Lung Association
Private
United States
Up to US $200,000
The Lung Cancer Discovery Award, offered by the American Lung Association, supports innovative research aimed at improving outcomes for lung cancer patients. With funding of $100,000 per year for up to two years, this award encourages groundbreaking projects that enhance diagnostic and therapeutic strategies, investigate genetic forms of lung cancer, and develop novel screening methods. The initiative is a vital step towards reducing lung cancer morbidity and mortality, ultimately improving patient care and saving lives.
Lung Cancer

Public Policy & Public Health Award

American Lung Association
Private
United States
Up to US $100,000
The Public Policy & Public Health Award by the American Lung Association aims to foster innovative research addressing critical public health issues impacting lung health. This grant, with a maximum award of $50,000 per year for up to two years, supports researchers in various disciplines to evaluate existing policies and propose new ideas. It encourages efforts to improve air quality and tackle lung disease, aligning with the mission of enhancing public health through informed policy-making.
Epidemiology & Public Health Public Policy Lung Cancer +4 more

OREF/Musculoskeletal Transplant Foundation Research Grant Prgram

Orthopaedic Research and Education Foundation
Private
United States
US $100,000
The OREF/MTF Biologics Research Grant encourages innovative research in biologics, focusing on reconstruction, bone regeneration, and transplantation, including stem cells. It is open to licensed U.S. orthopaedic surgeons and PhD researchers with faculty appointments. The grant seeks clinically relevant projects that demonstrate practical applications and multidisciplinary collaboration, promoting excellence in research. New investigators are especially encouraged to apply, ensuring a commitment to advancing orthopaedic science.
Human Genome & Genetics Cell Biology Synthetic Biology +4 more

OREF Prevention of Musculoskeletal Youth Sports Injuries Research Grant

Orthopaedic Research and Education Foundation
Private
Canada, United States
US $25,000
The Prevention of Musculoskeletal Youth Sports Injuries Grant provides essential funding for new investigators focused on clinical and social research aimed at reducing youth sports injuries. This initiative emphasizes the importance of clinical relevance in project proposals, ensuring that outcomes are practical and applicable. Only one grant will be awarded per institution each year, supporting innovative approaches to enhance youth sports safety and health.
Orthopedics Children’s Health & Pediatrics

CORE Funding- AAO-HNSF Percy Memorial Research Award

American Academy of Otolaryngology - Head & Neck Surgery Foundation
Private
Canada, United States
US $25,000
The AAO-HNSF Percy Memorial Research Award offers $25,000 for one year to support innovative research projects in otolaryngology-head and neck surgery. This grant aims to fund projects with clinical significance, encouraging the development of new long-term research initiatives. Applicants must submit a detailed budget and secure letters of support from their Department Chair and key personnel involved in the project. Funds cannot cover salaries or purchase equipment exceeding $500.
Health & Medicine Brain Injuries Chronic Illnesses +2 more

NEI Small Business Innovation Research (SBIR) Cooperative Agreement for Early-Stage Clinical Trials with Greater than Minimal Risk (U44-Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The NEI Small Business Innovation Research (SBIR) Cooperative Agreement aims to support small businesses in conducting early-stage clinical trials that pose greater than minimal risk. The program focuses on Phase I and II trials designed to evaluate interventions for vision disorders. Key deadlines for applications include January 30, 2024, and May 24, 2024, among others. Applicants are encouraged to consult with NEI staff prior to submission to ensure alignment with funding opportunities.
Eye Diseases & Disorders Medical Technology, Devices, and Equipment Biomedical Imaging

Spring 2026 Early Childhood Education Grant

Stranahan Foundation
Private
United States
Up to US $500,000
The Stranahan Foundation’s Early Childhood Education grant program aims to enhance access to high-quality early education for low-income children. Funding up to $1.5 million is available for innovative proposals that improve professional development for early educators. Key priorities include scalable coaching models, leadership development for under-resourced communities, and community-wide substitute teacher pools. This initiative is designed to tackle significant gaps identified in early childhood education and support effective learning environments.
Early Childhood Development Education - Preschool / Early Learning Educational Access & Equity +3 more

Systems-Based Approaches to Improve Patient Safety by Improving Healthcare Worker Safety and Well-Being (R01 Clinical Trial Optional)

US Department of Health and Human Services: Agency for Healthcare Research and Quality (AHRQ)
Federal Government
American Samoa, Guam +4 more
Up to US $2,000,000
The Systems-Based Approaches to Improve Patient Safety program aims to enhance patient safety by prioritizing healthcare worker safety and well-being. By focusing on systemic improvements, this initiative seeks to create a safer healthcare environment, recognizing that worker safety is integral to patient safety. The funding opportunity encourages innovative proposals that bring new insights from healthcare professionals, ultimately supporting AHRQ's mission to strengthen the patient safety movement.
Patient Care & Services Occupational Health & Safety Health Care Access & Delivery +1 more

GSK Research Grant: Social Determinants of Health, Diversity/Equity/Inclusion, and the intersection of patient care with workforce culture

American Academy of Otolaryngology - Head & Neck Surgery Foundation
Private
Canada, United States
Up to US $25,000
The GSK Research Grant supports research on Social Determinants of Health (SDOH) and Diversity/Equity/Inclusion (DEI) in Otolaryngology. With funding of $25,000 for one year, it encourages projects that explore the intersection of patient care and workforce culture. Investigators are invited to address disparities in care, diagnosis, and treatment paradigms while enhancing understanding of these critical dimensions in healthcare. Applications must include letters of support from department chairs and co-investigators.
Health Disparities & Social Determinants of Health Diversity, Equity & Inclusion

NIDCD Research Career Enhancement Award for Established Investigators (K18 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIDCD Research Career Enhancement Award for Established Investigators (K18) supports seasoned researchers in enhancing or redirecting their research through new skills acquisition. This funding opportunity addresses critical questions in hearing, balance, smell, taste, voice, speech, and language sciences. Key deadlines for applications span from June 2024 to February 2027, ensuring ample opportunity for researchers to apply and contribute to these vital fields.
Medical Education & Professional Training Hearing Disorders & Audiology Communication Disorders

Plant Genome Research Program (352500)

National Science Foundation (NSF)
Federal Government
United States
Unspecified amount
The Plant Genome Research Program (PGRP) focuses on genome-scale research to tackle vital biological, societal, and economic challenges. It promotes innovative tools and resources for the plant research community to explore significant scientific questions. The program emphasizes high-impact data accessibility and integration while supporting training and career development. PGRP offers two funding tracks: the Research-PGR Track for fundamental biological inquiries and the TRTech-PGR Track for advancements in functional plant genomics.
Plant Science Plant Genetics & Physiology Genetics & Genomics

SAA Native American Undergraduate Archaeology Scholarship

Society for American Archaeology
Private
Americas
Up to US $6,000
The SAA Native American Undergraduate Archaeology Scholarship, funded by the Society for American Archaeology, supports Native American students pursuing undergraduate studies in archaeology. With an award of up to $6,000 available annually, this scholarship aims to empower students and promote the preservation of cultural heritage through education and collaboration. It encourages participation from all Native peoples across the Americas, ensuring accessibility and support for educational advancement in the field of archaeology.
Archaeology Native American Culture & Heritage

SAA Native American Graduate Archaeology Scholarship

Society for American Archaeology
Private
Americas
Up to US $10,000
The SAA Native American Graduate Archaeology Scholarship, funded by the Society for American Archaeology, supports Native American graduate students pursuing studies in archaeology. Each year, one scholarship is awarded, providing up to $10,000 to cover tuition, travel, housing, and other educational expenses. This initiative aims to foster collaboration between archaeologists and Native American communities while promoting ethical practices and preservation of cultural heritage.
Archaeology Native American Culture & Heritage

Bertha Parker Cody Award for Native American Women

Society for American Archaeology
Private
Americas
Up to US $6,000
The Bertha Parker Cody Award, offered by the Society for American Archaeology, supports Native American, Alaska Native, and Native Hawaiian women pursuing undergraduate or graduate studies in archaeology and museum studies. This scholarship fosters educational advancement and collaboration between archaeologists and Indigenous communities, promoting ethical practices and cultural preservation. Funded in part by the Autry Museum of the American West, it aims to empower diverse voices within the field of archaeology and is available annually.
Archaeology Native American Culture & Heritage Museums & Cultural Institutions

Matthew Tobin Cappetta Archaeological Scholarship

Society for American Archaeology
Private
Americas
US $2,500
The Matthew Tobin Cappetta Archaeological Scholarship, offered by the Society for American Archaeology, supports graduate students focusing on the archaeology or ethnoarchaeology of the American Southwest and South American Andes. It covers tuition, course materials, and travel for field studies, encouraging collaboration with Native American communities. The scholarship prioritizes applicants from historically underrepresented groups and is renewable upon reapplication annually, provided students maintain a minimum GPA of 3.0.
Archaeology

Howard Vincent Kurtz Student Engagement Grant

United Institute for Theatre Technology Inc.
Private
United States
Up to US $1,200
The Howard Vincent Kurtz Student Engagement Grant, funded by USITT, supports emerging theater artists with financial assistance up to $1,200 for academic costs. Grants cover research, travel, and project completion, along with a complimentary conference registration. Eligible applicants include undergraduate and graduate students in theatrical design and technology, nominated by a USITT member. Winners receive mentorship for six months, fostering professional growth and development in the entertainment industry.
Theater

Elliott Antokoletz Fund

American Musicological Society Inc
Private
North America
US $500 - US $5,000
The Elliott Antokoletz Fund supports doctoral and post-doctoral research in twentieth-century music, honoring the legacy of esteemed scholar Elliott Antokoletz. It is open to Ph.D. students and recent graduates from North American universities, with an award range of $500 to $5000. Preference is given to applicants from institutions lacking financial support for musicological research. This initiative promotes creativity through music-centered research, ensuring equity and inclusion in the academic study of music.
Music

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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