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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,706 Results based on applied filters

Toor Scholarship for Strong Public-School Libraries

American Library Association (ALA)
Association/Society
United States
US $1,000
The Toor Scholarship for Strong Public-School Libraries, established by the Toor Family, honors the legacy of Jay and Ruth Toor, who advocated for state-certified librarians in every school. This scholarship supports U.S. public school librarians who create local marketing campaigns to promote their libraries as vital community resources. Each recipient receives a $1,000 stipend to attend the AASL National Conference and must present their project, contributing to the advancement of school librarianship.
Library Services

Community Action Fund

Ndn Collective Inc
Private
Alaska, Canada +3 more
Up to US $15,000

Community Action Fund

A grant for Indigenous frontline organizations, groups, and individuals for direct action initiatives.

The Community Action Fund (CAF) grants support non-violent direct actions and organizing efforts that are often urgent and time sensitive. CAF prioritizes frontline, grassroots and community-based efforts that defend Indigenous peoples rights, communities and Nations.

Community Action Fund Intent

This grant supports Indigenous frontline, grassroots, community-based groups and organizations, Tribes, communities and villages, and individuals leading non-violent direct action or movement-building work in their effort to DEFEND Indigenous People’s rights, and protect their land, air, water, and natural resources.

Indigenous Services Environmental Conservation Freshwater Conservation +3 more

AHRQ Health Services Research Dissertation Program (R36) (347918)

US Department of Health and Human Services: Agency for Healthcare Research and Quality (AHRQ)
Federal Government
American Samoa, Guam +4 more
Up to US $15,000
The AHRQ Health Services Research Dissertation Program (R36) provides crucial funding for doctoral candidates engaged in health services research. This program aims to support individuals in their academic pursuits, enabling them to contribute meaningfully to the field of healthcare. By fostering innovative research, AHRQ enhances the quality of health services and promotes evidence-based practices. Applications are due by 5:00 PM local time, ensuring timely submissions for those seeking to advance their academic careers.
Health & Medicine

Believe in Reading Grant

The Steve and Loree Potash Family Foundation
Association/Society
United States
Up to US $10,000
The Believe in Reading Grant, offered by The Steve and Loree Potash Family Foundation, targets established literacy programs with a proven track record. The foundation aims to support initiatives that address literacy across various age groups, particularly in areas of high need. Grants can be up to $10,000, with a focus on projects that earmark funds specifically for literacy. Applications are reviewed bi-monthly, and first-time applicants are limited to $3,000.
Literacy English for Speakers of Other Languages (ESOL) Education Vision Impairment Care & Services

CDV5 Foundation Grant

Cdv5 Foundation
Private
United States
Unspecified amount
The CDV5 Foundation Grant supports charitable organizations, churches, and government entities that meet IRS 501(c)(3) requirements. This grant aims to nurture successful children, foster stronger families, and cultivate healthier communities. Through partnerships, the foundation provides resources to help individuals reach their full potential. Applicants may submit one request annually for operating, capital, or program support, while event sponsorships are also considered. The foundation encourages applicants to consider their budget and history with the foundation when requesting funding.
Early Childhood Development Youth Development & Leadership Education - Preschool / Early Learning +6 more

Critical Needs List

Community Foundation Of Tampa Bay Inc
Private
United States
Up to US $250,000
The Critical Needs List by Community Foundation Tampa Bay addresses urgent, unforeseen needs of nonprofits that threaten their ability to serve the community. This innovative program allows nonprofits to submit requests for funding up to $250,000 for critical expenses such as emergency repairs and essential equipment replacement. With a focus on supporting local organizations, the program aims to match funding with community philanthropists, ensuring timely assistance to those in need.
Animal Welfare - General Art & Culture Basic Human Needs +9 more

Economics

National Science Foundation (NSF)
Federal Government
United States
Unspecified amount
The Economics program by the National Science Foundation supports research to enhance understanding of the U.S. economy and global systems. It prioritizes interdisciplinary studies and encourages diverse proposals, including those from junior faculty and underrepresented groups. Funding opportunities range from individual projects to doctoral dissertation improvement grants, emphasizing rigorous economic analysis and data collection. The program aims to strengthen links between economics and other disciplines, fostering innovative research in various economic subfields.
Economics

Translational Spectrum Grants

Craig H. Neilsen Foundation
Corporate
Canada, United States
Up to US $400,000
The SCI Research on the Translational Spectrum (SCIRTS) portfolio aims to promote innovative research that enhances function and alleviates complications following spinal cord injuries. It encourages studies that involve individuals with SCI, emphasizing translational significance in research designs. SCIRTS grants support diverse research areas, including mechanistic, preclinical, and clinical studies, to develop effective interventions. Funding categories include Postdoctoral Fellowships, Pilot Research Grants, and Senior Research Grants, targeting early-career and senior investigators to advance spinal cord injury research.
Spinal Cord Injuries

The Yass Prize

Yass Foundation for Education
Corporate
United States
US $1,000,000
The Yass Prize & STOP Awards Initiative aims to revolutionize education by recognizing and supporting exceptional education providers focused on Sustainable, Transformational, Outstanding, and Permissionless (STOP) education. Established in 2021, the initiative awards funds to organizations serving Pre-K to 12th grade students across the United States, fostering impactful partnerships and innovative practices. With a commitment to transforming educational experiences, the initiative celebrates the vital work of educators in response to contemporary challenges.
Educational Access & Equity Education System Policy & Reform Education - K through 12 +1 more

National Center for Construction Safety and Health Research and Translation (U54)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
American Samoa, Guam +4 more
US $3,000,000 - US $5,750,000
The National Center for Construction Safety and Health Research and Translation (U54) aims to enhance worker safety in the construction industry through innovative research and intervention strategies. By fostering partnerships and focusing on evidence-based solutions, the Center will address critical safety and health challenges faced by construction workers. The initiative aligns with NIOSH's strategic objectives, promoting collaboration among academic institutions and organizations to improve health outcomes and reduce the occupational health burden in this vital sector.
Occupational Health & Safety

Advocacy and Research Grants: Strengthening the Sector

The Meredith And Rosemary Willson Charitable Foundation (aka The Music Man Foundation)
Private
California, Los Angeles County, California +1 more
US $20,000 - US $250,000
The Music Man Foundation invites eligible organizations to apply for Advocacy and Research Grants aimed at supporting systemic change in the arts sector. Organizations must demonstrate their impact on music-related systems, showcase their priorities in the field, and outline their achievements. Grants will assist with research, advocacy training, and cross-sector initiatives to enhance community vitality and promote sustainable solutions, reflecting the Foundation's commitment to fostering positive arts engagement.
Arts / Culture Access & Participation Public / Community Art Art Education +1 more

National Meredith Willson Awards

The Meredith And Rosemary Willson Charitable Foundation (aka The Music Man Foundation)
Private
American Samoa, Guam +4 more
US $100,000 - US $1,000,000
The National Meredith Willson Awards provide multi-year operating support to organizations using music for systemic change. The Music Man Foundation will award grants of $50,000 to $500,000 to 5-10 selected organizations in 2026, focusing on their impact through music. Eligible organizations must have 501(c)(3) status, a history of music programming, and a commitment to systemic change. Applications will be evaluated on leadership, organizational capacity, and alignment with grant criteria.
Music Education

Electronics, Photonics and Magnetic Devices (345872)

National Science Foundation (NSF)
Federal Government
United States
Unspecified amount
The Electronics, Photonics and Magnetic Devices (EPMD) Program, funded by the National Science Foundation, promotes cutting-edge research on innovative devices utilizing electronics, photonics, and magnetics. The program aims to enhance micro-, nano-, and quantum-based technologies across diverse fields such as healthcare, energy, and communications. EPMD emphasizes the importance of novel materials and energy-efficient designs, fostering advancements that ensure improved functionality and reliability in future applications.
Physics Electrical Engineering

NDEP STEM Open NFO

US DOD: Dept. of the Army
Federal Government
United States
US $100,000 - US $10,000,000
The NDEP STEM Open NFO invites innovative proposals for research and implementation of effective STEM education and outreach programs. This continuously open announcement from the Department of Defense encourages submissions that align with key initiatives, including support for community colleges and strategic partnerships. As funding becomes available, amendments detailing specific topics and submission guidelines will be released. Applicants must submit white papers to express interest in full applications for potential funding consideration.
STEM / STEAM Education

National Book Fund Grant

ProLiteracy
Private
United States
US $500 - US $2,000 in in-kind support
The National Book Fund (NBF) offers grants to support adult education and literacy programs across the U.S. by providing New Readers Press materials. Grants typically range from $500 to $2,000, with applications considered for higher amounts if justified. Eligible applicants must have a defined project and use materials directly with learners. Priority is given to nonprofit organizations providing free literacy instruction. Note that individuals and lending libraries are not eligible for funding.
Literacy English for Speakers of Other Languages (ESOL) Education Adult Education +1 more

Action, Implementation, & Mitigation ( AIM) Grants

Coalitions & Collaboratives Inc
Private
United States
US $10,000 - US $75,000
The Action, Implementation, and Mitigation (AIM) Grants, offered by COCO, support organizations in enhancing wildfire risk reduction efforts. Since 2018, COCO has assisted over 90 groups, focusing on community resilience and restoration of fire-adapted ecosystems. Eligible applicants include nonprofits and local governments, with funding ranging from $10,000 to $75,000. Projects should align with broader wildfire strategies and require a 100% cash or in-kind match, promoting inclusive and effective community mitigation approaches.
Firefighting & Fire Prevention Fire Ecology

Communications, Circuits, and Sensing-Systems (346204)

National Science Foundation (NSF)
Federal Government
United States
Unspecified amount
The Communications, Circuits, and Sensing-Systems (CCSS) Program by the NSF funds innovative research in circuit hardware, signal processing, and system architectures. It aims to advance cyber-physical systems through cutting-edge technologies, including MEMS/NEMS and neurotechnologies. The program supports applications across diverse fields such as healthcare, environmental monitoring, and smart systems. Proposals are encouraged for high-speed communications, real-time sensing, and intelligent autonomous systems, fostering significant advancements in communication and sensing capabilities.
Computer Science & Engineering Mechanical Engineering Bioengineering

Growing Research Access for Nationally Transformative Equity and Diversity

National Science Foundation (NSF)
Federal Government
United States
Unspecified amount
The Growing Research Access for Nationally Transformative Equity and Diversity program, funded by the National Science Foundation, aims to enhance the research enterprise by addressing structural barriers and promoting inclusivity. By focusing on administrative support and innovative strategies, the initiative seeks to empower diverse organizations to participate in research. Proposals should target institution-wide impacts and scalable models that strengthen human capital and research practices, fostering a more equitable and competitive research landscape.
Science Diversity, Equity & Inclusion

It Gets Better: Change Makers Grants

IT GETS BETTER
Private
American Samoa, Guam +4 more
US $500 - US $10,000
The It Gets Better Project is offering 50 grants of up to $10,000 each to public and charter schools across the U.S. to enhance inclusivity for LGBTQ+ youth. Schools can propose projects such as enhancing library resources, artistic installations, or establishing support groups. The initiative aims to empower LGBTQ+ students and foster a supportive environment, ensuring that every school can participate in uplifting their communities and promoting equality.
Sexuality & LGBTQIA+ Rights LGBTQIA+ Services

FY 2025 EDA Public Works and Economic Adjustment Assistance Programs

US Department of Commerce: Economic Development Administration (EDA)
Federal Government
United States
US $100,000 - US $30,000,000
The FY 2025 EDA Public Works and Economic Adjustment Assistance Programs aim to enhance economic growth and resilience in distressed communities. EDA invites ongoing applications for funding, focusing on innovative approaches that leverage regional strengths. The updated NOFO emphasizes timely reviews and outlines submission procedures for core programs under the Public Works and Economic Development Act. Grantees are encouraged to develop unique initiatives that foster lasting economic prosperity.
Economic Services & Development

RKMF Nonprofit General Application

Richard King Mellon Foundation
Private
United States
Unspecified amount
The Richard King Mellon Foundation invites innovative proposals that align with their 2021-2030 Strategic Plan, aiming to invest over $1.2 billion to enhance opportunities in southwestern Pennsylvania. Their funding focuses on conservation, economic development, economic mobility, health and well-being, organizational effectiveness, and social-impact investments. The General Application offers flexibility without deadlines, allowing for a variety of support types, including project-specific and general operating funding, aimed at enriching community vitality and environmental stewardship.
Environmental Conservation Environmental Stewardship Renewable/Sustainable Energy +6 more

IAF Research Fellowship Program

Social Science Research Council
Private
Antigua and Barbuda, Argentina +20 more
US $20,000
The IAF Research Fellowship Program, administered by the Social Science Research Council, aims to support rigorous research on community-led development in Latin America and the Caribbean. The fellowship provides a $20,000 stipend for twelve months, fostering innovative solutions to pressing issues such as economic opportunity, migration, and social inclusion. Researchers are encouraged to explore how community-led models can create lasting impacts and respond to global trends, enhancing local resilience and development.
Cross-Cultural Understanding & Exchanges Community Development & Revitalization Social Justice / Human Rights +8 more

Abbey Mural Prize

National Academy of Design
Private
American Samoa, Guam +4 more
US $10,000 - US $40,000
The Abbey Mural Prize, established in 1932, supports the creation and restoration of public murals across the United States. This prestigious award, administered by the National Academy of Design since 1940, emphasizes projects that enhance community engagement and social activism through art. Grants typically range from $10,000 to $40,000, with a total annual funding cap of $125,000. Eligible applicants include artists, architects, and nonprofit organizations committed to impactful mural projects.
Public / Community Art

UEF Grant Program

United Engineering Foundation Inc
Private
United States
Up to US $800,000
The UEF Grant Program, offered by the United Engineering Foundation, supports innovative projects that enhance the engineering profession and public welfare. With an annual budget of nearly $800,000, the program awards 5 to 10 grants each year. Eligible applicants must be U.S.-based organizations with 501(c)(3) status. Preference is given to interdisciplinary proposals that engage the community and integrate various engineering fields, fostering collaboration and addressing important societal issues.
Engineering

Smart Growth Grants: Level 1, 2 & 3

National Association Of Realtors
Private
United States
Up to US $15,000
The Smart Growth Grants program, managed by the National Association of Realtors, aims to enhance community development through educational initiatives aligned with Smart Growth Principles. Available in three levels, the grants support REALTOR Associations in promoting sustainable land use, community planning, and stakeholder engagement. Maximum awards range from $3,000 to $15,000, depending on the grant level. Note that the program is currently not accepting applications for 2025 and will reopen in January 2026.
Real Estate & Housing Community Development & Revitalization Urban Planning

Progress, Accomplishment, Thriving, Hope (PATH) Scholarship

Ellucian Foundation
Private
Australia, Canada +8 more
US $1,500 - US $25,000
The PATH Scholarship, established by the Ellucian Foundation in 2020, aims to support higher education institutions in assisting students facing financial hardships. With over $2.9 million awarded, it has benefited more than 3,100 students. Eligible institutions can receive grants ranging from $10,000 to $25,000, with individual awards up to $1,500. This initiative encourages public two-year colleges, particularly Minority Serving Institutions, to apply and adapt award criteria to meet the needs of their students.
Education - Higher Education Educational Access & Equity Academic Scholarship Programs

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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