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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,706 Results based on applied filters

Emily Hall Tremaine Exhibition Award

The Emily Hall Tremaine Foundation Inc
Private
United States
US $50,000 - US $150,000
The Emily Hall Tremaine Exhibition Award, established in 1998, supports innovative, thematic exhibitions that present contemporary art within unconventional frameworks. It fosters creativity by offering funding up to $200,000 for curators partnering with non-profit spaces. The award encourages exploration of critical ideas, emphasizing intellectual quality and public impact. Eligible applicants include established curators and institutions, aiming to promote artistic expression while enhancing community engagement and discourse through diverse projects.
Visual Arts Performing Arts Architecture

Emily Hall Tremaine Exhibition Research Grant

The Emily Hall Tremaine Foundation Inc
Private
United States
US $10,000
The Emily Hall Tremaine Exhibition Research Grant supports innovative projects that explore contemporary art in new frameworks. With a focus on education in the United States, the foundation emphasizes the importance of research that challenges conventional thought. Grants of $10,000 are awarded to curators collaborating with established non-profits, promoting impactful exhibitions. The foundation aims to foster family unity and respect while addressing enduring societal issues through art, environment, and learning differences.
Visual Arts Performing Arts Architecture

Global Emergency Response and Recovery Partner Engagement: Expanding Efforts and Strategies to Improve Rapid Response to Public Health Emergencies Globally (343012)

Dept. of Health & Human Services: Centers for Disease Control & Prevention
Federal Government
United States
Up to US $376,500,000
The CDC's grant aims to enhance global public health emergency responses by engaging partners to improve rapid detection and intervention strategies. It seeks to build sustainable programs that strengthen resilience in communities affected by humanitarian crises. With periodic openings for applications, this initiative ensures a diverse roster of partners ready to tackle emerging public health threats effectively. The program underscores the importance of federal support in managing complex health emergencies worldwide.
Disaster Relief / Humanitarian Aid Epidemiology & Public Health

AHRQ Mentored Clinical Scientist Research Career Development Award (K08) (343035)

US Department of Health and Human Services: Agency for Healthcare Research and Quality (AHRQ)
Federal Government
United States
Up to US $90,000
The AHRQ Mentored Clinical Scientist Research Career Development Award (K08) aims to foster a diverse pool of skilled health services researchers. This funding opportunity supports career development for individuals pursuing research that aligns with AHRQ's mission and priorities. Eligible applicants will receive mentorship to enhance their research skills and contributions to the field. Overall, this initiative is crucial for addressing pressing healthcare research needs.
Medical Education & Professional Training Health & Medicine Science

Agility Grants

National Council on Problem Gambling Inc.
Corporate
United States
US $20,000 - US $40,000
Agility Grants, initiated by the National Council on Problem Gambling, aim to minimize gambling-related harm through funding nonprofit organizations for innovative prevention programs. These grants focus on addressing gaps in services and enhancing existing initiatives. Eligible applicants include U.S.-based 501(c)(3) organizations, with priority given to projects targeting at-risk populations. The program emphasizes community impact and requires evaluations to assess effectiveness, fostering collaboration and awareness within diverse communities affected by gambling.
Addiction & Substance Use Disorders

Tech for Good Impact Awards

Zendesk Inc
Corporate
Afghanistan, Albania +176 more
US $10,000 - US $50,000
The Zendesk Tech for Good Impact Awards support nonprofits by providing them with essential software, grants, and pro bono assistance to enhance their impact on vulnerable populations. The program aims to foster community connections, promote resilience during crises, and create career pathways in technology. Eligible organizations must demonstrate a commitment to utilizing technology in their services, enhancing their ability to support beneficiaries effectively. This initiative empowers nonprofits to leverage technology for greater social good.
Technology Access & Digital Literacy Community Services Career / College Preparation +3 more

Progressive Multiplier Grants

Progressive Multiplier Fund
Private
United States
Unspecified amount
The Progressive Multiplier Grants support U.S. based nonprofits and subsidiaries focused on generating independent revenue through innovative projects. These grants aim to empower organizations working towards democracy, justice, and environmental restoration, fostering civic engagement and equality. By funding campaigns and civic mobilization, the program seeks to build sustained progressive power, avoiding direct service or public education initiatives. Interested parties can submit letters of inquiry on a rolling basis when funding aligns with grant criteria.
Environment Social Justice / Human Rights Governance & Democracy +1 more

Phoebe Apperson Hearst Awards

National Congress of Parents & Teachers
Corporate
United States
Unspecified amount
The Phoebe Apperson Hearst Awards honor excellence in family engagement by recognizing PTAs that achieve top rankings through the National PTA School of Excellence program. These awards celebrate PTAs that effectively engage families in student success and school improvement initiatives. By participating, PTAs can develop best practices, create inclusive communities, attract action-oriented members, and gain national recognition as leaders in building strong family-school partnerships.
Parental Involvement in Education

Feed the Hungry COVID-19 Fund

American Humane
Private
United States
Unspecified amount
The Feed the Hungry COVID-19 Fund, launched by American Humane, addresses the urgent needs of animal shelters struggling during the pandemic. With many animals abandoned and facilities facing shortages, this fund aims to provide essential resources for food and supplies. American Humane, a leader in animal welfare for over a century, seeks to support shelters and rescue organizations fighting to maintain operations amid the crisis, ensuring the safety and care of vulnerable animals across the nation.
Animal Welfare - Domestic Animals & Pets

Tyson Foods: Sponsorships

Tyson Foods, Inc.
Corporate
United States
Unspecified amount
Tyson Foods invites sponsorship proposals that reflect its core values and contribute to community welfare, particularly in Springdale, Arkansas, and Dakota Dunes, South Dakota. Proposals should demonstrate clear community benefits, visibility of the event, and outline how funds will be utilized effectively. Organizations are encouraged to apply if they align with Tyson's mission of integrity and stewardship, ensuring that funding can support primary objectives while considering tax-deductible options.
Community Services Food Access & Hunger Human & Social Services +4 more

Gilead North America Grants

Gilead Sciences, Inc.
Corporate
Canada, United States
Unspecified amount
Gilead North America Grants support community-informed programs that enhance healthcare for vulnerable populations. Grants are available for innovative projects addressing HIV, liver diseases, oncology, and inflammatory diseases. Applications are invited from tax-exempt nonprofits based in the U.S. who focus on health equity and community engagement. Gilead prioritizes funding for projects that demonstrate a strong capability to deliver impactful outcomes, helping to eliminate barriers to healthcare and improve access to essential services.
Health Care Access & Delivery Health Disparities & Social Determinants of Health Medical Education & Professional Training +6 more

Schreiber Foods Foundation Grant

Schreiber Foods Foundation Inc
Private
Barry County, Missouri, Brown County, Wisconsin +16 more
US $1,000 - US $100,000
The Schreiber Foods Foundation Grant supports charitable organizations addressing food insecurity and basic needs in Wisconsin. Open year-round, it encourages nonprofits in Brown, Calumet, and surrounding counties to apply for funding, which typically ranges from $1,000 to $100,000. The foundation prioritizes innovative solutions that enhance community quality of life, promote self-sufficiency, and foster partnerships. Notably, it does not fund religious activities, individuals, or debt retirement, ensuring a focus on impactful community projects.
Food Access & Hunger Education Wellness & Healthy Living +5 more

Truth Initiative Tobacco/Vape-Free College Program

Truth Initiative Foundation
Private
United States
Up to US $20,000
The Truth Initiative Tobacco/Vape-Free College Program offers grants of up to $20,000 to U.S. colleges and universities aiming to implement 100% tobacco/vape-free policies. Additionally, grants of up to $10,000 are available for schools looking to enhance existing smoke-free policies to include e-cigarettes. This initiative seeks to engage students and create support from faculty and staff, ultimately fostering healthier campus environments.
Smoking

Indian Land Tenure Foundation - Cultural Awareness

Indian Land Tenure Foundation
Private
United States
Unspecified amount
The Indian Land Tenure Foundation (ILTF) offers a Cultural Awareness Grant aimed at revitalizing the cultural and spiritual values related to Indian land. This initiative supports American Indian nations in enhancing their ties to the land, which is vital for traditional practices and beliefs. Eligible entities include tribal governments and 501(c)(3) nonprofit organizations. Ineligible activities encompass advocacy efforts, land purchases, and direct funding to individuals, ensuring resources focus on community-centered cultural preservation.
Native American Culture & Heritage

Indian Land Tenure Foundation - Economic Opportunity

Indian Land Tenure Foundation
Private
United States
Unspecified amount
The Indian Land Tenure Foundation's Economic Opportunity Grant aims to empower American Indian nations by enhancing their control over reservation lands. This initiative addresses historical challenges in land ownership and economic development, providing essential resources and tools for communities to manage land effectively. By focusing on land acquisition and productive land use, the Foundation supports sustainable growth and cultural preservation, ultimately fostering economic self-sufficiency among Indigenous populations.
Native American Culture & Heritage Native American Services Economic Services & Development

Indian Land Tenure Foundation - Legal Reform Grant Program

Indian Land Tenure Foundation
Private
United States
Unspecified amount
The Indian Land Tenure Foundation's Legal Reform Grant Program aims to empower American Indian nations by addressing systemic barriers to land ownership and control. This initiative promotes collaboration on projects like estate planning, land policy reform, and engaging government leaders in discussions about tribal sovereignty. By focusing on legal reforms, the program seeks to rectify longstanding inequities and enhance the ability of tribes to manage their land effectively.
Native American Culture & Heritage Native American Services Legal Services

The Solidarity Fund Grant

Global Fund for Women
Private
Africa, Armenia +22 more
Unspecified amount
The Solidarity Fund Grant, part of the Black Feminist Fund, aims to empower Black feminist movements by providing essential resources. Acknowledging the historical underfunding of these movements, the fund supports groups led by Black women, girls, and gender-expansive individuals. It focuses on solidarity efforts that foster collaboration and joint campaigns, enabling activists to drive social change. This initiative is crucial for advancing justice, self-determination, and equity within communities, ensuring that Black feminist visions are amplified and sustained.
Black American Culture & Heritage Women's Rights & Equality Racial / Ethnic Justice & Rights

Confluence Program Grants

Conservation Alliance
Private
Canada, United States
US $140,000
The Confluence Grant Program, initiated by the Conservation Alliance in 2021, aims to strengthen partnerships with historically racially excluded groups. It awards four grants of $100,000 over two years to support projects that protect or restore natural places. The program emphasizes building meaningful relationships and sharing resources, ensuring that funded projects center on solutions led by impacted communities. By fostering collaboration and addressing funding gaps, the program enhances the conservation landscape for diverse voices.
Environmental Justice & Advocacy Environmental Conservation Asian / Pacific Island Culture & Heritage +3 more

ACLS Digital Justice Seed Grants

American Council of Learned Societies
Association/Society
United States
US $10,000 - US $25,000
The ACLS Digital Justice Seed Grants support projects that enhance equity and justice in digital scholarship, particularly focusing on marginalized communities. Funded by The Mellon Foundation, these grants foster innovative methodologies and resource sharing across disciplines. By promoting inclusivity in digital humanities, the program empowers scholars to engage with under-studied materials and develop sustainable practices, ensuring broader access to digital tools and expertise for impactful research initiatives.
Racial / Ethnic Justice & Rights Social Justice / Human Rights Data Science & Digital Information Systems +2 more

ACLS Digital Justice Development Grants

American Council of Learned Societies
Association/Society
United States
US $50,000 - US $100,000
The ACLS Digital Justice Development Grants, funded by The Mellon Foundation, aim to enhance justice and equity in digital scholarly practice. These grants support projects that engage with historically marginalized communities, including people of color and those with disabilities. By providing resources and coaching for sustainable project development, the program promotes inclusion in the digital humanities, ensuring that diverse voices contribute to shaping digital knowledge and cultural heritage.
Racial / Ethnic Justice & Rights Social Justice / Human Rights Data Science & Digital Information Systems +2 more

Indigo Oak Fund: Equal Justice Under the Law Grant Program

Vance R and Colleen H Andrus Family Foundation
Private
United States
Unspecified amount
The Indigo Oak Fund, based in Colorado, is dedicated to enhancing education, the arts, and social justice, particularly through its Equal Justice Under the Law Grant Program. This initiative supports organizations that promote fairness in the justice system, rehabilitation, and civic engagement. By funding programs focused on personal empowerment and equal opportunities, the fund aims to foster lifelong learning and improve lives, particularly for women and children in need.
Social Justice / Human Rights Juvenile Justice Reentry Services +1 more

PLTW Engineering - New Program (Caterpillar Foundation)

Project Lead The Way Inc
Private
Bexar County, Texas, Cass County, North Dakota +21 more
US $30,000
The PLTW Engineering program, supported by the Caterpillar Foundation, aims to enhance STEM education in underserved communities. Grants of $30,000 will help schools launch and expand these programs starting in the 2025-2026 academic year. Schools must offer at least two different PLTW Engineering courses over two years. Preference will be given to institutions with high-need student populations as determined by free and reduced lunch eligibility.
Engineering

Cancer Research Education Grants Program - Courses for Skills Development (R25 Clinical Trial Not Allowed) (350415)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,500,000
The Cancer Research Education Grants Program (R25) aims to enhance research education in areas crucial to the NIH mission. This program supports innovative courses that develop skills in cancer research, covering topics such as prevention, diagnosis, and treatment. Grant applications are encouraged to be creative and state-of-the-art, addressing the needs of patients and their families. Key deadlines for applications span from January 2024 to September 2026, ensuring ongoing support for educational initiatives.
Cancer / Oncology Medical Education & Professional Training

PLTW Engineering - Program Expansion (Caterpillar Foundation)

Project Lead The Way Inc
Private
Bexar County, Texas, Cass County, North Dakota +21 more
US $10,000
The PLTW Engineering program, supported by the Caterpillar Foundation, aims to enhance access to STEM education in underserved communities. This initiative focuses on expanding existing PLTW Engineering programs by introducing new courses, additional class periods, and teacher training for the 2025-2026 academic year. Preference is given to schools with a high-need student population, ensuring that those eligible for free or reduced lunch programs are prioritized for funding. This partnership fosters workforce readiness and empowers future innovators.
Engineering

PLTW Computer Science - Program Expansion (Caterpillar Foundation)

Project Lead The Way Inc
Private
Bexar County, Texas, Cass County, North Dakota +22 more
US $10,000
The PLTW Computer Science - Program Expansion grant, funded by the Caterpillar Foundation, aims to enhance STEM education in underserved communities. This initiative focuses on expanding existing PLTW Computer Science programs by adding courses, class periods, and training teachers for the 2025-2026 academic year. The grant prioritizes schools with a significant high-need student population, promoting workforce readiness and equipping students with essential skills for a changing world.
Computer Science & Engineering

PLTW Computer Science - New Program (Caterpillar Foundation)

Project Lead The Way Inc
Private
Bexar County, Texas, Cass County, North Dakota +22 more
US $20,000
The PLTW Computer Science program, supported by the Caterpillar Foundation, aims to enhance STEM education in underserved communities. Grants of $20,000 will be awarded to public and charter schools to implement PLTW Computer Science courses over two academic years. This initiative focuses on building workforce readiness and ensuring students gain essential skills in a rapidly evolving job market, thereby creating opportunities for future success.
Computer Science & Engineering

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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