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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,702 Results based on applied filters

Clinician Scholar Educator Award

Rheumatology Research Foundation
Private
United States
US $210,000
The Clinician Scholar Educator Award, funded by the Rheumatology Research Foundation, aims to enhance education in musculoskeletal and rheumatic diseases for future healthcare professionals. With an award amount of $210,000 over three years, this program supports rheumatology professionals dedicated to education and training, ensuring a well-prepared workforce to meet the growing needs of patients with rheumatic diseases.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

Pediatric Visiting Professorship

Rheumatology Research Foundation
Private
United States
Up to US $4,000
The Pediatric Visiting Professorship, funded by the Rheumatology Research Foundation, aims to recognize exceptional scientific abstracts from pediatric rheumatology fellows at ACR Convergence. This award facilitates knowledge sharing and promotes advancements in rheumatic disease care. The professorship spans two to three days and includes diverse teaching formats. Selected fellows receive a $1,000 honorarium for virtual visits or $1,500 for in-person engagements, along with reimbursement for travel expenses, enhancing the future of pediatric rheumatology education.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training +1 more

Mentored Nurse Practitioner/Physician Assistant Award for Workforce Expansion

Rheumatology Research Foundation
Private
United States
US $25,000
The Mentored Nurse Practitioner/Physician Assistant Award for Workforce Expansion, funded by the Rheumatology Research Foundation, aims to increase the number of rheumatology healthcare providers across the U.S. This initiative addresses the growing demand for specialists, particularly in underserved areas. With an award amount of $25,000 for one year, it equips new NP/PAs with essential skills and knowledge needed for successful integration into rheumatology practices, enhancing patient access to quality care.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

Health Professional Online Education Grant

Rheumatology Research Foundation
Private
United States
US $1,999
The Health Professional Online Education Grant, offered by the Rheumatology Research Foundation, aims to enhance the skills of non-physician rheumatology professionals. By covering registration costs for the Advanced Rheumatology Course, this grant addresses the growing need for knowledgeable healthcare providers in rheumatology, ensuring better patient care for those with rheumatic diseases. This initiative supports the Foundation's mission to cultivate a robust workforce and improve health outcomes for patients.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

Rheumatology Future Physician Scientist Award

Rheumatology Research Foundation
Private
United States
Up to US $60,000
The Rheumatology Future Physician Scientist Award aims to enhance the research training of promising students pursuing MD or DO degrees, including those in combined programs. This award supports emerging physician-scientists, promoting their investigative careers in rheumatology. Grants of up to $30,000 per year are available for research projects aligned with the Rheumatology Research Foundation's mission, which focuses on improving patient health outcomes in rheumatic diseases.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

Resident Research Preceptorship

Rheumatology Research Foundation
Private
United States
US $15,000
The Resident Research Preceptorship, funded by the Rheumatology Research Foundation, offers a $15,000 award for a three-month, full-time research experience. This initiative aims to inspire medical residents to explore careers in rheumatology research, enhancing the future workforce. By fostering mentorship and hands-on learning, the program supports the development of skilled rheumatology professionals, ultimately improving patient care for those with rheumatic diseases.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

PLTW Gateway - New Program (Burns and McDonnell)

Project Lead The Way Inc
Private
Adams County, Colorado, Alamance County, North Carolina +300 more
US $20,000
The PLTW Gateway program, in partnership with Burns and McDonnell, aims to enhance STEM education by supporting schools in eligible counties to implement PLTW Gateway units. With a total grant of $20,000, schools are encouraged to offer at least one unit per academic year, fostering real-world skills and engagement in STEM fields. This initiative seeks to increase access and participation in high-quality STEM learning experiences, ultimately preparing students for future careers.
STEM / STEAM Education

PLTW Gateway - Program Expansion (Burns and McDonnell)

Project Lead The Way Inc
Private
Adams County, Colorado, Alamance County, North Carolina +300 more
US $10,000
The PLTW Gateway program, in collaboration with Burns & McDonnell, aims to enhance STEM education by expanding access to Project Lead The Way initiatives in eligible communities. By providing grants for program expansion, the initiative encourages schools to implement new PLTW units and train teachers, empowering students with essential skills for future careers. This partnership seeks to inspire a new generation of learners through hands-on, real-world challenges, thereby fostering greater participation in STEM fields across various regions.
STEM / STEAM Education

PLTW Computer Science - Program Expansion (Burns and McDonnell)

Project Lead The Way Inc
Private
Adams County, Colorado, Alamance County, North Carolina +300 more
US $10,000
Burns and McDonnell, a 100% employee-owned firm, partners with Project Lead The Way (PLTW) to enhance access to STEM education. By expanding PLTW Computer Science programs in local schools, they aim to engage students in real-world challenges and equip them with essential skills. Eligible schools must be located in specific counties and serve a majority of students from low-income backgrounds. This initiative supports the growth of STEM education, fostering a brighter future for communities through enhanced learning opportunities.
Computer Science & Engineering STEM / STEAM Education

PLTW Computer Science - New Program (Burns and McDonnell)

Project Lead The Way Inc
Private
Adams County, Colorado, Alamance County, North Carolina +300 more
US $20,000
The PLTW Computer Science program, supported by Burns and McDonnell, aims to enhance STEM education in various communities by funding schools to implement PLTW courses. This partnership promotes student engagement with real-world challenges, preparing them for future careers in technology. With a total grant of $20,000, schools must offer multiple PLTW courses over two years, ensuring access to quality education for underserved populations.
Computer Science & Engineering STEM / STEAM Education

Community Care Corps RFP

Community Care Corps
Federal Government
United States
US $30,000 - US $200,000

Request for Proposals

Community Care Corps encourages organizations across the country to apply for 18-month grants ($30,000–$200,000) to develop and scale innovative volunteer programs that provide nonmedical assistance to older adults, adults age 18 and older with disabilities and family caregivers.

Projects funded through this initiative will increase the number of community-based volunteer programs available to provide nonmedical assistance while decreasing the number of older adults, adults with disabilities, and family caregivers who need assistance in maintaining independence in the community but are unable to obtain help. In doing so, the initiative will strengthen community-based supports that help people maintain independence, reduce unmet needs, and improve overall well-being.

Senior Services Caregiver Support / Respite Care Disability Care & Services +1 more

Rogersville Affiliate Grantmaking Program

Community Foundation of the Ozarks Inc.
Private
Greene County, Missouri, Webster County, Missouri
Up to US $3,000
The Rogersville Affiliate Grantmaking Program, managed by the Community Foundation of Rogersville, aims to enhance local life through strategic grantmaking. This initiative supports 501(c)(3) organizations and other IRS-approved entities serving Rogersville, promoting inclusivity and community empowerment. Grants range from $500 to $11,833, addressing the community's most pressing needs. Applications are accepted on a rolling basis, ensuring funding aligns with available resources and community priorities.
Community Services

NEI Institutional Mentored Physician Scientist Award (K12 Clinical Trial Optional) (348702)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $55,000
The NEI Institutional Mentored Physician Scientist Award (K12 Clinical Trial Optional) aims to foster innovative research career development for clinically trained vision scientists. This funding opportunity encourages institutions to develop programs that prepare scholars for independent research careers, particularly in minimal risk clinical trials. Emphasis is placed on recruiting underrepresented groups in research, ensuring a diverse pool of clinician investigators engaged in vision research.
Medical Education & Professional Training Vision Impairment Care & Services Eye Diseases & Disorders

Grief Reach: Changemaker Supported Community Expansion Cycle - up to $110,000

National Alliance for Children's Grief (NACG)
Private
United States
Up to US $110,000
The Grief Reach: Changemaker Supported Community Expansion Cycle offers up to $110,000 to enhance community programs for grieving children. Organizations are encouraged to innovate and expand their services to better meet community needs. The initiative, in partnership with the Judi’s House/JAG Institute, emphasizes training and resources for effective program evaluation over a three-year period, culminating in impactful community expansion projects.
Children’s Mental Health Mental Health & Psychiatric Diseases Family Services +1 more

Grief Reach: Changemaker Supported Community Expansion Cycle- up to $160,000

National Alliance for Children's Grief (NACG)
Private
United States
Up to US $160,000
The Grief Reach grant program, supported by the New York Life Foundation and the National Alliance for Children's Grief, invites innovative community expansion proposals to better serve grieving children. Eligible organizations can apply for funding up to $160,000 to enhance their programs, focusing on unique community needs. By collaborating with the Judi's House/JAG Institute, participants will receive essential training and resources for impactful program evaluation, fostering a supportive environment for children and families facing grief.
Mental Health & Psychiatric Diseases Youth Services Family Services +1 more

TruStage Foundation Grants and Sponsorships

TruStage Foundation
Private
United States
Unspecified amount
The TruStage Foundation focuses on fostering economic mobility through education and housing initiatives. By supporting K-12 literacy, mentoring, and affordable housing projects, the foundation aims to uplift marginalized communities. With a commitment to addressing racial and socioeconomic disparities, TruStage seeks to empower individuals and families to build a brighter future. Their funding is directed towards impactful programs that align with their mission, while avoiding causes that do not meet their criteria for economic mobility.
Literacy Tutoring & Mentoring Equitable & Affordable Housing +3 more

Calendar Year 2022 Disaster Water Grants

USDA: Rural Utilities Service (RUS)
Federal Government
United States
Unspecified amount
The Calendar Year 2022 Disaster Water Grants program, administered by the USDA's Rural Utilities Service, aims to provide funding for water infrastructure repairs in areas affected by federally declared disasters during 2022. Eligible applicants include public bodies, non-profit organizations, and tribes, all required to demonstrate capacity and legal authority. The grants support not only repairs but also the enhancement of system resilience to mitigate future risks.
Rural Development Disaster Relief / Humanitarian Aid Sanitation & Clean Drinking Water

Felix E. Martin Jr. Foundation: Community Leadership Fund Grant

Felix E Martin Jr Foundation Inc.
Private
United States
Unspecified amount
The Felix E. Martin Jr. Foundation Community Leadership Fund provides essential support for leadership development in Muhlenberg County, KY. It aims to empower individuals and groups seeking innovative solutions to local challenges. Eligible applicants include those pursuing personal leadership growth or researching effective community strategies. The fund underscores inclusivity, welcoming diverse applicants without discrimination. This initiative fosters a vibrant community by equipping leaders with the resources needed to effect positive change.
All fields of work Civic Affairs Art & Culture +1 more

TFish Fund Grant

TFish Fund
Private
Eastern Asia, United States
Up to US $10,000
The TFish Fund Grant aims to alleviate poverty in East Asia by empowering small but impactful NGOs to achieve sustainability and transparency. Founded in 2011, the Transparent Fish Fund partners with select organizations that focus on poverty alleviation. By providing financial aid, capacity building, and promoting accountability, the fund bridges the gap between Western donors and local NGOs, fostering a philanthropic spirit while addressing the complex social issues faced in the region.
Asian American Services

Early Stage Investigator HIV/AIDS Research Using Nonhuman Primate (NHP) Models (R21 Clinical Trial Not Allowed) (348960)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $400,000
This funding opportunity aims to support Early Stage Investigators (ESIs) in conducting preclinical HIV/AIDS research using Nonhuman Primate (NHP) models. Eligible applicants must have at least two years of postdoctoral experience and be within ten years of their terminal degree. The initiative aligns with the NIH Strategic Plan for HIV and HIV-Related Research, targeting the reduction of HIV incidence, development of therapies, and advancement in research areas related to HIV.
HIV / AIDS

Research Experiences for Undergraduates (348985)

National Science Foundation (NSF)
Federal Government
United States
US $5,000 - US $500,000
The Research Experiences for Undergraduates (REU) program, funded by the National Science Foundation (NSF), promotes active research participation among undergraduate students across various research areas. It supports two mechanisms: REU Sites, which engage multiple students in ongoing research, and REU Supplements, which enhance existing NSF-funded projects. Participants must be U.S. citizens, nationals, or permanent residents, and each REU opportunity has its unique application process.
Geoinformatics & Geospatial Sciences Biology Physics +14 more

Rails-to-Trails Conservancy: Trail Grants

Rails To Trails Conservancy
Private
United States
US $10,000 - US $25,000

Rails-to-Trails Conservancy (RTC) Trail Grants

RTC’s Trail Grants are building strong foundations in communities for equitable trail network development and activation—investing in transformative projects and programs that create more access to trails for more people across the country.  

Our grants support organizations at all levels—from local and national nonprofits to public agencies—with a focus on community-based leadership, engagement and long-term impact.  

Since 2008, RTC has provided over $3.7 million in grant funding to more than 280 organizations seeking to create, connect and maintain the nation’s trails, building vibrant trail networks that connect neighborhoods and regions, and make it possible for America to walk, bike and be active outside.

Trail Creation & Maintenance Pedestrian & Bike-Friendly Infrastructure

Trail Accelerator Grants- Spring Cycle Planning and Design

International Mountain Bicycling Association
Private
United States
US $10,000 - US $30,000
The Trail Accelerator Grants aim to enhance mountain bike trail communities by providing essential planning and design services. With funding between $10,000 to $30,000, these grants support local organizations in creating sustainable trail systems. The initiative encourages projects that increase access and promote community engagement, particularly focusing on diversity and inclusion. Applicants must demonstrate the capacity to match funds, ensuring collaborative efforts to improve trail networks and experiences for all riders.
Trail Creation & Maintenance Biking Pedestrian & Bike-Friendly Infrastructure

Mathematical Sciences Postdoctoral Research Fellowships

National Science Foundation (NSF)
Federal Government
United States
Up to US $190,000
The Mathematical Sciences Postdoctoral Research Fellowships (MSPRF) aim to support emerging leaders in mathematics and statistics. These fellowships enhance participants' research environments, ensuring significant scientific development. Awardees can choose between a Research Fellowship or a Research Instructorship, with funding available for research across various mathematical and statistical disciplines. Proposals are submitted directly to the NSF, and fellows must affiliate with eligible institutions or organizations.
Mathematics

Mathematical Sciences Research Institutes (349343)

National Science Foundation (NSF)
Federal Government
United States
US $1,500,000 - US $6,500,000
The Mathematical Sciences Research Institutes, supported by the National Science Foundation, serve as critical national resources aimed at advancing research in mathematics and statistics. These institutes facilitate the discovery and dissemination of knowledge while enhancing connections with related fields. Their activities attract top mathematical minds to tackle pressing problems and engage a diverse array of U.S.-based researchers, ultimately bolstering the impact of mathematical sciences across various disciplines.
Mathematics

Founders Project Fulfillment Grant

Children's Theatre Foundation of America (CTFA)
Private
United States
US $30,000
The Founders Project Fulfillment Grant, offered by the Children's Theatre Foundation of America (CTFA), is dedicated to supporting 501(c)(3) IRS-certified theatres with a strong commitment to artistic excellence for young audiences. Eligible organizations must have a minimum operating budget of $1,000,000 and a proven track record of diversity in leadership, making this grant a vital resource for fostering inclusive theatre experiences for children and families.
Theater Youth Involvement in the Arts Arts / Culture Access & Participation

Ash Grove Charitable Foundation Grant

Ash Grove Charitable Foundation
Private
United States
Up to US $25,000
The Ash Grove Charitable Foundation Grant supports public charities with 501(c)(3) status, focusing on capital projects that enhance community life in states where Ash Grove operates. With a commitment to environmental sustainability, education, and human services, the Foundation prioritizes funding for renovation and construction projects. Grants typically reach up to $25,000, aiming to foster better living standards and support local initiatives that are vital for community growth and resilience.
Community Services

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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