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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,702 Results based on applied filters

PLTW Gateway - New Program (Ardagh Group)

Project Lead The Way Inc
Private
Cook County, Illinois, Creek County, Oklahoma +12 more
US $30,000
The PLTW Gateway program, backed by Ardagh Group, aims to enhance educational opportunities in local communities. Over the next decade, this initiative will support over 500,000 PreK-12 students and provide exceptional training for more than 5,000 teachers across 2,000 schools in the U.S. The program focuses on fostering innovation and creativity through engaging STEM curricula, ensuring that educational resources are accessible and effective for all students.
Education - Preschool / Early Learning Education - K through 12 Teacher Development & Training +1 more

PLTW Engineering - New Program (Burns and McDonnell)

Project Lead The Way Inc
Private
Adams County, Colorado, Alamance County, North Carolina +300 more
US $40,000
The PLTW Engineering program, in partnership with Burns and McDonnell, aims to enhance STEM education by providing grants to public and charter schools in specific counties. This initiative empowers students to engage with real-world challenges through hands-on learning experiences. Eligible schools must offer PLTW Engineering courses, ensuring access to quality education for students from diverse backgrounds. With a total grant of $40,000 over two years, this program seeks to inspire the next generation of engineers and innovators.
STEM / STEAM Education Engineering

PLTW Engineering - Program Expansion (Burns and McDonnell)

Project Lead The Way Inc
Private
Adams County, Colorado, Alamance County, North Carolina +300 more
US $10,000
The PLTW Engineering Program Expansion by Burns and McDonnell aims to enhance STEM education in eligible communities. This initiative supports schools in expanding their existing PLTW Engineering programs, providing students with hands-on experiences and essential skills. The program focuses on empowering students through new courses and teacher training, ensuring access for underrepresented populations. By fostering excitement around STEM, Burns and McDonnell is committed to shaping the future workforce and enhancing educational opportunities in critical areas.
Engineering STEM / STEAM Education

Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 - Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
Central America, Puerto Rico +2 more
Unspecified amount
This funding opportunity aims to enhance health outcomes by addressing healthcare disparities related to non-communicable and chronic diseases in Latin America and among U.S. Hispanic populations. It encourages innovative, interdisciplinary research teams to develop and implement clinical and community-based interventions. Key partnerships with institutions in Latin America are essential for collaboration. Deadlines for applications range from February 2024 to June 2026, with specific dates for standard, renewal, and AIDS-related grant submissions.
Health Disparities & Social Determinants of Health Chronic Illnesses Hispanic and Latino Services

Unveiling Health and Healthcare Disparities in Non-Communicable and Chronic Diseases in Latin America: Setting the Stage for Better Health Outcomes Across the Hemisphere (R01 - Clinical Trials Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
Central America, Puerto Rico +2 more
Unspecified amount
This funding opportunity aims to address health and healthcare disparities in non-communicable and chronic diseases across Latin America. It encourages innovative, multi-disciplinary research focused on clinical epidemiology and public health policy evaluation. Collaborations should include key partners from Latin American institutions, fostering meaningful partnerships to tackle significant health challenges faced by U.S. Hispanics/Latinos. The initiative highlights multiple application deadlines for standard and AIDS-related grants, promoting timely submissions for impactful research.
Hispanic and Latino Services Health Disparities & Social Determinants of Health Chronic Illnesses

Marketing Sponsorships

State Farm Companies Foundation
Corporate
United States
Unspecified amount
State Farm Companies Foundation offers marketing sponsorships to organizations that align with their mission of building safer, stronger communities. They are open to partnerships that enhance their marketing strategies on both local and national levels. Interested parties can expect a review of their proposals within 2-3 weeks. This initiative aims to foster collaboration with various brands and causes that resonate with State Farm's vision.
Community Services

Macy Faculty Scholars Program

Josiah Macy Jr. Foundation
Private
United States
Up to US $125,000
The Macy Faculty Scholars Program, funded by the Josiah Macy Jr. Foundation, supports early-career educators in medicine and nursing, promoting their development as future leaders. Scholars receive substantial financial support, mentorship, and access to educational resources, including funding for professional development activities and participation in a Harvard Macy Institute course. This initiative aims to enhance the educational landscape by nurturing diverse talent in the healthcare education field.
Medical Education & Professional Training Nursing

Blavatnik National Awards for Young Scientists

Blavatnik Family Foundation
Private
United States
US $250,000
The Blavatnik National Awards for Young Scientists honor exceptional faculty-rank scientists and engineers in the U.S. Recognizing achievements in Life Sciences, Physical Sciences & Engineering, and Chemical Sciences, each Laureate receives $250,000 in unrestricted funds. Nominations come from a select group of institutions and previous Laureates, emphasizing innovation and impact. The awards celebrate the future potential of young researchers, fostering diversity in STEM fields. The ceremony takes place annually in New York City.
Science Engineering

Edward Mallinckrodt, Jr. Foundation: Grant

Edward Mallinckrodt Jr Foundation
Private
United States
Up to US $225,000
The Edward Mallinckrodt, Jr. Foundation provides crucial support for early-stage biomedical researchers in the first four years of their tenure-track positions at American institutions. With grants of $75,000 annually for up to three years, this funding aims to help investigators advance their projects towards securing independent funding. The foundation emphasizes the importance of a clear project description and requires a one to two-page lay summary, making it accessible to both scientific and non-scientific board members.
Biology Health & Medicine Science

Parker B. Francis Fellowship for Pulmonary Research

The Francis Family Foundation
Private
Canada, United States
Up to US $225,000
The Parker B. Francis Fellowship for Pulmonary Research offers three years of funding, totaling $225,000, for clinical and basic scientists transitioning to independent research careers in pulmonary and critical care medicine. Eligible candidates include those with relevant doctoral degrees, U.S. or Canadian citizenship, and a track record of research experience. The fellowship encourages diverse research topics, including bioethics in pulmonary medicine, while requiring mentorship and adherence to strict eligibility criteria.
Lung Cancer Respiratory Diseases & Systems

MIND Prize

The Pershing Square Foundation
Private
United States
US $750,000
The MIND Prize, funded by The Pershing Square Foundation, supports innovative research to combat neurodegenerative diseases like Alzheimer's. It empowers early-to-mid-career investigators to explore unconventional approaches and fosters collaboration across disciplines. Each winner receives $250,000 annually for three years, promoting advancements in neuroscience and creating a unique network for researchers. The initiative aims to enhance our understanding of brain health and tackle pressing societal challenges.
Neurological Diseases & Disorders Neuroscience Dementia & Alzheimer’s Disease

Biogen General Grants

Biogen Foundation Inc.
Corporate
United States
Unspecified amount

Biogen General Grants

Funding to support a project or program that does not fit any of the other defined grant categories.

Biosimilars Neurological Diseases & Disorders Musculoskeletal Diseases +2 more

Post-Doctoral Fellowships

American Parkinson Disease Association
Private
United States
Up to US $150,000
The American Parkinson Disease Association offers Post-Doctoral Fellowships to support research focused on Parkinson's disease. These fellowships, lasting two years, provide up to $75,000 per year to eligible post-doctoral trainees at U.S. institutions. Applicants must have completed their MD, PhD, or residency within two years prior to the award. Funding can cover direct research costs, but not travel or publication expenses over $1,000, ensuring resources are allocated effectively for impactful research.
Parkinson’s Disease

NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01 - Clinical Trial Required) (350657)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders (U01) invites applications to support clinical trials that require FDA oversight, aim to establish efficacy, or pose significant risks. This initiative, managed by the NIH, seeks to enhance interventions for communication disorders and encourages collaboration between NIDCD Project Scientists and investigators. Proposals are due by 5 PM local time, with Letters of Intent recommended 30 days prior to the deadline.
Communication Disorders

Next Gen Pregnancy Initiative Grants

Burroughs Wellcome Fund
Private
Canada, United States
Up to US $500,000
The Burroughs Wellcome Fund's Next Gen Pregnancy Initiative Grants aim to enhance research on pregnancy outcomes, addressing issues such as preterm birth and maternal health. With an emphasis on fostering diverse scientific collaboration, the initiative supports innovative proposals from researchers across various disciplines. Each grant offers up to $500,000 over four years, encouraging groundbreaking studies that explore the biological and environmental factors affecting pregnancy. This initiative seeks to improve health outcomes through informed research and interdisciplinary partnerships.
Maternal And Perinatal Health Health Disparities & Social Determinants of Health

George C. Cotzias, MD, Memorial Fellowship

American Parkinson Disease Association
Private
United States
US $375,000
The George C. Cotzias, MD, Memorial Fellowship, established by the American Parkinson Disease Association, supports young neurologists in their research and treatment of Parkinson's disease and related disorders. Funded at $125,000 annually for three years, this fellowship encourages recent graduates to develop their careers in neurology, ensuring they have the mentorship and resources necessary for success. The fellowship aims to honor Dr. Cotzias' legacy and inspire the next generation of leaders in neurology.
Parkinson’s Disease Neurological Diseases & Disorders

Kaiser Permanente Center for Gun Violence Research and Education Grant Program

Kaiser Permanente Advisory Services
Private
United States
Up to US $300,000
The Kaiser Permanente Center for Gun Violence Research and Education Grant Program aims to transform the landscape of gun violence research and education by funding initiatives that address community firearm violence and suicide. This program focuses on partnering with affected communities, integrating healthcare approaches, and providing substantial funding to enhance research capacity and intervention effectiveness. With funding available in two categories, the initiative seeks to promote evidence-based solutions that foster community healing and well-being.
Gun Violence Prevention Suicide Prevention

Postdoctoral Diversity Enrichment Grant Program

Burroughs Wellcome Fund
Private
Canada, United States
US $60,000
The Postdoctoral Diversity Enrichment Grant Program, funded by the Burroughs Wellcome Fund, offers $60,000 over three years to support underrepresented postdoctoral fellows in the U.S. and Canada. This initiative aims to enhance their career development through mentorship and networking opportunities. Since its inception in 2013, the program has awarded over 150 fellowships, investing more than $9 million to promote diversity in biomedical research and foster an inclusive scientific community.
Diversity, Equity & Inclusion Science Biology +1 more

AGA: Research Scholar Award

American Gastroenterological Association
Association/Society
Canada, Mexico +1 more
US $300,000
The AGA Research Scholar Award offers $100,000 per year for three years to early-career faculty in digestive disease research. Applicants must hold an MD or PhD and be in a full-time faculty position in North America. The award fosters scientific independence by requiring a minimum of 50% research effort. AGA membership is mandatory, and applicants are encouraged to self-assign their proposals to specific research categories. This award aims to support promising junior researchers in their pursuit of independent research careers.
Digestive System Health & Diseases

Community Practice Innovation Award

Rheumatology Research Foundation
Private
United States
Up to US $80,000
The Community Practice Innovation Award by the Rheumatology Research Foundation aims to foster innovative ideas from the rheumatology community that enhance practice implementation and sustainability. Grants, up to $80,000 for one year, support projects in quality improvement, implementation, and pilot studies. Recipients are expected to share findings with the broader community through presentations and disseminate tools developed with the funding. This initiative emphasizes improving patient care through effective collaboration and innovative practices.
Musculoskeletal Diseases Arthritis

Scientist Development Award

Rheumatology Research Foundation
Private
United States
Up to US $225,000
The Scientist Development Award from the Rheumatology Research Foundation supports early career professionals in rheumatology research. This award provides funding for salary and research training, aiming to enhance the skills of trainees and ensure a robust workforce in rheumatology. With a maximum of $75,000 per year, this initiative encourages innovative research and mentorship opportunities to improve treatment options for patients with rheumatic diseases.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

Career Development Bridge Funding Award: R Bridge

Rheumatology Research Foundation
Private
United States
US $200,000
The Career Development Bridge Funding Award from the Rheumatology Research Foundation aims to support early and mid-career researchers facing funding challenges. This program provides $200,000 over two years to help investigators refine their NIH or equivalent grant applications while pursuing innovative research in rheumatic diseases. By fostering the next generation of rheumatologists, the foundation seeks to enhance patient care and advance treatment options for those affected by these conditions.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

Pediatric Rheumatology Fellow Research Award

Rheumatology Research Foundation
Private
United States
Up to US $2,500
The Pediatric Rheumatology Fellow Research Award, offered by the Rheumatology Research Foundation, recognizes exemplary scientific abstracts from pediatric rheumatology fellows at ACR Convergence. With a $1,500 award and an additional $1,000 for travel expenses, this initiative aims to promote innovative research and enhance educational opportunities for future rheumatologists. The program underscores the importance of developing a skilled workforce to improve access to specialized care for patients with rheumatic diseases.
Musculoskeletal Diseases Arthritis Children’s Health & Pediatrics

Marshall J. Schiff, MD, Memorial Fellow Research Award

Rheumatology Research Foundation
Private
United States
Up to US $2,500
The Marshall J. Schiff, MD, Memorial Fellow Research Award, established by the Rheumatology Research Foundation, aims to support exceptional scholarship in rheumatology. This award not only honors Dr. Schiff's legacy but also recognizes fellows presenting at ACR Convergence. Recipients receive a $1,500 award plus $1,000 for travel expenses, ensuring they can attend this crucial meeting, which showcases the latest advancements in rheumatic disease research and care.
Musculoskeletal Diseases Arthritis

Fellowship Training Award for Workforce Expansion

Rheumatology Research Foundation
Private
United States
Up to US $150,000
The Fellowship Training Award for Workforce Expansion, offered by the Rheumatology Research Foundation, aims to improve access to rheumatology care by supporting the training of fellows at institutions facing funding constraints. This $50,000 per year award, available for up to three years, seeks to ensure a sufficient supply of rheumatology providers, particularly in underserved areas, thereby enhancing the quality of care for patients with rheumatic diseases.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

Fellowship Training Award

Rheumatology Research Foundation
Private
United States
Up to US $150,000
The Fellowship Training Award by the Rheumatology Research Foundation aims to enhance the rheumatology workforce by supporting fellows in ACGME-accredited training programs. The award provides $50,000 per year for up to three years, ensuring a steady supply of qualified rheumatology providers and educators. Special emphasis is placed on supporting underrepresented populations in medicine. This initiative is crucial for improving patient care in rheumatic diseases across diverse communities.
Musculoskeletal Diseases Arthritis Medical Education & Professional Training

Cognitive Neuroscience

National Science Foundation (NSF)
Federal Government
United States
Unspecified amount
The Cognitive Neuroscience (CogNeuro) Program by the National Science Foundation aims to fund proposals that deepen our understanding of the neural mechanisms of cognition and behavior. Successful applications will connect physiology, cognition, and behavior while also promoting outreach and mentoring within the field. Research topics include action, perception, memory, and decision-making. The program encourages broader impacts such as STEM outreach and public engagement in research, with a focus on diverse communities.
Neuroscience

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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