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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,691 Results based on applied filters

Jack and Jill of America Foundation Scholarship

United Negro College Fund Inc
Private
United States
Up to US $2,500

Jack and Jill of America Foundation Scholarship

The Jack and Jill of America Foundation Scholarship will provide need-based scholarships of up to $2,500 to service-oriented college freshmen who have completed a minimum of 60 hours of community service within the last 12 months. Awards will be issued in the 2025-2026 academic year, and may be renewed annually through the senior year.

The Jack and Jill of America Foundation is committed to the positive development of youth and future leaders. Through providing programs focused on financial literacy, education, mentoring, health and wellness, and early childhood development, the Foundation promotes the preparation of succeeding generations of leaders.

Education - Higher Education Community Services

The Coco Gauff Tennis Scholarship

United Negro College Fund Inc
Private
United States
Up to US $8,500

The Coco Gauff Tennis Scholarship

The Coco Gauff Tennis Scholarship will provide a need-based scholarship of up to $8,500 to eligible HBCU student-athletes competing on their intercollegiate tennis teams. Awards will be issued in the 2026-2027 academic year.

Education - Higher Education Sports & Athletics Tennis

UNCF STEM Scholars Program

United Negro College Fund Inc
Private
United States
Up to US $25,000

UNCF STEM Scholars Program

The UNCF STEM Scholars Program is an initiative designed to identify and provide scholarship and academic support for students who aspire to earn STEM degrees and to pursue careers in STEM fields, awarding 75 scholarships. The program enables highly capable young people to pursue undergraduate STEM majors and prepares them for successful careers in a variety of STEM professions.

Individual Award

  • Maximum total up to $25,000, please see Program Benefits below.
Education - Higher Education STEM / STEAM Education

Donald E. Heisinger Scholarship

Northwest Connecticut Community Foundation
Private
United States
US $750

Through the generosity of fundholders and donors, NCCF has awarded more than half a million dollars in scholarships to assist students in Northwest Connecticut with the cost of higher education.

NCCF awards more than $530,000 in scholarships a year. 

Donald E. Heisinger Scholarship

Academic Focus:

  • Accounting, Finance, or Business

Award:

  • $750

Established by the Dillon Family, this scholarship is awarded to a student whose primary residence is in Torrington and who pursues, or intends to pursue, a degree in accounting, finance, or business at an accredited university or college. This scholarship is not financially need-based. (No FAFSA required)

Education - Higher Education Business Education

Douglas and Janet Roberts Scholarship

Northwest Connecticut Community Foundation
Private
United States
US $4,000 - US $8,000

Through the generosity of fundholders and donors, NCCF has awarded more than half a million dollars in scholarships to assist students in Northwest Connecticut with the cost of higher education.

NCCF awards more than $530,000 in scholarships a year. 

Douglas and Janet Roberts Scholarship

Academic Focus:

  • Unspecified

Award Average:

  • $4,000-$8,000
Education - Higher Education

Eugene F. Zordan and Erminia Zordan Scholarship Fund

Northwest Connecticut Community Foundation
Private
United States
US $4,300

Through the generosity of fundholders and donors, NCCF has awarded more than half a million dollars in scholarships to assist students in Northwest Connecticut with the cost of higher education.

NCCF awards more than $530,000 in scholarships a year. 

Eugene F. Zordan and Erminia Zordan Scholarship Fund

Academic Focus:

Unspecified

Average Award:

  • $4,300

Established by Marie Zordan, this scholarship is awarded to undergraduate or graduate students who lives in NCCF’s *20-town service area.

Education - Higher Education

Edwin & Lanier File Ratcliff Memorial Scholarship

Beckley Area Foundation
Private
United States
Unspecified amount
The Edwin & Lanier File Ratcliff Memorial Scholarship, administered by the Beckley Area Foundation, supports students from southern West Virginia pursuing higher education. Established to alleviate college expenses, the scholarship targets deserving individuals committed to their academic goals. The Beckley Area Foundation, founded in 1985, connects donors and community partners to enhance local initiatives, focusing on education, health, and community development. This scholarship embodies the foundation's mission to inspire charitable giving and strengthen regional communities.
Education - Higher Education Career / College Preparation College Success / Persistence +1 more

Italian-American Republican Club Scholarship

Northwest Connecticut Community Foundation
Private
United States
US $350

Through the generosity of fundholders and donors, NCCF has awarded more than half a million dollars in scholarships to assist students in Northwest Connecticut with the cost of higher education.

NCCF awards more than $530,000 in scholarships a year. 

Italian-American Republican Club Scholarship

Academic Focus:

  • Political science, government, history or pre-law

Award Average:

  • $350

For Torrington residents of Italian descent who are entering their junior or senior year at a college or university and are majoring in political science, government, history or pre-law

Law Political Science History

NC Hunter and Jumper Association’s Norah Morris Memorial Scholarship Endowment

North Carolina Community Foundation Inc
Private
United States
More than US $1,000
The NC Hunter and Jumper Association’s Norah Morris Memorial Scholarship Endowment supports individuals pursuing higher education who have engaged in equestrian activities. Open to undergraduates, graduates, and adult re-entry students, the scholarship aims to assist those attending various educational institutions in the United States. Applications for NCCF scholarships will be accepted from December 16, 2025, to March 3, 2026. Be sure to check specific eligibility requirements for each scholarship.
Education - Higher Education Education - High School Academic Scholarship Programs +2 more

Computational Mathematics

National Science Foundation (NSF)
Federal Government
American Samoa, Guam +4 more
Up to US $1,200,000
The Computational Mathematics program supports research that integrates computation with mathematical analysis, encouraging innovative algorithm development and application. Proposals may range from individual projects to interdisciplinary teams, focusing on new computational techniques to address significant application challenges. The program also emphasizes training for junior mathematicians through hands-on research. Conference proposals must adhere to strict submission timelines to ensure review and funding opportunities, fostering collaboration within the mathematical sciences.
Mathematics

Linguistics

National Science Foundation (NSF)
Federal Government
United States
US $6,000,000
The Linguistics Program, supported by the National Science Foundation (NSF), promotes fundamental research in human language. It covers various areas including syntax, semantics, and phonetics, encouraging interdisciplinary projects that explore language production, comprehension, and social factors influencing language change. The program welcomes proposals from qualified scholars, including those focusing on endangered languages, while emphasizing the importance of basic research over applied methods. For more details, refer to the NSF's guidelines.
Linguistics

Agriculture and Food Research Initiative Competitive Grants Program Education and Workforce Development (361169)

USDA: National Institute of Food and Agriculture (NIFA)
Federal Government
United States
US $10,000 - US $650,000
The Agriculture and Food Research Initiative (AFRI) focuses on enhancing education and workforce development in food and agricultural sciences. It invites applications for various grants aimed at professional development, non-formal education for youth, community college training, and fellowships for both predoctoral and postdoctoral candidates. The program, managed by the USDA's National Institute of Food and Agriculture, emphasizes the cultivation of skills necessary for the future workforce in agriculture, with multiple deadlines for submissions.
Agriculture Workforce Preparation & Job Readiness Food Safety +1 more

ROSS Rapid Response Program

US HUD: Office of Public and Indian Housing (PIH)
Federal Government
American Samoa, Guam +4 more
US $112,500 - US $250,000
The ROSS Rapid Response Program (RRP) by the U.S. Department of Housing and Urban Development (HUD) provides expedited funding to assist communities in addressing urgent social needs. This program offers one-time cost-reimbursable grants for service coordination and direct services, especially in response to emergencies like natural disasters or public health crises. By streamlining the application process, the RRP empowers local leaders to efficiently support residents in HUD-assisted housing, promoting self-sufficiency and resilience.
Basic Human Needs Equitable & Affordable Housing

Postdoctoral Research Fellowships in Biology (361249)

National Science Foundation (NSF)
Federal Government
United States
Up to US $220,000
The National Science Foundation (NSF) is offering Postdoctoral Research Fellowships in Biology to support innovative research at the intersection of Artificial Intelligence (AI) and Biological Sciences. These fellowships aim to cultivate expertise in both fields, enabling scientists to leverage AI for breakthroughs in biotechnology and bio-system design. The program encourages proposals that utilize existing biological data and infrastructure to enhance discovery and innovation, ultimately benefiting human lives and the U.S. economy.
Biology Plant Science Plant Genetics & Physiology +1 more

Peter S. Slomianyj Scholarship Fund

North Carolina Community Foundation Inc
Private
United States
More than US $1,000
The Peter S. Slomianyj Scholarship Fund offers financial assistance to Subway employees and their children who meet specific eligibility criteria, including a minimum of 500 work hours over the past year and a GPA of 2.0 in high school or 2.5 in college. Applications for this scholarship will be open from December 16, 2025, to March 3, 2026. It is part of a broader initiative by the North Carolina Community Foundation to support students pursuing education at various institutions.
Education - Higher Education Education - High School Academic Scholarship Programs +1 more

National Quantum and Nanotechnology Infrastructure

National Science Foundation (NSF)
Federal Government
United States
US $500,000 - US $2,000,000
The National Quantum and Nanotechnology Infrastructure (NQNI) program, funded by the NSF, aims to enhance research capabilities across critical technologies. By creating an open-access network of user facility Sites, NQNI will support advancements in quantum technologies, AI, and more. This initiative encourages collaboration and innovation, providing resources for education, training, and workforce development to meet future national needs in quantum information science and engineering.
Biomathematics & Biological Modeling Nanomaterials & Nanotechnology

Pathways to Enable Secure Open-Source Ecosystems

National Science Foundation (NSF)
Federal Government
American Samoa, Guam +4 more
US $300,000 - US $1,500,000
The Pathways to Enable Secure Open-Source Ecosystems (PESOSE) program, funded by the National Science Foundation, aims to transform open-source research into sustainable ecosystems that tackle national and societal challenges. This initiative promotes innovation across various sectors, including AI and cybersecurity, by fostering strong governance and broad user engagement. PESOSE invites proposals to establish and enhance open-source ecosystems, ensuring their safety, security, and effectiveness in meeting emergent needs.
Engineering Computer Science & Engineering Emerging Technology Development

Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Gabriella Miller Kids First Pediatric Research Program invites applications for whole genome sequencing of pediatric cohorts. This initiative aims to explore the genetic basis of childhood cancers and congenital anomalies, enhancing our understanding of their etiology. Researchers are encouraged to propose sequencing methods, including whole genome and exome sequencing, to investigate genetic contributions and associations with cancer risk. The resulting data will be integrated into the Kids First Data Resource for broader research collaboration.
Children’s Health & Pediatrics Genetic Conditions & Birth Defects Pediatric Cancers

Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is launching a Notice of Funding Opportunity (NOFO) under the NIH HEAL initiative to enhance research on joint health and pain. This initiative aims to refine the understanding of joint tissues and pain mechanisms, expand clinical phenotyping, and support preclinical testing of novel therapies. Collaborations among experts in neurobiology, pain science, and rheumatic diseases are encouraged to foster innovative solutions for joint pain management.
Musculoskeletal Diseases Arthritis

Genomic Community Resources (U24 Clinical Trials Not Allowed)

National Institutes of Health
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The National Human Genome Research Institute (NHGRI) is launching a Notice of Funding Opportunity (NOFO) aimed at enhancing genomic research through the development and distribution of high-value resources. This initiative encourages collaborative efforts in genomic resource development and the integration of data science in clinical applications. While applications are not currently being accepted, prospective applicants are urged to prepare meaningful collaborations and projects ahead of the formal solicitation.
Cancer / Oncology Genetics & Genomics Human Genome & Genetics

Medical Scientist Training Program (MSTP)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Medical Scientist Training Program (MSTP) aims to cultivate skilled clinician-scientist leaders to meet the nation's biomedical research demands. It supports domestic organizations in developing dual-degree training that integrates clinical and research education, leading to both a clinical degree (e.g., M.D., D.O.) and a Ph.D. Through comprehensive mentoring and career development, MSTP prepares trainees for impactful careers in health-related research, ensuring a robust pipeline of qualified scientists.
Science Medical Education & Professional Training

Native American Research Centers for Health (NARCH)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Unspecified amount
The Native American Research Centers for Health (NARCH) program supports federally-recognized American Indian and Alaska Native Tribes and organizations in advancing health-related research. It aims to enhance research careers and infrastructure through a competitive application process. Funded by the US Dept. of Health & Human Services, this initiative invites eligible entities to apply, ensuring that only high-quality proposals undergo peer review for potential funding.
Native American Services Native American Culture & Heritage Indigenous Services

Network of the National Library of Medicine Regional Medical Libraries (UG4 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $600,000
The National Library of Medicine (NLM) is seeking applications to establish Regional Medical Libraries within the Network of the National Library of Medicine (NNLM). Since 1965, the NNLM has enhanced public health information access through partnerships with libraries and health organizations. The initiative aims to improve community engagement, disseminate NIH research findings, and foster collaborations to promote health literacy and access to biomedical data, thereby supporting local clinical research efforts.
Health & Medicine Library & Information Science Library Services

Network of the National Library of Medicine Training Center (U24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $750,000
The National Library of Medicine (NLM) is seeking applications for a Training Center under the Network of the National Library of Medicine (NNLM). This initiative aims to enhance professional development for librarians, community engagement, and access to health information. By fostering partnerships and disseminating NIH resources, the NNLM will broaden its impact and improve public understanding of health data and information. The NTC will develop innovative training curricula and materials to meet diverse audience needs.
Health & Medicine Library & Information Science Library Services

Network of the National Library of Medicine Coordinating Center (U24 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $1,500,000
The National Library of Medicine (NLM) is inviting applications for its Coordinating Center within the Network of the National Library of Medicine (NNLM). Established in 1965, the NNLM enhances public access to health information through collaboration with libraries and community organizations. The NCC will oversee network administration and evaluation, fostering partnerships and supporting local clinical research. This initiative aims to expand NIH engagement and improve public understanding of health resources and information available through the NNLM.
Health & Medicine Library & Information Science Library Services

HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
US $500,000 - US $800,000
The HEAL Initiative Whole Joint Health Program aims to advance research on the biological mechanisms of joint pain by exploring the interactions of various tissues within the joint. This innovative program will support clinical studies that focus on non-pharmacological interventions to enhance healing and improve quality of life for individuals suffering from chronic joint pain. By fostering a comprehensive understanding of joint health, the initiative aligns with the NIH's broader goals to reduce chronic pain and opioid dependency.
Musculoskeletal Diseases Orthopedics

Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Limited Competition Small Grant Program for the NCATS CTSA Program aims to empower KL2 scholars by funding diverse clinical and translational research projects. These grants support short-term studies, methodology development, and preliminary data collection, facilitating the transition to independent research careers. Applications will undergo NIH peer review, ensuring only high-quality proposals receive funding. This initiative fosters innovation in research methodologies and technology, ultimately enhancing the capabilities of emerging translational scientists.
Science Biology Health & Medicine +2 more

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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