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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,702 Results based on applied filters

C Spire Wireless Foundation Sponsorship

C Spire Wireless Foundation
Private
United States
Unspecified amount
The C Spire Wireless Foundation provides sponsorships primarily focused on STEM education, aiming to enhance digital literacy and workforce development in underserved communities. Organizations eligible for support must be 501(c)(3) tax-exempt entities dedicated to these educational initiatives. Preference is given to projects based in the foundation's service region. Proposals should be submitted at least 90 days prior to events for consideration, with a review process taking two to three weeks.
STEM / STEAM Education Workforce Preparation & Job Readiness Technology Access & Digital Literacy

Ernest F. Hollings Undergraduate Scholarship

National Oceanic and Atmospheric Administration (NOAA)
Federal Government
American Samoa, Guam +4 more
Up to US $40,000
The Ernest F. Hollings Undergraduate Scholarship offers up to $9,500 annually for two years, alongside a paid summer internship at NOAA. This program enhances students' training in oceanic and atmospheric sciences, aiming to increase public understanding and support for environmental stewardship. Eligible students must be U.S. citizens, enrolled full-time in relevant disciplines, and maintain a minimum GPA of 3.0. The experience fosters valuable skills and networks, with 100% of alumni recommending the scholarship.
Humanities & Social Science STEM / STEAM Education Engineering +12 more

NICHD Resource Program Grants in Bioinformatics (P41 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $8,750,000
The NICHD Resource Program Grants in Bioinformatics aim to support the operation and enhancement of vital bioinformatics databases for research on animal models of embryonic development. These grants promote user training, data curation, and interoperability with NIH resources, ensuring wide dissemination of critical tools and resources to the research community. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 30 days prior to the proposal deadline.
Biomedical informatics Developmental Biology / Embryology

AI for Economic Opportunity Fund

Gitlab Foundation
Private
United States
Up to US $250,000
The AI for Economic Opportunity Fund, established by the GitLab Foundation, aims to catalyze transformative economic opportunities using advanced AI technologies. This funding round invites bold proposals that leverage AI to enhance economic mobility, improve service delivery, and create new educational pathways. Grantees will receive $250,000 in funding, technical support, and access to a network of practitioners. The fund seeks projects that demonstrate ethical awareness and promote fairness in AI deployment.
Economic Rights, Justice, & Mobility Artificial Intelligence (AI) Economic Services & Development

BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The BRAIN Initiative's funding opportunity aims to support the establishment of facilities at minority-serving and IDeA-eligible institutions for the production and distribution of brain cell type-specific reagents. These reagents will enhance neuroscience research by enabling precise manipulation and access to brain cell types, facilitating advancements in understanding circuit functions in various species. The initiative encourages collaboration among awardees to optimize the use of these essential resources across the neuroscience community.
Neuroscience

Wallerstein Foundation Grant

Wallerstein Foundation for Geriatric Life Improvement Inc.
Private
United States
Unspecified amount
The Wallerstein Foundation for Geriatric Life Improvement is dedicated to enhancing the lives of elderly individuals through targeted support for non-profit organizations. Grants focus on critical areas such as dementia care, wellness programs, and community engagement initiatives. The foundation prioritizes projects that meet the unique needs of seniors, promoting health and active lifestyles. By funding specific projects rather than general support, the foundation aims to make a meaningful impact on the quality of life for senior citizens.
Senior Services Aging / Gerontology Dementia & Alzheimer’s Disease +3 more

Kauffman Foundation: Capacity Building Grant

Ewing Marion Kauffman Foundation
Private
Cass County, Missouri, Clay County, Missouri +4 more
US $100,000 - US $250,000
The Kauffman Foundation's Capacity Building Grant aims to enhance the organizational effectiveness of nonprofits through leadership development, strategic planning, and technology improvements. With funding between $100,000 and $250,000, this grant focuses on strengthening internal capacities rather than supporting specific programs. Organizations aligned with the foundation's strategic priorities and those demonstrating a capacity gap are encouraged to apply for these short-term, impactful grants.
Entrepreneurship Workforce Preparation & Job Readiness Career / College Preparation +6 more

Collective Impact Grant - Planning

Ewing Marion Kauffman Foundation
Private
Cass County, Missouri, Clay County, Missouri +4 more
Up to US $500,000
The Kauffman Foundation's Collective Impact Grant - Planning supports coalitions of high-capacity organizations aiming for systems-level change in the Kansas City area. Grants of up to $500,000 are available to facilitate nine months of planning for collaborative initiatives. Eligible applicants include both established and emerging coalitions, focusing on education, employer connections, and equitable access. This initiative aligns with the foundation's strategic priorities to enhance economic mobility for Kansas Citians.
Entrepreneurship Workforce Preparation & Job Readiness Career / College Preparation +5 more

Kauffman Foundation: Project Grant

Ewing Marion Kauffman Foundation
Private
Cass County, Missouri, Clay County, Missouri +4 more
More than US $250,000
The Kauffman Foundation's Project Grant aims to empower organizations to design and implement impactful multiyear projects that enhance economic mobility in the Kansas City region. Funding of $250,000 or more per year is available for projects focusing on education, skills development, and community engagement. While primarily serving the Kansas City area, grants may also be awarded to organizations from outside the region that can demonstrate a significant impact on local communities.
Entrepreneurship Workforce Preparation & Job Readiness Career / College Preparation +5 more

Kauffman Foundation: Research Grant

Ewing Marion Kauffman Foundation
Private
Cass County, Missouri, Clay County, Missouri +4 more
More than US $150,000
The Kauffman Foundation offers research grants to support projects that enhance understanding of economic mobility and strategic priorities in Kansas City. These grants are available to various organizations, including social welfare and for-profit entities. The foundation emphasizes the importance of community engagement and innovative approaches in addressing systemic barriers. Projects should align with focus areas like education, workforce development, and entrepreneurship, aiming to create equitable access and impactful outcomes.
Entrepreneurship Workforce Preparation & Job Readiness Career / College Preparation +5 more

Ruby Bridges Walk to School Day Mini-Grant

Safe Routes to School National Parternship
Private
United States
US $500 - US $1,000
The Ruby Bridges Walk to School Day Mini-Grant supports events that honor civil rights activist Ruby Bridges by encouraging students to walk to school and engage in discussions about activism, anti-racism, and anti-bullying. Grants of $500 or $1000 are available based on the number of students reached. This initiative aims to inspire positive changes within communities and promote meaningful dialogue among young people about social justice issues.
Youth Services Civic Engagement & Education Racial / Ethnic Justice & Rights +2 more

Gilead Medical Education Grants - Independent Medical Education Funding

Gilead Sciences Foundation
Private
American Samoa, Guam +4 more
Unspecified amount
Gilead Medical Education Grants fund innovative, data-driven programs that enhance healthcare infrastructure and support vulnerable communities globally. Focused on core therapeutic areas like HIV, liver diseases, and oncology, these grants aim to deliver impactful continuing medical education for healthcare providers. Eligible applicants include for-profit medical education companies and nonprofit organizations. Gilead prioritizes programs that demonstrate a strong capacity to achieve specific educational outcomes, ensuring that support reaches those who need it most.
Medical Education & Professional Training

Sheldon Danziger Pipeline Grants

Russell Sage Foundation
Private
United States
Up to US $65,000
The Pipeline Grants Competition by the Russell Sage Foundation aims to bolster early-career scholars and enhance diversity in the social sciences. It supports innovative research focusing on economic mobility and systemic inequalities in the U.S. Eligible applicants can receive up to $35,000 individually or $50,000 in teams. The foundation emphasizes methodological diversity and interdisciplinary collaboration, encouraging novel data usage. Projects should align with RSF's mission to improve social conditions, prioritizing underrepresented scholars from under-resourced institutions.
Climate Change Resilience & Equity Economic Rights, Justice, & Mobility Social Justice / Human Rights +8 more

Dissertation Research Grants

Russell Sage Foundation
Private
American Samoa, Guam +4 more
Up to US $15,000
The Russell Sage Foundation offers Dissertation Research Grants to support innovative research addressing key social science questions. Focus areas include behavioral science, immigration, and economic inequality, particularly benefiting underrepresented doctoral students. Grants of up to $15,000 are available for projects that demonstrate rigorous methods and relevance to U.S. social conditions. The foundation prioritizes diverse applicants and those lacking funding resources to ensure impactful research outcomes.
Social Justice / Human Rights Economic Rights, Justice, & Mobility Workers’ Rights +3 more

Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional) (356611)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $5,500,000
The Blueprint Neurotherapeutics Network (BPN) supports the development of biologic-based therapies for nervous system disorders. This initiative encourages innovative research in biologics, including proteins, antibodies, gene therapies, and cell therapies. The program facilitates collaboration with NIH-funded experts and contract research organizations, ensuring institutions retain IP rights for developed candidates. Key deadlines for grant applications span from January 2025 to July 2027, emphasizing the importance of timely submissions for interested applicants.
Pharmacology Neurological Diseases & Disorders

Research Experiences and/or Mentoring Networks through Research Education to Enhance Clinician-Scientists' Participation in NIDCDs Research (R25 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,250,000
The NIH R25 program enhances clinician-scientists' involvement in research by supporting educational activities aimed at recruiting individuals from diverse backgrounds into biomedical, behavioral, and clinical sciences. This initiative promotes the development of research experiences and mentoring networks to foster a robust research workforce. Applications are due by 5:00 PM local time of the applicant's organization, providing an opportunity for engaging with the NIH's mission.
Medical Education & Professional Training Hearing Disorders & Audiology Hearing Impairment Care & Services +1 more

Seeding Critical Advances For Leading Energy Technologies With Untapped Potential (Scaleup) Ready

United States Department of Energy (DOE)
Federal Government
American Samoa, Guam +4 more
US $5,000,000 - US $20,000,000
The Seeding Critical Advances for Leading Energy Technologies (Scaleup) Ready initiative by ARPA-E invites applications for funding to advance transformative energy technologies. This program supports innovative projects that demonstrate potential for significant market disruption and emphasizes rigorous project management and technology risk mitigation. Eligible organizations must have inventions conceived during an ARPA-E award, reported in the iEdison system, and hold relevant U.S. patent applications. For further details, visit ARPA-E's website.
Emerging Technology Development Energy Renewable/Sustainable Energy +2 more

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) (356617)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) grant aims to facilitate high-quality conferences that align with public health and scientific missions. Key deadlines include December 12, 2024, April 12, 2025, and August 12, 2025, among others, specifically for AIDS-related applications. This funding opportunity is provided by the US Department of Health & Human Services: National Institutes of Health (NIH).
Epidemiology & Public Health

Baptist Foundation of South Carolina: Grant Program

Baptist Foundation Of South Carolina Inc
Private
United States
Unspecified amount
The Baptist Foundation of South Carolina supports churches and ministries with grants aimed at 'Kingdom Growth' projects. Their mission focuses on utilizing God-given resources to enhance community impact. Grant requests are open to religious and charitable organizations that align with their purpose. Priority is given to local Baptist associations and convention entities. Eligible projects can receive up to 80% funding, ensuring that impactful ministry initiatives thrive within the community.
Disaster Relief / Humanitarian Aid Baptist Faith

Community Care Grant

Banfield Foundation
Private
United States
Unspecified amount
The Community Care Grant, offered by the Banfield Foundation, supports nonprofit organizations and local/state government agencies in providing affordable veterinary care to owned pets. Since 2015, the foundation has aimed to enhance preventive care through grants and partnerships, helping pets in crisis and underserved communities across the U.S. This initiative ensures that essential veterinary services are accessible to all pet owners, fostering a better world for pets.
Veterinary Science & Services Animal Welfare - Domestic Animals & Pets

Emergency Educational Grants

Elks National Foundation Inc
Private
United States
Unspecified amount
The Emergency Educational Grants offer vital financial support of up to $5,000 for undergraduate students who are children of deceased or totally disabled Elks. This grant is renewable for one year and is intended solely for educational purposes, helping cover costs such as tuition and books. Eligible applicants must demonstrate financial need and maintain full-time enrollment in an accredited U.S. college or university, while being unmarried and under 24 years old during the application year.
Education - Higher Education Academic Success & Enrichment

Elks National Foundation: Cornerstone Grants

Elks National Foundation Inc
Private
United States
Up to US $750

Cornerstone Grants

Do you volunteer with a nonprofit organization? Would you like additional funding to start or enhance a service project? Organize your own service project!

We know that as an Elks scholar, you already uphold the cornerstones of the Foundation: knowledge, integrity, charity and community. Now, we want to help you do more! The ENF is offering fifteen $500 Cornerstone Grants to any Elks scholar interested in starting or expanding a community service project. We are also offering six $250 bonuses for projects done in collaboration with an Elks Lodge.

Looking for project ideas?

Consider a cause that you are passionate about and partner with an organization addressing that need.

Talk to your sponsoring lodge about what sort of service project they’d like to see at the Lodge. Ask them about charitable projects they are currently involved with, and see if there are any projects they’d like to see enhanced. You can find contact information for a Lodge near you here.

Funding

  • The ENF is offering twenty $500 Cornerstone Grants to any Elks scholar interested in starting or expanding a community service project.
  • We are also offering fifteen $250 bonuses for projects done in collaboration with an Elks Lodge.

Community Services

Baskin Family Foundation Grant

Baskin Family Foundation
Private
United States
Unspecified amount
The Baskin Family Foundation Grant supports innovative organizations that focus on education and social justice. Established by Samuel and Hadassah Baskin, Sheldon Baskin, and Judy Wise, this grant aims to empower 501(c)(3) organizations to create meaningful change in their communities. By promoting forward-thinking initiatives, the foundation strives to enhance the lives of those it serves and foster equality in access to education.
Social Justice / Human Rights Education

Prader-Willi Syndrome Mini-Fellowship Grant ( up to $25,000)

Prader Willi Syndrome Association (Usa)
Private
United States
Up to US $25,000
The Prader-Willi Syndrome Mini-Fellowship Grant aims to enhance understanding of Prader-Willi Syndrome (PWS) through clinical proctorships. Offering up to $25,000 USD, this grant supports providers in shadowing experts in PWS while engaging in an academic project. PWSA | USA, dedicated to advancing research since 1983, focuses on high-impact projects that translate biomedical knowledge into effective treatments, ultimately improving the lives of those affected by PWS.
Endocrine & Metabolic Diseases Neurological Diseases & Disorders

NMDP Amy Strelzer Manasevit Research Program Grant

National Marrow Donor Program
Private
United States
Up to US $400,000
The NMDP Amy Strelzer Manasevit Research Program Grant supports early-career researchers in hematopoietic cell transplantation and cellular therapy. With a maximum funding of $400,000 over five years, it aims to address complications post-transplant, such as infection and relapse. This prestigious grant encourages innovative research proposals, particularly those targeting HLA-mismatched donor outcomes. By fostering new talent in the field, the program is essential for advancing our understanding of critical post-transplant challenges.
Cell Biology Hematological Systems

NMDP Barbara Buchbinder Nurse Research Program Grant

National Marrow Donor Program
Private
United States
US $25,000
The NMDP Barbara Buchbinder Nurse Research Program Grant supports pediatric BMT nurses conducting research to enhance transplant experiences and outcomes for children. With only 4% of federal funding allocated to childhood cancer, this program, honoring a dedicated nurse, aims to attract new talent to the field. Each selected Buchbinder Scholar receives a $25,000 award to pursue relevant investigations, emphasizing the importance of supportive care in pediatric allogeneic hematopoietic cell transplants.
Children’s Health & Pediatrics Hematological Systems Cell Biology +1 more

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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