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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,706 Results based on applied filters

Diana Jo Dreyer Memorial Scholarship

Foundation for Rural Service
Private
United States
Up to US $2,500
The Diana Jo Dreyer Memorial Scholarship, established by INDATEL Services LLC and the family of Diana Jo Dreyer, supports female students pursuing a business degree. This scholarship honors Diana's impactful career in telecommunications and her dedication to empowering women in the industry. Applicants must be graduating high school seniors, U.S. citizens, sponsored by an NTCA member, and interested in returning to rural communities after graduation. This initiative enriches the lives of young women in rural America.
Business Education

Everett Kneece Scholarship

Foundation for Rural Service
Private
United States
US $7,000
The Everett Kneece Scholarship, offered by the Foundation for Rural Service, provides a $7,000 award annually to a graduating high school senior who shows commitment to returning to a rural community. To be eligible, applicants must be U.S. citizens sponsored by an NTCA member and express interest in rural community service. This scholarship honors Everett Kneece's legacy of philanthropy and dedication to enhancing rural life through education.
All fields of work

Sarah Tyree Good Neighbor Scholarship

Foundation for Rural Service
Private
United States
US $5,000
The Sarah Tyree Good Neighbor Scholarship, provided by the Foundation for Rural Service, honors the legacy of Sarah Tyree, a champion for rural broadband. This scholarship is awarded to high school seniors who exemplify humanitarianism and community spirit. Eligible students must be U.S. citizens with a commitment to returning to rural areas post-graduation. The award supports educational endeavors, ensuring that future leaders have the resources they need to thrive.
All fields of work

Herbert and Isabel Bitz Memorial Scholarship

Foundation for Rural Service
Private
United States
US $5,000
The Herbert and Isabel Bitz Memorial Scholarship, established by Mr. Don Bitz, offers a $5,000 award annually to a graduating high school senior dedicated to rural America. Sponsored by a member of NTCA–The Rural Broadband Association, applicants must be U.S. citizens with intentions of returning to a rural community after graduation. This scholarship aims to support students who aspire to contribute to the quality of life in rural areas.
All fields of work

JSI Scholarship

Foundation for Rural Service
Private
United States
US $5,000
The JSI Scholarship, provided by the Foundation for Rural Service, awards $5,000 to four high school seniors interested in science, math, medicine, or engineering. Sponsored by a member of NTCA–The Rural Broadband Association, recipients are encouraged to return to rural communities after graduation. This initiative aims to enhance rural life through education and support, promoting the development of future leaders in essential fields.
Engineering Mathematics Science +1 more

TMS Scholarship

Foundation for Rural Service
Private
United States
US $1,500
The TMS Scholarship, provided by the Foundation for Rural Service, awards $1,500 annually to two deserving students from Ardmore Telephone or West Kentucky and Tennessee Telecommunications Cooperative. To qualify, applicants must be graduating high school seniors, U.S. citizens, sponsored by a member of the NTCA, and show interest in returning to rural communities post-graduation. This initiative aims to enhance educational opportunities and support the development of rural America.
All fields of work

Roger Cox Scholarship

Foundation for Rural Service
Private
United States
US $500 - US $1,000
The Roger Cox Scholarship, funded by the Foundation for Rural Service, offers a $1,000 scholarship to a high school senior residing in the Atlantic Telephone Membership Company service area in North Carolina, along with two $500 scholarships for rural residents of North and South Carolina. The scholarship aims to support students' educational journeys while encouraging them to return to rural communities post-graduation. Recipients are selected through a thorough review process.
All fields of work

Medical Scientist Training Program (MSTP) (T32)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Medical Scientist Training Program (MSTP) aims to cultivate a diverse group of physician-scientist leaders to address the nation's biomedical research needs. This program supports institutions in creating integrated dual-degree training that results in both medical and research doctorate degrees. By combining clinical practice with scientific research, MSTP graduates will advance health-related research, focusing on improving training effectiveness, alumni retention in research careers, and workforce diversity. NIGMS emphasizes comprehensive training elements for impactful careers.
Medical Education & Professional Training Science

NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) (352846)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH Support for Conferences and Scientific Meetings (R13) provides funding for high-quality conferences that align with public health and scientific missions. Key deadlines for applications include April 12, August 12, and December 12 for the years 2024 through 2026, with specific deadlines for AIDS-related grants as well. This funding opportunity aims to foster collaboration and dissemination of important research findings in relevant fields.
Health & Medicine Science Epidemiology & Public Health

Knowles Teaching Fellowship

Knowles Teacher Initiative
Private
United States
More than US $50,000
The Knowles Teaching Fellowship supports emerging high school science and mathematics teachers in the U.S. Ideal candidates possess a strong academic background, leadership skills, and a commitment to teaching. The fellowship emphasizes comprehensive development through mentoring and financial support, including grants for classroom materials and stipends to alleviate financial burdens. By fostering a community of over 500 educators, the program aims to enhance teaching quality and sustainability in the profession over a five-year trajectory.
Education - K through 12 Teacher Development & Training STEM / STEAM Education

FWW Fellowship Award

Foundation for Womens Wellness Inc.
Private
United States
Up to US $5,000
The FWW Fellowship Award supports emerging physicians and scientists dedicated to advancing women’s health research. Awardees, pursuing MD or PhD programs at U.S. institutions, explore critical health topics such as cardiovascular disease, leading female cancers, and the role of hormones. This initiative encourages diverse applicants and promotes innovative proposals that address health concerns disproportionately affecting women. With a commitment to fostering research excellence, the FWW Fellowship Award empowers the next generation of health leaders.
Women's Health

FWW Research Awards

Foundation for Womens Wellness Inc.
Private
United States
US $25,000
The FWW Research Awards support short-term studies focused on critical women’s health issues such as cardiovascular disease, female cancers, and hormonal influences on health. Eligible applicants include MDs or PhDs affiliated with accredited institutions. Research proposals must align with FWW's priority areas, and financial support must be confirmed to ensure project completion. Note that sociological studies are not funded, and only one application per Principal Investigator is allowed.
Women's Health

Addressing HCP Knowledge Gaps in Baseline Assessments for Adults with Ulcerative Colitis Starting S1P Receptor Modulator Therapy

Pfizer, Inc.
Corporate
United States
Up to US $100,000
This program aims to enhance education for healthcare professionals regarding new therapies and patient management in ulcerative colitis (UC). It focuses on multi-channel educational strategies to address the evolving landscape of UC treatment. Key areas include educating on new oral therapies, transitioning to advanced therapies, and managing isolated proctitis. Organizations such as healthcare institutions and medical education companies are eligible to apply, ensuring a comprehensive approach to improving UC care.
Digestive System Health & Diseases Crohn’s Disease And Colitis

T.E.A.L. Research Grant

Tell Every Amazing Lady About Ovarian Cancer Foundation
Private
United States
Up to US $20,000
The T.E.A.L. Research Grant supports innovative ovarian cancer research initiatives aligned with the mission of the Tell Every Amazing Lady About Ovarian Cancer Foundation. Designed for researchers affiliated with 501(c)3 not-for-profit institutions in the U.S., the grant aims to enhance women's health awareness and education regarding ovarian cancer. While the application period for 2025 is currently closed, interested parties should anticipate further updates in spring 2026.
Gynecological Cancers

Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42- Clinical Trial Optional) (352883)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $2,352,688
The Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42) program invites small business concerns to develop innovative technologies aimed at enhancing minority health and addressing health disparities. This initiative emphasizes the creation of effective, affordable, and culturally acceptable solutions for NIH-defined populations. Key deadlines for applications span from June 2024 to December 2026, with optional Letters of Intent encouraged 30 days prior to submission.
Minority Services Health Disparities & Social Determinants of Health Medical Technology, Devices, and Equipment

Innovations for Healthy Living - Improving Minority Health and Eliminating Health Disparities (R43/R44 - Clinical Trial Optional) (352882)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Up to US $2,352,688
The Innovations for Healthy Living program invites eligible U.S. small businesses to apply for SBIR grants aimed at improving minority health and eliminating health disparities. The initiative encourages innovative proposals for effective, affordable, and culturally acceptable solutions. Key deadlines for applications span from June 2024 to December 2026, with optional Letters of Intent recommended 30 days prior to submission. This funding opportunity supports projects that address health challenges faced by underserved populations.
Minority Services Health Disparities & Social Determinants of Health Medical Technology, Devices, and Equipment

Association of American Educators Foundation: National Teacher Scholarship

Association of American Educators Foundation
Association/Society
United States
Up to US $500
The Association of American Educators Foundation offers the National Teacher Scholarship to promote professional excellence among educators. This scholarship provides funding for various professional development opportunities, including conferences and learning materials, with awards up to $500. Available to full-time educators who haven't received AAE funding in the last two years, the scholarship aims to enhance the quality of education across the nation while supporting educators' growth and collaboration.
Teacher Development & Training

Hearst Foundation: Health Grant

William Randolph Hearst Foundation
Private
United States
More than US $100,000
The Hearst Foundation's Health Grant aims to support nonprofits that enhance healthcare access for underserved populations in the U.S. Focused on improving skills and increasing healthcare practitioners, the grant also emphasizes public health and medical research. With a history of funding significant projects, the foundation prioritizes programs that address the complex needs of low-income, rural, and elderly communities. This commitment ensures a sustainable impact on national health outcomes while supporting innovative healthcare delivery systems.
Health Care Access & Delivery Health Facilities & Clinics Epidemiology & Public Health +3 more

Addressing Health Inequities in Clinical Diagnostics (R43/R44 Clinical Trials Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Unspecified amount
The Addressing Health Inequities in Clinical Diagnostics initiative invites Small Business Concerns to develop innovative clinical diagnostics that rectify health disparities in diverse patient populations. Applications should identify a specific inequity in current diagnostic practices and propose actionable solutions. This funding opportunity promotes inclusivity in clinical settings, ensuring that diagnostics are effective across varied demographics. All submissions must adhere to the deadline of 5:00 PM local time for the applicant organization.
Biomedical Imaging Health Disparities & Social Determinants of Health Medical Technology, Devices, and Equipment

Addressing Health Inequities in Clinical Diagnostics (R41/R42 Clinical Trials Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
United States
Unspecified amount
The Addressing Health Inequities in Clinical Diagnostics program invites Small Business Concerns to develop innovative clinical diagnostics that tackle health disparities. This initiative emphasizes identifying and addressing issues within existing clinical diagnostics that contribute to inequities, ensuring inclusive solutions for diverse patient populations. By fostering advancements in clinical lab assays and point-of-care devices, the program aims to create equitable healthcare opportunities for all.
Health Disparities & Social Determinants of Health Biomedical Imaging Medical Technology, Devices, and Equipment

Institutional Translational Research Training Program (T32 - Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Institutional Translational Research Training Program (T32) aims to prepare trainees for advancing basic research into clinical applications. This program focuses on developing essential skills in experimental design, statistical analysis, and effective science communication. Participants, including advanced predoctoral students and postdoctoral fellows, will engage in a two-year training program that fosters collaboration among neuroscientists and clinicians, ultimately equipping them to tackle basic research challenges and translate discoveries into viable therapies.
Neuroscience Medical Education & Professional Training

Hearst Foundation: Education Grant

William Randolph Hearst Foundation
Private
United States
More than US $100,000
The Hearst Foundation: Education Grant aims to support outstanding nonprofits that promote education across various levels, focusing primarily on higher education. With a minimum grant size of $100,000, the foundation prioritizes organizations demonstrating significant impact and sustainability. They support innovative educational models, professional development, and scholarships, specifically targeting underserved populations. Since the 1940s, the foundation has evolved while maintaining its commitment to fostering healthy and productive lives for all individuals in the United States.
Education - Higher Education Education - Preschool / Early Learning Education - K through 12 +3 more

NEA Foundation- Student Success Grants

The NEA Foundation for the Improvement of Education
Private
United States
Up to US $5,000
The NEA Foundation's Student Success Grants support educators in creating innovative learning experiences that foster critical thinking, problem-solving, and cultural understanding among students. This initiative encourages project-based and personalized learning, enabling students to engage with real-world challenges. Applicants must be members of the National Education Association and can use grant funds for educational materials and experiences. The focus is on enhancing academic skills, communication, and collaboration, ultimately promoting joy in learning.
Cross-Cultural Understanding & Exchanges Education - K through 12 Academic Success & Enrichment +2 more

Hearst Foundation: Social Service Grant

William Randolph Hearst Foundation
Private
United States
More than US $100,000
The Hearst Foundation's Social Service Grant focuses on tackling chronic poverty by funding direct-service organizations that implement effective solutions for economic independence and family strengthening. With a mission to support diverse nonprofits in the U.S., the Foundation allocates approximately 15% of its total funding to social services, prioritizing scalable programs that serve significant populations. The minimum grant size is $100,000, and special consideration is given to organizations addressing affordable housing, domestic violence, and youth development.
Sustainability Food Access & Hunger Family Services +10 more

NEA- Envision Equity Grants

The NEA Foundation for the Improvement of Education
Private
United States
Up to US $5,000
The NEA Envision Equity Grants empower educators to implement innovative projects that foster cultural understanding, anti-racism, and civic engagement among students. With funding of up to $5,000, these grants support diverse educational initiatives over a 12-month period. Eligible applicants include NEA members, and funds can be allocated for resources, materials, and professional development aimed at enhancing student learning experiences. Projects that prioritize critical thinking and collaboration are particularly encouraged.
Cross-Cultural Understanding & Exchanges Diversity, Equity & Inclusion Civic Engagement & Education

CFA Ministry Grants

The Kentucky Annual Conference of The United Methodist Church
Association/Society
United States
Up to US $500
The CFA Ministry Grants Initiative, part of the Kentucky Conference's mission, supports local churches in developing ministries focused on stewardship, technology, and leadership development. Eligible churches can apply for grants up to $500, with each church allowed to submit two applications annually. This initiative aims to foster generosity and enhance church leadership, providing essential resources to help congregations grow and effectively fulfill their mission of making disciples of Jesus Christ.
Christianity Technology Access & Digital Literacy Civic Leadership Development

AES Infrastructure Grants

American Epilepsy Society
Private
United States
Up to US $50,000
The AES Infrastructure Grant, offered by the American Epilepsy Society, provides up to $50,000 to support the development of national or international multicenter research programs. This funding is intended for organizational planning sessions, infrastructure development, and pilot projects, facilitating future investments from other organizations. These grants are available annually in the spring, enabling researchers to enhance their collaborative efforts.
Epilepsy

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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