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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,706 Results based on applied filters

AAD Advocate Of The Year Award

American Academy of Dermatology
Association/Society
United States
Unspecified amount in in-kind support
The AAD Advocate Of The Year Award, presented by the American Academy of Dermatology Association, honors exceptional grassroots advocacy efforts in dermatology. This prestigious award promotes year-round advocacy and highlights the significant impact of dedicated individuals. Eligibility includes active participation in legislative efforts and direct engagement with legislators. It aims to inspire and recognize those who contribute to the advancement of dermatology and skin health through advocacy initiatives.
Skin Diseases & Dermatology Health Policy & Advocacy Skin Cancers

Development Advocacy Grant

American Academy of Dermatology
Association/Society
United States
Unspecified amount
The Development Advocacy Grant by AADA supports state dermatology societies new to advocacy, providing essential funding for health policy initiatives and lobbying. This program is tailored for states with limited prior funding, ensuring a simplified application process to encourage participation. Eligible states must align their projects with AADA's policy priorities and submit a final report detailing advocacy progress. This initiative fosters growth in advocacy efforts, empowering societies to influence key legislation effectively.
Skin Diseases & Dermatology Health Policy & Advocacy

Established Advocacy Grant

American Academy of Dermatology
Association/Society
United States
Unspecified amount
The Established Advocacy Grant, offered by the AADA, provides crucial financial support to state dermatology societies that have previously received multiple advocacy grant awards. This program aims to enhance health policy initiatives, focusing on specific legislative priorities. Eligible states must align their applications with AADA’s policy priorities and demonstrate their advocacy efforts through a detailed plan. Compliance with IRS regulations and timely reporting is mandatory for continued funding.
Skin Diseases & Dermatology Health Policy & Advocacy

AIAA Foundation Classroom Grant Program

American Institute of Aeronautics and Astronautics
Private
United States
Up to US $500
The AIAA Foundation Classroom Grant Program provides funding of up to $500 for K-12 teachers to enhance student learning in STEM subjects, particularly in Aerospace. The program encourages innovative projects that address unmet educational needs. Schools can apply for a maximum of two grants per year. Eligible projects include STEM demonstration kits and robotics supplies, while funding for items like audio-visual equipment and travel is not permitted.
STEM / STEAM Education

Prof. Chan Two-Year College Award for the Engaged Teaching of Biology

National Association of Biology Teachers
Private
United States
Unspecified amount
The Prof. Chan Two-Year College Award for the Engaged Teaching of Biology recognizes outstanding contributions by Two-Year College faculty who develop and implement innovative, inclusive pedagogical approaches. Sponsored by Sarah McBride and John Melville, this award emphasizes the impact of teaching on a broader student population and includes a $500 travel grant for the NABT Professional Development Conference, fostering professional development and collaboration among biology educators.
Teacher Development & Training Biology

Two-Year College Biology Teaching Award

National Association of Biology Teachers
Private
United States
Unspecified amount
The Two-Year College Biology Teaching Award, sponsored by the National Association of Biology Teachers (NABT), recognizes outstanding biology educators in two-year colleges who implement innovative teaching techniques. This award highlights the importance of culturally responsive pedagogies that foster equity and inclusion in various learning environments. Recipients receive a $500 travel honorarium, a recognition plaque, and one year of complimentary NABT membership, supporting their professional development and commitment to enhancing biology education.
Biology Teacher Development & Training

Vernier Science Education Inspiration Grants

Vernier Science Education
Corporate
United States
Approximately US $1,000 in in-kind support
The Vernier Science Education Inspiration Grants support innovative K-12 and college educators in the U.S. who creatively use Vernier technology to engage students in hands-on STEM education. Each grant includes $1,000 in Vernier technology, a one-year license for the Vernier Graphical Analysis™ Pro app, and three hours of virtual professional development. This initiative aims to inspire scientific curiosity and enhance STEM literacy among students.
STEM / STEAM Education

ACLS Leading Edge Fellowships

American Council of Learned Societies
Association/Society
United States
More than US $142,000
The ACLS Leading Edge Fellowships provide recent humanities PhDs with the opportunity to work with nonprofit organizations focused on social justice. Over 24 months, fellows receive a stipend of $70,000 in the first year and $72,000 in the second, along with relocation funds and health insurance. The program emphasizes diversity and inclusion, encouraging applications from all eligible scholars to enhance their professional skills in meaningful roles.
Humanities & Social Science Social Justice / Human Rights

Mckesson Foundation Grant: below $25,000

McKesson Foundation
Private
Canada, United States
Up to US $25,000
The McKesson Foundation Grant provides funding up to $25,000 for organizations focused on improving health outcomes in underserved communities. Established in 1943, the foundation prioritizes health equity through strategic partnerships aimed at reducing cancer burdens, preparing healthcare professionals, and enhancing crisis response efforts. Eligible applicants include national and local nonprofits targeting specific regions in the U.S. and Canada. The foundation emphasizes projects that align with its mission and demonstrate significant community impact.
Food Access & Hunger Cancer / Oncology Disaster Relief / Humanitarian Aid +8 more

Young Investigators Research Forum

American Academy Of Sleep Medicine Foundation
Private
United States
Unspecified amount
The Young Investigators Research Forum offers a unique opportunity for early career sleep scientists to enhance their research skills. Funded by the AASM Foundation, this program provides travel scholarships for participants to attend the 2025 forum in Bethesda, MD. Participants will engage with senior investigators, learn about funding mechanisms, and refine their research proposals. This forum is designed to build a supportive network, fostering collaborations and mentorship in the field of sleep and circadian research.
Sleep Medical Education & Professional Training

Strategic Research Grant: Sleep Health Disparities Research

American Academy Of Sleep Medicine Foundation
Private
United States
US $50,000 - US $250,000
The Strategic Research Grant for Sleep Health Disparities Research, offered by the AASM Foundation, aims to address significant gaps in knowledge related to sleep disorders among disadvantaged populations in the U.S. This initiative focuses on enhancing screening, diagnosis, and treatment effectiveness, while promoting innovative interventions tailored to culturally diverse groups. The grant supports impactful research that seeks to mitigate sleep health disparities, ultimately improving health outcomes for racial/ethnic minorities, socioeconomically disadvantaged individuals, and other underserved communities.
Patient Care & Services Sleep Health Disparities & Social Determinants of Health

Wilhelm Family Foundation Grants

The Wilhelm Family Foundation
Private
United States
Unspecified amount
The Wilhelm Family Foundation Grants aim to enhance access to artistic resources by funding diverse nonprofit arts organizations. Prioritizing projects that engage with environmental and climate issues, the foundation seeks to support creative expression and collaboration in underserved communities. Emphasizing equality and sustainability, it fosters artistic practices that empower individuals and promote cultural dialogue. Grants are typically awarded to small organizations, focusing on community engagement and longevity in the arts sector.
Art for Social Change Public / Community Art Arts / Culture Access & Participation

BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS (R18 - Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,250,000
The BRAIN Initiative seeks innovative proposals for preclinical proof of concept studies on novel recording and modulation technologies aimed at diagnosing and treating central nervous system (CNS) disorders. This initiative supports diverse, multidisciplinary teams to enhance our understanding of the human CNS and prepare technologies for first-in-human studies. Applications are due by 5:00 PM local time, with optional Letters of Intent encouraged 60 days prior to the proposal deadline.
Neuroscience Medical Technology, Devices, and Equipment

BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $7,500,000
The BRAIN Initiative invites applications for clinical studies aimed at advancing devices for recording and modulation in the human central nervous system. This funding opportunity focuses on small clinical trials that provide vital data for device development, particularly for treatments of central nervous system disorders. Investigators are encouraged to explore both non-significant and significant risk studies to enhance understanding of device functionality and design, ultimately contributing to improved clinical outcomes.
Neurological Diseases & Disorders Medical Technology, Devices, and Equipment

BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,500,000
The BRAIN Initiative aims to foster innovation in the development of next-generation devices for recording and modulating the human central nervous system. This funding opportunity encourages clinical studies and translational research to create advanced therapeutic and diagnostic devices for neurological disorders. Applicants are advised to submit Letters of Intent 60 days before the proposal deadline. This initiative emphasizes milestones and collaboration with NIH staff throughout the project.
Neuroscience Neurological Diseases & Disorders Medical Technology, Devices, and Equipment

The Active Fund Grant

Kelly S Brush Foundation
Private
United States
Approximately US $3,500
The Active Fund Grant, offered by the Kelly Brush Foundation, supports individuals with paralysis from spinal cord injuries in acquiring adaptive sports equipment. This initiative aims to foster active lifestyles and inclusivity through sports. First-time applicants are prioritized for the Fall 2025 cycle, with grants averaging around $3,500, though they can vary. Eligible applicants can receive full or partial awards or a Try-It-First grant to gain experience with the equipment. For guidelines, please refer to the provided FAQs.
Spinal Cord Injuries

Equity in Mathematics Grant (PK-6)

National Council of Teachers of Mathematics
Association/Society
United States
Up to US $8,000
The Equity in Mathematics Grant (PK-6) aims to enhance mathematics education for underrepresented student groups, addressing disparities linked to race, gender, and culture. Funded by the National Council of Teachers of Mathematics, this grant supports innovative classroom materials and lesson plans that focus on improving student achievement. Eligible applicants include classroom teachers and collaborative groups. The initiative seeks proposals that reflect best practices in mathematics education while fostering equity and inclusivity in learning environments.
Mathematics Teacher Development & Training Educational Access & Equity +1 more

Robert Silman Award

James Marston Fitch Charitable Foundation
Private
United States
Up to US $15,000
The Robert Silman Award, presented biennially by the James Marston Fitch Charitable Foundation, recognizes innovative proposals in the preservation, restoration, or adaptive reuse of the built environment. Open to professionals in various design fields, the award encourages originality and practical applications that advance preservation in the U.S. With a funding limit of $15,000, it seeks projects that demonstrate a clear plan for dissemination and positive community impact, especially for underrepresented groups.
Architecture Engineering Historic Preservation +6 more

Classroom Research Grant PK-6

National Council of Teachers of Mathematics
Association/Society
United States
Up to US $6,000
The Classroom Research Grant PK-6, offered by the National Council of Teachers of Mathematics, aims to foster collaborative research between teachers and mathematics educators in Pre-K-6 classrooms. This grant supports innovative projects focusing on curriculum development, instructional methods for diverse learners, and technology integration in mathematics education. Successful proposals should lead to publishable research articles that demonstrate a significant impact on student learning outcomes.
Mathematics Teacher Development & Training STEM / STEAM Education +1 more

Classroom Research Grant 7-12

National Council of Teachers of Mathematics
Association/Society
United States
Up to US $6,000
The Classroom Research Grant 7-12, offered by the National Council of Teachers of Mathematics, aims to promote classroom-based research in mathematics education. This grant encourages collaboration between college or university mathematics educators and grades 7-12 teachers, focusing on enhancing curriculum, engaging diverse students, and integrating technology. Successful proposals should address research design, data analysis, and anticipated impacts on student learning, ultimately leading to a publishable article in relevant mathematics education journals.
Mathematics Teacher Development & Training STEM / STEAM Education +1 more

Connecting Mathematics to Other Subject Areas Grant

National Council of Teachers of Mathematics
Association/Society
United States
Up to US $4,000
The Connecting Mathematics to Other Subject Areas Grant, offered by the National Council of Teachers of Mathematics, aims to enhance high school mathematics education through interdisciplinary lessons and materials. Grants support the creation of resources that facilitate mathematical modeling while connecting math to real-world contexts. Eligible applicants are educators teaching math in grades 9-12, and proposals should include a timeline for development and expected student impact.
Mathematics Teacher Development & Training STEM / STEAM Education

Early Career Research Grant

National Council of Teachers of Mathematics
Association/Society
United States
Up to US $10,000
The Early Career Research Grant, offered by the National Council of Teachers of Mathematics, supports innovative research in mathematics education by early career educators and doctoral candidates. This grant encourages projects that enhance teaching practices and contribute to scholarly publications. Proposals should focus on research design, data analysis, and the impact on mathematics learning. Preference is given to those bridging research and practical application, fostering collaboration with preservice teachers.
Mathematics Teacher Development & Training STEM / STEAM Education

Improving Students' Understanding of Geometry Grant

National Council of Teachers of Mathematics
Association/Society
United States
Up to US $4,000
The Improving Students' Understanding of Geometry Grant, provided by the National Council of Teachers of Mathematics, aims to enhance students' comprehension and application of geometry through innovative activities. Eligible applicants include educators teaching at the Pre-K-8 level, with proposals integrating technology and linking geometry to various fields such as art and science. The grant seeks to foster a deeper appreciation of geometry, ensuring that students achieve a greater understanding of its relevance in everyday contexts.
Mathematics Teacher Development & Training STEM / STEAM Education

Advanced Mathematics Education CourseWork Scholarship for Grades 9–12 Teachers

National Council of Teachers of Mathematics
Association/Society
United States
Up to US $3,000
The Advanced Mathematics Education Course Work Scholarship, offered by the National Council of Teachers of Mathematics, aims to enhance the teaching skills of educators in grades 9-12. This grant provides financial support for advanced courses in mathematics education, emphasizing specific mathematics topics. Eligible applicants must have at least three years of teaching experience and dedicate a significant portion of their day to teaching mathematics. This initiative seeks to foster high-quality mathematics instruction across schools.
Mathematics Teacher Development & Training STEM / STEAM Education

Centers of Research Excellence in Science and Technology - Research Infrastructure for Science and Engineering

National Science Foundation (NSF)
Federal Government
United States
US $100,000 - US $2,000,000
The CREST program by the NSF aims to bolster research capabilities at minority-serving institutions (MSIs) through education and research integration. It specifically supports STEM doctoral programs and encourages proposals in high-priority areas such as AI and climate change. By enhancing the institutional capacity, the program seeks to increase the number of underrepresented doctoral graduates in STEM fields, thereby fostering diversity and innovation in scientific research.
STEM / STEAM Education Data Science & Digital Information Systems Artificial Intelligence (AI) +13 more

Gable Grants Program

Lowe's Foundation
Private
United States
US $100,000 - US $1,000,000
The Lowe's Foundation Gable Grants Program aims to address the skilled trades labor shortage by investing $50 million over five years to train 50,000 job-ready workers. The program supports community and technical colleges, as well as community-based nonprofit organizations, to enhance their skilled trades education initiatives. Eligible organizations can apply for grants from March 1, 2025, to October 1, 2025, to foster workforce development in essential trades such as HVAC, plumbing, and construction.
Workforce Preparation & Job Readiness Vocational & Trade Education

Sharing Language Diversity Fellowship

Endangered Language Fund Inc
Private
United States
Up to US $30,000
The Sharing Language Diversity Fellowship supports Ph.D. students engaged in Indigenous language documentation and data archiving. Funded by the Endangered Language Fund, it encourages sustainable public sharing of linguistic materials, aiming for equitable access to research. With grants up to $30,000, recipients must publicly archive documentation materials within three years, ensuring compliance with community wishes and best practices. This initiative fosters a culture of Open Access in linguistics, benefiting both scholars and Indigenous communities.
Linguistics Native American Culture & Heritage

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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