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Best Massachusetts Grants for Nonprofits

Find nonprofit grants in Massachusetts, including opportunities in Boston, Worcester, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$3.29B

Total funding

$5K

Median grant

10,000+ grants
$3.29B total
$5K median

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9,801 Results based on applied filters

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) (356879)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $100,000
This funding opportunity invites applications for pilot projects focused on understudied proteins linked to rare diseases. The goal is to generate preliminary data and tools related to these proteins, which belong to druggable families with known rare disease associations. By supporting innovative research, this initiative aims to facilitate the characterization of these proteins, ultimately contributing to advancements in understanding and treating rare diseases.
Human Genome & Genetics Rare Diseases

Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
This Funding Opportunity Announcement (FOA) aims to advance the identification and evaluation of candidate biomarkers for neurological and neuromuscular disorders. By facilitating the clinical development of neurotherapeutics, the FOA encourages research that includes both animal studies and preliminary human evaluations. The ultimate goal is to produce biomarkers ready for rigorous analytical and clinical validation, enhancing the effectiveness of treatments in clinical practice.
Biomedical informatics Neurological Diseases & Disorders Musculoskeletal Diseases

Computational Approaches to Curation at Scale for Biomedical Research Assets (R01 Clinical Trial Not Allowed) (356888)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,000,000
The NIH is seeking innovative computational approaches to enhance the curation of biomedical research assets at scale. This initiative aims to accelerate access to secure datasets and computational models, facilitating transformative discoveries in biomedical science. Key deadlines for applications range from January 2025 to January 2027, covering standard, renewal, and AIDS-related grants. Applicants are encouraged to submit Letters of Intent 30 days prior to application deadlines to ensure a streamlined review process.
Biomedical informatics Epidemiology & Public Health Health Information Technology

Reboot Representation Grant

Reboot Representation Tech Coalition
Association/Society
United States
Unspecified amount
The Reboot Representation Tech Coalition aims to significantly increase the number of Black, Latina, and Native American women earning computing bachelor’s degrees. They invite qualified organizations to submit grant inquiries focused on recruiting and retaining these women in tech. Programs that leverage existing resources and operate across multiple regions will be prioritized, and the Coalition seeks initiatives backed by substantial research and community trust.
Computer Science & Engineering Diversity, Equity & Inclusion Women's Rights & Equality +4 more

Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program (UC2- Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Biomedical Research Environment and Sponsored Programs Administration Development (BRE-SPAD) Program, funded by the NIH, aims to enhance the biomedical research landscape by supporting resource-limited organizations. It targets domestic institutions with limited research resources and few doctoral students in biomedical fields, promoting broader participation in research and boosting administrative capacities for sponsored programs. Applications are due by 5:00 PM local time of the applicant organization, ensuring timely submissions.
Biology Health & Medicine

Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional) (356925)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,750,000
This grant opportunity from the NIH aims to enhance mechanistic research on precision probiotic therapies through a biphasic R61/R33 award mechanism. It encourages innovative studies to identify specific biological factors influencing probiotic responses, thereby improving clinical outcomes. The program supports up to five years of research, with the initial phase focused on discovering unique host characteristics and the second phase assessing improvements in probiotic efficacy through rigorous studies.
Integrative & Alternative Health Microbiomes

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32) (357140)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) supports eligible institutions in enhancing research training for predoctoral and postdoctoral candidates. This initiative aims to foster a diverse workforce in biomedical and clinical research, ensuring that training programs are comprehensive, engaging, and career-oriented. Key deadlines for applications are set from January 2025 through September 2027, with specific dates for standard and AIDS-related applications.
Science Biology Health & Medicine +1 more

Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed) (357138)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $275,000
This funding opportunity from the NIH encourages groundbreaking research to enhance, develop, and preserve animal models and related biological materials for studies impacting human health. The program seeks innovative methodologies that can improve the diagnosis and management of diseases affecting animal use in biomedical research. Projects must demonstrate relevance across multiple NIH Institutes to align with broader research goals, emphasizing diverse body systems and disease categories.
Biology Diseases & Conditions

The Land and Water Conservation Fund: Outdoor Recreation and Legacy Partnership Program

Connecticut Department of Energy and Environmental Protection
State/Local Government
American Samoa, District of Columbia +5 more
US $300,000 - US $15,000,000
The Land and Water Conservation Fund's Outdoor Recreation Legacy Partnership Program aims to enhance recreational opportunities in underserved communities through significant funding. Offering matching grants up to 50%, with awards ranging from $300,000 to $15,000,000, this program encourages applicants to connect with the Connecticut Department of Energy and Environmental Protection early in the application process for guidance. This initiative supports large-scale projects that improve access to recreational facilities.
Outdoor Recreation Parks & Public Spaces

Special Wildlife Funds - Duck Stamp Grants - Canada

Canada Department Of Natural Resources
State/Local Government
Canada, United States
Up to US $500,000
The Special Wildlife Funds - Duck Stamp Grants program in Canada focuses on the development of waterfowl propagation areas specifically for the Mississippi Flyway. It supports projects in Manitoba and Saskatchewan aimed at enhancing breeding populations of migratory waterfowl. This initiative is funded through the sale of State Migratory Waterfowl Stamps and is targeted at not-for-profit organizations dedicated to the conservation and promotion of wild waterfowl, ensuring sustainable habitats and effective management practices.
Water Resource Management

Limited Competition: Small Grant Program for ORIP Special Emphasis Research Career Award (SERCA) K01 Recipients (R03 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $150,000
The Limited Competition Small Grant Program for ORIP SERCA K01 Recipients provides funding to early-stage veterinary scientists to enhance their research capabilities and transition to independent investigator status. This initiative addresses challenges faced by these researchers, including reliance on funding from senior investigators. Grants support pilot studies, secondary data analysis, and development of research methodologies, aiming to foster independence within a two-year timeframe without funding clinical trials.
Veterinary Science & Services Biology

NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed) (357201)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $200,000
The NIDCR Small Grant Program for New Investigators (R03) supports early-stage scientists in dental and craniofacial research. It funds pilot studies and developmental projects aimed at generating preliminary data for future Research Project Grant (R01) applications. Key deadlines for applications include February 16, June 16, and October 16 from 2025 to 2027, addressing the need for timely submissions in this competitive funding landscape.
Dental Health

Live Más Scholarship

Taco Bell Foundation Inc
Private
United States
Unspecified amount
The Live Más Scholarship, offered by the Taco Bell Foundation, supports students aged 16-26 pursuing higher education and workforce readiness. Emphasizing passion and impact, applicants showcase how their interests drive positive change in their communities. The foundation is dedicated to breaking down educational barriers, fostering creativity across various fields including arts, technology, and entrepreneurship. This initiative empowers young dreamers to turn their aspirations into actionable goals, creating meaningful contributions to society.
Education - Higher Education Vocational & Trade Education Career / College Preparation +2 more

Simons Dissertation Fellowship in Mathematics

Simons Foundation Inc.
Private
United States
Up to US $38,400
The Simons Dissertation Fellowship in Mathematics, offered by the Simons Foundation, supports exceptional Ph.D. students in their final years of study. This fellowship, honoring co-founder Jim Simons, provides $19,200 annually for research support and departmental funds, commencing September 1, 2025. Eligible candidates must be full-time Ph.D. students in a U.S. mathematics department, entering their third year. The program emphasizes research quality, significance, and potential impact.
Mathematics

Betsy & Ryan Colwell Mentorship Scholarships for Women in Thoracic Surgery

The Thoracic Surgery Foundation
Private
Canada, Mexico +1 more
Up to US $2,500
The Betsy & Ryan Colwell Mentorship Scholarships for Women in Thoracic Surgery support early-career female cardiothoracic surgeons by facilitating mentor relationships and networking opportunities at the WTS Annual Conference. Each scholarship, valued at $2,500, covers conference registration, lodging, and travel expenses. Two scholarships will be awarded annually starting in 2025, aiming to empower women in a specialty where they are underrepresented and help them navigate their challenging career path.
Cardiovascular Diseases & Systems Surgery

Core Research Grants: Future of Work

Russell Sage Foundation
Private
United States
Up to US $200,000
The Future of Work program by the Russell Sage Foundation investigates the decline in quality of low-wage jobs in the U.S. It explores factors such as outsourcing, immigration, union decline, and technological changes. Current research focuses on minimum wage impacts, offshoring effects, and job search behaviors influencing employment outcomes, particularly for women and minorities in the post-recession labor market. This grant aims to enhance understanding of these critical issues affecting low-education workers.
Employment Services Workers’ Rights

Core Research Grants: Race, Ethnicity, and Immigration

Russell Sage Foundation
Private
United States
Up to US $200,000
The Russell Sage Foundation's Core Research Grants program focuses on Race, Ethnicity, and Immigration, aiming to foster interdisciplinary research on the changing demographics of the U.S. population. This initiative encourages innovative collaboration among social scientists to enhance research quality and support the ideals of a pluralistic society. By building on insights from previous programs, it seeks to address critical questions concerning race and ethnicity within the context of immigration.
Immigration & Refugee Rights Racial / Ethnic Justice & Rights Humanities & Social Science

Core Research Grants: Social, Political, and Economic Inequality

Russell Sage Foundation
Private
United States
Up to US $200,000
The Russell Sage Foundation’s Core Research Grants program addresses social, political, and economic inequalities in the U.S. It investigates the factors contributing to these disparities and their impact on various outcomes, including education and civic participation. Launched in 2001 and renamed in 2018, the program aims to enhance understanding of how inequalities affect mobility and representation. Researchers with a doctorate or substantial experience are encouraged to apply, fostering high-level scholarly research in this critical field.
Humanities & Social Science Economics Political Science +2 more

Core Research Grants: Behavioral Science and Decision Making in Context

Russell Sage Foundation
Private
United States
Up to US $200,000
The Russell Sage Foundation's Core Research Grants support innovative research in Behavioral Science and Decision Making. This program emphasizes interdisciplinary approaches, inviting insights from economics, psychology, sociology, and law to enhance our understanding of decision-making processes across various societal contexts. Applications are open to scholars with a doctorate, focusing on critical issues such as policing, housing, and immigration, while encouraging a blend of theoretical and empirical research to inform public policy.
Economics Psychology Political Science +9 more

Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed) (357250)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,500,000
The Chemical Countermeasures Research Program (CCRP) Initiative aims to support vital research on the harmful effects of acute exposure to Ultra-Potent Synthetic (UPS) opioids, including fentanyl and its combinations. This funding opportunity encourages studies that enhance understanding and mitigation strategies for these substances, focusing on both immediate and long-term health impacts. Applications are due by 5:00 PM local time, with optional Letters of Intent accepted 30 days prior to the proposal deadline.
Drug Use Disorder Addiction & Substance Use Disorders Drug Safety

NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional) (357256)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The NIH StrokeNet initiative invites applications for clinical trials and biomarker studies aimed at stroke treatment, recovery, and prevention. This funding opportunity encourages collaborative projects that validate promising interventions and scientific aims within the NIH StrokeNet framework. Key deadlines for submissions span from February 2025 to November 2026, with support provided by the National Coordinating Center and Regional Coordinating Centers to ensure efficient study implementation and participant recruitment.
Stroke

NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $249,000
The NCI Pathway to Independence Award (K99/R00) supports talented postdoctoral researchers in transitioning to independent faculty positions. This program provides essential NCI research funding to facilitate the development of competitive, independent research careers. Applications are due by 5:00 PM local time of the applicant's organization, emphasizing the importance of timely submissions for prospective awardees.
Biology Health & Medicine Medical Education & Professional Training

Applied regulatory science research to evaluate and treat cardiotoxicity of oncology therapeutics

US Department of Health & Human Services: Food and Drug Administration (FDA)
Federal Government
United States
Unspecified amount
This grant aims to enhance applied regulatory science research for the evaluation and treatment of cardiotoxicity associated with oncology therapeutics. The initiative will facilitate collaboration with the FDA to develop effective methodologies and solutions, ensuring that research outcomes are directly relevant to regulatory decision-making. Key activities include regular communication with funded investigators and a focus on improving detection and management of cardiotoxicity, ultimately leading to impactful publications and presentations.
Cancer / Oncology Drug Safety

Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required) (357282)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $1,125,000
The Academic Research Enhancement Award (AREA) supports small-scale research at institutions that receive limited NIH funding, emphasizing biomedical research for undergraduate students. This program aims to enhance the research environment and provide valuable experiences for students. Eligible institutions must award baccalaureate science degrees and have received no more than $6 million in NIH support over four of the last seven years. This funding opportunity encourages investigator-initiated minimal risk clinical trials to advance NIH missions.
Biology Health & Medicine Medical Education & Professional Training

Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed) (357004)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Unspecified amount
The Stimulating Hematology Investigation: New Endeavors (SHINE) program aims to enhance nonmalignant hematology research aligned with the goals of the NIDDK, NIA, and NHLBI. It invites R01 grant applications focused on innovative and early translational hematology topics, fostering growth in this critical research area. Key deadlines for applications span from February 2025 to October 2027, allowing for both standard and renewal submissions.
Aging / Gerontology Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases +6 more

NIA Academic Leadership Career Award (K07 Independent Clinical Trial Not Allowed) (357000)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $150,000
The NIA Academic Leadership Career Award (K07) provides funding for established investigators to strengthen research capacity in aging and Alzheimer's Disease. The program supports the development of educational infrastructure, mentorship, and career development activities. Key deadlines for applications include February 12, June 12, and October 12 from 2025 to 2027. This award is specifically for research not involving independent clinical trials, allowing applicants to gain experience in trials led by others.
Aging / Gerontology Dementia & Alzheimer’s Disease

Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional) (357003)

US Dept. of Health & Human Services: National Institutes of Health (NIH)
Federal Government
American Samoa, Guam +4 more
Up to US $2,500,000
The Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional) aims to enhance cancer treatment by integrating imaging and liquid biopsy assays. This initiative, led by the National Cancer Institute (NCI), encourages grant applications focused on assessing therapy responses and resistance emergence in patients. Key deadlines for submissions span from February 2025 to January 2028, providing ample opportunities for researchers to contribute to this vital area of cancer research.
Cancer / Oncology Biomedical Imaging

Massachusetts Grants for Nonprofits Highlights

Massachusetts grants for nonprofits provide funding to support innovation in education, technology, and public health. The following grants help organizations tackle challenges, promote sustainability, and enhance quality of life for communities across the state.


Search Instrumentl's Massachusetts Grants Database


Find 247 funding opportunities for nonprofits in Massachusetts, with $68.5M available. Instrumentl provides nonprofits with deadline management tools, customized grant searches, and strategic insights to support impactful projects across the state.

Last updated: November 2, 2026. Next update: December 6, 2026.

Grant Insights : Massachusetts Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

200+ Massachusetts grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

96 Massachusetts grants for nonprofits over $25K in average grant size

77 Massachusetts grants for nonprofits over $50K in average grant size

59 Massachusetts grants for nonprofits supporting general operating expenses

200+ Massachusetts grants for nonprofits supporting programs / projects

2,000+ Grants on Instrumentl focused on Human & Social Services

3,000+ Grants on Instrumentl focused on Education

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Massachusetts grants for Nonprofits?

Most grants are due in the first quarter.

Q1
31.6%
Q2
25.7%
Q3
18.6%
Q4
24.1%

Typical Funding Amounts

What's the typical grant amount funded for Massachusetts Grants for Nonprofits?

Grants are most commonly $27,500.

$250 $250 Min.
$27,500 $27.5 K Median
$410,471 $410.5 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

According to data from the IRS, funding for nonprofits in Massachusetts increased drastically from 2021 to 2022. The 20.67% increase saw funding amounts jump from $11.7B in 2021 to $14.1B in 2022. The most common grant focus areas in Massachusetts during this time were professional societies, associations, research institutes and/or public policy analysis, and alliance/advocacy organizations. Suffolk County, Middlesex County, and Norfolk County received the most funding across the state.

Instrumentl is the only complete grant solution that allows nonprofits to discover opportunities, cultivate relationships, apply for grants, streamline the application process, and report on grant management.

Learn more about how to find grants for your nonprofit.

When applying for funding, nonprofits in Massachusetts should be aware that of the available grants, 31.6% are due in Q1, while 25.7% are due in Q2. Fewer application deadlines fall in Q4 and Q3 as 24.1% and 18.6%, respectively, are due during these periods.

There are more than 200+ grants with a total of $68,548,642 in funding available to Massachusetts nonprofits. These grants, which have a median funding amount of $27,500, support organizations that address everyday challenges, promote sustainability, and enhance the quality of life for communities across the state.

The majority of grants available to Massachusetts nonprofits are funded by private organizations. State and local governments and corporations also provide funding for grants.

  • Private Organizations: Private organizations provide 124 grant opportunities that support causes such as environmental conservation, sustainability, and health and medicine.
  • State and Local Government: State and local government agencies support 77 grants and provide funding for agriculture, museums and cultural institutions, and homeland security.
  • Corporations: Corporations fund 22 grants for Massachusetts nonprofits that support homelessness services, entrepreneurship, affordable housing, and more.
    • Be sure to review all grant application requirements and deadlines to improve your chances of securing funding.

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