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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,679 Results based on applied filters

Career Awards for Medical Scientists

Burroughs Wellcome Fund
Private
Canada, United States
US $700,000
The Career Awards for Medical Scientists (CAMS), established by the Burroughs Wellcome Fund, offers $700,000 over five years to support early career physician scientists transitioning to independence in academic biomedical research. This highly competitive program aims to enhance research innovation and public service by fostering a diverse scientific workforce. Proposals in basic biomedical, disease-oriented, or translational research, particularly those incorporating artificial intelligence or addressing climate change and human health, are encouraged.
Medical Education & Professional Training Science Health & Medicine +1 more

Career Awards at the Scientific Interface

Burroughs Wellcome Fund
Private
Canada, United States
US $560,000
The Burroughs Wellcome Fund's Career Awards at the Scientific Interface provide $560,000 over five years to support early-career researchers transitioning from physical and computational sciences to biological sciences. Launched in 1999, these awards aim to enhance academic research careers for U.S. and Canadian citizens, permanent residents, and temporary residents, fostering a diverse and innovative scientific workforce essential for advancing human health.
Science Biology Mathematics +3 more

Investigators in the Pathogenesis of Infectious Disease Grant Program

Burroughs Wellcome Fund
Private
Canada, United States
US $505,000
The Investigators in the Pathogenesis of Infectious Disease Grant Program, funded by the Burroughs Wellcome Fund, aims to support early-career assistant professors studying human infectious diseases. With a budget of $505,000 over five years, it encourages innovative research on the interplay between human systems and infectious agents, fostering multidisciplinary approaches to enhance our understanding of disease mechanisms and health maintenance.
Infectious & Parasitic Diseases

AFAR Grants for Junior Faculty and Glenn Foundation for Medical Research (GFMR) Grants for Junior Faculty

American Federation for Aging Research
Private
United States
Up to US $160,000
The AFAR Grants for Junior Faculty and Glenn Foundation for Medical Research offer up to $160,000 for one- to two-year research projects focusing on the biology of aging. Aimed at early career faculty, these grants support innovative studies not limited to age-related diseases but rather the fundamental mechanisms of aging. Approximately 10 grants will be awarded in 2026, with funding starting July 1. Applicants must be independent investigators within 10 years of their postdoctoral training.
Aging / Gerontology Developmental Biology (non-medical)

Diana Jacobs Kalman/AFAR Graduate Student Awards in Geroscience

American Federation for Aging Research
Private
United States
US $5,000
The Diana Jacobs Kalman/AFAR Scholarships for Research in the Biology of Aging offer MD, DO, PhD, or combined-degree students the opportunity to conduct research on aging. Established by Diana Jacobs Kalman, a leader in aging science, the program addresses the challenges of an aging population. By awarding up to ten scholarships, it aims to foster innovative research and improve the quality of life for older adults. Proposed projects should focus on specific areas like immune function, inflammation, and genetic control of longevity.
Aging / Gerontology Developmental Biology (non-medical)

Glenn Foundation for Medical Research Discovery Award

American Federation for Aging Research
Private
United States
US $525,000
The Glenn Foundation for Medical Research Discovery Award, in partnership with the American Federation for Aging Research, aims to fund innovative research that explores the biological mechanisms of normal aging. This award supports projects with a strong potential for groundbreaking discoveries, particularly from researchers new to the aging field. Up to two awards of $525,000 over three years will be granted, promoting scientific collaboration at designated conferences.
Aging / Gerontology

Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research Grant

American Federation for Aging Research
Private
Canada, United States
US $54,840 - US $75,000
The Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research Grant aims to support postdoctoral fellows in their research on the biology of aging. In partnership with the American Federation for Aging Research, this program offers up to 10 grants of $75,000 each for one year, emphasizing the need for research that translates basic aging biology into clinical applications. Applicants must be postdoctoral fellows in qualified non-profit settings in the U.S. and meet specific eligibility criteria.
Aging / Gerontology

Herman Frasch Foundation Grant

American Chemical Society
Association/Society
United States
Up to US $250,000
The Herman Frasch Foundation Grant, administered by the American Chemical Society, supports research in agricultural chemistry with practical benefits for U.S. agriculture. Eligible applicants include tenured or tenure-track faculty within seven years of their first appointment. Grants of $50,000 annually for five years are available, with a focus on training students and disseminating research findings. The next application period opens on November 5, 2026, following a five-year cycle.
Chemistry Biochemistry

FPTR: Acute Care Research Grant

Foundation for Physical Therapy Research
Private
United States
US $80,000
The FPTR: Acute Care Research Grant aims to support high-quality research relevant to acute care physical therapy practice. With a total funding of $80,000, this grant encourages innovative studies that can enhance the understanding and application of physical therapy methods. The Foundation for Physical Therapy Research prioritizes projects that address pressing clinical questions and contribute to the evidence base for effective practices while promoting equity in health care.
Physical Therapy

The Spirit of St. Louis Women’s Fund Grant

Spirit of St. Louis Women's Fund
Association/Society
Franklin County, Missouri, Jefferson County, Missouri +6 more
US $20,000 - US $50,000
The Spirit of St. Louis Women's Fund Grant aims to enhance the Greater St. Louis community through informed grant-making, fostering women's engagement in philanthropy. The fund prioritizes diversity, equity, and inclusion while supporting organizations focused on arts, education, environment, health, and social services. Grants range from $5,000 to $25,000 for single-year projects and $100,000 for multi-year initiatives. Eligible nonprofits must demonstrate community impact and financial stability, ensuring effective use of funds to address pressing needs.
Art & Culture Education Environment +2 more

LFF: Nature-Based Climate Action Grant

The Lumpkin Family Foundation
Private
United States
US $2,500 - US $50,000
The LFF: Nature-Based Climate Action Grant aims to support initiatives that leverage natural systems to combat climate change. By funding projects focused on tree planting, prairie restoration, and carbon sequestration, the program seeks to engage communities and enhance understanding of climate challenges. Ideal applicants include rural organizations working to create measurable environmental impacts while fostering collaboration and policy change. This grant represents an opportunity for organizations ready to take significant strides in addressing the climate crisis.
Climate Change Resilience & Equity Habitat & Ecosystem Restoration Carbon / Greenhouse Gas Reduction +2 more

Core Research Grants: Immigration and Immigrant Integration

Russell Sage Foundation
Private
United States
Up to US $200,000
The Russell Sage Foundation's Immigration and Immigrant Integration Grants aim to fund innovative research that explores the dynamics of race, citizenship, and legal status in relation to immigrant outcomes in the U.S. This initiative seeks to understand the complex interplay of policies and social factors affecting immigrants and native-born populations across various racial and ethnic groups. Researchers are encouraged to utilize diverse data sources to deepen insights into immigration integration and the societal implications of legal status.
Immigrant Services Immigration & Refugee Rights

Learning Engineering Tools Competition

Tools Competition
Association/Society
Countries
Unspecified amount
The Learning Engineering Tools Competition is a significant funding opportunity aimed at fostering educational technology innovations. It seeks to leverage digital tools, big data, and learning science to improve learner outcomes globally. This competition encourages diverse participants, from students to established companies, to develop solutions that can generate valuable learning data. By promoting collaboration among educators, researchers, and tech innovators, the initiative aims to advance the field of learning engineering and enhance educational practices.
Computer Science & Engineering Educational Access & Equity Literacy

FAA Aviation Research Grants Program

US Department of Transportation: Federal Aviation Administration (FAA)
Federal Government
United States
Up to US $6,000,000
The FAA Aviation Research Grants Program invites applications for aviation research grants aimed at supporting innovative research for civil aviation growth. Eligible applicants, primarily colleges and non-profit institutions, can propose studies across various scientific disciplines. The program emphasizes advanced research in areas like air traffic control, communications, and human factors, promoting the development of technologies that enhance safety and efficiency in aviation and commercial space transportation.
Aviation

1772 Foundation: Historic Properties Redevelopment Programs

1772 Foundation
Private
United States
US $10,000 - US $75,000
The 1772 Foundation, in collaboration with the National Preservation Partners Network, is opening its 2026 grant cycle for Historic Property Redevelopment Programs (HPRP). This initiative aims to support nonprofit organizations in the U.S. focused on historic property revitalization. Eligible organizations must hold a 501(c)(3) designation and be NPPN members. Grants typically range from $50,000 to $75,000, promoting sustainable practices that address community revitalization and heritage conservation.
Historic Preservation

MEAF National Grant

Mitsubishi Electric America Foundation
Private
United States
US $10,000 - US $200,000
The Mitsubishi Electric America Foundation (MEAF) National Grant funds innovative projects that empower youth with disabilities, enhancing their leadership and employment skills. Grants typically range from $10K to $100K per year for one to two years. MEAF seeks proposals that break down employment barriers, support U.S. youth with disabilities, and promote inclusive practices. Projects should demonstrate a plan for national dissemination and measurable outcomes, particularly benefiting young veterans transitioning to civilian life.
Children With Disabilities

Luce Indigenous Knowledge Fellowship

Henry Luce Foundation
Private
American Samoa, Guam +4 more
Up to US $75,000
The Luce Indigenous Knowledge Fellowship, launched by the First Nations Development Institute and the Henry Luce Foundation, supports Native knowledge holders and makers in their transformative work. With ten fellowships of $75,000 each, this two-year program fosters growth and collaboration across diverse fields such as agriculture, climate change, and cultural revitalization. Fellows will engage in community-building through required convenings, enhancing their leadership skills and professional networks to benefit Native communities.
Native American Culture & Heritage

Louis N. Cassett Foundation Grant

Louis N. Cassett Foundation
Private
United States
Unspecified amount
The Louis N. Cassett Foundation provides grants to support a variety of charitable endeavors, particularly focusing on organizations in the Philadelphia and South Florida areas. As a private foundation operating under Section 501(c)(3) of the Internal Revenue Code, it empowers tax-exempt organizations to apply for funding. The Foundation does not impose religious affiliation requirements on recipients, ensuring that support is inclusive and aimed at a broad range of charitable, cultural, and educational projects.
Basic Human Needs Poverty Alleviation & Services Education +5 more

PLTW Engineering - Program Expansion (Arconic Foundation)

Project Lead The Way Inc
Private
American Samoa, Guam +4 more
US $20,000
The PLTW Engineering program, supported by Arconic Foundation, aims to expand STEM education in public and charter schools across several states. This grant will help cover costs for necessary equipment and training, focusing on high-need student populations. Eligible schools must implement PLTW's Advanced Manufacturing course by the 2026-2027 school year. The initiative is designed to ignite student interest in engineering and increase enrollment in STEM disciplines.
Engineering

PLTW Engineering - New Program (Arconic Foundation)

Project Lead The Way Inc
Private
American Samoa, Guam +4 more
US $20,000
The PLTW Engineering grant, supported by the Arconic Foundation, aims to enhance STEM education by funding the implementation of PLTW Engineering courses in schools. This initiative prepares students for future careers by igniting their passion for engineering. Grants will cover startup costs for new programs or expansions of existing ones. Eligible schools must offer PLTW's Advanced Manufacturing course for the 2026-2027 school year, ensuring access to essential resources and training for educators.
Engineering

PLTW Launch - Program Expansion (John Deere)

Project Lead The Way Inc
Private
Aiken County, South Carolina, Alamance County, North Carolina +143 more
US $5,000
The PLTW Launch - Program Expansion grant, funded by the John Deere Foundation, aims to enhance access to STEM education for underserved communities. This initiative supports schools in expanding their PLTW programs and includes training for teachers and resources for students. Priority is given to schools near John Deere facilities that demonstrate need and a commitment to student participation in STEM activities. The project aligns with the foundation's goal to impact one million youth by 2030.
STEM / STEAM Education Teacher Development & Training

PLTW Launch - New Program (John Deere)

Project Lead The Way Inc
Private
Barnes County, North Dakota, Black Hawk County, Iowa +22 more
US $10,000
The PLTW Launch program, in partnership with the John Deere Foundation, aims to enhance STEM education access for underserved communities. This initiative supports schools in implementing PLTW Launch modules, fostering equitable opportunities for students. With a commitment to enroll at least 50% of students from the Free and Reduced Lunch program, the program focuses on real-world skills development to prepare youth for future challenges. The goal is to empower one million students by 2030.
STEM / STEAM Education

PLTW Gateway - New Program (John Deere)

Project Lead The Way Inc
Private
Barnes County, North Dakota, Black Hawk County, Iowa +22 more
US $20,000
The PLTW Gateway program, supported by the John Deere Foundation, aims to enhance STEM education access for underserved communities. By 2030, they intend to assist 1 million youth through inclusive educational opportunities. Schools within 40 miles of John Deere facilities can apply for grants to implement PLTW Gateway units, promoting real-world skill development. Priority is given to schools that demonstrate need and ensure student enrollment in these programs, fostering a strong foundation for future success.
STEM / STEAM Education

PLTW Gateway - Program Expansion (John Deere)

Project Lead The Way Inc
Private
Aiken County, South Carolina, Alamance County, North Carolina +143 more
US $10,000
The PLTW Gateway program expansion, funded by the John Deere Foundation, aims to enhance access to STEM education for underserved students in John Deere communities. With a commitment to support 1 million youth by 2030, this initiative provides grants to schools seeking to expand their existing PLTW programs. Eligible schools must be within proximity of John Deere facilities and demonstrate a significant enrollment of students participating in free and reduced lunch programs, ensuring equitable educational opportunities.
STEM / STEAM Education Teacher Development & Training

PLTW Computer Science - Program Expansion (John Deere)

Project Lead the Way inc.
Private
Aiken County, South Carolina, Alamance County, North Carolina +143 more
US $10,000
The PLTW Computer Science program, in collaboration with the John Deere Foundation, aims to enhance access and participation in STEM for underserved students in John Deere home communities. This initiative focuses on expanding existing Computer Science programs in schools, ensuring equitable educational opportunities, and developing critical skills through real-world challenges. The partnership is part of a commitment to support 1 million underrepresented youth by 2030, fostering inclusivity in education.
Computer Science & Engineering Teacher Development & Training

PLTW Computer Science - New Program (John Deere)

Project Lead The Way Inc
Private
Aiken County, South Carolina, Alamance County, North Carolina +143 more
US $20,000
The PLTW Computer Science program, funded by the John Deere Foundation, aims to enhance STEM opportunities for underserved students in John Deere communities. This initiative supports schools initiating or expanding PLTW Computer Science courses starting in the 2025-2026 academic year. With a commitment to inclusive education, the foundation seeks to empower students by providing essential resources and opportunities to develop critical skills that will serve them in future careers.
Computer Science & Engineering Teacher Development & Training

PLTW Engineering - New Program (John Deere)

Project Lead The Way Inc
Private
Barnes County, North Dakota, Black Hawk County, Iowa +22 more
US $35,000
The John Deere Foundation, in partnership with PLTW, aims to enhance access to engineering programs for underserved students in its home communities. This initiative is part of a 10-year commitment to support equitable educational opportunities. By providing grants, the foundation encourages schools to expand their PLTW Engineering courses, fostering critical STEM skills to empower students. Eligible schools must be near John Deere facilities and demonstrate a commitment to inclusivity and student engagement in engineering education.
Engineering

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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