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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,709 Results based on applied filters

Regenerative Agriculture Foundation Grant

Regenerative Agriculture Foundation
Private
United States
Unspecified amount
The Regenerative Agriculture Foundation Grant supports organizations that promote regenerative practices, emphasizing the value of people, plants, animals, and the planet. With a focus on BIPOC-led initiatives, the foundation encourages systemic change in agricultural systems through collaborative funding. Grants are available to U.S.-based organizations that align with RAF's vision and engage in transformative efforts. The competitive grantmaking process is by invitation only, ensuring targeted support for impactful projects.
Sustainable Agriculture & Agroecology

Kids to Parks Day School Grants Program

National Park Trust Inc
Private
American Samoa, Guam +4 more
Up to US $1,000
The Kids to Parks Day School Grants Program offers funding up to $1,000 for Title I schools in the U.S. to enhance student engagement with parks and public lands. This initiative encourages hands-on learning experiences through outdoor activities and stewardship projects, promoting environmental education and healthy lifestyles. Eligible classrooms can apply, emphasizing student involvement in the application process. The program aims to empower students and teachers to foster a deeper connection with nature and their communities.
Parks & Public Spaces Education - K through 12 Education - Preschool / Early Learning

National Fund for Sacred Places Grant Program

Partners For Sacred Places Inc
Private
American Samoa, Guam +4 more
US $50,000 - US $500,000
The National Fund for Sacred Places Grant Program supports historic houses of worship in the U.S. through matching grants ranging from $50,000 to $250,000. This initiative, in collaboration with the National Trust for Historic Preservation, aims to enhance community engagement and preserve culturally significant buildings. Applicants are encouraged to demonstrate their historical relevance and community service, particularly those representing underrepresented groups. The program prioritizes urgent repair needs and projects that foster inclusivity and accessibility.
Historic Preservation Religion & Spirituality

Cash for Classrooms Grants

Casey's General Stores, Inc
Private
United States
US $3,000 - US $50,000
Casey's Cash for Classrooms Grants support K-12 public and nonprofit private schools through funding for physical improvements, material needs, teacher support, and community engagement. In 2025, $900,000 was awarded across 80 grants, allowing schools to enhance their learning environments. With a commitment to community engagement, Casey's has donated $15 million since 2019, emphasizing their dedication to making life better for communities and guests. Grants range from $3,000 to $50,000, with funds required to be used within 12 months.
Education - K through 12 Teacher Development & Training Academic Success & Enrichment +1 more

Lemelson Foundation Grant

The Lemelson Foundation
Private
Cameroon, Central African Republic +10 more
Unspecified amount
The Lemelson Foundation Grant supports initiatives in invention education and entrepreneurship, aiming to empower young inventors and foster innovation. With over $300 million provided since its inception, the Foundation focuses on strengthening ecosystems for invention in the U.S. and developing countries. Organizations interested in aligning with their mission are encouraged to take an eligibility quiz and submit inquiries through their contact form. This commitment is crucial for driving impactful solutions to global challenges.
Entrepreneurship STEM / STEAM Education

Philanthropic Impact Fund RFP

Vanguard Charitable Endowment Program
Private
United States
US $50,000 - US $100,000
The Philanthropic Impact Fund (PIF) by Vanguard Charitable aims to strengthen nonprofit organizations and philanthropic infrastructure. It focuses on integrating AI, educating donors, and enhancing the narrative around the nonprofit sector. Grants typically range from $50,000 to $100,000, with larger requests considered. Organizations must be 501(c)(3) registered nonprofits to apply. This funding is a strategic investment in resilience and sustainability, addressing critical needs in the sector.
Volunteerism & Philanthropy Nonprofit Growth & Development

Awards for Advancing Minority Mental Health

American Psychiatric Association Foundation
Private
United States
US $5,000
The Awards for Advancing Minority Mental Health, established by the American Psychiatric Association Foundation in 2003, aim to honor community organizations that promote mental health awareness in underserved minority communities. These awards recognize efforts to improve access to quality mental health services, enhance treatment quality, and address cultural barriers. Organizations must have been operational for at least two years and demonstrate innovative approaches to mental health challenges.
Mental Health & Psychiatric Diseases Wellness & Healthy Living Health Disparities & Social Determinants of Health

The Thomases Family Endowment of the Youngstown Area Jewish Federation (with a United States mailing address)

Youngstown Area Jewish Federation
Private
Israel, United States
US $1,500 - US $22,000
The Thomases Family Endowment, established by Irwin Thomases, aims to uphold his philanthropic values by supporting organizations serving the Jewish and secular communities. Eligible applicants must focus on the Akko & Matte Asher regions or the Mahoning and Shenango Valleys. They can apply for multi-year grants of up to $50,000 annually, but those receiving direct allocations from the Youngstown Area Jewish Federation are ineligible. This endowment continues to promote a spirit of tzedakah.
Judaism Jewish Culture

Vince Lombardi Cancer Foundation Fund

Vince Lombardi Cancer Foundation Inc
Private
United States
More than US $60,000
The Vince Lombardi Cancer Foundation (VLCF) has played a pivotal role in cancer research and education since its inception in 1971, raising over $21 million to support innovative treatments and compassionate care. This private foundation invites applications from recognized healthcare institutions, focusing on funding scientific and medical fellowships. VLCF is dedicated to preventing cancer and improving patient care, ensuring that the spirit of excellence continues in the fight against this disease.
Cancer / Oncology

Solidaire Network: Janisha R. Gabriel Movement Protection Fund

Solidaire Network
Private
United States
Unspecified amount
The Solidaire Network's Janisha R. Gabriel Movement Protection Fund supports frontline organizers facing security threats while fostering long-term safety. With $7.9 million allocated, the fund aids groups working towards racial, climate, gender, and reproductive justice. Despite a pause on new applications due to high demand, the fund remains committed to resourcing movement partners and addressing the disproportionate targeting of marginalized leaders amidst rising aggression from right-wing forces.
Black American Services Racial / Ethnic Justice & Rights

Native Arts & Cultures Foundation: LIFT Grants

Native Arts & Cultures Foundation
Private
United States
US $10,000
The Native Arts & Cultures Foundation's LIFT program offers critical support to early career Native artists through one-year grants of $10,000. This initiative aims to nurture emerging voices and foster community engagement while promoting environmental sustainability. Selected artists will benefit from professional development training and culturally appropriate evaluations to enhance their artistic practices. By providing vital resources, LIFT empowers artists to advance their careers and contribute meaningfully to their communities.
Art for Social Change Poetry Writing & Literature +7 more

Libraries Transforming Communities: Accessible Small and Rural Libraries' Grant

American Library Association (ALA)
Association/Society
American Samoa, Guam +4 more
US $10,000 - US $20,000
The Libraries Transforming Communities: Accessible Small and Rural Libraries' Grant, initiated by the American Library Association (ALA), aims to enhance accessibility and community engagement in small and rural libraries serving people with disabilities. With funding up to $20,000, selected libraries will receive support for projects that improve library services and facilities. This initiative promotes collaboration with community members to identify and address accessibility needs, ensuring libraries effectively serve diverse populations.
Library Services Library & Information Science Disability Care & Services

Jay L. Smith Family Foundation Grants

Jay L. Smith Family Foundation
Private
United States
Unspecified amount
The Jay L. Smith Family Foundation provides grants to tax-exempt non-profit organizations in the United States, primarily focusing on healthcare, family values, and supporting the disadvantaged. With a strong commitment to Alzheimer's research, the foundation has funded various initiatives including elderly care, domestic violence prevention, and cancer research. Their mission is to enhance the quality of life for individuals and communities through meaningful contributions, aiming to address critical social issues and promote well-being.
Senior Services Suicide Prevention Dementia & Alzheimer’s Disease +6 more

Can'd Aid: Crush It Crusade Grant

Can'd Aid
Private
American Samoa, Guam +5 more
US $4,000 - US $10,000
The Can'd Aid: Crush It Crusade Grant empowers nonprofits, local education, and government organizations to enhance recycling efforts. With grants ranging from $3,000 to $8,000, the program supports initiatives that promote recycling at community events, engage volunteers, and foster inclusive outreach. Since 2014, over 125 organizations have benefited from this funding, driving impactful change through community engagement and environmental stewardship.
Waste Management

Gateway Regional Environment Fund Grant Program

St Louis Community Foundation
Private
Jefferson County, Missouri, Madison County, Illinois +4 more
Up to US $100,000
The Gateway Regional Environment Fund Grant Program, managed by the St. Louis Community Foundation, aims to support initiatives in the St. Louis metro area that reduce the carbon footprint. By funding projects that address greenhouse gas emissions, GREF plays a crucial role in combating climate change locally. This program encourages community engagement and innovation to create a sustainable future for the region.
Carbon / Greenhouse Gas Reduction

The Community Heart & Soul Seed Grant Program

Community Heart & Soul
Private
American Samoa, Guam +4 more
US $10,000
The Community Heart & Soul Seed Grant Program offers $10,000 in startup funding for community-driven groups in small towns to adopt the Community Heart & Soul model. Applications are accepted until 11:59 p.m. EST on the last business day of each month, with funding decisions made the following month. This initiative aims to empower residents to engage in local development and foster community connections.
Community Development & Revitalization Rural Development

J.W. Couch Foundation: Storytelling Grant

Jesse W Couch Charitable Foundation
Private
United States
More than US $50,000
The J.W. Couch Foundation Grant focuses on supporting Wildlife Conservation nonprofit organizations that align with their mission of community betterment and environmental protection. The foundation seeks partnerships with organizations that promote animal wellbeing, early childhood education, teacher support, and outdoor activities. Eligible applicants must be registered 501(c)3 nonprofits or for-profit entities aligned with their charitable programs. This grant emphasizes collaboration and community engagement to create lasting impacts.
Historic Preservation Environmental Conservation Renewable/Sustainable Energy +10 more

Morgan Stanley Alliance for Children’s Mental Health Innovation Awards

Morgan Stanley Foundation Inc.
Corporate
United States
US $100,000
Morgan Stanley Alliance for Children’s Mental Health Innovation Awards aim to fund innovative mental healthcare solutions for children in the U.S. This initiative invites U.S.-based 501(c)(3) charities with revenues under $5 million to submit projects. With up to $550,000 in grants, the program focuses on addressing critical mental health issues among youth, fostering equity in access to care, and supporting nonprofits led by young leaders. Awards include up to $100,000 for general and $50,000 for Next Gen projects.
Depression / Anxiety Children’s Mental Health Social / Emotional Learning & Development

APA Foundation: Helping Hands Grants

American Psychiatric Association Foundation
Private
United States
Up to US $5,000
The APA Foundation's Helping Hands Grants provide up to $5,000 to medical schools for projects aimed at improving mental health education and assistance in under-served communities. Initiated in 2005, this program empowers medical students to lead initiatives that promote awareness of mental illness and encourage community service, particularly among minority populations. By partnering with community agencies, these projects foster a deeper interest in psychiatry while addressing critical mental health needs.
Mental Health & Psychiatric Diseases Addiction & Substance Use Disorders

Bar Success Intervention Grant Program

AccessLex Institute
Private
United States
US $150,000 - US $300,000
The Bar Success Intervention Grant Program, funded by AccessLex Institute, aims to enhance bar exam passage rates for at-risk law students and graduates. With grants ranging from $150,000 to $300,000 for programs lasting 12 to 24 months, the initiative seeks data-driven solutions that are scalable and replicable. Eligible applicants include U.S. nonprofit organizations and law schools. Programs should feature clear goals, measurable objectives, and a robust evaluation plan to ensure effectiveness and sustainability.
Standardized Testing Services

Monarch Watch: Free Milkweeds Grant

Monarch Watch
State/Local Government
United States
Unspecified amount in in-kind support
Monarch Watch offers a Free Milkweeds Grant for habitat restoration projects aimed at supporting the monarch butterfly population. The program provides free milkweed plugs to schools and educational non-profits that demonstrate clear educational goals, long-term maintenance plans, and adequate space for the plants. With over 730,000 milkweeds distributed since 2015, this initiative plays a vital role in restoring habitats along key migration routes in the eastern and western U.S.
Environmental Education Horticulture & Gardening Habitat & Ecosystem Restoration

Patagonia Grants: International Grants - Australia

Patagonia Org
Corporate
Argentina, Australia +20 more
US $5,000 - US $20,000

Patagonia supports environmental organisations with bold, direct-action agendas and a commitment to long-term change.

We support innovative work that addresses the root causes of the environmental crisis and seeks to protect both the environment and affected communities. We focus on places where we’ve built connections through outdoor recreation and through our network of retail stores, nationally and internationally.

We believe local battles to protect a specific stand of forest, a stretch of river, an indigenous wild species or a community from a polluting refinery build public support and confront larger, more complex issues like climate change, biodiversity loss and environmental justice.

We encourage work that brings underrepresented communities to the forefront of the environmental movement and defends communities whose health and livelihoods are threatened by environmental exploitation.

We support multipronged campaigns that push for greater environmental protections and force the government to abide by its own laws.

We fund work that:

  • builds an equitable, inclusive and diverse environmental movement
  • confronts systemic bias, discrimination and injustice in environmental policy or outdoor spaces
  • is action-oriented
  • focuses on root causes
  • has a clear strategy
  • identifies specific goals and objectives that can be effectively measured to evaluate success
  • builds public involvement and civic engagement

Patagonia believes that the most direct path to real change is through building grassroots momentum.

Our funding focuses on organisations that have or can create a strong base of support. Because we’re a privately held company, we have the freedom to fund risk-taking, off-the-beaten-track groups, and that’s where we believe our small grants are most effective.

Environment Environmental Justice & Advocacy Land / Habitat Conservation

Home Depot Foundation's Path to Pro Scholarship

Thdf Ii Inc
Corporate
United States
US $2,500
The Home Depot Foundation's Path to Pro Scholarship aims to support U.S. veterans and train skilled tradespeople. With a commitment of $750 million by 2030, the Foundation has already trained over 44,000 participants. The program collaborates with industry leaders to address the skilled labor gap, offering resources and training in various trades such as carpentry and plumbing. By providing opportunities for high school seniors and graduates, this initiative fosters career development in the home improvement sector.
Vocational & Trade Education

Shaw's Foundation Grants

Shaw's Supermakets Charitable Foundation
Private
United States
Unspecified amount
Shaw's Foundation Grants support nonprofit organizations that enhance community well-being, focusing on hunger, youth education, and health. Eligible organizations must be 501(c)(3) certified and serve specific regions like California and Hawaii. An employee sponsor is mandatory for applications in these areas. The grant review process typically takes about eight weeks, and the foundation prioritizes collaborations with local partners to maximize community impact.
Food Access & Hunger Education Youth Services +2 more

The Bank of America Foundation Sponsorship Program

Bank Of America Charitable Foundation Inc
Private
United States
Unspecified amount
The Bank of America Foundation Sponsorship Program aims to enhance economic mobility and social progress in low- and moderate-income communities through partnerships with nonprofit organizations. This initiative focuses on critical areas such as workforce education, basic needs like food and housing, and community development. The Foundation invested $350 million last year and encourages employee volunteerism and giving, supporting nonprofits in various sectors, including arts, culture, and diversity initiatives.
Community Development & Revitalization Workforce Preparation & Job Readiness Food Access & Hunger +6 more

Moody’s Community Impact Grant Program

Moody’s Investors Service, Inc.
Corporate
Argentina, Brazil +21 more
Unspecified amount
The Moody's Community Impact Grant Program supports organizations with tax-exempt status to foster social and economic equality. Established by Moody's Foundation, it prioritizes initiatives that empower underestimated communities and entrepreneurs, driving innovation and ecological restoration. The foundation focuses on inclusive growth, providing resources for small businesses and community resilience. Eligible organizations must be registered charities under U.S. IRS guidelines, while ineligible entities include individuals and those promoting unlawful discrimination.
Business Development Entrepreneurship Habitat & Ecosystem Restoration

HAF: Patient Assistance Grant

Hemophilia Alliance Foundation
Private
United States
Up to US $8,000
The HAF: Project/Patient Assistance Grant, established by the Hemophilia Alliance Foundation, aims to empower eligible organizations to enhance their capacities and provide direct financial assistance to consumers. With funding ceilings of $8,000 for local organizations and $10,000 for national entities, it supports initiatives that improve service delivery and patient assistance, reflecting a commitment to the hemophilia and inheritable blood disorders communities.
Hematological Systems

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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