Upcoming Webinar
How Funders Feel About AI, and What Keeps Them Saying Yes.
Wed, Oct 14 @ 2PM ET

Skip to main content
Main content

Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

Skip the search. Get matched with grants that fit your non-profit.

Skip the search.

Get matched with grants that actually fit.

Smart recommendations based on your profile — in minutes.

Find me grants

Filters

9,706 Results based on applied filters

H.S. Lopez Family Foundation Grant

Hs Lopez Family Foundation
Private
United States
Unspecified amount
The H.S. Lopez Family Foundation Grant focuses on funding innovative projects that enhance the quality of life, primarily in Arizona. With an emphasis on health, education, and welfare, the foundation aims to support not-for-profit organizations that address critical community needs. Grants are awarded to initiatives that demonstrate potential for lasting impact and community benefit, encouraging sustainable support beyond the foundation's involvement.
Education Health & Medicine Human & Social Services

McClure Family Foundation Grant

McClure Family Foundation
Private
United States
Unspecified amount
The McClure Family Foundation Grant honors the legacy of Charles and Dorothy McClure by supporting nonprofit organizations that strengthen families and communities. The foundation aims to promote the arts, historic preservation, education, faith-based initiatives, and the well-being of mankind. Eligible applicants include public charities, governmental units, and established churches. The foundation values personal connections with applicants and encourages endeavors that foster community responsibility and individual leadership.
Art & Culture Historic Preservation Education +2 more

NBO Foundation - Community Impact Fund Grants

Nicholas B. Ottaway Foundation
Private
United States
US $3,000 - US $20,000
The Nicholas B. Ottaway Foundation's Community Impact Fund Grants aim to enhance community well-being by supporting 501(c)(3) organizations focused on underrepresented populations. Grants range from $3,000 to $20,000 and are intended for projects in areas like disaster relief and sexual health. First-time applicants must submit a letter of intent before applying. The foundation prioritizes projects in regions where its members live and work, ensuring local engagement and impact.
Reproductive Health Sexual Assault / Abuse Vision Impairment Care & Services

Parkinson Family Foundation Grant

Parkinson Family Foundation
Private
United States
US $1,000 - US $5,000
The Parkinson Family Foundation Grant supports organizations focusing on Food & Water, Faith & Evangelism, and Health & Humanitarian Efforts. Applications are open year-round, with grants ranging from $1,000 to $5,000; larger requests are typically declined. Eligible applicants include schools, state governments, and 501(c)(3) nonprofits. The Foundation emphasizes selectivity and prioritizes organizations with established relationships and those promoting American ideals like freedom and justice.
Food Access & Hunger Sanitation & Clean Drinking Water Disaster Relief / Humanitarian Aid +2 more

Rea Charitable Trust Grant

Rea Charitable Trust
Private
United States
Unspecified amount
The Rea Charitable Trust, established in 2009 by Mrs. Isabel McClintic Rea, prioritizes support for charitable organizations that focus on the arts. Administered by Comerica Bank & Trust, the trust provides funding through structured application periods for organizations based on their names. Eligible applicants must be 501(c)(3) organizations, limited to one application per year. The trust aims to uphold Mrs. Rea's legacy by fostering artistic endeavors within the community.
Art & Culture Humanities & Social Science Art Education

Sparkplug Foundation Grant

Sparkplug Foundation
Private
Israel, Palestine, State of +1 more
US $10,000 - US $15,000
The Sparkplug Foundation Grant supports innovative projects from early-stage organizations and established non-profits in education, community organizing, and music. The foundation emphasizes community-led initiatives that address systemic injustices and engage marginalized populations. Grants are available for one year and prioritize projects with small budgets that lack extensive funding sources. The foundation encourages applications from diverse communities, particularly those led by Black, Indigenous, People of Color, and LGBTQ individuals, fostering equitable access to resources.
Music Educational Access & Equity Academic Success & Enrichment +2 more

CORE Funding- AAO-HNSF Maureen Hannley Research Grant

American Academy of Otolaryngology - Head & Neck Surgery Foundation
Private
Canada, United States
Up to US $50,000
The AAO-HNSF Maureen Hannley Research Grant offers $50,000 for one year to support research addressing clinical gaps in otolaryngology. Eligible applicants include otolaryngologists in the U.S. or Canada, emphasizing projects with direct patient significance. The grant encourages junior faculty and mandates a letter of support from department chairs. Funds cannot cover principal investigator salaries but can support non-clerical staff. This initiative aims to enhance the development of independent researchers focused on patient-oriented outcomes.
Health & Medicine Otorhinolaryngology

AHNS Pilot Grant

American Head & Neck Society (AHNS)
Association/Society
Canada, United States
Up to US $20,000
The AHNS Pilot Grant offers $20,000 for one year to support innovative research in head and neck oncology. It is aimed at medical students, residents, and junior faculty who are AHNS members. The grant encourages clinical and translational studies that focus on the prevention, diagnosis, and treatment of neoplastic diseases in this field. Applicants must submit letters of support from their department and advisors to ensure adequate resources and supervision during the project.
Health & Medicine

H & R Block Foundation Community Impact Grant

H & R Block Foundation
Corporate
Clay County, Missouri, Jackson County, Missouri +3 more
US $150,000 - US $500,000

About Us

Our History

Since its founding, The H & R Block Foundation has been committed to assisting underserved individuals and improving the quality of all aspects of life. The Foundation supports nonprofit organizations that increase access to the arts, build stable neighborhoods, offer diverse learning opportunities, and expand access to services that respond to all individuals’ physical and emotional needs. The Foundation continues to support the H&R Block culture by aligning resources and leadership to create positive social change.

Grants

Community Impact

The H & R Block Foundation awards grants that help nonprofits improve or strengthen services, enhance operations, and achieve greater results. The Foundation’s grant strategy focuses on the following:

  • Helping underserved individuals pursue and attain post-secondary education
  • Improving the quality of life throughout neighborhoods in greater Kansas City
  • Enhancing nonprofits’ operational efficiency and service delivery and strengthening major community assets and institutions

Since its inception, The H & R Block Foundation has invested over $84 million in various charitable organizations.

Grants FAQ

The Foundation’s areas of focus are:

  • Arts & Culture
  • Education
  • Health & Human Service
  • Neighborhood Revitalization

There are no fixed minimum or maximum amounts, though most grants do not exceed $150,000.  

The Foundation’s sister organization, the Marion and Henry Bloch Family Foundation makes single-year and multiyear grants that typically fall in the range of $150,000 to $500,000. Grants may be funded by either Foundation, as determined by Foundation staff.

Art & Culture Community Development & Revitalization Education - Higher Education +5 more

Brennan Family Foundation Grant

Brennan Family Foundation
Private
United States
Unspecified amount
The Brennan Family Foundation, established in 1990 by Edward J. Brennan, aims to support charitable, educational, and religious institutions. With a mission to inspire youth development, the foundation provides financial assistance primarily to health care and educational organizations, religious entities, and the arts. Their strategic annual review process ensures that contributions effectively serve our most valuable resource—children. The foundation continues to honor Brennan's legacy of charitable responsibility.
Performing Arts Education Christianity +4 more

Sponsoring Conference Participation in Support of Healthy Communities, Consumer Empowerment, and Veterans’ Health

New York State Health Foundation
Private
United States
Up to US $4,000
The New York Health Foundation is offering sponsorship for nonprofits and community organizations to participate in conferences that support healthy communities, consumer empowerment, and veterans' health. This initiative aims to enhance the visibility of innovative work being done in New York, particularly for those historically marginalized. By facilitating attendance at local, state, and national events, the Foundation seeks to empower organizations to showcase their impactful programs and connect with key stakeholders.
Community Health Education Health Care Access & Delivery Epidemiology & Public Health

GSF Foundation Grant

GSF Foundation
Private
Clark County, Nevada, Cook County, Illinois +23 more
Unspecified amount
The GSF Foundation Grant supports 501(c)(3) non-profit organizations that enhance the lives of children and families in need. Applications must be submitted by a current GSF Associate who nominates the organization and its project. Since 2002, the foundation has funded over 600 organizations nationwide. It emphasizes personal involvement and contributions from associates, focusing on essential needs such as education tools, food, and shoes for children. Grants are reviewed at local and national meetings.
Children’s Health & Pediatrics Youth Services Family Services +3 more

John Jamison Iron Mountain Education Fund Grant

Iron Mountain Foundation
Private
Asia, Australia +10 more
US $2,000
The John Jamison Iron Mountain Education Fund provides scholarships to encourage educational pursuits among the children of Iron Mountain employees. Established in 2004, it awards $2,000 to selected applicants and $4,000 to those majoring in STEM fields. Eligibility includes dependent children of full-time employees at the Director level and below, along with deceased employees' children. The number of scholarships varies annually based on available funds, supporting students in their quest for higher education.
Academic Scholarship Programs Mathematics STEM / STEAM Education +4 more

Jordan Fund Grant

Jordan Fund
Private
United States
Unspecified amount
The Jordan Fund, established by John & Kelly Olerud in 2003, is dedicated to supporting children with special needs and their families. This grant-making organization assists children with substantial disabilities up to age twenty-one, covering costs for respite, therapy, and essential equipment not provided by insurance. By funding 501(c)(3) organizations, the Jordan Fund aims to enhance the quality of life for these children and their families.
Children With Disabilities

George H. Nettleton Foundation Grant

George H. Nettleton Foundation
Private
Cass County, Missouri, Clay County, Missouri +4 more
Up to US $50,000
The George H. Nettleton Foundation Grant aims to enhance the quality of life for older adults in the Greater Kansas City area by funding unmet basic needs. The foundation envisions a healthy senior population and invites both new and existing programs to apply. Grants typically average under $100,000 and can extend for a maximum of two years. Agencies must be licensed 501C3 and serve specific counties in Missouri and Kansas.
Senior Services

Skadden Foundation Fellowship

Skadden Foundation
Private
United States
Unspecified amount
The Skadden Fellowship Foundation, established in 1988, offers two-year fellowships for law graduates to engage in public interest law. With a focus on serving the legal needs of impoverished communities, the program has funded over 900 fellows who contribute significantly to public service. The fellowship covers salaries and benefits, ensuring dedicated legal talent addresses critical issues. Skadden fosters ongoing support through newsletters and reunions, solidifying its commitment to improving legal services across the United States.
Legal Services Law

AHRF Discovery Grants

American Hearing Research Foundation
Private
United States
Up to US $50,000
The AHRF Discovery Grants support innovative research on hearing and balance disorders, offering up to $50,000 for one year. Targeting early-career investigators, these grants aim to generate preliminary data for larger funding applications. Special consideration is given to projects exploring Meniere's disease and sudden hearing loss. Grants cover direct research costs, excluding principal investigator salaries and indirect expenses. The initiative strives to fund promising studies that can advance our understanding of auditory and vestibular health.
Hearing Disorders & Audiology Meniere’s Disease

Trio Foundation of St. Louis Grant

Trio Foundation of St. Louis
Private
St. Clair County, Illinois, St. Louis City, Missouri +1 more
Up to US $25,000
The Trio Foundation of St. Louis Grant aims to enhance community well-being and promote equity through its new funding framework. Established over two decades ago, the foundation focuses on empowering marginalized groups, particularly those facing discrimination based on race, gender, and socioeconomic status. The grant supports initiatives in women's economic empowerment, arts accessibility, and environmental justice, fostering authentic relationships with community partners to create lasting impact in the St. Louis region.
Arts / Culture Access & Participation Art & Culture Youth Services +17 more

Lilly Endowment: Religion Grants

Lilly Endowment Inc
Private
United States
Unspecified amount
Lilly Endowment Inc. focuses on enriching the religious lives of Christians in the U.S. by supporting diverse congregations and theological education. It aims to foster community development, youth education, and public understanding of religion. The Endowment prioritizes initiatives that improve life quality in Indiana while considering national projects that align with its mission. Notably, it emphasizes nurturing the faith of young people and ensuring all congregations have capable leaders to meet contemporary challenges.
Christianity

Saigh Foundation Grant

Saigh Foundation
Private
Clinton County, Illinois, Franklin County, Missouri +10 more
Unspecified amount
The Saigh Foundation Grant supports St. Louis-area non-profit organizations focused on improving the lives of children and youth through educational and healthcare initiatives. Applications are accepted electronically via the foundation's online portal. The foundation does not fund annual appeals, capital campaigns, or organizations outside the metropolitan St. Louis area, ensuring that resources are maximized for local impact.
Education - K through 12 Education - Preschool / Early Learning Children’s Health & Pediatrics

Crossroads Charitable Foundation Grants

Crossroads Hospice Charitable Foundation
Private
United States
Unspecified amount
The Crossroads Hospice Charitable Foundation is committed to enhancing community awareness of hospice and palliative care services. It supports nonprofit organizations that provide end-of-life care and grief recovery resources. Through educational initiatives and financial grants, the Foundation aims to promote excellent hospice care and assist caregivers. Organizations eligible for funding must be 501(c)(3) nonprofits, and the Foundation does not fund administrative costs or general funding. Grant applications are accepted once per year.
Hospice / End of Life Care

Hall Family Foundation Grant

Hall Family Foundation
Private
Cass County, Missouri, Clay County, Missouri +4 more
Unspecified amount
The Hall Family Foundation Grant focuses on enhancing the quality of life in Kansas City by funding initiatives that elevate community spirit, promote equity, and create strong educational foundations. Prioritizing economic opportunities for marginalized communities, the foundation supports projects that foster inclusivity and holistic approaches to poverty reduction. With a commitment to innovative and collaborative efforts, the foundation aims to ensure that all community members can realize their potential and thrive.
Education - Preschool / Early Learning Education - K through 12 Education System Policy & Reform +12 more

Blake-Nuttall Fund Grants

Nuttall Ornithological Club Inc
Private
United States
US $1,000 - US $5,000
The Blake-Nuttall Fund Grants, offered by the Nuttall Ornithological Club Inc, support vital ornithological research, conservation, and education efforts focused on the birds of New England and the Northeast. Eligible organizations must be tax-exempt under section 501(c)(3) of the Internal Revenue Code, while applications from individuals or private foundations are not considered. This initiative aims to foster a deeper understanding and protection of avian species in the region.
Ornithological Conservation Ornithology

Chatlos Foundation Grant

Chatlos Foundation
Private
United States
Up to US $10,000
The Chatlos Foundation provides grants to nonprofit organizations in the U.S. and globally, focusing on Bible colleges, religious causes, liberal arts colleges, medical concerns, and social issues. Grants typically range from $2,000 to $20,000, depending on the category. The Foundation prioritizes program support and typically funds requests under $10,000. Eligible organizations must be U.S.-based, tax-exempt for at least two years, and aligned with the Foundation's mission, ensuring that funded projects achieve independence.
Christianity Education - Higher Education Health Facilities & Clinics +9 more

Charitable Monetary Donations (Requests under $10,000)

Alcon Foundation
Corporate
United States
Unspecified amount
The Alcon Foundation focuses on enhancing global eye health through charitable monetary donations to 501(c)(3) organizations. Grants aim to support programs that improve access to quality eye care and education, fostering community development. Eligible applicants must demonstrate high-quality services, well-defined goals, and the ability to report outcomes. The foundation does not fund organizations that discriminate or are not 501(c)(3) compliant, ensuring that resources are directed towards impactful initiatives.
Vision Impairment Care & Services Eye Diseases & Disorders

United Company Foundation Grant

United Company Foundation
Private
United States
Unspecified amount
The United Company Foundation, established in 1986, provides grants to support charitable organizations in Bristol, VA, Bristol, TN, and Southwest Virginia. This private non-profit focuses on areas such as food, shelter, education, the arts, health, and youth services, emphasizing fiscal responsibility and innovative approaches. By prioritizing accountability and measurable outcomes, the Foundation aims to foster long-term improvements in the community it serves.
Child Welfare Services Education - K through 12 Food Access & Hunger +6 more

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

Browse Missouri Grants by Focus Area

Filter Missouri Grants by Location

Browse Grants by Counties within Missouri

Adair County Andrew County Atchison County Audrain County Barry County Barton County Bates County Benton County Bollinger County Boone County Buchanan County Butler County Caldwell County Callaway County Camden County Cape Girardeau County Carroll County Carter County Cass County Cedar County Chariton County Christian County Clark County Clay County Clinton County Cole County Cooper County Crawford County Dade County Dallas County Daviess County DeKalb County Dent County Douglas County Dunklin County Franklin County Gasconade County Gentry County Greene County Grundy County Harrison County Henry County Hickory County Holt County Howard County Howell County Iron County Jackson County Jasper County Jefferson County Johnson County Knox County Laclede County Lafayette County Lawrence County Lewis County Lincoln County Linn County Livingston County Macon County Madison County Maries County Marion County McDonald County Mercer County Miller County Mississippi County Moniteau County Monroe County Montgomery County Morgan County New Madrid County Newton County Nodaway County Oregon County Osage County Ozark County Pemiscot County Perry County Pettis County Phelps County Pike County Platte County Polk County Pulaski County Putnam County Ralls County Randolph County Ray County Reynolds County Ripley County Saline County Schuyler County Scotland County Scott County Shannon County Shelby County St. Charles County St. Clair County Ste. Genevieve County St. Francois County St. Louis City St. Louis County Stoddard County Stone County Sullivan County Taney County Texas County Vernon County Warren County Washington County Wayne County Webster County Worth County Wright County

Browse Grants by Major US Cities within Missouri

Explore Grants Outside of Missouri

Browse Grants by Other States or Regions