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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,706 Results based on applied filters

PNC Foundation: Foundation Grant

PNC Foundation
Private
Accomack County, Virginia, Adams County, Colorado +667 more
Unspecified amount
The PNC Foundation aims to enhance the lives of individuals in local communities through partnerships with nonprofit organizations. Their focus includes promoting educational opportunities, particularly for early childhood education, and supporting economic development initiatives. Grants are available for organizations that benefit low- to moderate-income families and enhance community growth. The foundation prioritizes programs that foster sustainability and diversity, ensuring a lasting impact on the communities they serve.
Education - Preschool / Early Learning Teacher Development & Training Music Education +16 more

John W. Newman Memorial Scholarship

Hamilton Community Foundation (Aurora, NE)
Private
United States
Unspecified amount
The John W. Newman Memorial Scholarship is aimed at Hamilton County high school alumni who are in their second or third year of law school, pursuing a full-time juris doctorate at an accredited institution in the U.S. Selection is based on academic performance, ambition, societal contributions, and financial need, ensuring that deserving students receive support in their legal education.
Law

Alcon Foundation Grant (Requests greater than $10,000)

Alcon Foundation
Corporate
United States
More than US $10,000
The Alcon Foundation Grant aims to enhance eye care services and improve patient access, with a focus on educational and training programs. The foundation also supports cultural and community development initiatives that uplift the quality of life in areas where Alcon operates, including cities like Fort Worth, Houston, and Irvine. However, it does not fund non-501(c)(3) organizations, athletic leagues, or fundraising events, among other exclusions.
Eye Diseases & Disorders

Alpha Foundation Grant

Alpha Foundation Inc.
Private
United States
Unspecified amount
The Alpha Foundation Grant, established in 1997, focuses on enhancing the human condition by supporting educational, scientific, and charitable organizations. With a strong emphasis on biotechnology, the foundation aims to aid in disease discovery and cure. Eligible applicants must be tax-exempt 501(c)(3) organizations, primarily operating in Madison County, Alabama. The foundation does not fund individuals or political activities, ensuring its resources directly benefit public charities.
Biotechnology Diseases & Conditions

Creating Opportunity & Independence Grant

Craig H. Neilsen Foundation
Corporate
Canada, United States
US $25,000 - US $200,000
The Craig H. Neilsen Foundation's Creating Opportunity & Independence Grant supports programs and research that enhance the quality of life for individuals with spinal cord injuries (SCI). It welcomes applications from nonprofit organizations and rehabilitation facilities in the U.S. and Canada, focusing on projects that foster independence, community participation, and capacity-building. Priority is given to initiatives that demonstrate broad impact and involve individuals with SCI, ensuring their needs and perspectives shape the proposed activities.
Spinal Cord Injuries

FDC Foundation Grant

FDC Foundation
Private
United States
Unspecified amount
The FDC Foundation, established in 2008, is a private non-profit dedicated to providing grants to 501(c)(3) public charities across three main areas: Health & Nutrition, Education, and Housing. The foundation supports initiatives that improve nutrition, assist diabetic individuals, enhance early childhood development, and promote housing opportunities for those in need. However, it does not fund for-profit entities or international organizations, nor does it provide grants for specific excluded purposes.
Early Childhood Development Writing & Literature Integrative & Alternative Health +6 more

Rachael Ray Save Them All Grants

Best Friends Animal Society
Private
United States
Up to US $50,000
The Rachael Ray Save Them All Grants support innovative projects aimed at enhancing the lifesaving efforts for cats and dogs in U.S. shelters. Eligible organizations, including public and private shelters and rescue groups, can apply for up to $50,000 to fund initiatives like intake prevention services, medical care for at-risk pets, and shelter enrichment programs. All projects must align with the mission of increasing adoption rates and improving animal welfare within the Best Friends Network.
Animal Welfare - Domestic Animals & Pets

EBF: Neighborhood Donations

Eastern Bank Foundation
Corporate
United States
US $100 - US $1,000
The Eastern Bank Foundation (EBF) is dedicated to empowering communities through its Neighborhood Donations initiative. By investing over $16 million in local organizations, EBF aims to support vital services and promote equity in Eastern Massachusetts, Southern New Hampshire, and Rhode Island. This program allows contributions to non-501(c)(3) organizations, reinforcing EBF's commitment to partnership and community-driven solutions, with donations typically ranging from $100 to $1,000.
Employment Services Education Health Care Access & Delivery +5 more

Reeves Foundation: Macular Degeneration Research Grant

Carl Marshall Reeves and Mildred Almen Reeves Foundation Grant
Private
United States
US $2,500 - US $125,000
The Reeves Foundation supports research aimed at understanding and treating macular degeneration, a condition that has personally affected the founder's family. Established in 1997, the foundation allocates 50% of its grants to research and the other half to local charities in Columbus, Indiana. Nonprofit organizations exempt under IRS code 501(c)(3) are eligible to apply, but funds cannot be used for administrative costs. The foundation prioritizes equipment purchases and partnerships with other funding sources.
Eye Diseases & Disorders

Raskob Foundation: Domestic Grants

Raskob Foundation For Catholic Activities Inc
Private
American Samoa, Guam +4 more
US $15,000 - US $35,000
The Raskob Foundation offers domestic grants to organizations located in the U.S. and its territories. Founded in 1945, this private, non-profit foundation focuses on supporting Catholic institutions. Eligible applicants must be tax-exempt 501(c)(3) organizations, listed in the P.J. Kenedy Official Catholic Directory. However, requests from individuals and certain projects, such as debt reduction or completed projects, are not accepted. The foundation emphasizes its commitment to philanthropy and community support.
Volunteerism & Philanthropy Catholicism

Griffin Family Charitable Foundation Grant

Griffin Family Charitable Foundation
Corporate
Audrain County, Missouri, Montgomery County, Missouri
Unspecified amount
The Griffin Family Charitable Foundation Grant, established in 1998 by Anna Margaret Griffin in honor of her father, Dr. Fred Griffin, supports public charities in Audrain and Montgomery Counties. With over $1 million awarded in grants and scholarships, the Foundation focuses on educational, scientific, and charitable initiatives. Dr. Griffin's legacy of service and commitment to the community continues through this foundation, ensuring that vital resources are provided to enhance the lives of local residents.
All fields of work

Pratt Family Foundation Grant

Pratt Family Foundation Inc.
Private
United States
Unspecified amount
The Pratt Family Foundation Grant, established in 1999, supports initiatives in education, healthcare, and community welfare. It prioritizes organizations that aid housing assistance, support for women in crisis, and disadvantaged youth programs, particularly in North Carolina. The Foundation favors established religious and charitable organizations that are tax-exempt and have a local presence. Preference is given to areas connected to the Pratt family, such as Texas and Florida, ensuring impactful contributions to community development.
Disaster Relief / Humanitarian Aid Youth Services Domestic Violence +7 more

Tilles Fund Grant

Rosalie Tilles Nonsectarian Charity Fund 313743
Private
Bond County, Illinois, Calhoun County, Illinois +14 more
Unspecified amount
The Tilles Fund Grant focuses on innovative charitable investments in the Greater St. Louis Area, aiming to support children with developmental, intellectual, and physical disabilities. The foundation seeks to partner with effective non-profit organizations that demonstrate measurable outcomes in education and community impact. Since 1926, the Tilles Foundation has been committed to providing essential services and educational opportunities, ensuring disadvantaged children have the tools they need for a brighter future.
Children With Disabilities Education - K through 12 Education - Higher Education

McGowan Charitable Fund Grants

William G. McGowan Charitable Fund
Private
Cook County, Illinois, Eagle County, Colorado +9 more
Unspecified amount
The William G. McGowan Charitable Fund provides grants focusing on Education, Human Services, and Healthcare initiatives. The fund prioritizes programs with measurable outcomes that aim to alleviate poverty and suffering. Eligible organizations must be 501(c)(3) nonprofits and align with the fund's mission to create sustainable change. Applications are accepted by invitation only in specific regions, with a rolling deadline. The fund seeks collaborative efforts to maximize impact across its program areas.
Education - Preschool / Early Learning Early Childhood Development After School / Summer Educational Programs +15 more

Youth Initiative Grant

Weyerhaeuser Family Foundation
Private
United States
Up to US $30,000
The Youth Initiative Grant, provided by the Weyerhaeuser Family Foundation, aims to support innovative programs that enhance resilience and psycho-social health for youth aged 14-21 affected by trauma from Adverse Childhood Experiences (ACEs). Grants are available for new programs or therapeutic components within their first year. The foundation prioritizes organizations that actively engage with beneficiaries and implement holistic approaches to service delivery, ensuring long-term sustainability and effective evaluation of program impacts.
Domestic Violence Child Welfare Services Crisis Intervention +4 more

Karen Colina Wilson Foundation Grant

Karen Colina Wilson Foundation
Private
United States
US $500 - US $10,000
The Karen Colina Wilson Foundation Grant supports programs for children, youth, and women, enhancing their health and well-being through education, art, literature, and music. Established in 2006, the foundation aims to make a positive difference in their lives, particularly in Southern and Western Wayne County, Michigan. Grants typically range from $500 to $10,000, often as matching funds, fostering broader fundraising efforts by local nonprofit organizations.
Education Artist Training & Development Children’s Mental Health +13 more

John M. O'Quinn Foundation Grant

John M Oquinn Foundation
Private
United States
Unspecified amount
The John M. O'Quinn Foundation Grant, established in 1986, has contributed over $192 million to various charitable activities, focusing primarily on Houston and its surrounding areas. The Foundation supports tax-exempt organizations and governmental units, emphasizing conservation, education, healthcare, and programs for underprivileged youth. Grants are not available for type III supporting organizations, individuals, or foreign charities, ensuring a targeted impact within the local community.
Education Environmental Conservation Youth Services +1 more

McKesson Foundation Grant: above $25,000

McKesson Foundation
Private
Canada, United States
More than US $25,000
The McKesson Foundation Grant provides funding above $25,000 to support health equity initiatives across North America. Founded in 1943, its mission focuses on removing barriers to quality healthcare for vulnerable communities. The foundation prioritizes projects that align with strategic pillars: reducing cancer burdens, preparing the healthcare workforce, and enhancing crisis response. Eligible organizations include national and local nonprofits. Funding is limited to specific regions and assessed based on demonstrated need and expected impact.
Cancer / Oncology Medical Education & Professional Training Career / College Preparation +8 more

Ina Calkins Board Grant

Ina Calkins Board
Private
Jackson County, Missouri
Unspecified amount
The Ina Calkins Board Grant supports 501(c)(3) nonprofits in Kansas City, Missouri, providing approximately $200,000 annually. Founded in 1930, it aims to assist organizations that promote total abstinence from alcohol, care for the elderly, and support children's welfare. Grants are awarded to enhance social services, education, and health care for those in need. Eligible organizations must serve residents of Kansas City, ensuring that aid benefits the local community.
Youth Development & Leadership Alcoholism Senior Services +7 more

HTR Foundation Grant

HTR Foundation
Private
United States
Unspecified amount
The HTR Foundation Grant supports the preservation of American Civil War sites and educational projects related to this heritage. Grants are available to tax-exempt organizations and government agencies, focusing on land acquisition and public engagement while excluding endowments, individual support, and local interest projects. This initiative promotes the historical, cultural, and environmental legacy of the United States, ensuring the continued education and awareness of the Civil War's significance.
American History Battlefield Preservation

Lend A Hand Society: Book Mission Grant

Lend A Hand Society
Private
United States
US $500 - US $2,000
The Lend A Hand Society offers the Book Mission Grant to assist low-income individuals and families by funding the acquisition of books for educational institutions and libraries. This initiative supports various programs focused on emergency assistance and camperships for children. Non-profit organizations across the United States can apply, with grants aimed at enhancing literacy and education. Grantees must provide reports detailing the use of funds and project progress, ensuring transparency and accountability.
Library Services

Tommy Wells Foundation Grant

Tommy Wells Foundation
Corporate
United States
Up to US $500
The Tommy Wells Foundation Grant supports youth aged 4-18 in music and hockey programs by providing financial assistance. As a 501(c)(3) nonprofit, the Foundation raises funds to honor Tommy Wells' legacy. Organizations in the greater Nashville, TN area are preferred for funding. The TWF encourages applicants to request funds for those who will benefit most, ensuring accountability by requiring confirmation of fund usage within a year.
Music Education Hockey

Whitaker Foundation - Arts & Parks Grants

Mr and Mrs Lyndon C Whitaker Charitable Foundation
Private
Bond County, Illinois, Calhoun County, Illinois +20 more
Unspecified amount
The Whitaker Foundation, established in 1975, supports arts and parks initiatives in St. Louis, Missouri. By funding arts organizations and park projects, it enriches community life through creativity and shared spaces. Eligible applicants must have 501(c)(3) status and provide free public programming. The foundation does not fund playgrounds, sports leagues, or individual grants, ensuring support is directed towards impactful community projects that promote relaxation, beauty, and celebration.
Parks & Public Spaces Art History Visual Arts +4 more

Sorenson Legacy Foundation Grant

Sorenson Legacy Foundation
Private
United States
Unspecified amount
The Sorenson Legacy Foundation Grant aims to improve lives through support for education, health care, community development, and innovation. Established by James and Beverley Sorenson, the foundation focuses on enhancing art education, medical technologies, and community assistance in Utah. It prioritizes projects that foster artistic growth, promote innovative solutions, and address health care challenges while aiding vulnerable populations. The foundation's commitment to enriching lives reflects a deep-rooted belief in the power of education and community engagement.
Performing Arts Art Education Artist Training & Development +16 more

NewSchools: Innovative Schools Grant

NewSchools Venture Fund
Private
United States
US $150,000 - US $250,000
The NewSchools: Innovative Schools Grant supports education leaders aiming to create new public and charter schools that address the unique needs of today's students. With funding ranging from $150,000 to $250,000, the grant emphasizes equity and innovative educational models. Applications are encouraged before the December 10, 2024 priority deadline, with the final deadline on January 8, 2025. This initiative seeks to empower diverse communities through transformative educational solutions.
Education - K through 12

Elsa U. Pardee Foundation- Grant for Supporting Innovative Cancer Research

Elsa U. Pardee Foundation
Private
United States
Unspecified amount
The Elsa U. Pardee Foundation has been a pioneer in cancer research funding since 1944, providing over $110 million to more than 300 institutions across the U.S. It supports innovative approaches by both new and established researchers, ensuring diverse ideas receive necessary funding. Additionally, the Foundation addresses immediate financial needs for cancer patients, allocating about one-third of its grants to assist those in need. This dual focus on research and patient support distinguishes the Foundation in the fight against cancer.
Cancer / Oncology

Collins Medical Trust Grant

Collins Medical Trust
Private
United States
Up to US $40,000
The Collins Medical Trust Grant, established in 1956, supports health-related research and professional education for tax-exempt organizations. Eligible applicants include institutions with approved tax status and a commitment to equal opportunity. Early career investigators are encouraged to apply, but funds cannot be used for individual benefits or political activities. The Trust prioritizes projects in Oregon and does not support product development for industry. Applications are accepted thrice yearly, with specific deadlines for timely consideration.
Diseases & Conditions Health & Medicine Medical Education & Professional Training

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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