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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,706 Results based on applied filters

NCRG Large Grant

International Center for Responsible Gaming
Private
United States
Up to US $187,500
The NCRG Large Grant, provided by the International Center for Responsible Gaming, supports high-quality research on gambling disorders and responsible gambling. Eligible applicants can request up to $75,000 annually for a maximum of 24 months, totaling $187,500. The grant emphasizes scientific rigor through its advisory board, ensuring only the best proposals receive funding. This initiative aims to advance understanding and treatment of gambling-related issues through peer-reviewed research.
Addiction & Substance Use Disorders

Rapid Outcomes from Agricultural Research (ROAR) Grant Program

Foundation for Food and Agriculture Research (FFAR)
Private
United States
Up to US $250,000
The Rapid Outcomes from Agricultural Research (ROAR) Grant Program, managed by the Foundation for Food and Agriculture Research (FFAR), provides urgent funding for research addressing unexpected threats to the food supply. This program supports diverse projects related to pest and pathogen outbreaks, facilitating quicker responses than traditional funding avenues. With grants up to $150,000, ROAR aims to enhance agricultural resilience by fostering collaborations among researchers, institutions, and organizations to combat emerging challenges in the food and agriculture sector.
Plant Pathology Agricultural Pest Management

Major Research Grants on Reducing Inequality

William T Grant Foundation Inc
Private
United States
US $100,000 - US $600,000
The Major Research Grants on Reducing Inequality, funded by the William T Grant Foundation, support research aimed at reducing inequality in youth outcomes for ages 5-25 in the U.S. Grants range from $100,000 to $600,000 over 2-3 years. Studies can explore various systems such as education, mental health, and justice, focusing on mechanisms for change, intervention effectiveness, and improved measurement of inequality.
Social Justice / Human Rights

Institutional Challenge Grant

William T Grant Foundation Inc
Private
United States
US $650,000
The Institutional Challenge Grant aims to foster collaborative research by requiring institutions to adapt their policies and enhance capacities for meaningful partnerships. It encourages applications from diverse leadership teams in youth-serving areas, focusing on addressing inequalities in youth outcomes. The grant outlines four key goals: strengthening partnerships, pursuing a joint research agenda, facilitating institutional change, and enhancing collaborative capacities for producing actionable research evidence.
Juvenile Justice Child Welfare Services Children’s Mental Health +4 more

Ted & Shannon Skokos Foundation Grant

Ted and Shannon Skokos Foundation
Private
United States
Unspecified amount
The Ted & Shannon Skokos Foundation Grant, established in 2008, supports nonprofit organizations in arts, education, humanity, and faith. It prioritizes visionary leadership, community impact, sustainability, organizational strength, and collaboration. The foundation seeks to fund eligible 501(c)(3) nonprofits that align with its mission and positively influence communities, particularly in Dallas, Texas, and Arkansas, where the founders have personal connections.
Art & Culture Human & Social Services Education +1 more

Impact Fund Grants

The Impact Fund
Private
United States
US $10,000 - US $50,000
The Impact Fund provides recoverable grants to legal services nonprofits and small law firms working on social, environmental, and economic justice issues. With over $10 million awarded since 1992, the fund supports impactful litigation addressing systemic injustices. Grants range from $10,000 to $50,000 and prioritize cases directly involving affected communities. Recipients must repay the grant amount with interest if they recover fees or costs, ensuring sustainability for future funding.
Social Justice / Human Rights Environmental Justice & Advocacy Economic Rights, Justice, & Mobility +1 more

CFCM: Community Support Grants

Community Foundation of Central Missouri
Private
Adair County, Missouri, Audrain County, Missouri +8 more
US $500 - US $1,500
The Community Foundation of Central Missouri (CFCM) promotes community well-being through its Community Support Grants. Since 2010, CFCM has focused on addressing local needs by funding nonprofit projects in areas such as health, education, arts, and community improvement. Eligible organizations must be 501(c)(3) nonprofits or local government entities serving central Missouri. CFCM seeks partnerships that align with its mission to enhance lives and foster sustainable community investments.
Environmental Conservation Human & Social Services Aging / Gerontology +18 more

Making a Difference in Real-World Bioethics Dilemmas Grant

The Greenwall Foundation
Private
United States
Unspecified amount
The Greenwall Foundation's Making a Difference in Real-World Bioethics Dilemmas Grant seeks proposals for innovative research addressing pressing bioethics issues in healthcare, policy, and practice. Projects should focus on topics such as trust in science, healthcare bias, public health crises, and healthcare access. The Foundation aims to support inclusive bioethics that incorporates diverse perspectives, promoting impactful solutions to real-world dilemmas while ensuring that bioethics remains central to decision-making in health-related fields.
Medical Ethics Health Policy & Advocacy Epidemiology & Public Health +1 more

HDR Foundation U.S. Community Grant

HDR Foundation
Corporate
United States
More than US $5,000
The HDR Foundation Grant Cycle supports community organizations aligned with HDR's values, focusing on education, healthy communities, and environmental stewardship. This employee-funded initiative emphasizes the importance of employee engagement in grant proposals, requiring a clear scope of work and completion within a year. Eligible applicants include U.S.-based nonprofits, educational institutions, and tribal governments, while grants are not provided for faith-based organizations or individual support.
Wellness & Healthy Living Preventative Healthcare Education - Preschool / Early Learning +8 more

Sidney Stern Memorial Trust Grant

Sidney Stern Memorial Trust
Private
United States
Unspecified amount
The Sidney Stern Memorial Trust Grant supports charitable, scientific, medical, and educational organizations that are 501(c)(3) certified. This private funder emphasizes impactful service to diverse populations without discrimination. Grants must be utilized within the United States and cannot be awarded to individuals, political candidates, or lobbying efforts. The Trust is dedicated to enhancing the general welfare through soundly-managed initiatives that contribute significantly to community needs.
Health & Medicine Education Science +1 more

Global Perspectives in Teacher Preparation and Teacher Professional Development Grant

Longview Foundation
Private
United States
US $10,000 - US $22,000
The Longview Foundation's Internationalizing Teacher Preparation Grants aim to enhance teachers' global competencies through collaborative projects and online education. Established in 1966, the foundation prioritizes partnerships among institutions and the integration of global perspectives into teacher training. Successful proposals will demonstrate significant outreach, sustainable practices beyond the funding period, and collaboration with state education agencies. Grants range from $10,000 for single institutions to $30,000 for multi-institution initiatives, fostering a broader impact on K-12 education.
Teacher Development & Training

W. M. Keck Research Grant Program

W. M. Keck Foundation
Private
United States
US $1,000,000 - US $1,300,000
The W. M. Keck Foundation's Research Grant Program funds innovative medical research and engineering projects that challenge existing paradigms and explore new territories. Eligible applicants include research universities and independent institutes. Grants support groundbreaking technologies and methodologies, with emphasis on high-risk projects that could lead to transformative impacts. However, funding excludes general operating expenses and grants to individuals. The Foundation awards grants biannually, with an emphasis on interdisciplinary approaches.
Health & Medicine Engineering Science

Bauer Trust Fund Grant

Anthony F. Bauer Trust Fund
Private
United States
US $3,000 - US $5,000
The Bauer Trust Fund Grant supports charitable organizations benefiting blind or handicapped persons. Established by Anthony F. Bauer, it aims to provide lasting support for those in need. To be eligible, organizations must be 501(c)(3) exempt and primarily operate in Connecticut. The fund does not support general operating costs, endowments, individuals, or political activities. This initiative reflects Mr. Bauer's legacy of generosity and commitment to aiding vulnerable communities.
Disability Care & Services Vision Impairment Care & Services

Brookreson Trust Grant

Marie H. Brookreson Trust
Private
United States
US $5,000 - US $10,000
The Brookreson Trust Grant aims to support financing homes for the blind and organizations that assist them. This grant is targeted towards 501(c)(3) exempt organizations across all states. The program focuses on key areas such as education, health, and human services, ensuring that vital resources are directed towards enhancing the quality of life for the visually impaired community. Grants are specifically intended for initiatives that facilitate housing and support services.
Vision Impairment Care & Services

Ella B. Cleveland Trust Grant

Ella B. Cleveland Trust
Private
United States
Unspecified amount
The Ella B. Cleveland Trust Grant supports charitable medical research organizations focusing on leukemia, muscular dystrophy, and cerebral palsy. Established in memory of Ella B. Cleveland, the trust prioritizes 501(c)(3) entities and has no geographic limitations, though it often funds organizations in Georgia. Applications are accepted year-round, with an average grant size of $5,000, and total annual giving ranging from $10,000 to $15,000.
Leukemia Muscular Dystrophy Cerebral Palsy

Gilbert Memorial Fund Grant

J. Roland Gilbert, Mary R. Gilbert and Elizabeth A. Gilbert Memorial Fund
Private
United States
US $10,000 - US $40,000
The Gilbert Memorial Fund Grant supports organizations conducting innovative medical research. Established in memory of the Gilbert family, this fund aims to promote advancements in various areas of medicine. Applications are accepted year-round, with a review meeting held annually on March 1. Grants typically range from $10,000 to $40,000, and eligible organizations must be recognized as 501(c)(3) entities. This initiative reflects a commitment to enhancing healthcare through research and development.
Health & Medicine

Marsh Foundation Grant

The Edward N. and Margaret G. Marsh Foundation
Private
United States
US $52,000 - US $150,000
The Marsh Foundation Grant provides funding for charitable, scientific, literary, and educational purposes, focusing primarily on medical research in El Paso, Texas. Established under the will of Edward N. Marsh, the foundation offers grants ranging from $52,000 to $150,000, with an average total giving of $200,000 annually. Organizations must qualify as 501(c)(3) entities to be eligible, although there are no geographic limitations. Applications are accepted year-round, with a deadline of June 30 for review.
Education Health & Medicine Human & Social Services

Community Organizing Grants Program

Peace Development Fund
Private
American Samoa, Guam +6 more
Approximately US $5,000
The Community Organizing Grants Program by the Peace Development Fund empowers local organizations to drive social justice initiatives. It supports groups that foster grassroots leadership and systemic change while dismantling oppression. Grants are primarily for general support, focusing on projects that align with their mission. Eligible organizations include those in the U.S., Haiti, and Mexico, while excluding completed projects or lobbying activities. This initiative encourages sustainable, community-based solutions and diverse alliances for a just society.
Social Justice / Human Rights

DEW Foundation Grant

DEW Foundation
Private
Adair County, Missouri, Adams County, Illinois +189 more
Unspecified amount
The DEW Foundation Grant supports tax-exempt charitable organizations globally, aiming to promote the common good through financial contributions and personal involvement. The foundation prioritizes charities where family members are actively involved and focuses on ministries, health, education, and community service. While it may fund its own projects, it typically does not exceed 10% of an organization's operating budget and avoids supporting politically affiliated causes or normal church operations. Innovative and effective organizations are especially welcome.
Health & Medicine Disaster Relief / Humanitarian Aid Human & Social Services +4 more

The Pettus Foundation Grants

St Louis Community Foundation
Private
St. Louis City, Missouri, St. Louis County, Missouri
US $5,000 - US $25,000
The Pettus Foundation Grants focus on enhancing self-reliance and productivity in underserved communities through targeted funding in St. Louis. They support nonprofit initiatives in workforce development, youth development, and education, with a keen interest in early childhood education and job training programs. Applications are by invitation only, facilitated by the St. Louis Community Foundation, emphasizing robust governance and collaboration with multiple funding partners. Typical grants range from $5,000 to $25,000.
Workforce Preparation & Job Readiness Education - K through 12

Marcy Shulman Memorial Organization Grant Program

Colburn-Keenan Foundation
Private
United States
Up to US $5,000
The Marcy Shulman Memorial Organization Grant Program, established by the Colburn-Keenan Foundation, supports organizations improving the lives of individuals with chronic illnesses, particularly within the bleeding disorders community. Proposals should enhance health and quality of life, with examples including educational programs and facility upgrades. Only 501(c)3 organizations are eligible, and they may receive one grant per cycle. Applications must be submitted at least two months prior to the project start date.
Hematological Systems Chronic Illnesses

Family Fun & Connections Event Grant Program

Colburn-Keenan Foundation
Private
United States
US $1,000
The Family Fun & Connections Event Grant Program, initiated by the Colburn-Keenan Foundation, aims to support community engagement through events for families affected by bleeding disorders. This program, established after a successful 10th Anniversary Celebration, offers $1,000 grants for various fun activities such as dance parties, BBQs, and outdoor adventures. It emphasizes the foundation's commitment to enhancing the lives of those with chronic illnesses and promoting community strength and advocacy.
Hematological Systems Chronic Illnesses

Harris & Frances Block Foundation Grant

Harris and Frances Block Foundation
Private
United States
Up to US $35,000
The Harris and Frances Block Foundation, established in 2001, supports small grassroots organizations focused on social and environmental justice. They prioritize equitable solutions and sustainable community development, funding initiatives related to environmental education, justice, and food security. Grants are available to non-profit, tax-exempt organizations in specific geographical areas including Vermont, North Carolina, Virginia, and New York City, excluding funding for lobbying, land acquisition, and scholarships.
Food Access & Hunger Environmental Justice & Advocacy Agricultural Education +2 more

Engagement Award: Capacity Building

Patient-Centered Outcomes Research Institute
Association/Society
United States
Up to US $300,000
The Engagement Award: Capacity Building aims to enhance the skills of patients and stakeholders in patient-centered outcomes research (PCOR) and comparative effectiveness research (CER). With funding of up to $300,000 for projects lasting up to two years, this initiative seeks to foster meaningful participation from patients, families, and caregivers. The Patient-Centered Outcomes Research Institute (PCORI) anticipates distributing up to $25 million for these efforts in fiscal year 2026, emphasizing community engagement in research.
Health & Medicine

Conservation Alliance Grants

Conservation Alliance
Private
United States
Up to US $50,000
The Conservation Alliance Grants program is currently under evaluation, leading to a pause in the member-directed grant cycle as the organization aligns its funding with its strategic plan launching in 2025. This initiative aims to harness the collective efforts of businesses and outdoor communities to protect North America's wild places through impactful and efficient grant-making. Future funding will focus on projects that enhance habitat, support Indigenous initiatives, and address climate change.
Land / Habitat Conservation Outdoor Recreation Climate Change Resilience & Equity

L’Oréal USA For Women in Science Fellowship

L’Oréal USA
Corporate
United States
US $75,000
The L’Oréal USA For Women in Science Fellowship empowers women postdoctoral scientists by providing annual grants to support their research in STEM fields. This initiative not only recognizes their contributions but also encourages them to serve as role models for future generations. With a long-standing partnership with the AAAS, the program has awarded over $5 million to 105 scientists, demonstrating a strong commitment to advancing women's roles in science and technology.
Engineering Mathematics Science +2 more

Ittleson Foundation: Environmental Program Grants

Ittleson Foundation
Private
United States
Unspecified amount
The Ittleson Foundation Environmental Program Grants support innovative projects that enhance environmental activism through education and grassroots efforts. In 2025, grants will focus on initiatives that strengthen environmental movements and engage new constituencies, particularly in environmental equity. The Foundation has provided resources since 1932 to improve public policy and community welfare, alternating its grantmaking focus annually between mental health and environmental initiatives.
Environmental Justice & Advocacy

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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