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Best Missouri Grants for Nonprofits

Find nonprofit grants in Missouri, including opportunities in St. Louis, Kansas City, and Springfield. Updated listings for 501(c)(3) organizations statewide.

10,000+

Available grants

$2.60B

Total funding

$5K

Median grant

10,000+ grants
$2.60B total
$5K median

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9,706 Results based on applied filters

Donaghue Foundation: Another Look Grant

Patrick and Catherine Weldon Donaghue Medical Research Foundation
Private
United States
Unspecified amount
The Donaghue Foundation's Another Look Grant focuses on enhancing health and well-being for older adults in long-term care facilities. It prioritizes research that utilizes existing datasets and includes stakeholders to inform project development. High-priority topics include improving palliative care, workforce innovations, and addressing disparities in care quality. This program is open to PhD investigators from tax-exempt institutions in the U.S., aiming to foster impactful health-related research that enhances care quality for seniors.
Residential Care & Nursing Homes

Donaghue Foundation: Greater Value Portfolio Grant Program

Patrick and Catherine Weldon Donaghue Medical Research Foundation
Private
United States
Up to US $500,000
The Donaghue Foundation's Greater Value Portfolio Grant Program aims to enhance healthcare value by funding innovative research projects for two years, with awards up to $400,000. It encourages proposals that address issues such as high costs, disparities, and inefficiencies in care. Eligible applicants include Ph.D. researchers at nonprofit institutions partnered with healthcare organizations. The program seeks actionable solutions to improve patient care and reduce the burden of low-value healthcare on communities.
Health Care Access & Delivery Health & Medicine Health Policy & Advocacy +1 more

North Central Soybean Research Grant Program (NCSRP)

North Central Soybean Research Program (NCSRP)
Private
United States
Unspecified amount
The North Central Soybean Research Grant Program (NCSRP) aims to enhance soybean production through collaborative research and outreach. By investing in innovative projects, it addresses key challenges in soybean yield, profitability, and environmental sustainability. The program encourages proposals that focus on genetic improvement, pest control, and production practices tailored for the North Central region. Funded projects are expected to deliver practical benefits to soybean farmers while fostering communication and collaboration among stakeholders in the industry.
Agricultural Crops

GM Corporate Giving Grants

General Motors Foundation Inc
Corporate
Adams County, Colorado, Arapahoe County, Colorado +40 more
Unspecified amount
The GM Corporate Giving Grants support U.S.-based 501(c)(3) nonprofit organizations focused on STEM education and transportation initiatives. Applications are accepted from January to September, with a requirement to submit requests at least three months before the program’s start date. GM emphasizes charitable contributions in the communities where it operates, ensuring that organizations align with its values. The grant amount is not limited and is assessed based on the proposed program's merit and needs.
Automotive Safety Public Transportation & Mass Transit Systems Real Estate & Housing +11 more

GF Research Grants: Pediatric Research - Pediatric Health

Gerber Foundation
Private
American Samoa, Guam +4 more
Up to US $350,000
The Gerber Foundation provides research grants focused on enhancing the health and nutrition of infants and young children, particularly those aged 0-3. The foundation seeks innovative projects that address critical health issues and improve developmental outcomes. Grants support applied research, diagnostic tools, and treatment regimens that promise significant advancements in pediatric health. Eligible applicants include tax-exempt organizations, emphasizing a commitment to projects with a direct impact on children's well-being in the U.S.
Children’s Health & Pediatrics

The Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)

American Federation for Aging Research
Private
United States
Up to US $225,000

The Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76)

The National Institute on Aging (NIA), The John A. Hartford Foundation, and the National Institute on Neurological Disorders and Strokes (NINDS) are collaborating on this initiative to develop of a cadre of talented scientists prepared and willing to take an active leadership role in transformative change that will lead to improved health care outcomes.

Emerging leaders are clinically trained (primarily physician) early-stage investigators who have begun to establish research careers and have shown signs of leadership potential who will use this award to further develop the tools, skills and resources to have a significant impact in their field of expertise. 

The National Institute on Aging is pursuing this initiative to recruit talented new investigators who have begun to establish research programs and through this award will be ready to assume leadership roles in their field of expertise and well poised to change theory, practice and health outcomes related to the health of older individuals. Unlike other mentored K awards candidates for this award must have received competitively awarded research support as a PD/PI at the faculty level and have had prior leadership responsibilities in the clinical or research domain.

It is anticipated that seven to ten awards will be granted in 2017, up to 5 years of funding limited to $225,000 in direct costs per year. 

Aging / Gerontology

Graham Foundation: Grants To Individuals

Graham Foundation for Advanced Studies in the Fine Arts
Private
United States
Up to US $20,000
The Graham Foundation for Advanced Studies in the Fine Arts, established in 1956, supports innovative projects that explore architecture's role in society and culture. It offers grants to individuals for production and presentation, as well as research and development, focusing on diverse ideas that provoke critical dialogue. The foundation prioritizes first-time applicants and seeks to amplify underrepresented perspectives while fostering collaboration across various disciplines in the arts and education.
Architecture Landscape Architecture Urban Planning

Graham Foundation: Grants To Organizations

Graham Foundation for Advanced Studies in the Fine Arts
Private
United States
Up to US $30,000
The Graham Foundation for Advanced Studies in the Fine Arts offers grants to organizations focused on architecture and its role in society. Established in 1956, the Foundation promotes innovative projects that encourage public dialogue, raise awareness, and foster experimentation in the field. Grants, not exceeding $30,000, support diverse practitioners and initiatives, enhancing discourse in architecture, design, visual arts, and related fields. The Foundation encourages projects that demonstrate originality, feasibility, and potential for meaningful impact.
Architecture Urban Planning Landscape Architecture

Goodyear Community Support Grant

Goodyear Tire & Rubber Company
Corporate
United States
Unspecified amount
The Goodyear Community Support Grant aims to empower nonprofit organizations that align with Goodyear's community engagement focus areas. With a strong commitment to safe, smart, and sustainable initiatives, Goodyear supports programs fostering safe mobility, inspiring students through education, and addressing environmental and societal needs. This grant serves as a catalyst for positive change, helping communities thrive by focusing on volunteerism and impactful partnerships.
Sustainability Waste Management Energy Efficiency & Conservation +3 more

Joseph E. and Marjorie B. Jones Foundation Grants

Joseph E. and Marjorie B. Jones Foundation
Private
United States
Unspecified amount
The Joseph E. and Marjorie B. Jones Foundation is a private philanthropic organization committed to enhancing life quality in the greater Washington, D.C. area. The foundation focuses on human services, healthcare, and educational initiatives, believing in the inherent dignity of all individuals. It supports projects that foster community trust and partnership while avoiding funding for basic research, scholarships, or sectarian activities. The foundation aims to inspire and uplift communities through strategic partnerships.
Education Health & Medicine Human & Social Services

Greenwall Faculty Scholars Program

The Greenwall Foundation
Private
United States
More than US $5,000
The Greenwall Faculty Scholars Program supports junior faculty in bioethics research, offering 50% salary support for three years and project funding of $5,000 annually. Scholars engage in community-building through semi-annual meetings, mentoring, and philosophical seminars. Priority is given to applicants from underrepresented backgrounds and those not yet considered for tenure. This program aims to drive innovative research that addresses pressing ethical issues in clinical and public health settings, fostering future bioethics advancements.
Biology Medical Ethics

HHF: Emerging Research Grant (ERG)

Hearing Health Foundation
Private
United States
Up to US $100,000
The Hearing Health Foundation's Emerging Research Grants (ERG) program supports innovative research in hearing and balance, providing up to $50,000 per year for promising projects. Since 1958, it has fostered early-career researchers and led to significant advancements in the field. Eligible applicants must be affiliated with U.S. institutions and hold relevant advanced degrees. The program emphasizes underfunded areas and encourages applications that expand knowledge and research capabilities in hearing health.
Hearing Disorders & Audiology Meniere’s Disease Otorhinolaryngology

Curry Family Foundation Grant

The Curry Family Foundation
Private
Bates County, Missouri, Caldwell County, Missouri +13 more
Up to US $25,000
The Curry Family Foundation Grant aims to support local non-profit organizations working to enhance the lives of endangered children and disadvantaged individuals. It offers funding for program development, operational expenses, equipment and building renovations, and matching funds. Eligibility is limited to 501(c)(3) tax-exempt organizations in the Kansas City metropolitan area, with specific ineligibilities including capital campaigns and discrimination based on race, creed, or other factors.
Education Human & Social Services Art & Culture +4 more

Stafford Family Charitable Trust Grant

Stafford Family Charitable Trust
Private
Audrain County, Missouri, Boone County, Missouri +9 more
Unspecified amount
The Stafford Family Charitable Trust, established in 1988, has contributed over $1.5 million to enhance the Central Missouri community. Founded by J.W. "Stan" Stafford and Lois Smith Stafford, the trust supports local colleges and family-oriented organizations. With a focus on capital funding requests, it aids institutions that are tax-exempt and serve the Central Missouri area, including various counties such as Boone, Callaway, and Cole.
All fields of work

Roblee Foundation Grant

Joseph H. and Florence A. Roblee Foundation
Private
Miami-Dade County, Florida, St. Clair County, Illinois +2 more
US $5,000 - US $30,000
The Roblee Foundation Grant supports initiatives that promote equity in race, ethnicity, and gender. It prioritizes funding for proposals that empower marginalized communities through women's issues, youth opportunities, and early childhood education. Grants are available for projects in the St. Louis area and Miami-Dade, FL. Applicants must consult with foundation staff before submission. The foundation focuses on early, catalytic, and movement-building approaches to create lasting change and improve lives.
Early Childhood Development Child Care Services Education - Preschool / Early Learning +17 more

Congregation Mini Grants

Lutheran Foundation of St. Louis
Corporate
Clinton County, Illinois, Franklin County, Missouri +10 more
Up to US $10,000

Lutheran School Mini Grants

The Foundation continues to encourage congregations to reach out to their surrounding communities through organized, effective social service outreach ministry efforts. We also recognize congregations are looking for innovative ways, outside the traditional social service outreach model, to build relationships and engage their communities.

We look to accomplish this in two ways:

  • Supporting congregations as they work to engage and serve their neighbors and community through planning and program implementation grants.
  • Strengthening the ability of congregations to engage in community engagement efforts through coaching assistance, mentoring, and training (through Send Me St. Louis).Examples of Possible Ministry Projects

Congregation Community Engagement is defined for this Funding Focus Area as activities, services, or efforts designed to reach out to others on a local level (St. Louis metropolitan region). Examples include both serving the immediate needs of people and efforts to engage and build relationships with the community. The focus is on bringing the care of Jesus Christ into the lives of hurting people in the community, rather than serving the congregation’s own members. This funding focus area is not meant to support “Word and Sacrament” activities.

  • Health care/mental health services
  • Fitness/healthy living programs
  • English as a second language
  • After-school mentoring/tutoring
  • Social activities for seniors
  • Community revitalization
  • Recreation activities
  • Home repair/beautification
  • Partnerships with local schools/other institutions
  • Social enterprise/business that benefits the community and/or creates space for relationships
  • One-time events (run by the congregation) to meet a need in the community

Idea Exploration

Congregations should know what they want to do and have an idea of how to get started. If you are not at this point, coaching services to assist your congregation are offered through Lutheran Foundation’s relationship with Send Me St. Louis. Services include coaching and guidance on:

  • mapping the congregation’s and community’s assets, 
  • researching opportunities for social service outreach ministry, and/or
  • planning for a social service outreach ministry.

There are no grant deadlines for the Congregation Mini Grants. Application can be made at any time of the year.

Human & Social Services Senior Services English for Speakers of Other Languages (ESOL) Education +14 more

Weil Foundation Grant

The Weil Foundation
Private
United States
Up to US $300,000
The Weil Foundation provides grants to advance integrative medicine through education, research, and policy reform. Primarily aimed at non-profit healthcare organizations and medical schools, these grants support the development of educational programs in integrative medicine. Each grant is awarded for one year, with the possibility for recipients to apply for additional funding in subsequent years. The Foundation emphasizes cooperation, respect for grant-seekers, and transparency in its operations.
Integrative & Alternative Health

KTGF Fellowship Programs

Klingenstein Third Generation Foundation
Private
United States
Up to US $100,000
The KTGF Fellowship Programs, funded by the Klingenstein Third Generation Foundation, offer $100,000 over two years to support post-doctoral and junior faculty research on ADHD and depression in children, particularly from low-income and under-resourced backgrounds. This initiative aims to foster promising early-career scientists while producing impactful research that benefits affected children and families. Applications are accepted from September 1 to December 15, with specific eligibility criteria outlined for candidates.
Mental Health & Psychiatric Diseases Children’s Mental Health Depression / Anxiety

BMS Corporate Giving

Bristol Myers Squibb Foundation Inc
Private
United States
Unspecified amount
Bristol Myers Squibb is dedicated to enhancing healthcare and advancing scientific knowledge through its Corporate Giving program. By supporting various organizations, BMS aims to improve health equity and access to essential medicines for underserved populations. Their focus includes charitable donations, medical education, and community support initiatives. This commitment reflects BMS's goal to make a positive impact on patients' lives and foster strong communities where their employees work and live.
HIV / AIDS Cancer / Oncology Cardiovascular Diseases & Systems +5 more

Stout Foundation Grant

The Charles H. Stout Foundation
Private
United Kingdom, United States
Up to US $33,000
The Stout Foundation Grant supports organizations aligned with the values of its founder, Mr. Stout. Grants are awarded exclusively to entities with 501(c)(3) tax-exempt status and focus on charitable, educational, and scientific purposes. Preference is given to organizations with low overhead costs and those located in areas frequented by Foundation members. The Foundation aims to promote effective use of funds while remaining flexible in its grant-making approach.
Child Abuse & Neglect Animal Welfare - General Literacy +5 more

MacKenzie Foundation Grant

Scott R. MacKenzie Foundation
Private
United States
Unspecified amount
The Scott R. MacKenzie Foundation offers grants to support innovative genetic research aimed at advancing cures for diseases like cancer, diabetes, lung, and heart diseases. Only U.S.-based tax-exempt organizations with over five years of operation can apply. The Foundation emphasizes collaboration among research entities to enhance genome sequencing and disease detection. By funding these initiatives, they aim to foster awareness and progress in genetic research for future generations.
Cancer / Oncology Cardiovascular Diseases & Systems Endocrine & Metabolic Diseases

BNSF Railway Foundation Grant Program

BNSF Foundation
Private
Acadia Parish, Louisiana, Adams County, Colorado +658 more
US $1,000 - US $10,000
The BNSF Railway Foundation provides grants to enhance community quality of life across 28 states, focusing on educational, cultural, and social service initiatives. With over $150 million contributed since 2000, the foundation emphasizes projects with strong local engagement and BNSF employee involvement. Eligible organizations include public charities, local governments, and tribal governments, while ineligible entities encompass religious organizations and those with discriminatory practices. Priority is given to environmental, health, and cultural projects.
Recreation Environment Art & Culture +6 more

Lillian and Larry Goodman Foundation Grant

Lillian and Larry Goodman Foundation
Private
Israel, United States
Unspecified amount
The Lillian and Larry Goodman Foundation Grant focuses on enhancing Jewish life in the U.S. and Israel, addressing drug abuse, and combating hunger. Established in 1994, the foundation supports various charitable organizations, prioritizing the preservation of Jewish culture and child welfare. It funds programs in Israel, particularly in Be'er Sheva, and aims to strengthen communities in Chicago and beyond. The foundation emphasizes mental health, substance abuse prevention, and food security initiatives.
Jewish Culture Judaism

FWW: Research Award

Foundation for Womens Wellness Inc.
Private
United States
Unspecified amount
The FWW Research Award supports innovative, short-term studies aimed at enhancing women's health, particularly in areas such as cardiovascular disease, female cancers, and hormonal impact on health. Eligible applicants include MDs and PhDs affiliated with accredited institutions. The program prioritizes research with direct clinical applications and seeks proposals that promise to attract additional funding for further study. Notably, sociological research is excluded from funding consideration.
Women's Health

Alkermes Medical Education Grants

Alkermes
Corporate
United States
Unspecified amount
Alkermes Medical Education Grants support educational initiatives aimed at enhancing patient care through continuing medical education. Proposals are invited for activities related to schizophrenia, bipolar disorder, narcolepsy, and idiopathic hypersomnia. Funding is available for various CME formats, focusing on practical training and understanding treatment complexities. Eligible applicants include U.S.-based organizations that are either non-profit or accredited CME providers. This initiative prioritizes innovative strategies to improve healthcare outcomes and knowledge dissemination.
Addiction & Substance Use Disorders Mental Health & Psychiatric Diseases Sleep

WKKF Grant

WK Kellogg Foundation
Private
Haiti, Mexico +1 more
Unspecified amount
The WKKF Grant, offered by the W.K. Kellogg Foundation, is dedicated to fostering a future where every child and family thrives. With a focus on nurturing early education, accessible healthcare, and equitable food systems, this grant supports initiatives that empower communities across the U.S. and parts of Mexico and Haiti. Organizations meeting IRS regulations and being legal entities, particularly 501(c)(3) nonprofits, are encouraged to apply for funding to create lasting impacts in their communities.
Maternal And Perinatal Health Dental Health Workforce Preparation & Job Readiness +11 more

ICRG Seed Grant

International Center for Responsible Gaming
Private
United States
Up to US $40,000
The ICRG Seed Grant supports innovative research aimed at understanding and treating gambling disorders. With a focus on pilot studies, secondary data analysis, and developing new methodologies, it encourages both established and early-career researchers to apply for funding up to $40,000. The grant emphasizes the importance of addressing critical issues in gambling research while ensuring the inclusion of diverse participant groups. This initiative aims to enhance public education and promote responsible gaming practices.
Addiction & Substance Use Disorders

Missouri Grants for Nonprofits Highlights

Missouri grants for nonprofits provide funding to support education, healthcare, rural development, and community engagement programs. The following grants empower organizations to tackle local challenges, enhance sustainability, and improve quality of life across Missouri.


Search Instrumentl's Missouri Grants Database


Discover 136 funding opportunities for nonprofits in Missouri, with $47.6M available. Instrumentl supports organizations with strategic grant discovery, deadline tracking tools, and funder insights to drive impactful programs across the state.

Last updated: October 5, 2026. Next update: November 1, 2026.

Grant Insights : Missouri Grants for Nonprofits

Grant Availability

How common are grants in this category?

Common — grants in this category appear regularly across funding sources.

100+ Missouri grants for nonprofits grants for nonprofits in the United States, from private foundations to corporations seeking to fund grants for nonprofits.

37 Missouri grants for nonprofits over $25K in average grant size

29 Missouri grants for nonprofits over $50K in average grant size

25 Missouri grants for nonprofits supporting general operating expenses

100+ Missouri grants for nonprofits supporting programs / projects

3,000+ Grants on Instrumentl focused on Education

2,000+ Grants on Instrumentl focused on Human & Social Services

Grant Deadline Distribution

Over the past year, when are grant deadlines typically due for Missouri grants for Nonprofits?

Most grants are due in the first quarter.

Q1
33.7%
Q2
26.8%
Q3
18.7%
Q4
20.8%

Typical Funding Amounts

What's the typical grant amount funded for Missouri Grants for Nonprofits?

Grants are most commonly $13,750.

$375 $375 Min.
$13,750 $13.8 K Median
$587,301 $587.3 K Average
$40,331,313 $40.3 M Max.

Frequently asked questions

Missouri nonprofits have access to a vast selection of funding opportunities. Currently, more than 100+ unique grants are available, with a total of $47,571,363 in funding. The median grant award in Missouri is $13,750. Of these opportunities, 37 grants exceed $25,000, with 25 grants funding general operating expenses and 100+ grants funding specific programs and projects.

Missouri nonprofits can tap into a wide network of funding sources, including federal programs, private foundations, associations, and corporate sponsors. Here’s a breakdown of available grants:

  • Private funders: Private foundations offer the majority of funds in Missouri, with over 79 grants available, focusing on ecosystem restoration and environmental conservation.
  • State and Local Governments: The state of Missouri offers 25 grants, primarily for recreation, agriculture, and farming.
  • Corporate Funders: Corporate foundations support 21 grants, focusing on children’s mental health and public safety.

While government grants provide large awards, keep in mind that they require substantial compliance.

To maximize your chances of success, it's important to apply for grants in Missouri at the right time. According to current data, Q1 is the best time to submit applications, with 33.7% of grant deadlines falling during this quarter. Q2 and Q4 follow behind, accounting for 26.8% and 20.8% of grant deadlines, respectively. However, Q3 is the slowest, with only 18.7% of grants accepting applications. It is important to keep this data in mind when planning your annual grants strategy.

Grant funding in Missouri has greatly increased over the past several years. IRS funding reports indicate that the total grant funding in Missouri surged from $3.7 billion in 2021 to $4.5 billion in 2022. This marks a 22.12% increase in funding for Missouri. The largest areas for funding included single-organization support, professional societies and associations, and alliance/advocacy organizations. The top-funded counties in Missouri during this time were St. Louis County, Jackson County, and St. Louis City.

Finding the right grant can be overwhelming, but Instrumentl streamlines the grant discovery process by identifying specialized grants that align with nonprofit missions in Missouri. Beyond tracking the latest opportunities, the platform also sends deadline reminders, organizes multiple applications at once, and analyzes funder-giving trends to improve success rates.

If you are interested in finding foundation grants, see how Instrumentl can help.

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